Abstract:
:Endoscopic ultrasound guided fine-needle aspiration biopsy is a reliable and accurate method for the diagnosis of submucosal lesions of the gastrointestinal tract. We report the cytopathologic findings of a case of duodenal high-grade neuroendocrine carcinoma in a 68-year-old woman who presented with melena and marked anemia, 45 years after kidney transplantation. Imaging studies performed in the work-up of melena showed a duodenal mass, which on endoscopy proved to be an exophytic, villous duodenal lesion, 3 cm from the ampulla. Forceps biopsy of the exophytic lesion showed a villous adenoma. Endoscopic ultrasound additionally revealed an underlying submucosal lesion and EUS-guided fine needle aspiration of this submucosal mass and of the enlarged mesenteric lymph nodes was diagnostic of a high-grade neuroendocrine carcinoma. The aspirates showed abundant cellularity with tumor cells arranged in sheets and occasional loose clusters. The neoplastic cells had a moderate amount of pale cytoplasm and large round to oval hyperchromatic nuclei with focally prominent nucleoli. Mitoses, apoptotic bodies and necrotic debris were also present. The tumor cells were strongly and diffusely positive for cytokeratin AE1/AE3, synaptophysin and chromogranin and showed a very high proliferative fraction on Ki67 staining, supporting the diagnosis of a high-grade neuroendocrine carcinoma. This is to our knowledge the first case of high-grade neuroendocrine carcinoma of the duodenum diagnosed by EUS-FNA. This case also emphasizes the diagnostic value of EUS-FNA sampling of the submucosal and intramural component of villous tumors of the gastrointestinal tract when mucosal forceps biopsies show only benign findings.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Tasso DM,Attam R,Aslan DL,Pambuccian SEdoi
10.1002/dc.21603subject
Has Abstractpub_date
2012-01-01 00:00:00pages
62-8issue
1eissn
8755-1039issn
1097-0339journal_volume
40pub_type
杂志文章abstract::Collagenous spherulosis of the breast is a rare incidental finding frequently associated with other benign lesions of the breast. The estimated incidence of this innocuous condition is only about 0.2% in cytological material. It is of utmost importance to differentiate collagenous spherulosis from its malignant mimics...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.20632
更新日期:2007-06-01 00:00:00
abstract::Fine-needle aspiration (FNA) of the thyroid for papillary carcinomas is highly sensitive. We sought to determine if the sensitivity of FNA for papillary carcinoma is correlated with the size of the tumor. We reviewed the results of thyroid resections for the last 12 years and correlated the findings with clinical and ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:High-risk Human papillomavirus (HR-HPV)-associated head and neck squamous cell carcinoma (HNSCC) is a distinct epidemiologic and pathologic disease. The data of HR-HPV testing on fine-needle aspiration (FNA) materials of cervical lymph nodes in patients with metastatic HNSCC are limited. METHODS:We retrospe...
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更新日期:2016-10-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199806)18:6<449::aid-dc13>
更新日期:1998-06-01 00:00:00
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journal_title:Diagnostic cytopathology
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更新日期:1991-01-01 00:00:00
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journal_title:Diagnostic cytopathology
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更新日期:1999-09-01 00:00:00
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199809)19:3<221::aid-dc14>
更新日期:1998-09-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.22858
更新日期:2012-06-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1995-06-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/1097-0339(200008)23:2<127::aid-dc13>3.0.co
更新日期:2000-08-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840010406
更新日期:1985-10-01 00:00:00
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doi:10.1002/dc.24080
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
abstract:INTRODUCTION:Urothelial carcinoma (UCC) of the bladder is the most common malignancy of the urinary tract. The performance of urine cytology (UCy) after radical cystectomy (RC) and urinary diversion is quite variable and there is no consensus regarding its role in post-treatment surveillance. The goal of this study is ...
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journal_title:Diagnostic cytopathology
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更新日期:2014-04-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20826
更新日期:2008-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23694
更新日期:2017-06-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
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journal_title:Diagnostic cytopathology
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doi:10.1002/dc.24690
更新日期:2021-01-02 00:00:00
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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更新日期:2016-12-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00