Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum.

Abstract:

:Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Two males with bloody ND, one, without any palpable mass and another with underlying mass, were evaluated on ND cytology. The presence of loose papillaroid clusters and cell sheets with mild atypia was seen in ND smears itself in case 1. The discharge was more copious in case 2, but the ND smears were paucicellular. The presence of tall columnar cells in ND smears as well as in the FNA from underlying mass with clear features of malignancy was helpful in reaching the diagnosis of papillary carcinoma in case 2. Histopathology in case 1 was a spectrum of ADH to DCIS, whereas in case 2, was tubulopapillary carcinoma. Following two cases highlight the importance of the cytological evaluation of ND smears.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Sood N

doi

10.1002/dc.24080

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

121-126

issue

2

eissn

8755-1039

issn

1097-0339

journal_volume

47

pub_type

杂志文章
  • Cytodiagnosis of primary thyroid lymphoma with histologic correlation: A case report.

    abstract::Primary thyroid lymphoma is a very rare disease. Here, we present a case of primary diffuse large B-cell lymphoma (DLBCL) in a 48-year-old female involving thyroid gland. The patient had thyroid swelling for 15 years which rapidly increased during last 5 months. Fine needle aspiration cytology revealed monomorphic lar...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21730

    authors: Mondal SK

    更新日期:2012-05-01 00:00:00

  • Epithelioid angiosarcoma: a neoplasm with potential diagnostic challenges.

    abstract::Epithelioid angiosarcomas are extremely rare tumors associated with poor prognosis and early metastases. Its epithelioid cytomorphology and limited vasoformation make it difficult to distinguish from more common malignancies, such as, carcinoma. This can be a potential diagnostic pitfall for the cytopathologist. In th...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21187

    authors: Lin CF,DeFrias D,Lin X

    更新日期:2010-02-01 00:00:00

  • Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

    abstract::Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24042

    authors: Ishida M,Arimoto T,Sandoh K,Okano K,Ebisu Y,Ito H,Matsumoto M,Mizokami T,Kita M,Okada H,Tsuta K

    更新日期:2019-03-01 00:00:00

  • Pilomyxoid astrocytoma of the pineal region: cytopathological features and differential diagnostic considerations by intraoperative smear preparation.

    abstract::Pilomyxoid astrocytoma (PMA) is a recently identified type of pilocytic astrocytoma (PA) with shorter progression-free and overall survival, higher rate of recurrence, and higher risk of leptomeningeal spread compared to pilocytic tumors (WHO grade 2 designation). A case is presented here in which intraoperative impri...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23133

    authors: Hayashi T,Haba R,Kushida Y,Katsuki N,Shibuya S,Kadota K,Matsunaga T,Miyake K,Tamiya T

    更新日期:2015-02-01 00:00:00

  • Leiomyosarcoma of the urinary bladder: a diagnostic challenge in urine cytology.

    abstract::Most of the available data in the literature describe the cytomorphological features of exfoliated malignant epithelial cells in urine. There are no established diagnostic features that characterize the morphology of exfoliated malignant mesenchymal tumor in urine. Here we highlight the problems in the diagnosis of th...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20053

    authors: Hemachandran M,Nada R,Rajwanshi A

    更新日期:2004-10-01 00:00:00

  • Hormone receptor status and HER2/neu overexpression determined by automated immunostainer on routinely fixed cytologic specimens from breast carcinoma: correlation with histologic sections determinations and diagnostic pitfalls.

    abstract::Although fine-needle aspiration cytology is a routine procedure for the diagnosis of breast carcinoma, cytologic specimens have rarely been used for evaluation of hormone receptor status and HER2/neu overexpression. In order to compare the biological markers on cytology and on histology, routinely fixed smears of 110 ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20007

    authors: Moriki T,Takahashi T,Ueta S,Mitani M,Ichien M

    更新日期:2004-04-01 00:00:00

  • Paranuclear blue inclusions: an aid in the cytopathologic diagnosis of primary and metastatic pulmonary small-cell carcinoma.

    abstract::Accurate diagnosis of small-cell carcinoma of the lung (SCLC) is clinically important because of the therapeutic implications. SCLC must be distinguished from non-small-cell carcinoma (NSCLC) and lymphoma. Paranuclear blue inclusions (PBIs) were recently described as a feature of metastatic SCLC on air-dried Wright-st...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840100408

    authors: Mullins RK,Thompson SK,Coogan PS,Shurbaji MS

    更新日期:1994-01-01 00:00:00

  • Application of immunostaining for muscle specific actin in detection of myoepithelial cells in breast fine-needle aspirates.

    abstract::Myoepithelial cells play an important role in the interpretation of breast fine-needle aspiration biopsy, since these cells are believed to be a component of a benign process in breast lesions. Myoepithelial cells are usually easy to recognize, however, other cells can morphologically simulate myoepithelial cells and ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840130115

    authors: Masood S,Lu L,Assaf-Munasifi M,McCaulley K

    更新日期:1995-07-01 00:00:00

  • Distinction between bronchioloalveolar carcinoma and hyperplastic pulmonary proliferations: a cytologic and morphometric analysis.

    abstract::The objectives of this study were to identify key cytologic features for the morphologic differentiation of bronchioloalveolar carcinoma from reactive pulmonary proliferations, and to determine if morphometry of the cytologic specimens could provide additional data to distinguish the two processes. We analyzed 15 morp...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199705)16:5<396::aid-dc4>3

    authors: Zaman SS,van Hoeven KH,Slott S,Gupta PK

    更新日期:1997-05-01 00:00:00

  • Primary signet ring cell carcinoma of the pancreas: Cytopathology review of a rare entity.

    abstract::Primary signet ring cell carcinoma of the pancreas (PSRCCP) is an extremely rare diagnosis that has not been extensively studied in literature. Primary and metastatic neoplasms to the pancreas may exhibit cytomorphological similarities to signet ring cells, posing diagnostic challenges. In this article, we review PSRC...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.24324

    authors: El Hussein S,Khader SN

    更新日期:2019-12-01 00:00:00

  • Intraabdominal desmoplastic small round cell tumor: cytopathologic findings in two cases.

    abstract::Intraabdominal desmoplastic small round cell tumor (DSRCT) is an extremely rare entity. This study describes fine-needle aspiration, ascitic fluid, and touch imprint cytomorphology of DSRCT in 2 patients with extensive abdomino-pelvic disease. Cytopathologic features were unique and showed good morphologic correlation...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199806)18:6<449::aid-dc13>

    authors: Ali SZ,Nicol TL,Port J,Ford G

    更新日期:1998-06-01 00:00:00

  • Metastatic breast carcinoma in pleural fluid: Correlation of receptor and HER2 status with the primary carcinoma-a pilot study.

    abstract:BACKGROUND:Documenting the four molecular subtypes of breast carcinoma is significant as they determine response to therapy, disease free interval and survival. Our aim was to document the subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23607

    authors: Francis IM,Alath P,George SS,Jaragh M,Al Jassar A,Kapila K

    更新日期:2016-12-01 00:00:00

  • Cytomorphological patterns of M. bovis BCG and M. tuberculosis on fine needle aspiration biopsies: does HIV make a difference?

    abstract::To determine if fine needle aspiration (FNAB) of mycobacterial lymphadenopathy can differentiate infection with M. bovis BCG (BCG) from M. tuberculosis (TB) and whether HIV status affects discriminatory cytological features. A retrospective study of culture positive, fine needle aspiration biopsies of lymph nodes in c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21378

    authors: Schubert PT,Cotton MF,Wright CA

    更新日期:2011-04-01 00:00:00

  • A case of endocervical minimal deviation adenocarcinoma with varicolored cytopathologic features on Pap smear.

    abstract::We report a case of minimal deviation adenocarcinoma (MDA) of the uterine cervix showing varicolored cytopathologic features on Papanicolaou (Pap) smear, which may indicate features suggestive of lobular endocervical glandular hyperplasia (LEGH)-adenocarcinoma sequence. A 57-year-old woman presented with a profuse amo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23932

    authors: Omori M,Kondo T,Nakazawa K,Shinohara S,Watanabe Y,Fukasawa H,Nakazawa T,Hashi A,Hirata S

    更新日期:2018-08-01 00:00:00

  • Epithelioid cell granulomas in urine cytology smears: Same cause, different implications.

    abstract::Tuberculosis of the urinary tract is usually secondary to tuberculosis of the kidney. Multinucleated giant cell histiocytes, often with peripheral nuclei (Langhans' cells), may be identified. Acid-fast bacilli on smear or positive urine cultures confirm the diagnosis. Similar findings can also be seen in patients trea...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21327

    authors: Arora SK,Gupta N,Nijhawan R,Mandal AK

    更新日期:2010-10-01 00:00:00

  • Fine-needle aspiration biopsy of anaplastic large cell lymphoma, small cell variant with prominent plasmacytoid features: case report.

    abstract::Anaplastic large cell lymphoma (ALCL), according to the new WHO classification, is a diagnosis limited to T/NK cell lymphomas. We present a case that demonstrates a new morphologic variant of ALCL with significant possible pitfalls for the cytopathologist. A fine-needle aspiration biopsy of a cervical lymph node showe...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10056

    authors: Gatter KM,Rader A,Braziel RM

    更新日期:2002-02-01 00:00:00

  • Preoperative diagnosis of well-differentiated neuroendocrine tumor in common hepatic duct by brush cytology: A case report.

    abstract::The biological behavior of neuroendocrine tumors (NETs) is heterogeneous and differs from that of cholangiocarcinoma, which is the most common malignant tumor of the biliary tree. However, the preoperative diagnosis of NET in the biliary tree is extremely difficult and to our knowledge, diagnosis by brush cytology has...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24173

    authors: Choi J,Lee KJ,Kim SH,Cho MY

    更新日期:2019-07-01 00:00:00

  • Pancreatic lymphoma: A cytologic diagnosis challenge.

    abstract::Very rarely lymphoma primarily or secondarily involves the pancreas. Involvement of the pancreatic parenchyma with lymphoma clinically may mimic pancreatic ductal adenocarcinoma (PDA) and other mass-forming pancreatic lesions. Endoscopic ultrasound fine needle aspiration (EUS-FNA) is the first step in the diagnostic p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24349

    authors: Savari O,Al-Duwal Z,Wang Z,Ganesan S,Danan-Rayes R,Ayub S

    更新日期:2020-04-01 00:00:00

  • Endoscopic ultrasonography-fine needle aspiration of solid pancreatic masses: Do we need the fourth pass? A prospective study.

    abstract:BACKGROUND:Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) is important for the differential diagnosis of solid pancreatic lesions. Sample adequacy is related to the number of needle passes, and European guidelines recommend three to four needle passes with a standard EUS-FNA needle. We aimed to eval...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24669

    authors: Teodorescu C,Gheorghiu M,Zaharie T,Rusu I,Pojoga C,Bolboacă SD,Seicean R,Petrusel L,Seicean A

    更新日期:2020-11-21 00:00:00

  • Foamy alveolar casts: diagnostic specificity for Pneumocystis carinii pneumonia in bronchoalveolar lavage fluid cytology.

    abstract::Pneumocystis carinii pneumonia (PCP) is a major infectious complication of immunodeficiency states, including the acquired immunodeficiency syndrome (AIDS). Bronchoalveolar lavage (BAL) is a safe and effective procedure for making this diagnosis. In addition to the characteristic organisms, both histologic and cytolog...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840040206

    authors: Stanley MW,Henry MJ,Iber C

    更新日期:1988-01-01 00:00:00

  • Diagnosis of systemic lupus erythematosus in an elderly male by pericardial fluid cytology: a case report.

    abstract::Although pleural and pericardial effusions are common and may rarely be the initial manifestation of disease, there are few reports of SLE diagnosed in a cytopathology laboratory. We describe an unusual case of SLE in a 75-year-old man who presented with cardiac tamponade. Cytologic examination of the pericardial flui...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199805)18:5<346::aid-dc8>3

    authors: Fazio J,Friedman HD,Swerdlow J,Michiel RR

    更新日期:1998-05-01 00:00:00

  • Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

    abstract:OBJECTIVE:To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). METHODS:Patients who underwent EC surgery that included a follow-up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24444

    authors: Kilic D,Yetimalar MH,Bezircioglu I,Yigit S

    更新日期:2020-07-01 00:00:00

  • Fine-needle aspiration cytology and immunocytochemistry of orbital masses.

    abstract::A series of 85 fine-needle aspiration (FNA) biopsies from orbital space occupying lesions of 82 patients are reviewed. A total of 32 benign lesions and 49 malignant lesions were conclusively diagnosed. In two cases the aspirates were insufficient for diagnosis. Of two cases, which were cytologically suspicious for lym...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20375

    authors: Tani E,Seregard S,Rupp G,Söderlund V,Skoog L

    更新日期:2006-01-01 00:00:00

  • Sputum cytology by the Saccomanno method in diagnosing lung malignancy.

    abstract::From 1,488 patients, satisfactory sputum was available for cytologic diagnosis. Overall diagnoses were correct in 85.4% of patients, false negative in 193 patients (13.0%), and false positive in 24 patients (1.6%). In patients with a malignant lung process, cytologic diagnoses were correct in 228 patients (54.2%) and ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840010406

    authors: Risse EK,van't Hof MA,Laurini RN,Vooijs PG

    更新日期:1985-10-01 00:00:00

  • Cervical tuberculosis detection in Papanicolaou-stained smear: case report with review of literature.

    abstract::Genital tract tuberculosis is usually secondary to an extragenital tubercular focus. Cervical tuberculosis, however, is rare accounting for up to 3% of all genital tract diseases. The diagnosis of tuberculosis is usually established on multiple cervical biopsies followed by bacteriological confirmation. There are only...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.21082

    authors: Gupta R,Dey P,Jain V,Gupta N

    更新日期:2009-08-01 00:00:00

  • Cytologic diagnosis of adenocarcinoma on bile duct brushings in the presence of stent associated changes: A retrospective analysis.

    abstract:BACKGROUND:Bile duct brushing (BDB) cytology, for the characterization of bile duct strictures, can be challenging to interpret when associated with a stent. Our study aims to identify the cytologic criteria for the diagnosis of adenocarcinoma in BDBs in the presence of a stent. METHODS:A database search (January 2010...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24052

    authors: Goyal A,Sharaiha RZ,Alperstein SA,Siddiqui MT

    更新日期:2018-10-01 00:00:00

  • Prognostic value of breast cancer cytologic grading: a retrospective study of 213 cases.

    abstract::The authors evaluate 213 consecutive breast cancer cases with positive fine-needle aspiration cytology. Cytologic smears were reviewed and classified according to a grading system. A correlation between cytologic grading and pathological stage (T and N category) was observed. Univariate analysis of 5-yr overall surviv...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090210

    authors: Ciatto S,Bonardi R,Herd-Smith A,Cariaggi P,Confortini M,Bulgaresi P

    更新日期:1993-01-01 00:00:00

  • Diagnostic value of eosinophils in pleural effusion: a prospective study of 26 cases.

    abstract::Eosinophilic pleural effusions (EPFs), defined as the presence of 10% or more eosinophils in the pleural fluid, are relatively rare. Their diagnostic and prognostic significance, however, remains controversial, as most of the studies are based almost entirely on retrospective case studies. This prospective study exami...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10227

    authors: Matthai SM,Kini U

    更新日期:2003-02-01 00:00:00

  • The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions.

    abstract::Distinguishing mucinous from nonmucinous cystic lesions of the pancreas often constitutes a diagnostic dilemma. The clinical management differs between such lesions; therefore it is important to make an accurate preoperative diagnosis. Various centers have reported conflicting results regarding their ability to detect...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20558

    authors: Moparty B,Logroño R,Nealon WH,Waxman I,Raju GS,Pasricha PJ,Bhutani MS

    更新日期:2007-01-01 00:00:00

  • Myoepithelial carcinoma of the parotid gland metastatic to the kidney: case report and review of the literature.

    abstract::Myoepithelial carcinoma is a rare locally aggressive malignant neoplasm of the salivary glands. The tumor is composed almost exclusively of tumor cells with myoepithelial differentiation and characterized by infiltrative growth and potential for distant metastasis. Tumor cells often display morphologic heterogeneity w...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.21196

    authors: Wang Z,Herrington B,Schwartz MR,Laucirica R

    更新日期:2010-04-01 00:00:00