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Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum.

Abstract：

:This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined with deferasirox. Smaller lesions were observed in infected rabbits receiving the combination therapy, although it favored disease dissemination to the lungs. The present results show that micafungin alone is ineffective against P. insidiosum, and the combination micafungin-deferasirox might have deleterious effects for the host.

journal_name

J Mycol Med

journal_title

Journal de mycologie medicale

authors

Zanette RA,Jesus FP,Pilotto MB,Weiblen C,Pötter L,Ferreiro L,Alves SH,Santurio JM

doi

10.1016/j.mycmed.2014.09.002

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

91-4

issue

1

eissn

1156-5233

issn

1773-0449

pii

S1156-5233(14)00261-3

journal_volume

25

pub_type

杂志文章

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