Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

Abstract:

:Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the left ovary, and bilateral salpingo-oophorectomy was performed. The Papanicolaou smear of the imprint cytological specimen of the left ovarian tumor revealed presence of two distinct components. The first component included thyroid follicles, which was composed of flat sheets of polygonal epithelial cells without nuclear groove and intranuclear inclusion. The other component was composed of trabecular clusters of columnar cells containing round to slender nuclei with "salt and pepper" chromatin. Immunocytochemical analysis revealed that synaptophysin was expressed in the latter component. Therefore, a cytodiagnosis of strumal carcinoid was made. Histopathological analyses confirmed the diagnosis of strumal carcinoid. Albeit rare, carcinoid tumor occurs in the ovary, and the recognition of characteristic nuclear features and cellular arrangement leads to correct cytodiagnosis. Presence of struma ovarii component suggests an ovarian origin. Moreover, immunocytochemical analysis for neuroendocrine markers aids its differential diagnosis from granulosa cell tumor and carcinoma arising from struma ovarii.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Ishida M,Arimoto T,Sandoh K,Okano K,Ebisu Y,Ito H,Matsumoto M,Mizokami T,Kita M,Okada H,Tsuta K

doi

10.1002/dc.24042

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

218-221

issue

3

eissn

8755-1039

issn

1097-0339

journal_volume

47

pub_type

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