Abstract:
:Telomerase is inactive in most somatic cells, but has been found to be reactivated in a majority of cancers. Our principal goal was to test whether the presence of telomerase activity concurred with positive cytology, and was thus of potential use in detecting cancer cells in effusions. The telomeric repeat amplification protocol (TRAP) assay and cytological examination were performed in a blinded fashion on 91 unselected effusions, for which laboratory processing was done according to standard procedures. In our series, 30% (27/91) of samples were found to be malignant by cytology. Of these, 19 (70%) were also positive in the TRAP assay. Of the 8 telomerase-negative cytology-positive samples, RNA integrity was generally poor, indicating suboptimal sample conservation for molecular analysis. Negative cytology in the presence of telomerase activity was observed in 17 effusions. Of these, 11 were from patients with advanced cancer, and thus a diagnosis of malignant effusion should be suspected. The TRAP assay for telomerase activity holds promise in the analysis of effusions, but its routine use as an adjunct to cytology awaits further confirmation of its positive predictive value.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Braunschweig R,Yan P,Guilleret I,Delacretaz F,Bosman FT,Mihaescu A,Benhattar Jdoi
10.1002/1097-0339(200103)24:3<174::aid-dc1036>3.0.subject
Has Abstractpub_date
2001-03-01 00:00:00pages
174-80issue
3eissn
8755-1039issn
1097-0339pii
10.1002/1097-0339(200103)24:3<174::AID-DC1036>3.0.journal_volume
24pub_type
杂志文章abstract::Paget's disease of the vulva is a rare entity; since it may show the same clinical symptoms as benign chronic vulvitis, it may result in a delayed diagnosis. A 63-year-old woman was found to have an eczematoid pink to red lesion located in the vulva. Scraping cytology of the vulva showed isolated malignant cells of Pa...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21160
更新日期:2010-02-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) and Kras gene mutations are crucial for discriminating patients responsive to anti-EGFR drugs in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), respectively. The majority of NSCLCs come to clinical attention at an advanced stage when surgery is no longer recomme...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22905
更新日期:2013-07-01 00:00:00
abstract::Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor of the pineal region of adults. We herein describe on a 34-year-old female the cytologic features of a PTPR studied using Diff-Quik stain. The patient presented hydrocephalia secondary to a pineal tumor. During surgery an intraoperative pathol...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23560
更新日期:2016-12-01 00:00:00
abstract::The cytomorphologic findings in fine-needle aspirates from 7 cases of salivary duct carcinoma (SDC) are reviewed and correlated with the histologic features. Malignant cytologic characteristics are clear in this tumor, and no false-negative results were obtained. But the absence of cribriform or papillary groups sugge...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199808)19:2<120::aid-dc11>
更新日期:1998-08-01 00:00:00
abstract::Cytological evaluation of cervical smears has been carried out in 4,338 women attending the Gynecology and Obstetrics Department and Family Planning Clinic of Queen Mary's Hospital, Lucknow, India, since April 1971. The incidence of cervical dysplasia was found to be 4.6% (205 out of 4,338) in the series, while malign...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840030107
更新日期:1987-03-01 00:00:00
abstract::Lung carcinoma is one of the commonest causes of cancer related death. Fine-needle aspiration cytology (FNAC) is a well-established technique in the diagnosis of various malignant tumors. FNAC is now an important technique in classifying lung carcinomas and also detecting salient mutational changes in lung carcinomas....
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.24089
更新日期:2019-04-01 00:00:00
abstract::We present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine-needle aspiration biopsies. The physaliferous cells in signet-ring, pearl-like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrangements are also desc...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840020112
更新日期:1986-01-01 00:00:00
abstract::Primary lymphoma of the breast (PLB) is a rare disease, representing 0.04-0.5% of all malignant breast neoplasms. We present a patient with bilateral breast involvement by a high-grade diffuse large B-cell lymphoma, which was diagnosed initially by fine-needle aspiration cytology (FNAC). Mammography revealed a diffuse...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20184
更新日期:2005-02-01 00:00:00
abstract::Sclerosing stromal tumor (SST) of the ovary is a distinct subtype of sex cord-stromal tumor, which is derived from the ovarian stroma and, in turn, from the sex cords of the embryonic gonads. It is a benign tumor, predominantly, unilateral in nature and mostly involves the right side of the ovary. Histopathological fe...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21639
更新日期:2012-04-01 00:00:00
abstract::Marginal zone B cell lymphomas (MZBCLs) represent a category of non-Hodgkin's lymphoma which may arise in a wide variety of extranodal organs where they are termed low grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT). MZBCLs may involve primarily lymph nodes and or spleen where they are designated mo...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199904)20:4<190::aid-dc2>3
更新日期:1999-04-01 00:00:00
abstract::Epithelioid gastrointestinal stromal tumors (GISTs) may cause significant diagnostic confusion on fine-needle aspiration (FNA) with carcinomas, neuroendocrine tumors, and melanoma, particularly when metastatic. This study characterizes the cytologic features of nine cases of epithelioid GISTs that were obtained by com...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10293
更新日期:2003-08-01 00:00:00
abstract::Adenomyoepithelioma is an uncommon tumor of the breast which clinically presents as a discrete nodule and histologically is composed of lumenal spaces lined by a mixture of epithelial and myoepithelial cells. It has a spectrum of histologic appearances which are gradually gaining wider recognition. There are, however,...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120311
更新日期:1995-05-01 00:00:00
abstract::We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were sugg...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23725
更新日期:2017-09-01 00:00:00
abstract::An 86-year-old Caucasian female presented with two weeks history of discomfort discharging urine, occasional hematuria, and suprapubic pain. The patient had a history of left salpingo-oophorectomy for an ovarian tumor, performed four years earlier. Ultrasound showed a solid mass surrounding the orifice of the left ure...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10095
更新日期:2002-06-01 00:00:00
abstract::Basal cell adenocarcinoma (BCAC) of salivary glands is uncommon low-grade malignancy. Only 19 cases of preoperative cytology were reported up to date. We present here a new case of BCAC arising in the minor salivary gland. Tumor was composed of clustered or isolated roundish, dark cells with small and regular nuclei. ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.23919
更新日期:2018-08-01 00:00:00
abstract::Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region. It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components. There are only few case reports describing the fine needle as...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21159
更新日期:2010-01-01 00:00:00
abstract::This study investigates the potential value of the nuclear matrix protein NMP179 as a marker of abnormal squamous cells in ThinPrep slides. Forty-six cervical scrapes were collected as cell suspensions and ThinPrep slides were prepared. They were double-immunostained for NMP179 and Cytokeratin 18 (CK18), an endocervic...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20061
更新日期:2004-09-01 00:00:00
abstract::The purpose of this study was to assess whether the same principles to evaluate renal transplant by fine-needle aspiration (FNA) for rejection could be applied to pancreatic allograft. Between 1996-1998, 25 ultrasound-guided FNAs on 13 patients with pancreatic allograft were performed and ThinPrep made. The percentage...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10179
更新日期:2002-11-01 00:00:00
abstract::The following is a correction to the original article that appeared in Diagnostic Cytopathology 1999;21:413-418. Owing to a publisher's error, Figure 4C on p. 415 was incorrectly reproduced. The correct illustrations and captions for this page are given here. ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200002)22:2<136::aid-dc19>
更新日期:2000-02-01 00:00:00
abstract::Primary hydatid disease of the skeletal muscle without systemic involvement is rare. The purpose of this report is to document the novel clinical presentation and the interesting facets of fine-needle aspiration in a case of hydatid disease. It was a case of primary hydatid cyst of the left supraspinatus muscle in an ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22925
更新日期:2014-03-01 00:00:00
abstract::The objective of this study was to evaluate the cytologic spectrum of small cell lesions of liver as diagnosed by fine-needle aspiration (FNA). Of 304 FNAs of liver that were performed in our institution between 1990 and 1994, 29 were classified as small-cell lesions. The final diagnoses were as follows: small-cell un...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199807)19:1<29::aid-dc6>3.
更新日期:1998-07-01 00:00:00
abstract::Given the prevalence of human papilloma virus (HPV) infection, an attempt was made to determine whether certain factors such as keratinization and/or squamous atypia are associated with its development. Review of our gynecologic cytology files from 1989 yielded 1,615 specimens showing parakeratosis and/or hyperkeratos...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120107
更新日期:1995-02-01 00:00:00
abstract::The aim of this study were (1) To correlate koilocytosis with high risk HPV(HrHPV) DNA in urinary bladder carcinoma and (2) To compare detection of koilocytosis on tissue sections and urine cytology. Biopsy and cytologic specimens from 33 patients of urinary bladder carcinoma were analyzed. HPV DNA was detected by PCR...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20978
更新日期:2009-03-01 00:00:00
abstract::Primary neuroendocrine carcinoma (carcinoid tumor) is among the rarest of middle-ear (ME) neoplasms, with only a rare case of metastatic disease having been reported. Fine-needle aspiration biopsy (FNAB) was performed in a 51-yr-old male with a two-decade history of multiple local recurrences from a right middle-ear n...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2031
更新日期:2001-09-01 00:00:00
abstract::Anaplastic thyroid carcinoma (ATC) is a rare but aggressive form of undifferentiated thyroid carcinoma which arises from previously well-differentiated thyroid carcinomas, such as papillary carcinoma or follicular carcinoma. We report on an interesting case of ATC found in an enlarging neck mass with metastatic papill...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23016
更新日期:2014-08-01 00:00:00
abstract::The Barr body is the inactive X chromosome in a female somatic cell. It is readily identified as plano-convex structure of 2-3 micron in diameter on the periphery of the nuclear membrane. The aim of this study is to evaluate the significance of Barr body count in malignant ovarian tumors on fine needle aspiration cyto...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21688
更新日期:2012-11-01 00:00:00
abstract::The serosal cavities are frequent sites of tumor metastasis. The distinction between carcinoma cells, inflammatory cells, and reactive or malignant mesothelial cells can be difficult in cytology. Multicolor flow cytometry (FCM) provides the opportunity to evaluate multiple antigens simultaneously, making it possible t...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21047
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:The 2012 American Society for Colposcopy and Cervical Pathology Consensus Guidelines provide information for managing abnormal cervical cancer screening tests and cancer precursors. According to these guidelines for Pap smear diagnosis of Atypical squamous cells of undetermined significance, reflex high risk...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24158
更新日期:2019-07-01 00:00:00
abstract::The diagnosis of nodular sclerosing classical Hodgkin lymphoma (NSCHL) by fine-needle aspiration (FNA) biopsy has historically been a diagnostic challenge due to the usual paucicellularity of the specimen. This case report, and other previously published reports, suggests that there is another facet to the potentially...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21829
更新日期:2014-03-01 00:00:00
abstract::Adenoid squamous-cell carcinoma (ASCCa) is an uncommon cancer which occurs most frequently in the skin of the head and neck region of elderly, sun-exposed individuals. Histologically, ASCCa is characterized by gland-like, "adenoid" cell groups with a central, detached acantholytic cellular component and an intact peri...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120218
更新日期:1995-03-01 00:00:00