Abstract:
OBJECTIVE:The effect of candidemia on immunologic parameters in breast tumor bearing patients is not well studied. Here, we hypothesised that candidemia in the tumor background may change the outcome of immunologic parameters and tumor condition. METHOD:Mice were divided into four groups, including normal, tumor, Candida infected (only Candidiasis) and tumor/Candidiasis groups. Tumor changes were recorded daily after tumor transplantation and induction of candidemia. Splenocytes of mice were harvested, cultured, and stimulated with PHA; afterwards, IL-4, IL-10, IFN-γ, TNF-α and TGF-β cytokines were assessed using ELISA kits. We also evaluated the population of CD4+CD25+Foxp3+ regulatory T cells in the tumor infiltrated and splenocytes. RESULTS:The results showed that infection with C. albicans decreased the IFN-γ/IL-4 ratio in tumor/candidiasis and candidiasis groups versus their non-infected controls. IL-10, TGF-β and TNF-α levels increased in the candidiasis group. In addition, Candidemia led to an increase in the Treg population in tumor microenvironment and splenocytes of experimental groups compared with non-infected controls. Finally, candidemia increased tumor growth of tumor/Candidiasis group compared with the tumor group. CONCLUSION:It seems that systemic infection with C. albicans could not only induce regulatory T cells but also result in dysregulation of cytokine network and thereby facilitate tumor growth.
journal_name
J Mycol Medjournal_title
Journal de mycologie medicaleauthors
Ahmadi N,Ahmadi A,Kheirali E,Hossein Yadegari M,Bayat M,Shajiei A,Amini AA,Ashrafi S,Abolhassani M,Faezi S,Yazdanparast SA,Mahdavi Mdoi
10.1016/j.mycmed.2018.10.006subject
Has Abstractpub_date
2019-04-01 00:00:00pages
49-55issue
1eissn
1156-5233issn
1773-0449pii
S1156-5233(18)30182-3journal_volume
29pub_type
杂志文章abstract::Diagnosis of invasive aspergillosis for patients with high risk of infection is based on the monitoring of Aspergillus antigenemia assessed by the detection of galactomannan in serum by a sandwich-type ELISA (Biorad(®)). The validation of the method was displayed according to the guide COFRAC SH GTA 04. The internal q...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.12.048
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Vulvovaginal candidiasis (VVC) is the most prevalent vaginitis in women, accounting for 10 million medical referrals a year. Vaginal clotrimazole is a drug of choice for VVC treatment. However, increased drug resistance to this microorganism has led to an interest in naturally derived antifunga...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mycmed.2017.07.003
更新日期:2017-12-01 00:00:00
abstract::One hundred and twenty-five samples were collected from eight different sites in the vicinity of Sanjay Gandhi National Park (SGNP) and screened for the presence of keratinophilic fungi using hair baiting technique for isolation. Seventy-three isolates were recovered and identified. The cultures were identified using ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.08.004
更新日期:2014-12-01 00:00:00
abstract:THE AIM:The daily aeromycological monitoring of fungal spores in the city of Tetouan during the period 2009-2011, to determine their diversity, their predominance and their interannual and seasonal variation. MATERIAL AND METHODS:The spore sampling was undertaken using a Burkard volumetric spore trap. RESULTS:The out...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.02.018
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:Dermatophytes are taxonomically classified in the genera Trichophyton, Microsporum, and Epidermophyton. Pleomorphism, cultural variability, slow growth and sporulation, and the need for additional physiological tests make dermatophytes notoriously difficult to identify. The present study aimed to compare the ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.10.022
更新日期:2015-03-01 00:00:00
abstract::Malassezia pachydermatis is an important opportunistic agent of dermatitis and otitis in dogs. M. pachydermatis is generally treated with topical therapies using combinations of antifungal, antimicrobial and anti-inflammatory agents. We investigated the in vitro activities of carvacrol (CRV), cinnamaldehyde (CIN) and ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.003
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE OF THE STUDY:Candidiasis and dermatophytoses are benign infections in humans and animals, but they are very dreaded diseases in immunocompromised individuals. These infections become resistant to different treatments which make them more dangerous. In this work, we tried to find a new way for treating them. S...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.06.003
更新日期:2018-09-01 00:00:00
abstract::Tricyclazole as a common fungicide wildly used to control rice blast disease in the Asian country may induce azole resistance in Aspergillus fumigatus isolates. The main reason of the acquired azole resistance is probably environmental exposure through wide fungicide use in agriculture. The present study was conducted...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.12.007
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Candidemia is a nosocomial infection of increasing importance, associated with high morbidity and mortality. The aim of this study is to describe the species distribution, risk factors, management and outcomes of patients with candidemia. METHODS:We conducted a retrospective study at Centro Hospitalar Unive...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.08.002
更新日期:2019-12-01 00:00:00
abstract::To study invasive pulmonary Aspergillosis (IPA), we depleted neutrophils in mice using the monoclonal antibody anti-Gr-1/Ly-6G. Immunocompetent and neutropenic mice were infected via intratracheal with conidia of Aspergillus fumigatus clinical isolates, characterized as either higher or lower elastase producers. Neutr...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.10.003
更新日期:2019-06-01 00:00:00
abstract::Currently, marine organisms have a very important source of new molecules in pharmacology and thus in the development of new bioactive products. The organic and aqueous extracts of two marine sponges, Cinachyrella tarentine collected during two different seasons, winter and summer, and Cliona viridis collected in two ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2010.11.005
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:In this study, we demonstrate that vitamin D3 had fungicidal activity against Candida albicans. MATERIAL AND METHODS:The susceptibility of the yeast strain to the vitamin D3 was investigated by the antimicrobial screening using modified agar diffusion method, minimum fungistatic concentrations (MFCs) and min...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.10.003
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:This study aimed at providing original data on fungemia in the Centre Hospitalier de Mayotte in terms of prevalence, epidemiological characteristics of infected patients, yeast species distribution and profile of in vitro antifungals susceptibility. METHODS:A total of 223 positive blood cultures for yeasts w...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101081
更新日期:2020-11-18 00:00:00
abstract::Mycetomas are localized chronic inflammatory infectious diseases involving subcutaneous tissues, skin and bones. We report a case of mycetoma in a 40-year-old farmer from the north of Senegal. The clinical appearance of the lesions suggested primarily the diagnosis of a soft tissue malignant tumor. Mycetoma diagnosis ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2013.10.002
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:Otomycosis, a superficial fungal infection of the external auditory canal (EAC), is a disease with exceptionally high prevalence. AIM:The aim of this study was to determine the prevalence of otomycosis, the distribution of causative species and to evaluate epidemiological characteristics of these infectio...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101011
更新日期:2020-09-01 00:00:00
abstract::Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involv...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.09.005
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Comparing the activities of secreted enzymes in different fungal species can improve our understanding of their pathogenic role. Secretion of various enzymes by Candida species has been considered for determination of their virulence in different Candida infections including vulvovaginitis. AIMS:The aim o...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2017.01.009
更新日期:2017-06-01 00:00:00
abstract::This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.09.002
更新日期:2015-03-01 00:00:00
abstract::Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.03.005
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:This study was carried out to show possible similarities between discoid lupus erythematosus clinical signs and histopathological findings and dermatophytosis. PATIENT AND METHODS:A 43-year-old woman with diffused erythematous scaling lesions on her neck was studied. Skin biopsy was performed using H&E and P...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2011.12.001
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to evaluate the anticandidal activity of biologically synthesized silver nanoparticles using the culture filtrate of Streptomyces sp.VITPK1. MATERIALS AND METHODS:Silver nanoparticles were synthesized using the culture filtrate of Streptomyces species isolated from brine spr...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2014.03.004
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS AND METHODS:This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2013.11.004
更新日期:2014-06-01 00:00:00
abstract::Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans a...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.10.004
更新日期:2017-03-01 00:00:00
abstract::Mucormycosis is a progressive, opportunistic fungal infection with a high risk of mortality. Also mucormycosis may attack any organ system and may be accompanied by hemodynamic instability and difficult airway management. This study aimed to evaluate the anesthetic management of patients undergoing surgical resection ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2019.07.001
更新日期:2019-09-01 00:00:00
abstract::Three chalcones, 2'-hydroxy-4,4',6'-trimethoxychalcone, 2'-hydroxy-4,4',6'-tetramethoxychalcone, and 3,2'-dihydroxy-4,4',6'-trimethoxychalcone, were isolated from the leaves of Piper hispidum in a bioguided fractionation of crude extract. The antimicrobial activity of crude extract of P. hispidum leaves was determined...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.03.002
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To determine the fungal species isolated from skin lesions of different animals suspected of having dermatomycoses and their prevalence in different regions of Iran. MATERIALS AND METHODS:A total of 1011 animals (292 dogs, 229 cats, 168 horses, 100 camels, 98 cows, 60 squirrels, 37 birds, 15 sheep, 6 goats, ...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2016.04.007
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:In Mauritania, only an investigation carried out 26 years ago allows to report epidemiological findings about tinea capitis in Nouakchott. The objective of this study was to reactualize the tinea capitis epidemiological, clinical and mycological profile in school children and to compare this profile in urb...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2020.101048
更新日期:2020-10-13 00:00:00
abstract::The research concerns algae of the genus Prototheca. They are found in the natural environment and they can cause a disease in animals and humans called protothecosis. The aim of the study was to evaluate the in vitro activity of the fruit and vegetable rinse agent SunSmile® Fruit & Vegetable Rinse (Sunrider Internati...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2018.03.008
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:In this paper, we describe the preparation and synthesis of several enynediesters, conjugated diynes and acetylenic compounds from starting materials comprising one hydroxyl and one acetylenyl group and their antifungal activity. MATERIALS AND METHODS:For synthesis of the compounds, a combined solution of N,...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章
doi:10.1016/j.mycmed.2012.06.001
更新日期:2012-09-01 00:00:00
abstract::Saksenaea vasiformis is an emerging human pathogen, belonging to the order Mucorales of the subphylum Mucormycotina, most often associated with rhino-cerebral, cutaneous and subcutaneous infections following trauma. A review of the published literature was attempted on the occasion of a cutaneous leg infection with fa...
journal_title:Journal de mycologie medicale
pub_type: 杂志文章,评审
doi:10.1016/j.mycmed.2019.06.005
更新日期:2019-09-01 00:00:00