Abstract:
OBJECTIVE:Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. MATERIALS AND METHODS:Selected plant parts were collected, shade dried and powdered. Plant powders were extracted with ethanol and their antifungal potency was investigated against and clinical dermatophytes. The antioxidant effect of the extracts was screened using DPPH assay. Minimal Inhibitory Concentration (MIC) and Minimal Fungicidal Concentration (MFC) were estimated for the extracts. Ten plant extracts showed maximum MFC and they were selected to study their efficacy in interfering with ergosterol biosynthesis. Fluconazole-35μg/mL known fungicide was used as control. The most active extracts were taken for biocompatibility studies using 3T3-L1 fibroblast cell lines. RESULTS:The ethanol extract of Phyllanthus reticulates leaves showed good antifungal activity compared to other plant extracts. The MIC and MFC for Phyllanthus reticulatus were 62.5 and 250μg/mL against M. pachydermatitis and T. rubrum respectively. The ethanol extracts of Phyllanthus reticulatus, Coldenia procumbens, Thespesia populnea and Senna alata significantly lowered the release of ergosterol by 16.37, 19.53, 24.79, and 21.44%, respectively. The ethanol extract of Phyllanthus reticulatus leaves was more biocompatible to host cells than other active extracts. CONCLUSION:Our study indicated that the ethanol extract of Phyllanthus reticulates leaves showed promising activity against dermatophytes. It could be a potential material for future development of antidermatophytic agents.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Chellappandian M,Saravanan M,Pandikumar P,Harikrishnan P,Thirugnanasambantham K,Subramanian S,Hairul-Islam VI,Ignacimuthu Sdoi
10.1016/j.mycmed.2017.11.001subject
Has Abstractpub_date
2018-03-01 00:00:00pages
143-149issue
1eissn
1156-5233issn
1773-0449pii
S1156-5233(16)30271-2journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:The aim of this study was the detection of Aspergillus species and Mycobacterium tuberculosis together in bronchoalveolar lavage (BAL) using of multiplex PCR. MATERIAL AND METHODS:In this study, from September 2012 until June 2013, 100 bronchoalveolar lavage (BAL) specimens were collected from patients suspe...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2015.02.041
更新日期:2015-06-01 00:00:00
abstract::To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.mycmed.2017.02.007
更新日期:2017-06-01 00:00:00
abstract::Dermatophytes are responsible for widespread superficial fungal infections, currently representing a real public health problem. Some of the fungi involved in these mycoses are transmitted by pets, illustrating great host specificity within this fungal group. Thus, a new variety of zoophilic dermatophyte has been desc...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.05.005
更新日期:2016-09-01 00:00:00
abstract::Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.003
更新日期:2019-12-01 00:00:00
abstract::The growing trends of emergence of antifungal-resistant Candida strains has recently been inspired the researchers to design new antifungal agents with novel mechanisms of action. Glabridin is an originally natural substrate with multiple biological activities which propose it as a novel anticancer, antimicrobial and ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.05.002
更新日期:2017-09-01 00:00:00
abstract::Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans a...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.10.004
更新日期:2017-03-01 00:00:00
abstract::Currently, marine organisms have a very important source of new molecules in pharmacology and thus in the development of new bioactive products. The organic and aqueous extracts of two marine sponges, Cinachyrella tarentine collected during two different seasons, winter and summer, and Cliona viridis collected in two ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2010.11.005
更新日期:2011-03-01 00:00:00
abstract::Diagnosis of invasive aspergillosis for patients with high risk of infection is based on the monitoring of Aspergillus antigenemia assessed by the detection of galactomannan in serum by a sandwich-type ELISA (Biorad(®)). The validation of the method was displayed according to the guide COFRAC SH GTA 04. The internal q...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.12.048
更新日期:2013-03-01 00:00:00
abstract::Yeasts can adhere to medical implants and cause infections responsible for high morbidity and mortality among hospitalized patients. The objective of this study is to investigate the infectivity on peripheral vascular catheters collected from general surgery and cardiology in University Hospital of Tlemcen. The result...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2017.10.002
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Rhizopus microsporus is one of the main causative agents of mucormycosis. These mycoses are mostly described as isolated cases involving uncontrolled diabetes mellitus or immunosuppressed patients. In this work we report a nosocomial outbreak of mucormycosis due to R. microsporum involving three young immuno...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.09.002
更新日期:2018-12-01 00:00:00
abstract::Candida nivariensis is a cryptic fungal species classified within the Candida glabrata complex. It was described for the first time in 2005 by the means of DNA sequencing. We report a rare case of C. nivariensis deep-seated infection occurring in a 77-year-old man hospitalized for cysto-prostatectomy. Phenotypic testi...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2020.101042
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Definition, diagnosis and treatment of allergic fungal sinusitis remain difficult and controversial despite the increasing number of publications. We report a case of an allergic fungal sinusitis with a review of the literature. CLINICAL CASE:A 45-year-old man consulted for sinusal polyposis resistant to ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2015.09.007
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS AND METHODS:This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2013.11.004
更新日期:2014-06-01 00:00:00
abstract:UNLABELLED:Yeasts occur as part of the normal human microbiota. Nevertheless, some species are opportunistic, affecting immunocompromised patients such as those undergoing oncologic treatment. OBJECTIVE:To detect the presence of yeasts in patients suffering from head and neck cancer who are receiving radiation therapy...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.08.002
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.12.002
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:Candida albicans is the most prevalent fungal pathogen in humans. Due to the development of drug resistance, there is today a need for new antifungal agents for the efficient management of C. albicans infections. Therefore, we reviewed antifungal activity, mechanisms of action, possible synergism with anti...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2016.10.002
更新日期:2017-03-01 00:00:00
abstract::One hundred and twenty-five samples were collected from eight different sites in the vicinity of Sanjay Gandhi National Park (SGNP) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. Seventy-three isolates were recovered and identified. The cultures were identified using ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.08.004
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:The increasing importance of dermatophytoses and emerging resistance of dermatophytes to current synthetic antifungals have stimulated the search for safer and more effective alternative drugs from natural sources. The present study was carried out to identify antagonistic bacteria of soil origin with strong ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.01.117
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Otomycosis, a superficial fungal infection of the external auditory canal (EAC), is a disease with exceptionally high prevalence. AIM:The aim of this study was to determine the prevalence of otomycosis, the distribution of causative species and to evaluate epidemiological characteristics of these infectio...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101011
更新日期:2020-09-01 00:00:00
abstract::In the end of May 2012, a meeting of the group "sérodiagnostic fongique" of the "Société française de mycologie médicale" had concerned quality controls to use, in particular, in the follow-up of Elisa techniques. A preliminary investigation showed that the internal quality controls (CIQ), according to the terms defin...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.11.001
更新日期:2013-03-01 00:00:00
abstract::Tineabarbae is a rare form of dermatophytosis that affects hair follicles of the beard and moustache. Dermoscopy could prove useful to identify parasitism of hair of the beard, just as it has proven useful in the diagnosis of Tineacapitis. We present the first fully documented case series of T. barbae with clinical, d...
journal_title:Journal de mycologie medicale
pub_type:
doi:10.1016/j.mycmed.2020.101104
更新日期:2020-12-15 00:00:00
abstract::The authors report a case of multifocal African histoplasmosis with polymorphic skin involvement occuring in a patient without proven immunosuppression. He was a young 22-year-old patient from eastern Senegal - but born in Ouganda - who presented with polymorphic skin lesions: ombilicated papulo-nodules, gums and ulce...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.03.004
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Dermatophytes are taxonomically classified in the genera Trichophyton, Microsporum, and Epidermophyton. Pleomorphism, cultural variability, slow growth and sporulation, and the need for additional physiological tests make dermatophytes notoriously difficult to identify. The present study aimed to compare the ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.10.022
更新日期:2015-03-01 00:00:00
abstract::The aim of this research is to verify the yeast species isolated from oral mucosa in street mixed-breed dogs and to determine the antifungal profiles. After capturing and sedating the animals, oral mucosa samples were collected from fifty dogs and the materials were inoculated on Sabouraud dextrose agar with chloramph...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101010
更新日期:2020-12-01 00:00:00
abstract::Symptomatic candiduria often occurs in patients with indwelling bladder catheters or immunocompromised host. Isolation of Candida in urine in high-risk patients should primarily be considered as a marker for candidemia. Hematological and genitourinary malignancies are one of the main risk factors associated with Candi...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2017.01.006
更新日期:2017-06-01 00:00:00
abstract::Emericella nidulans is a species that has only rarely been implicated in human disease after cataract surgery. Here, we report the first postoperative case in the literature, as far as we know. The patient was a 50-year-old patient presented with mild anterior uveitis one week after cataract surgery, and hypopion deve...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2015.12.010
更新日期:2016-09-01 00:00:00
abstract::This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.09.002
更新日期:2015-03-01 00:00:00
abstract:UNLABELLED:Onychomycosis is the most common nail disease and its prevalence in the literature is estimated between 18 and 50%. The main objective of this study is to describe the epidemiology of onychomycosis and specify the most frequently fungal agents isolated at the University Hospital of Casablanca. MATERIAL AND ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.10.002
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Unive...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.002
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:This study aimed at providing original data on fungemia in the Centre Hospitalier de Mayotte in terms of prevalence, epidemiological characteristics of infected patients, yeast species distribution and profile of in vitro antifungals susceptibility. METHODS:A total of 223 positive blood cultures for yeasts w...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101081
更新日期:2020-11-18 00:00:00