Abstract:
:A prospective study was conducted on 100 patients divided in two groups who underwent fiberoptic bronchoscopy (FOB). Group I consisted of 60 cases of suspected lung malignancy on clinical and radiological examination, while group II consisted of 40 cases of nonneoplastic lung diseases. Pre-FOB sputum, bronchoalveolar lavage (BAL), and bronchial brushing (BB) were done in all the cases, while forceps biopsy (FB), transbronchial needle aspiration (TBNA), and transthoracic needle aspiration were done in 56, 25, and 15 patients, respectively. BB and FB showed a sensitivity of 70.83 and 70% respectively in the diagnosis of malignancy. BAL was found to be positive in 37.5% patients. TBNA had the highest sensitivity of 83.33% whereas pre-FOB sputum and post-FOB sputum were positive only in 27.58 and 29.06% cases. In nonneoplastic group, BAL showed sensitivity of 80 and 83.33% in diagnosing tuberculosis and fungal diseases whereas BB was positive in 60 and 66.66% patients, respectively. Thus a combination of various cytohistological techniques results in a statistically significant increase in the diagnostic yield of various neoplastic and nonneoplastic lung diseases. BB, FB, and TBNA are complimentary in diagnosis of various lung malignancies whereas BAL is a useful procedure in detection of infectious diseases.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Garg S,Handa U,Mohan H,Janmeja AKdoi
10.1002/dc.20577subject
Has Abstractpub_date
2007-01-01 00:00:00pages
26-31issue
1eissn
8755-1039issn
1097-0339journal_volume
35pub_type
临床试验,杂志文章abstract::The purpose of this study was to assess whether the same principles to evaluate renal transplant by fine-needle aspiration (FNA) for rejection could be applied to pancreatic allograft. Between 1996-1998, 25 ultrasound-guided FNAs on 13 patients with pancreatic allograft were performed and ThinPrep made. The percentage...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10179
更新日期:2002-11-01 00:00:00
abstract::We present a case in which a primary diagnosis of gout was made by fine-needle aspiration. The patient had a right distal ulnar mass, and the initial clinical and radiological diagnoses were that of giant cell tumor of tendon sheath. While tophi are the hallmark of gout, they rarely undergo aspiration because of the k...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199609)15:3<246::AID-DC14>
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:Hürthle cell (HC) metaplasia is an important feature of chronic lymphocytic (Hashimoto) thyroiditis (HT). However, it is rarely observed in juvenile form HT. In a study based on fine needle aspiration cytology, the cytomorphological difference between pediatric HT and its adult form was studied, with special...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.24140
更新日期:2019-05-01 00:00:00
abstract::Pancreatic pheochromocytomas are rare and typically diagnosed by local resection. We present the first reported case of metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and cytology. A 67-year-old female presented with 2 to 3 months of abdominal pai...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.24326
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Swellings in the hand and wrist are frequently encountered in clinical practice and fine needle aspiration cytology (FNAC) is used as a primary diagnostic modality in most of them. A wide spectrum of lesions can be encountered at these sites. The aim of this study was to report the prevalence and spectrum of...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24050
更新日期:2018-10-01 00:00:00
abstract::Metastatic cancer involving the uterine cervix is exceedingly rare, and accounts for less than 1% of cancer deaths. The cervix is an uncommon location for metastatic lesions due to its limited blood supply and fibrous stroma and metastatic melanoma of the cervix is particularly infrequent. To the best of our knowledge...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24058
更新日期:2018-12-01 00:00:00
abstract::Nephroblastoma (Wilms' tumor) is the most common childhood renal tumor and usually presents with a histology and cytology consisting of blastemal, epithelial, and stromal cells. Effusions are not uncommon and may suggest an unfavorable prognosis when containing anaplastic tumor cells. In the present case, we report th...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20535
更新日期:2006-09-01 00:00:00
abstract::Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23248
更新日期:2015-07-01 00:00:00
abstract::Sixty-six unselected breast cancers were analyzed in cytologic smears and histologic sections for the expression of Ki-67, proliferating cell nuclear antigen (PCNA), estrogen receptor protein (ERP), and p53 protein using a standard immunochemical method. The results, expressed as both positive cases and labelling inde...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840110206
更新日期:1994-01-01 00:00:00
abstract::We have shown that SurePath when compared to conventional Paps fails to increase HSIL detection. In this study, assessment of test performance characteristics for the FocalPoint showed that sensitivity was 96% when manual screening was used as the "gold standard." When cervical biopsy, however, was used as the "gold s...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10373
更新日期:2003-11-01 00:00:00
abstract::The presence of pericellular lacunae has been cited as a useful criterion in distinguishing between benign and malignant effusions from body cavities. This study assessed the presence of pericellular lacunae in 75 specimens of malignant and 38 specimens of benign effusions. In a large number of cases, lacunae could no...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199609)15:3<193::AID-DC4>3
更新日期:1996-09-01 00:00:00
abstract::Although pleural and pericardial effusions are common and may rarely be the initial manifestation of disease, there are few reports of SLE diagnosed in a cytopathology laboratory. We describe an unusual case of SLE in a 75-year-old man who presented with cardiac tamponade. Cytologic examination of the pericardial flui...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199805)18:5<346::aid-dc8>3
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Cytology specimens are the main samples used for the diagnosis of advanced lung cancer. The objective of our study was to assess anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 receptor tyrosine kinase (ROS1) genes by an amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR) us...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24404
更新日期:2020-06-01 00:00:00
abstract::Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to de...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.23668
更新日期:2017-03-01 00:00:00
abstract::The cytologic findings in 13 cases of cervical adenocarcinoma in situ (mean age 33.9 yr) were compared with those in 9 cases of cervical invasive adenocarcinoma (mean age 45.7 yr). All diagnoses were confirmed by biopsy. The major differences found were that a necrotic background (66% invasive vs. 0% in situ) and macr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120206
更新日期:1995-03-01 00:00:00
abstract::The aim of this study were (1) To correlate koilocytosis with high risk HPV(HrHPV) DNA in urinary bladder carcinoma and (2) To compare detection of koilocytosis on tissue sections and urine cytology. Biopsy and cytologic specimens from 33 patients of urinary bladder carcinoma were analyzed. HPV DNA was detected by PCR...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20978
更新日期:2009-03-01 00:00:00
abstract::Tumors of the head and neck are extremely diverse and a subset are poorly differentiated and difficult to classify. Recently, a new entity has been described with rhabdoid and/or plasmacytoid cytologic features and a characteristic genetic signature-inactivation of the SMARCB1 (INI-1) tumor suppressor gene. To date, o...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23503
更新日期:2016-08-01 00:00:00
abstract::Sentinel lymph nodes (SLN) isolated in 40 patients of breast carcinoma (stage T(1)/T(2)) were evaluated intraoperatively by imprint cytology and frozen section. Rapid immunohistochemistry (IHC) was done in cases where both imprint smears and frozen sections were negative for any metastatic tumor deposits. The results ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21120
更新日期:2009-12-01 00:00:00
abstract::Metastatic urothelial carcinoma (UC) to serous effusion (SE) is extremely rare and its cytomorphological features have only been described in case reports. In this study, we searched the pathology database at University of Michigan for SEs due to metastatic UC in the last 20 years. A total of 25 cases from 20 patients...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22896
更新日期:2013-07-01 00:00:00
abstract::Giant cell tumour (GCT) of bone is a distinctive neoplasm, which has only recently been included within the diagnostic purview of the cytopathologist. Four cases of GCT of bone diagnosed primarily and exclusively by fine needle aspiration cytology (FNAC), presenting at unusual sites, are presented with a view to highl...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10188
更新日期:2002-12-01 00:00:00
abstract::We report the cytomorphologic features of 16 fine-needle aspiration (FNA) biopsies of seminoma obtained from 16 male patients. The aspirates included two primary gonadal tumors (one occurring in a cryptorchid testis), two primary mediastinal tumors, and 12 metastases (two with unknown primaries). Analysis of the aspir...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120409
更新日期:1995-06-01 00:00:00
abstract::Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has become a widely used method of pre-operatively evaluating pancreatic masses. This technique introduces gastrointestinal contamination into the specimen, which poses a diagnostic pitfall. The cytomorphologic features of these contaminants have no...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20343
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:The number of "renal incidentalomas" is on the rise due to increasing use of radiologic studies. Image-guided core needle biopsies (CNB) with touch preparations are performed to guide specimen collection and triage of sample for additional studies. Results allow the clinical team to make appropriate treatmen...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24253
更新日期:2019-10-01 00:00:00
abstract::We report a case of nodal nevus present in enlarged lymph nodes with changes of dermatopathic lymphadenopathy sampled by fine-needle aspiration (FNA) cytology prior to clinical evaluation of the patient. This lymph node pathology was established later by lymph node excisional biopsy, by which along with a skin biopsy ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20101
更新日期:2004-09-01 00:00:00
abstract::The objectives of this study were to identify key cytologic features for the morphologic differentiation of bronchioloalveolar carcinoma from reactive pulmonary proliferations, and to determine if morphometry of the cytologic specimens could provide additional data to distinguish the two processes. We analyzed 15 morp...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199705)16:5<396::aid-dc4>3
更新日期:1997-05-01 00:00:00
abstract::Telomerase is inactive in most somatic cells, but has been found to be reactivated in a majority of cancers. Our principal goal was to test whether the presence of telomerase activity concurred with positive cytology, and was thus of potential use in detecting cancer cells in effusions. The telomeric repeat amplificat...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/1097-0339(200103)24:3<174::aid-dc1036>3.0.
更新日期:2001-03-01 00:00:00
abstract::Clear-cell lesions of the parotid gland are uncommon but when studied by fine-needle aspiration may result in a clinically important but cytologically difficult differential diagnosis. Clear-cell lesions involving the parotid include acinic cell neoplasm, clear cell oncocytoma, mucoepidermoid carcinoma, primary clear-...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840090621
更新日期:1993-12-01 00:00:00
abstract::Multiple myeloma (MM) with central nervous system (CNS) infiltration is uncommon and the diagnosis is more complicated than that of MM. Here we report two cases of CNS MM that was diagnosed by cerebrospinal fluid cytology examination. Cerebrospinal fluid cytology examination can help to detect malignant cells and immu...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23600
更新日期:2017-01-01 00:00:00
abstract::Although fine-needle aspiration cytology is a routine procedure for the diagnosis of breast carcinoma, cytologic specimens have rarely been used for evaluation of hormone receptor status and HER2/neu overexpression. In order to compare the biological markers on cytology and on histology, routinely fixed smears of 110 ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20007
更新日期:2004-04-01 00:00:00
abstract::Salivary duct carcinoma (SDC) is an extremely rare and highly aggressive primary epithelial neoplasm of the salivary glands associated with increased tendency for lymph node and vascular metastases. Histologically, this lesion resembles intraductal cribriform and comedo carcinoma of the breast. Fine-needle aspiration ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840110111
更新日期:1994-01-01 00:00:00