Abstract:
:Infection due to Coccidioides spp., a dimorphic fungal pathogen, usually presents as a chronic pulmonary disease, occasionally with pulmonary nodules. On cytology, large spherules filled with endospores are typically seen. We report an unusual case of coccidioidomycosis in a 39-year-old female from an area nonendemic for Coccidioides and without other known risk factors for infection. Fine-needle aspiration of the patient's cavitary lung lesion revealed Coccidioides spp., which demonstrated atypical delicate septate hyphal forms and chains of conidia, with none of the large spherules typical of Coccidioides spp. Atypical hyphal and other forms of Coccidioides spp. have been reported in several studies, primarily from biopsy or tissue resection specimens. However, this is the first case to our knowledge that the organism has presented solely as conidial and atypical hyphal forms in an aspirated specimen. Pathologists who are unfamiliar with this atypical hyphal formation may misdiagnose the organism as several different fungi, including Aspergillus spp. or Fusarium spp. It is important to differentiate among fungi, as antifungal treatments may vary. Cytologists should be aware of the diverse morphologies demonstrated by Coccidioides spp. and include this organism in their differential diagnosis, even in patients seemingly devoid of pertinent risk factors.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Schuetz AN,Pisapia D,Yan J,Hoda RSdoi
10.1002/dc.21613subject
Has Abstractpub_date
2012-02-01 00:00:00pages
163-7issue
2eissn
8755-1039issn
1097-0339journal_volume
40pub_type
杂志文章abstract::Salivary duct carcinoma is a high grade malignancy which histologically strongly resembles ductal carcinoma of the breast. The findings from five cases of histologically proven salivary duct carcinoma sampled by preoperative fine-needle aspiration (FNA) cytology are presented. Characteristic cytomorphologic features i...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199706)16:6<526::aid-dc11>
更新日期:1997-06-01 00:00:00
abstract::Mites were observed in 55 pulmonary specimens examined routinely over a 4.5-yr period. The 55 specimens included 33 spontaneous and 12 aerosol-induced sputum samples, nine bronchial washings, and one fine-needle aspirate. Two specimens contained only fragments of mites; however, in most cases the mites were relatively...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840050416
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:High-risk Human papillomavirus (HR-HPV)-associated head and neck squamous cell carcinoma (HNSCC) is a distinct epidemiologic and pathologic disease. The data of HR-HPV testing on fine-needle aspiration (FNA) materials of cervical lymph nodes in patients with metastatic HNSCC are limited. METHODS:We retrospe...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23548
更新日期:2016-10-01 00:00:00
abstract::We report an extremely rare case of skin collision tumor between primary Merkel cell carcinoma (MCC) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) first diagnosed on ultrasound-guided fine-needle aspiration biopsy (US-FNA). A 95-year-old female with a history of CLL presented with a slow growin...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.23127
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). METHODS:Patients who underwent EC surgery that included a follow-up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24444
更新日期:2020-07-01 00:00:00
abstract::Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exp...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21859
更新日期:2013-07-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area. When ACC presents outside of these locations, the diagnosis may become more challenging. We describe three cases of ACC presenting in extra-salivary gland sites. Two cases were metastatic; in ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20500
更新日期:2006-07-01 00:00:00
abstract::Myoepithelial carcinoma is a rare locally aggressive malignant neoplasm of the salivary glands. The tumor is composed almost exclusively of tumor cells with myoepithelial differentiation and characterized by infiltrative growth and potential for distant metastasis. Tumor cells often display morphologic heterogeneity w...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.21196
更新日期:2010-04-01 00:00:00
abstract::Tumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis. Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thy...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21725
更新日期:2012-12-01 00:00:00
abstract::Calcinosis cutis is an uncommon condition, and calcific deposits in patients with end-stage renal disease are now somewhat rare, due to improvement in management. Since calcific deposits may clinically resemble a tumor, it is feasible to investigate them by fine-needle aspiration cytology (FNAC). A 52-yr-old male with...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199812)19:6<465::aid-dc13>
更新日期:1998-12-01 00:00:00
abstract::Four cases of renal angiomyolipoma (AML) diagnosed by fine-needle aspiration biopsy (FNAB) are reported. One case was associated with the clinical complex of tuberous sclerosis. The tumors were solitary in two cases and multiple and bilateral in the fourth. The cytologic features of the four cases were similar to thos...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840100110
更新日期:1994-01-01 00:00:00
abstract::Barrett's esophagus is a premalignant condition in which the normal stratified squamous epithelium of the esophagus is replaced by metaplastic glandular epithelium. Patients with Barrett's esophagus are at increased risk for the development of esophageal adenocarcinoma. Because dysplasia precedes the development of fr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0339(199804)18:4<312::aid-dc13>
更新日期:1998-04-01 00:00:00
abstract::We present a series of three cases of unsuspected thyroid carcinoma presenting as bony lesions and initially studied by fine-needle aspiration (FNA). This series consists of two cases of follicular carcinoma and a third case of Hurthle cell carcinoma. FNA was performed on all three lesions. In two of these cases, a de...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200005)22:5<313::aid-dc11>
更新日期:2000-05-01 00:00:00
abstract::The Barr body is the inactive X chromosome in a female somatic cell. It is readily identified as plano-convex structure of 2-3 micron in diameter on the periphery of the nuclear membrane. The aim of this study is to evaluate the significance of Barr body count in malignant ovarian tumors on fine needle aspiration cyto...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21688
更新日期:2012-11-01 00:00:00
abstract::The diagnosis on fine needle aspiration of salivary gland tumors with a myoepithelial component is challenging because myoepithelial cells can have a wide cytomorphologic spectrum. The authors report a case of a pleomorphic adenoma of the parotid gland that expands the spectrum of appearances that myoepithelial cells ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24301
更新日期:2019-12-01 00:00:00
abstract::The aim of this study is to evaluate the diagnostic values of the fluorescence in situ hybridization (FISH), NMP22 BladderChek, and liquid-based cytology (LBC) in the detection of bladder urothelial carcinoma (UC). Consecutive voided urine samples were collected from 138 in-house patients with a variety of urologic co...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22969
更新日期:2013-10-01 00:00:00
abstract::Fine-needle aspiration (FNA) is a valuable technique to use in the evaluation of breast lesions; however, inadequate and discrepant diagnoses do occur. To identify the source and nature of inaccuracies related to the method we studied 39 cases in which FNA posed diagnostic problems. These problems could be attributed ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070523
更新日期:1991-01-01 00:00:00
abstract::The dark (hyperchromatic) cerebriform nucleus was recently described as a frequent finding in histopathology sections of papillary carcinoma of the thyroid. In the present study, we tried to determine the frequency of dark cerebriform nuclei in the fine-needle aspiration (FNA) smears of papillary thyroid carcinomas an...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20022
更新日期:2004-03-01 00:00:00
abstract::GATA binding protein 3 is a zinc finger transcription factor with high affinity for urothelial tissue and is a promising immunohistochemical marker in detection of urothelial carcinomas (UC). We studied its usefulness in metastatic high-grade UC. This study was performed on cell blocks (CB) of fine needle aspirates fr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23131
更新日期:2014-09-01 00:00:00
abstract::Solitary fibrous tumor is a rare lesion of serosal membranes. In a pleural location, it may be confused clinically with a localized mesothelioma or a peripheral lung tumor. A transthoracic needle aspiration can be done to obtain material for a diagnosis in these easily accessible tumors. In the literature, there are o...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199802)18:2<118::aid-dc7>3
更新日期:1998-02-01 00:00:00
abstract::The authors present a case of cardiac angiosarcoma diagnosed by fine-needle aspiration (FNA) in a 33-year-old male. A percutaneous right atrial mass biopsy was performed via a right internal jugular venous approach and under echocardiographic guidance. FNA showed pleomorphic spindle-shaped cells present singly and in ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20532
更新日期:2007-03-01 00:00:00
abstract::Primary thyroid lymphoma is a very rare disease. Here, we present a case of primary diffuse large B-cell lymphoma (DLBCL) in a 48-year-old female involving thyroid gland. The patient had thyroid swelling for 15 years which rapidly increased during last 5 months. Fine needle aspiration cytology revealed monomorphic lar...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21730
更新日期:2012-05-01 00:00:00
abstract::Most granulomas of the prostate are nonspecific; infectious, post-operative, and allergic lesions are much less common. Fine-needle aspiration findings in the typical case are distinctive and easily recognized. Several series have been reported, but few have included histologic follow-up. We describe three cases of gr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070513
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Documenting the four molecular subtypes of breast carcinoma is significant as they determine response to therapy, disease free interval and survival. Our aim was to document the subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23607
更新日期:2016-12-01 00:00:00
abstract::Signet-ring lymphoma is a rare entity in which the synthesis or secretion of immunoglobulins is impaired, producing a signet-ring appearance to the lymphoma cells. A case of this type of lymphoma is described, and the cytologic aspects of the cells obtained from the fixative fluid are described. ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840020413
更新日期:1986-12-01 00:00:00
abstract::A case of cytomegalovirus (CMV) sialadenitis in a patient with acquired immunodeficiency syndrome (AIDS) diagnosed by fine-needle aspiration biopsy (FNAB) is reported. Although a diagnosis of CMV sialadenitis can be established on Diff-Quik-stained slides, the characteristic viral changes are the best appreciated on s...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200002)22:2<101::aid-dc8>3
更新日期:2000-02-01 00:00:00
abstract::Distinguishing mucinous from nonmucinous cystic lesions of the pancreas often constitutes a diagnostic dilemma. The clinical management differs between such lesions; therefore it is important to make an accurate preoperative diagnosis. Various centers have reported conflicting results regarding their ability to detect...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20558
更新日期:2007-01-01 00:00:00
abstract::Two homosexual men with parotid swellings were shown to be human immunodeficiency virus (HIV)-positive. They initially presented with a painless solitary parotid mass accompanied by diffuse cervical lymphadenopathy. In case 1, the patient further developed bilateral multiple cystic lesions. Aspirate preparations from ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070212
更新日期:1991-01-01 00:00:00
abstract::Granulosa cell tumors (GCT) of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors (MGCT). Between 2000 and 2014, eight cases of MGCT were diagnosed by FNA. Clini...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23535
更新日期:2016-12-01 00:00:00
abstract::Tuberculosis of the urinary tract is usually secondary to tuberculosis of the kidney. Multinucleated giant cell histiocytes, often with peripheral nuclei (Langhans' cells), may be identified. Acid-fast bacilli on smear or positive urine cultures confirm the diagnosis. Similar findings can also be seen in patients trea...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21327
更新日期:2010-10-01 00:00:00