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Murine model of invasive pulmonary Aspergillosis: Follow-up of tissue injury, fungal burden and mortality with distinct elastase production strains.

Abstract：

:To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutropenic animals exhibited 100% mortality in 5 days, for both strains, and were observed survival curves overlapped, lungs with angioinvasion, rupture of bronchial and vascular walls, associated with exuberance of conidia filamentation. The immunocompetent animals infected with the lower elastase producer strain presented with upregulated inflammatory processes, and a lack of conidia filamentation in the tissue. The fungal burden in the lungs was not different in the immunocompetent and neutropenic groups. These findings confirm the protective role of neutrophils against A. fumigatus and suggest that the fungal elastinolytic activity is not a critical virulence factor but may be involved in tissue injury.

journal_name

J Mycol Med

journal_title

Journal de mycologie medicale

authors

Silva RLH,Rosa-Milani E,Brunaldi MO,Maffei CML

doi

10.1016/j.mycmed.2018.10.003

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

112-119

issue

2

eissn

1156-5233

issn

1773-0449

pii

S1156-5233(18)30190-2

journal_volume

29

pub_type

杂志文章

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