Fine-needle aspiration biopsy of HPV-related squamous cell carcinoma of the head and neck: Current ancillary testing methods for determining HPV status.


:Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to determine the HPV-status has significant prognostic and treatment implications as HPV-related tumors have a more favorable prognosis and response to nonsurgical therapies. While several different ancillary testing methods are available that have proven effective for determining HPV status in FNA specimens from HNSCCs, there is currently no consensus regarding HPV testing in this setting. Diagn. Cytopathol. 2017;45:221-229. © 2016 Wiley Periodicals, Inc.


Diagn Cytopathol


Diagnostic cytopathology


Bernadt CT,Collins BT




Has Abstract


2017-03-01 00:00:00












  • Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review.

    abstract::Granulosa cell tumors (GCT) of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors (MGCT). Between 2000 and 2014, eight cases of MGCT were diagnosed by FNA. Clini...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Harbhajanka A,Bitterman P,Reddy VB,Park JW,Gattuso P

    更新日期:2016-12-01 00:00:00

  • Diagnosis of peripheral T-cell lymphoma by fine-needle aspiration biopsy: a cytomorphologic and immunophenotypic approach.

    abstract::The diagnosis of T-cell lymphomas by fine-needle aspiration biopsies (FNAB) is extremely difficult. This is mainly due to the rarity of the disease, the morphologic similarity to reactive lymphadenopathy, and the difficulty in identifying abnormal T-cell antigen expression. We studied FNAB of histologically proven T-c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Al Shanqeety O,Mourad WA

    更新日期:2000-12-01 00:00:00

  • A morphologic and statistical comparative study of small-cell carcinoma and non-Hodgkin's lymphoma in fine-needle aspiration biopsy material from lymph nodes.

    abstract::Small-cell carcinoma (SmC) and high-grade non-Hodgkin's lymphoma (NHL) are aggressive neoplasms that require prompt diagnosis and treatment. An immediate diagnosis can be obtained using fine-needle aspiration biopsy (FNAB) material from lymph nodes (LNs), which are clinically or radiologically suspicious for tumor inv...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: De Las Casas LE,Gokden M,Mukunyadzi P,White P,Baker SJ,Hermonat PL,You H,Korourian S,Malak SF,Miranda RN

    更新日期:2004-10-01 00:00:00

  • Fine needle aspiration cytology of lobular carcinoma in situ on ThinPrep.

    abstract::Lobular carcinoma in situ (LCIS) of the breast is a recognized marker for increased risk of invasive carcinoma and has well-established histologic criteria. However, its detection and diagnosis on FNA of breast has not been well defined. Cytology slides (all ThinPrep) of 11 cases with biopsy-proven LCIS at Beth Israel...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ayata G,Wang HH

    更新日期:2005-05-01 00:00:00

  • Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases.

    abstract::Five cases of mammary Paget's disease were diagnosed by nipple scrape cytology. The neoplastic material obtained was abundant in two cases, moderate in one, but in two, only a few cell aggregates feature in three cases and this, together with dense tumour cell cytoplasm and the background of keratinous debris, may imp...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Samarasinghe D,Frost F,Sterrett G,Whitaker D,Ingram D,Sheiner H

    更新日期:1993-01-01 00:00:00

  • Cytologic diagnosis of metastatic ovarian adenocarcinoma in the urinary bladder: a case report and review of the literature.

    abstract::A 53-yr-old woman with a 13-mo history of recurrent ovarian papillary serous adenocarcinoma presented with persistent microscopic hematuria. The patient was undergoing chemotherapy for her recurrent ovarian tumor when she was referred to the urology service for microscopic hematuria. An intravenous pyelogram was norma...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Edgerton ME,Hoda RS,Gupta PK

    更新日期:1999-03-01 00:00:00

  • Spindle cell lipoma of the breast: a case report and literature review.

    abstract::Fine-needle aspiration cytology (FNA) was performed on a breast lump in a 66-year-old female, clinically thought to be a carcinoma. The cytological findings were reported as suspicious of malignancy. Subsequent histological examination showed a tumour macroscopically and microscopically identical with six other cases ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Lew WY

    更新日期:1993-08-01 00:00:00

  • Fine-needle aspiration cytology in azoospermic males.

    abstract::Bilateral testicular fine-needle aspiration cytology (FNAC) was performed in 100 males, including 10 controls with normal fertility and 90 infertile azoospermic males. The various seminiferous tubular cells were easily identified in smears. It was possible to give a cytological diagnosis in histologic terms by analysi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Rajwanshi A,Indudhara R,Goswami AK,Radhika S,Das A,Sharma SK,Vaidyanathan S,Datta BN

    更新日期:1991-01-01 00:00:00

  • Micronucleus assay in buccal smears of breast carcinoma patients.

    abstract::The aim of this study is to compare micronucleus assay in buccal smear of breast carcinoma patients versus normal benign cases as control group. In this prospective study, we selected a total 32 patients of carcinoma of breast and 49 patients of benign breast lesions diagnosed in fine needle aspiration cytology (FNAC)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Dey P,Samanta S,Susheilia S

    更新日期:2012-08-01 00:00:00

  • Evolution of Pap testing at a community hospital: a ten year experience.

    abstract::Over a 10-year period the Pap program at our community hospital laboratory progressed from the use of 100% conventional smears to predominantly ThinPrep (TP) and then to nearly 100% SurePath (SP). During this period the annual Pap volume grew from less than 20,000 to nearly 50,000. This retrospective review focuses on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Nance KV

    更新日期:2007-03-01 00:00:00

  • Prevalence of epithelial abnormalities and high-risk human papilloma virus in cervicovaginal Pap smears of population subgroups as a guide toward evidence-based best practice.

    abstract:BACKGROUND:The 2012 American Society for Colposcopy and Cervical Pathology Consensus Guidelines provide information for managing abnormal cervical cancer screening tests and cancer precursors. According to these guidelines for Pap smear diagnosis of Atypical squamous cells of undetermined significance, reflex high risk...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Siddiqi A,Webb F,Smotherman C,Shuja S,Mubeen A,Lai K

    更新日期:2019-07-01 00:00:00

  • Metastatic meningioma in fine-needle aspiration (FNA) of the lung: cytomorphologic finding.

    abstract::Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellu...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Baisden BL,Hamper UM,Ali SZ

    更新日期:1999-05-01 00:00:00

  • Fine-needle aspiration cytology of seminoma: a review of 16 cases.

    abstract::We report the cytomorphologic features of 16 fine-needle aspiration (FNA) biopsies of seminoma obtained from 16 male patients. The aspirates included two primary gonadal tumors (one occurring in a cryptorchid testis), two primary mediastinal tumors, and 12 metastases (two with unknown primaries). Analysis of the aspir...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Caraway NP,Fanning CV,Amato RJ,Sneige N

    更新日期:1995-06-01 00:00:00

  • Pancreatic lymphoma: A cytologic diagnosis challenge.

    abstract::Very rarely lymphoma primarily or secondarily involves the pancreas. Involvement of the pancreatic parenchyma with lymphoma clinically may mimic pancreatic ductal adenocarcinoma (PDA) and other mass-forming pancreatic lesions. Endoscopic ultrasound fine needle aspiration (EUS-FNA) is the first step in the diagnostic p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Savari O,Al-Duwal Z,Wang Z,Ganesan S,Danan-Rayes R,Ayub S

    更新日期:2020-04-01 00:00:00

  • Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor.

    abstract::Acinar cell carcinoma (ACC) and islet cell tumor (ICT), both rare pancreatic neoplasms, can be diagnosed accurately and rapidly with the use of imaging-guided fine-needle aspiration biopsies. The specific cytologic features of these tumors are described in a series of 17 patients, and histologic and immunocytochemical...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Labate AM,Klimstra DL,Zakowski MF

    更新日期:1997-02-01 00:00:00

  • Cystic major salivary gland lesions: Utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis.

    abstract:INTRODUCTION:The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularit...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Allison DB,McCuiston AM,Kawamoto S,Eisele DW,Bishop JA,Maleki Z

    更新日期:2017-09-01 00:00:00

  • Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions.

    abstract::To assess the utility of chemical analysis for parathyroid hormone in the rinse (PTH-r) obtained via fine-needle aspiration (FNA) in the setting of inadvertently sampled parathyroid tissue or lesions (PTL) during "thyroid" or "neck" FNA, the authors review their experience at a large, tertiary care academic medical ce...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Owens CL,Rekhtman N,Sokoll L,Ali SZ

    更新日期:2008-04-01 00:00:00

  • Follicular thyroid lesions coexisting with Hashimoto's thyroiditis: incidence and possible sources of diagnostic errors.

    abstract::Our objectives were to study the types and incidence of thyroid follicular lesions coexisting with Hashimoto's thyroiditis (HT), the pitfalls in their cytodiagnosis, and the effect on management. All cases of HT diagnosed by fine-needle aspiration (FNA) and/or histology over a 7-yr period were retrospectively studied....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kollur SM,El Sayed S,El Hag IA

    更新日期:2003-01-01 00:00:00

  • Increased detection of clue cells in smears from cervical intraepithelial lesions with reduced expression of COX-2.

    abstract::The relation between the detection of clue cells in cervical smears of women with CIN and the expression of COX-2 in these lesions were determined. Samples from 228 women, treated due to CIN and who underwent cervical conization, were obtained. Hybrid Capture II and Pap smear samples were collected immediately before ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Figueiredo PG,Sarian LO,Tambascia JK,Simões JA,Rabelo-Santos SH,Discacciati MG,Derchain S

    更新日期:2008-10-01 00:00:00

  • Mites in pulmonary cytology specimens.

    abstract::Mites were observed in 55 pulmonary specimens examined routinely over a 4.5-yr period. The 55 specimens included 33 spontaneous and 12 aerosol-induced sputum samples, nine bronchial washings, and one fine-needle aspirate. Two specimens contained only fragments of mites; however, in most cases the mites were relatively...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Farley ML,Mabry LC,Hieger LR

    更新日期:1989-01-01 00:00:00

  • Synovial sarcoma metastatic to the parotid gland: A possible pitfall in salivary gland fine needle aspiration cytology. Report of a case with immunocytochemical and fluorescence in situ hybridization findings.

    abstract::We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were sugg...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Fulciniti F,Barizzi J,Martin V,Tarallo V,Ermanni S

    更新日期:2017-09-01 00:00:00

  • Cytologic diagnosis of pseudomyxoma peritonei: common and uncommon causes.

    abstract::Pseudomyxoma peritonei (PP) refers to accumulation of mucus in the peritoneal cavity, regardless of cause or pathogenesis. We have reviewed 8 cases of PP diagnosed in our institution over the past 5 years. Pertinent cytologic features include a mucinous background with mesothelial cells and histiocytes. Two cases cont...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pisharodi LR,Bedrossian CW

    更新日期:1996-02-01 00:00:00

  • Diagnosis of umbilical metastasis (Sister Mary Joseph's nodule) by fine-needle aspiration: an immunocytochemical study.

    abstract::During a ten year period, since we introduced needle aspiration cytology at our institution, we have diagnosed five cases of umbilical metastasis (Sister Mary Joseph's nodule). In none of the cases was any false negative or false positive diagnosis rendered and the primary carcinoma was found below the diaphragm. In a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gupta RK,Naran S,McHutchison AG,Lallu S,Fauck RJ

    更新日期:1994-01-01 00:00:00

  • Can glandular lesions be diagnosed in pap smear cytology?

    abstract::Many reports have been published on the accuracy of the cervical vaginal smear for squamous lesions, and the literature contains fewer reports on the accuracy of the cervical vaginal smear for glandular lesions. The sensitivity of glandular lesion diagnosis depends on the subtype of lesion. The diagnostic sensitivity ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Raab SS

    更新日期:2000-08-01 00:00:00

  • Optimal specimen processing of fine needle aspirates of non-Hodgkin lymphoma.

    abstract:UNLABELLED:Fine needle aspiration (FNA) in conjunction with flow cytometry (FC) is a useful technique for non-Hodgkin's lymphoma (NHL) diagnosis. We sought to investigate the effect of storage medium and time to processing on lymph node (LN) FNA viability. Benign LN FNAs were distributed among Roswell Park Memorial Ins...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Shetuni B,Lakey M,Kulesza P

    更新日期:2012-11-01 00:00:00

  • Inspissated cyst fluid in endoscopic ultrasound-guided fine needle aspiration of pancreatic cysts.

    abstract:BACKGROUND:Inspissated cyst fluid may be identified on pancreatic cyst aspiration cytology. We report on the cytomorphologic characteristics of inspissated cyst fluid on EUS-FNA of pancreatic cysts and correlate this finding with histopathology or multimodal (cytology, cyst fluid analysis, molecular pathology, imaging)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Chebib I,Albanese E,Scourtas A,Pitman MB

    更新日期:2018-05-01 00:00:00

  • Comparative cytologic findings of in situ and invasive adenocarcinoma of the uterine cervix.

    abstract::The cytologic findings in 13 cases of cervical adenocarcinoma in situ (mean age 33.9 yr) were compared with those in 9 cases of cervical invasive adenocarcinoma (mean age 45.7 yr). All diagnoses were confirmed by biopsy. The major differences found were that a necrotic background (66% invasive vs. 0% in situ) and macr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Keyhani-Rofagha S,Brewer J,Prokorym P

    更新日期:1995-03-01 00:00:00

  • Functional parathyroid carcinoma. Cytology, histology, and ultrastructure of a case.

    abstract::A case of a functional parathyroid carcinoma that recurred 1 year after being resected is presented. The clinical and laboratory data and the histologic structure are presented with confirmatory electron microscopy. The preoperative aspiration biopsy showed findings suggestive of parathyroid carcinoma although simulta...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: de la Garza S,Flores de la Garza E,Hernández Batres F

    更新日期:1985-07-01 00:00:00

  • The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses: developed and approved at the National Cancer Institute workshop in Bethesda, MD, December 12-13, 1988.

    abstract::The Bethesda System for reporting cervical/vaginal diagnoses, introduced in this article, is a flexible guideline and can be modified as appropriate to meet the needs of cytopathologists, referring physicians, and patients. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章



    更新日期:1989-01-01 00:00:00

  • Fine-needle aspiration versus large-needle biopsy or cutting biopsy in evaluation of thyroid nodules.

    abstract::This report describes our experience with both fine-needle aspiration (FNA) biopsies and large-needle biopsies (LNB) or core biopsies (CB) performed at the same time on 23 patients out of a series of 309 patients examined by the FNA technique. There was no significant differences in diagnostic accuracy of tissue obtai...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Silverman JF,West RL,Finley JL,Larkin EW,Park HK,Swanson MS,Fore WW

    更新日期:1986-01-01 00:00:00