Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall.

Abstract:

:We report the findings from an aspiration biopsy and resection of a chordoma-like tumorous mass in the wall of the thorax of a 36-yr-old man with immunohistochemical, ultrastructural, and cytogenetic studies. The 4-cm oval tumor was an incidental finding on physical examination, and no other lesions were identified after comprehensive radiologic studies. The aspirate was composed of sheets and nests of cells with distinct borders in a myxoid and fibrillary extracellular matrix. The neoplastic cells were uniform and round or polygonal with abundant pale blue vacuolated cytoplasm and small round, central or eccentric nuclei. On electron microscopy, mitochondrial rough endoplasmic reticulum complexes were seen in neoplastic cells. These features were similar to those of a conventional chordoma. However, the cytogenetic pattern, 43, XY ,-1, -2, der (5)t(1p;5q), -6, add(8p) ,add(10q), was not typical. In addition, the neoplastic cells were positive for vimentin, S-100, AE1/AE3, CAM 5.2, and CK 19; were focally positive for EMA and smooth muscle actin; and were negative for cytokeratin 1 and 10 (34 beta E12), CK 7, CK 8 (35H 11B), CK 17, and CK 20. The cytogenetic and immunohistochemical patterns were different from conventional chordoma and its peripheral counterpart, chordoma periphericum, suggesting the diagnosis of parachordoma. To the best of our knowledge, this is the first report of fine-needle aspiration of this newly defined and rare entity.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Tong G,Perle MA,Desai P,Kumar A,Waisman J

doi

10.1002/dc.10288

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

18-23

issue

1

eissn

8755-1039

issn

1097-0339

journal_volume

29

pub_type

杂志文章
  • Liesegang rings in renal cyst fluid.

    abstract::Peculiar ring-like structures identified as Liesegang rings (LRs) were found in renal cyst fluid from three patients with benign renal cysts. They ranged in size from 5 to 820 mu. Most had a double-layer outer wall with equally spaced radial cross-striations and an amorphous central nidus. Special stains were performe...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840060310

    authors: Katz LB,Ehya H

    更新日期:1990-01-01 00:00:00

  • Polymicrobial lung infection in postrenal transplant recipient diagnosed by fine-needle aspiration cytology.

    abstract::Tuberculous and fungal infections are among the non-neoplastic lesions of the lung, in which fine-needle aspiration cytology (FNAC) has proven to be a useful technique in both immunocompromised and immunocompetent patients. The presence of polymicrobial infection in a renal transplant recipient is documented in the li...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21198

    authors: Duggal R,Rajwanshi A,Gupta N,Lal A,Singhal M

    更新日期:2010-04-01 00:00:00

  • Fine-needle aspiration cytology in locally advanced breast adenocarcinoma: a case with complete response to preoperative chemotherapy in association with granulomatous inflammatory reaction.

    abstract::Preoperative chemotherapy for locally advanced breast carcinoma (stage IIIA,B) is increasingly utilized demonstrating a 70 to 95% objective response and 15 to 35% complete response. A 70-yr-old woman presented with a 9 cm left upper outer quadrant breast mass associated with overlying skin redness and a 2.5 cm left ax...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840100413

    authors: Costa MJ,Stewart G,Perez EA,Goodnight JE

    更新日期:1994-01-01 00:00:00

  • The cytopathological spectrum of lymphomas in effusions in a tertiary center in Taiwan.

    abstract::Lymphomas presenting in effusions could either be primary or secondary, with very limited data from Taiwan. METHODS:We retrospectively reviewed effusion lymphomas from our archives in a tertiary center from July 2011 to June 2019. RESULTS:We identified 59 specimens from 43 patients, including 7 cases with primary ef...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24626

    authors: Wang RC,Chen YH,Chen BJ,Chuang SS

    更新日期:2021-02-01 00:00:00

  • Cytology of embryonal rhabdomyosarcoma: a cytologic, light microscopic, electron microscopic, and immunohistochemical study of seven cases.

    abstract::A correlated cytologic and histologic study of seven cases of embryonal rhabdomyosarcoma is presented. The diagnosis of rhabdomyosarcoma was established by light and electron microscopy and immunohistochemistry of the operative specimens. The cytologic appearance of the smears corresponded well with the histopathologi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840040405

    authors: Seidal T,Walaas L,Kindblom LG,Angervall L

    更新日期:1988-01-01 00:00:00

  • Hodgkin's lymphoma: diagnostic difficulties in fine-needle aspiration cytology.

    abstract::It is commonly believed that cytodiagnosis of Hodgkin's lymphoma (HL) is much easier than that of non-Hodgkin lymphoma (NHL). However, recognition of certain NHL subtypes with Reed-Sternberg (R-S)-like cells and results of immunohistochemical studies point to the contrary. To study the limitations of cytology in diagn...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21064

    authors: Das DK,Francis IM,Sharma PN,Sathar SA,John B,George SS,Mallik MK,Sheikh ZA,Haji BE,Pathan SK,Madda JP,Mirza K,Ahmed MS,Junaid TA

    更新日期:2009-08-01 00:00:00

  • Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum.

    abstract::Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Tw...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24080

    authors: Sood N

    更新日期:2019-02-01 00:00:00

  • Corpora amylacea in pleural effusion.

    abstract::Corpora amylacea are predominantly found in the brain, prostate, and lung. Recent characterizations of their components suggest an important role in protection and clearing. We report the presence of corpora amylacea in pleural effusion in a patient with lupus. The differential diagnoses and potential significance are...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24684

    authors: Mani H,Wang BG

    更新日期:2020-12-21 00:00:00

  • GCT of proximal phalanx of ring finger: a case report.

    abstract::Giant-cell tumor (GCT) of bone arising from phalanx of a finger is extremely rare. Rizzoli Orthopedic Institute in their study on 900 treated cases of GCT from 1947-1997 reported only 0.9% incidence of GCT in bones of the hand. There was no case of GCT of the phalanges in that series. We report here a case of GCT of b...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21715

    authors: Khare P,Kishore B,Gupta RJ,Vanita,Dhal A

    更新日期:2012-08-01 00:00:00

  • Rounded atelectasis: diagnosis by fine-needle aspiration cytology.

    abstract::Rounded atelectasis, a rare, benign mass lesion, is most often seen in association with asbestos-related pleural changes. Often a presumptive diagnosis can be made on the basis of characteristic CT and chest radiographic findings. However, not infrequently radiographic imaging fails to differentiate rounded atelectasi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080617

    authors: Miller WT Jr,Gupta PK,Grippi MA,Miller WT

    更新日期:1992-01-01 00:00:00

  • Fine-needle aspiration cytologic features of pseudovascular adenoid squamous-cell carcinoma of the lung.

    abstract::Pseudovascular adenoid squamous-cell carcinoma (PASCC) is an epithelial malignancy with spindle-cell features that can mimic vascular neoplasms, particularly angiosarcoma, in its morphologic characteristics. There have been only a few surgical pathology reports of PASCC arising in the lung, skin, and breast. We descri...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199910)21:4<265::aid-dc7>3

    authors: Smith AR,Raab SS,Landreneau RJ,Silverman JF

    更新日期:1999-10-01 00:00:00

  • Primary signet ring cell carcinoma of the pancreas: Cytopathology review of a rare entity.

    abstract::Primary signet ring cell carcinoma of the pancreas (PSRCCP) is an extremely rare diagnosis that has not been extensively studied in literature. Primary and metastatic neoplasms to the pancreas may exhibit cytomorphological similarities to signet ring cells, posing diagnostic challenges. In this article, we review PSRC...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.24324

    authors: El Hussein S,Khader SN

    更新日期:2019-12-01 00:00:00

  • Post-thyroid FNA testing and treatment options: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.

    abstract::The National Cancer Institute (NCI) sponsored the NCI Thyroid Fine Needle Aspiration (FNA) State of the Science Conference on October 22-23, 2007 in Bethesda, MD. The 2-day meeting was accompanied by a permanent informational Web site and several on-line discussion periods between May 1 and December 15, 2007 (http://t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20832

    authors: Layfield LJ,Abrams J,Cochand-Priollet B,Evans D,Gharib H,Greenspan F,Henry M,LiVolsi V,Merino M,Michael CW,Wang H,Wells SA

    更新日期:2008-06-01 00:00:00

  • Cervical tuberculosis detection in Papanicolaou-stained smear: case report with review of literature.

    abstract::Genital tract tuberculosis is usually secondary to an extragenital tubercular focus. Cervical tuberculosis, however, is rare accounting for up to 3% of all genital tract diseases. The diagnosis of tuberculosis is usually established on multiple cervical biopsies followed by bacteriological confirmation. There are only...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.21082

    authors: Gupta R,Dey P,Jain V,Gupta N

    更新日期:2009-08-01 00:00:00

  • Hyperplastic and neoplastic endocrine cells of the pancreas in aspiration biopsy.

    abstract::Aspiration biopsy of four primary endocrine tumors of the pancreas showed single and large sheets of tumor cells. Tumor cells were polygonal in shape with ill-defined, filmy or granular cytoplasm and regular round nuclei containing a finely granular chromatin pattern and inconspicuous or prominent nucleoli. Focal glan...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840020306

    authors: Nguyen GK,Rayani NA

    更新日期:1986-09-01 00:00:00

  • Predictors of human papilloma virus in patients with keratinization.

    abstract::Given the prevalence of human papilloma virus (HPV) infection, an attempt was made to determine whether certain factors such as keratinization and/or squamous atypia are associated with its development. Review of our gynecologic cytology files from 1989 yielded 1,615 specimens showing parakeratosis and/or hyperkeratos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120107

    authors: Hudock J,Hanau CA,Hawthorne C,Jordan AG

    更新日期:1995-02-01 00:00:00

  • Breast filariasis diagnosed by needle aspiration cytology.

    abstract::A case of nodular lesion of the breast in a 37 year old female caused by filariasis is described. The case is instructive since the diagnosis was made by fine-needle aspiration cytology. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080419

    authors: SenGupta SK,Webb S,Cooke RA,Igo JD

    更新日期:1992-01-01 00:00:00

  • Clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas: a clinicopathologic study of three cases and review of the literature.

    abstract::Solid pseudopapillary tumors are rare pancreatic neoplasms of uncertain pathogenesis that rarely metastasize and usually occur in young women. We describe the clinical, imaging, and cytopathological features of solid pseudopapillary tumor of the pancreas. We reviewed the clinical presentation, imaging, morphologic/imm...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20365

    authors: Bhanot P,Nealon WH,Walser EM,Bhutani MS,Tang WW,Logroño R

    更新日期:2005-12-01 00:00:00

  • From conventional fluid cytology to unusual histological diagnosis: report of four cases.

    abstract::Malignant small round cell tumors represent a diagnostic challenge for cytologists and pathologists. This case series describes four cases of unusual metastasis of small round cell tumors subtypes into body cavities generating effusions in which fluid cytological examination suggested the neuroendocrine origin of the ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21771

    authors: Oliveira MJ,de Almeida LP,Wengerkievicz AC,Siqueira SA,Antonangelo L

    更新日期:2013-04-01 00:00:00

  • Chlamydia/gonorrhea combo and HR HPV DNA testing in liquid-based pap.

    abstract::Residual material from liquid-based pap (LBP) test has been used for molecular testing of Human Papilloma Virus (HR HPV) DNA. LBP test specimens (1,025) were evaluated to determine how often residual material was insufficient to perform microbiological testing. The specimens were tested for Chlamydia trachomatis and N...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20325

    authors: Hawthorne CM,Farber PJ,Bibbo M

    更新日期:2005-09-01 00:00:00

  • GATA3 expression in metastatic urothelial carcinoma in fine needle aspiration cell blocks: a review of 25 cases.

    abstract::GATA binding protein 3 is a zinc finger transcription factor with high affinity for urothelial tissue and is a promising immunohistochemical marker in detection of urothelial carcinomas (UC). We studied its usefulness in metastatic high-grade UC. This study was performed on cell blocks (CB) of fine needle aspirates fr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23131

    authors: Siddiqui MT,Seydafkan S,Cohen C

    更新日期:2014-09-01 00:00:00

  • Fine-needle aspiration of cystic nephroma (multilocular cyst of the kidney).

    abstract::Cystic nephromas are rare tumors of the kidney most commonly affecting boys or adult females. The fine-needle aspiration cytomorphology has not yet been described. A renal cystic mass in a 56 year old female was aspirated under ultrasound guidance. Papanicolaou stained smears of the cyst fluid revealed markedly atypic...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080408

    authors: Clark SP,Kung IT,Tang SK

    更新日期:1992-01-01 00:00:00

  • Fine-needle aspiration cytology of ameloblastoma and malignant ameloblastoma: a study of 12 cases.

    abstract::Ameloblastoma is an odontogenic tumor with aggressive biological behavior, high recurrence rate, and a complex microscopic appearance with many different histologic patterns. Primary ameloblastoma is also described in extragnathic locations. Because of its wide morphologic spectrum, which is mirrored also in cytologic...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21823

    authors: Klapsinou E,Stavros A,Smaragda A,Despoina P,Dimitra D

    更新日期:2013-03-01 00:00:00

  • Liquid fixation of endometrial brush cytology ensures a well-preserved, representative cell sample with frequent tissue correlation.

    abstract::Endometrium was obtained by brushing 656 hysterectomy specimens with a MedScand cytobrush (Hollywood, FL) in order to evaluate linking an easy-to-use liquid fixative with brush-sampling of the endometrium, and to determine the fixative's operating characteristics when applied to brush-sampling the endometrium. Liquid-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199605)14:4<367::AID-DC16>

    authors: Maksem JA,Knesel E

    更新日期:1996-06-01 00:00:00

  • Cytology of sclerosing epithelioid fibrosarcoma in pleural effusion.

    abstract::We report a case of sclerosing epithelioid fibrosarcoma focusing on its cytological features in pleural effusion. A 32-year-old man had noticed a tumor in his left buttock 5 years earlier but had not sought treatment because the tumor had been painless. He visited our hospital because the tumor had gradually increased...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21310

    authors: Tsuchido K,Yamada M,Satou T,Otsuki Y,Shimizu S,Kobayashi H

    更新日期:2010-10-01 00:00:00

  • Diagnostic intraocular fine-needle aspiration biopsy--An experience in three cases of retinoblastoma.

    abstract::Ophthalmoscopically guided intraocular fine-needle aspiration biopsy (FNAB) under general anesthesia was performed in three suspected cases of retinoblastoma (Rb). The first case presented with uveitis and the second with unusual radiological features. The third case had classical clinical features of bilateral Rb but...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199911)21:5<331::aid-dc7>3

    authors: Sen S,Singha U,Kumar H,Ghose S,Sarkar T,Bajaj MS

    更新日期:1999-11-01 00:00:00

  • Use of cytology centrifuged supernatants improves cost and turnaround time for targeted next generation sequencing.

    abstract:BACKGROUND:Molecular testing is an essential step in providing patients with advanced non-small-cell lung cancer (NSCLC), the most appropriate front-line targeted therapies. We recently implemented targeted NGS on previously discarded cytology centrifuged supernatant (CCS). METHODS:In this study, we reviewed our imple...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24548

    authors: Gokozan H,Harbhajanka A,Bomeisl P,Michael CW,Sadri N

    更新日期:2020-12-01 00:00:00

  • Concordance between thyroid nodule sizes measured by ultrasound and gross pathology examination: effect on patient management.

    abstract::Ultrasound examination (US) is an essential tool in the evaluation of thyroid nodules. The size determined by US is used to distinguish between clinical vs. nonclinical thyroid nodules i.e. greater than or equal to or less than 1 cm. In this study, we evaluated the concordance between the sizes of thyroid nodules meas...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20714

    authors: Deveci MS,Deveci G,LiVolsi VA,Gupta PK,Baloch ZW

    更新日期:2007-09-01 00:00:00

  • Immunocytochemical analysis of receptors for estrogen and progesterone in fine-needle aspirates from human breast carcinomas.

    abstract::Monoclonal antibodies were used for a preoperative analysis of estrogen receptors (ERs) and progesterone receptors (PgRs) in fine-needle aspirates from 44 primary human breast carcinomas. The semiquantitative receptor values obtained in cytologic specimens correlated well with those from enzyme immunoassay analysis on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840060205

    authors: Skoog L,Humla S,Isaksson S,Tani E

    更新日期:1990-01-01 00:00:00

  • The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions.

    abstract:BACKGROUND:All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due to injury of serosal surfaces from mesothelioma or malignant ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23653

    authors: Sadullahoglu C,Nart D,Veral A

    更新日期:2017-02-01 00:00:00