Abstract:
:Tumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis. Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thyroid follicular adenoma. Papanicolaou staining, CD26/DPPIV activity staining, and HE staining were performed and the specimens were observed morphologically. Immunohistochemical analysis using antibodies against p53 and PTEN was performed. Genetic mutation of PTEN exons was performed using the laser capture microdissection method. The nuclear area of the CD26/DPPIV-positive cells was significantly larger than that of the CD26/DPPIV-negative cells. p53 expression was not observed any specimen. PTEN expression was observed in 18 of 19 cases. DNA sequence analysis did not reveal mutations in exons 5-9 of PTEN in the immunohistochemically PTEN-negative case. In accordance with our previous reports, we found that observation of concomitant CD26-positive and PTEN-negative status in cases of follicular adenoma suggests a state close to follicular carcinoma or progression to cancer, thus warranting careful follow-up.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Miyake Y,Aratake Y,Sakaguchi T,Kiyoya K,Kuribayashi T,Marutsuka K,Ohno Edoi
10.1002/dc.21725subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1047-53issue
12eissn
8755-1039issn
1097-0339journal_volume
40pub_type
杂志文章abstract::Acute myeloid leukemia (AML) is the fifth most common malignancy in children. Extramedullary involvement in acute myeloid leukemia is rare and can be seen in soft tissues, central nervous system, skin and lymphoreticular organs. The clinical presentations can often be non-specific and hence, the diagnosis can be very ...
journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 临床试验,杂志文章
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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journal_title:Diagnostic cytopathology
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更新日期:2002-04-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2048
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dc.21345
更新日期:2010-12-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20607
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dc.20270
更新日期:2005-06-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21120
更新日期:2009-12-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23397
更新日期:2016-02-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20921
更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21460
更新日期:2011-10-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20841
更新日期:2008-08-01 00:00:00
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journal_title:Diagnostic cytopathology
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更新日期:2015-03-01 00:00:00
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journal_title:Diagnostic cytopathology
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