Lipid-rich carcinoid tumor of the thymus gland: diagnosis by fine-needle aspiration biopsy.

Abstract:

:In this report we describe the cytologic features of an unusual thymic carcinoid tumor containing prominent cytoplasmic lipid vacuoles that was diagnosed by fine-needle aspiration biopsy. The tumor presented as a presternal subcutaneous mass in an 81-yr-old female, with a contiguous mediastinal mass on computed tomography. The cytomorphologic features included numerous discohesive cells with eccentric, round to oval nuclei, granular chromatin, and scant cytoplasm containing numerous intracytoplasmic, clear vacuoles. The neoplastic cells were reactive for neuroendocrine markers by immunocytochemistry and showed reactivity of the intracytoplasmic vacuoles with an oil red-O stain for neutral lipid. Ultrastructural examination confirmed the presence of intracytoplasmic lipid vacuoles and neurosecretory granules. Subsequent surgical excision confirmed the diagnosis. We believe this to be the first report describing these features in a primary thymic carcinoid tumor. The differential diagnosis of mediastinal tumors with clear-cell features and cytoplasmic vacuolization is also discussed.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Smith NL,Finley JL

doi

10.1002/dc.2020

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

130-3

issue

2

eissn

8755-1039

issn

1097-0339

pii

10.1002/dc.2020

journal_volume

25

pub_type

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