Serous fluid cytology as a means of detecting hemophagocytosis in Epstein-Barr virus-induced autoimmune hemolytic anemia.

Abstract:

:The case of a 22-yr-old male who after a brief febrile episode developed autoimmune hemolytic anemia and right pulmonary infiltrate with pleural effusion is presented. Cytologic examination of the pleural fluid revealed lymphocytosis and hemophagocytosis, primarily of red blood cells (RBCs) by mature histiocytes. There was accompanying splenomegaly, laboratory evidence of hepatic dysfunction, and retroperitoneal lymphadenopathy. Besides profound reduction of red blood cells in the peripheral blood, there was reduction of lymphocytes and platelets. As a neoplastic process was ruled out by bone marrow and pleural biopsies, the disease was considered to be virus-induced and was halted and progressively regressed with early institution of vigorous antiinflammatory therapy with adrenocortical steroids. Upon reviewing the case, examination of the bone marrow biopsy disclosed limited hemophagocytosis of RBCs and lymphocytes by histiocytes and considerable viral cytopathic effect on hematopoietic cells (red and white cell precursors and megakaryocytes), which by appropriate immunolabelling was identified as induced by Epstein-Barr virus. A virus-related acquired hemophagocytic syndrome in its early stages was probably present, yet an undesirable clinical outcome was averted by early institution of vigorous steroid therapy. The need to recognize early hemophagocytic changes in cytologic specimens for early institution of appropriate therapy is emphasized. The possibility of erythrophagocytosis, also manifested during the course of an autoimmune hemolytic process and unrelated to hemophagocytic syndrome, is discussed.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Zaharopoulos P

doi

10.1002/dc.2048

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

248-52

issue

4

eissn

8755-1039

issn

1097-0339

pii

10.1002/dc.2048

journal_volume

25

pub_type

杂志文章
  • Chondroid syringoma diagnosed by fine needle aspiration cytology.

    abstract::Chondroid syringoma is a rare benign skin adnexal tumor of eccrine/apocrine origin affecting commonly the head and neck region. It used to be previously called as mixed tumor of skin because of the presence of both the epithelial and mesenchymal components. There are only few case reports describing the fine needle as...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21159

    authors: Kumar B

    更新日期:2010-01-01 00:00:00

  • Adenoviral cytopathic changes in pleural fluid: A unique cytological presentation mimicking malignancy.

    abstract::Adenoviruses are emerging as important viral pathogens in immunocompromised patients due to immunodeficiency diseases and recently hematopoietic stem cell and solid organ transplant recipients, impacting morbidity and even mortality. Immunocompromised children are prone to respiratory infection, due to alterations in ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24662

    authors: Harbhajanka A,Michael CW

    更新日期:2020-11-16 00:00:00

  • Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervix.

    abstract::Lobular endocervical glandular hyperplasia (LEGH) is a cervical lesion with pyloric gland metaplasia. Minimal deviation adenocarcinoma (MDA) is an extremely well differentiated form of endocervical adenocarcinoma (AC). To date, it is difficult to differentiate LEGH from MDA because they share similar clinical, radiolo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20859

    authors: Hashi A,Yuminamochi T,Xu JY,Kondo T,Katoh R,Hoshi K

    更新日期:2008-08-01 00:00:00

  • Fine-needle aspiration cytology of adrenal cryptococcosis: a case report.

    abstract::A case of adrenal cryptococcosis diagnosed by fine-needle aspiration biopsy cytology in a 58-yr-old man is presented. The organisms were easily seen with routine modified Wright stain (Diff-Quik) as variably sized yeasts, some with a brightly eosinophilic capsule. The diagnosis was confirmed with mucicarmine and silve...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840070123

    authors: Powers CN,Rupp GM,Maygarden SJ,Frable WJ

    更新日期:1991-01-01 00:00:00

  • Limiting factors for cytopathological diagnosis of high-grade squamous intraepithelial lesions: a cytohistological correlation between findings in cervical smears and loop electrical excision procedure.

    abstract::The present study sought possible factors leading to the cytological diagnosis of atypical squamous cells of uncertain significance (ASCUS) in cases of high-grade squamous intraepithelial lesions (HSIL). Based on retrospective histopathological analysis of loop electrical excision procedure (LEEP) products that diagno...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10035

    authors: Pinto AP AP,Tuon FF,Torres LF,Collaço LM

    更新日期:2002-01-01 00:00:00

  • Atypical squamous cells of undetermined significance: A cytohistological study in a colposcopy clinic.

    abstract::Cytohistologic correlation was performed by 3 observers on 100 atypical squamous cells of undetermined significance (ASCUS) cases from a colposcopy clinic. Our objectives were to: 1) subclassify ASCUS cases and determine their clinical significance; 2) assess the independent predictive value of different cytologic par...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199909)21:3<211::aid-dc14>

    authors: Ettler HC,Joseph MG,Downing PA,Suskin NG,Wright VC

    更新日期:1999-09-01 00:00:00

  • Current utilization of breast FNA in a cytology practice.

    abstract::Over the past decade, core biopsy rapidly replaced fine needle aspiration (FNA) in evaluation of diseases of the female breast in many centers in the USA. The inability to diagnose invasive cancer by FNA, and the general feeling of unease in interpretation of cytologic specimens among pathologists who are not trained ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20987

    authors: Simsir A,Rapkiewicz A,Cangiarella J

    更新日期:2009-02-01 00:00:00

  • Fine-needle aspiration cytology of pancreatoblastoma in a young woman: report of a case and review of the literature.

    abstract::Pancreatoblastoma is a rare tumor and has been reported only four times in the cytologic literature, three times in fine-needle aspiration (FNA) biopsy and once in an imprint of resected tumor. We are reporting the fourth case of FNA cytology with immunohistochemical and electron microscopic studies. The patient is a ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.20355

    authors: Zhu LC,Sidhu GS,Cassai ND,Yang GC

    更新日期:2005-10-01 00:00:00

  • Usefulness of Auto Cyto Fix (membrane filter method) for the application of immunohistochemistry.

    abstract::We developed the Auto Cyto Fix (ACF) 1000 as an experimental model, which was adapted as a membrane filter method for automatically making smear preparations fixed with 95% ethanol. In this study, immunohistochemistry was applied to the cells smeared on the membrane filter, and effectiveness was examined. Twenty-four ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10041

    authors: Iijima J,Shiina Y,Ohkoudo M,Sakuma K

    更新日期:2002-01-01 00:00:00

  • Effectiveness of AutoPap system location-guided screening in the evaluation of cervical cytology smears.

    abstract::Location-guided screening is a feature of the AutoPap primary screening software. Areas of the smear most likely to contain an abnormality are identified for prompt review by the cytotechnologist, thereby facilitating diagnostic accuracy and reducing laboratory workload. A two-armed retrospective study comprising 6,00...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20081

    authors: Stevens MW,Milne AJ,Parkinson IH,Nespolon WW,Fazzalari NL,Arora N,Dodd TJ

    更新日期:2004-08-01 00:00:00

  • Cytological features of mammary analogue secretory carcinoma of salivary gland: fine-needle aspiration of seven cases.

    abstract::Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion. There have been few case reports on the cytopathologic features of MASC to date. We examined the clinicopathological and cytological features of seven cases of MASC defined by RT-PCR a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23139

    authors: Higuchi K,Urano M,Takahashi RH,Oshiro H,Matsubayashi J,Nagai T,Obikane H,Shimojo H,Nagao T

    更新日期:2014-10-01 00:00:00

  • Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids.

    abstract::Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23248

    authors: Omori M,Kondo T,Yuminamochi T,Nakazawa K,Ishii Y,Fukasawa H,Hashi A,Hirata S

    更新日期:2015-07-01 00:00:00

  • Sputum cytology by the Saccomanno method in diagnosing lung malignancy.

    abstract::From 1,488 patients, satisfactory sputum was available for cytologic diagnosis. Overall diagnoses were correct in 85.4% of patients, false negative in 193 patients (13.0%), and false positive in 24 patients (1.6%). In patients with a malignant lung process, cytologic diagnoses were correct in 228 patients (54.2%) and ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840010406

    authors: Risse EK,van't Hof MA,Laurini RN,Vooijs PG

    更新日期:1985-10-01 00:00:00

  • Cytopathological features of solitary fibrous tumor of the pleura: a study of 5 cases.

    abstract::Solitary fibrous tumor is a rare lesion of serosal membranes. In a pleural location, it may be confused clinically with a localized mesothelioma or a peripheral lung tumor. A transthoracic needle aspiration can be done to obtain material for a diagnosis in these easily accessible tumors. In the literature, there are o...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199802)18:2<118::aid-dc7>3

    authors: Weynand B,Collard P,Galant C

    更新日期:1998-02-01 00:00:00

  • Testicular cytology in azoospermia.

    abstract::Two hundred-seventy-five azoospermic males were subjected to fine-needle aspiration (FNA) cytologic study of testis with the aim of determining the cause of azoospermia; 534 aspirates from these patients were classified as follows: normal spermatogenesis (162), hypospermatogenesis (mild, moderate, or severe, 226), abs...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090108

    authors: Verma AK,Basu D,Jayaram G

    更新日期:1993-01-01 00:00:00

  • Utility of cell blocks in the diagnosis of thyroid aspirates.

    abstract::Cell blocks (CBs) are often prepared with fine-needle aspirates (FNAs) from multiple organs as an adjunct to smears in the diagnosis of aspirated lesions. However, the literature contains few reports on their utility with regard to specific organ sites. At our institution, CBs are made routinely on FNAs when there is ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20385

    authors: Sanchez N,Selvaggi SM

    更新日期:2006-02-01 00:00:00

  • Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma.

    abstract::Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults. It has been described in numerous sites; however, the breast is one of the least common locations. We herein report a case of ALCL arising in the breast of a 36-yr-old pregnant woman. To our knowledge this is t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20442

    authors: Iyengar P,Reid-Nicholson M,Moreira AL

    更新日期:2006-04-01 00:00:00

  • Scrape cytology of the ovaries: potential role in intraoperative consultation of ovarian lesions.

    abstract::Intraoperative diagnosis of ovarian lesions can be achieved by gross examination with the help of frozen sections and/or cytologic examination. Various cytologic techniques, including imprint, fine-needle aspiration, and scrape, may be used. In this study, we evaluated the application of scrape cytology in the diagnos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10273

    authors: Khunamornpong S,Siriaunkgul S

    更新日期:2003-05-01 00:00:00

  • Prognostic value of breast cancer cytologic grading: a retrospective study of 213 cases.

    abstract::The authors evaluate 213 consecutive breast cancer cases with positive fine-needle aspiration cytology. Cytologic smears were reviewed and classified according to a grading system. A correlation between cytologic grading and pathological stage (T and N category) was observed. Univariate analysis of 5-yr overall surviv...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090210

    authors: Ciatto S,Bonardi R,Herd-Smith A,Cariaggi P,Confortini M,Bulgaresi P

    更新日期:1993-01-01 00:00:00

  • Cytological diagnosis of juvenile xanthogranuloma: A rare histiocytic disorder.

    abstract::Juvenile xanthogranuloma (JXG) is a rare type of non-Langerhan cell histiocytic disorder, which is mostly confined to skin of head and neck. It is a self-limiting benign condition, which does not require surgery. We present a case of 8-month-old girl child with multiple yellowish brown colored papules over scalp, face...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24310

    authors: Chauhan S,Diwaker P,Singh A,Gogoi P,Arora VK

    更新日期:2020-01-01 00:00:00

  • The use of gastric salvage cytology in the diagnosis of malignancy: a review of 731 cases.

    abstract::Over an 8-yr period at the Houston Veterans Hospital, 731 endoscopic gastric salvage cytologies were performed in 671 patients, with surgical biopsy also done in 660. Seventy-six patients subsequently had tissue biopsy-proven or resection-proven malignancies. Salvage cytology had a sensitivity of 91% and a specificity...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840060102

    authors: Green LK,Zachariah S,Graham DY

    更新日期:1990-01-01 00:00:00

  • Fine-needle aspiration cytology of recurrent and metastatic mixed mesodermal tumors.

    abstract::We report the cytological and clinical findings of 16 fine-needle aspirates (FNAs) performed on recurrent (n = 6) and metastatic (n = 10) mixed mesodermal tumors (MMMTs). The median interval between the primary diagnosis and FNA was 16 mo. Primary sites were the endometrium (n = 11), the ovary (n = 3), the cervix (n =...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840110404

    authors: Mourad WA,Sneige N,Katz RL,Caraway NP,Fanning TV

    更新日期:1994-12-01 00:00:00

  • The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses: developed and approved at the National Cancer Institute workshop in Bethesda, MD, December 12-13, 1988.

    abstract::The Bethesda System for reporting cervical/vaginal diagnoses, introduced in this article, is a flexible guideline and can be modified as appropriate to meet the needs of cytopathologists, referring physicians, and patients. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840050318

    authors:

    更新日期:1989-01-01 00:00:00

  • Micronucleus assay in buccal smears of breast carcinoma patients.

    abstract::The aim of this study is to compare micronucleus assay in buccal smear of breast carcinoma patients versus normal benign cases as control group. In this prospective study, we selected a total 32 patients of carcinoma of breast and 49 patients of benign breast lesions diagnosed in fine needle aspiration cytology (FNAC)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21589

    authors: Dey P,Samanta S,Susheilia S

    更新日期:2012-08-01 00:00:00

  • Diagnosis of peripheral T-cell lymphoma by fine-needle aspiration biopsy: a cytomorphologic and immunophenotypic approach.

    abstract::The diagnosis of T-cell lymphomas by fine-needle aspiration biopsies (FNAB) is extremely difficult. This is mainly due to the rarity of the disease, the morphologic similarity to reactive lymphadenopathy, and the difficulty in identifying abnormal T-cell antigen expression. We studied FNAB of histologically proven T-c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200012)23:6<375::aid-dc2>3.0.co;

    authors: Al Shanqeety O,Mourad WA

    更新日期:2000-12-01 00:00:00

  • Cytomorphological features of high-grade intraepithelial neoplasia/carcinoma of the cervix following chemoradiotherapy.

    abstract:BACKGROUND:Cervicovaginal cytology as a follow-up study in women with a history of a cervical carcinoma treated with chemo-radiotherapy (CRT) plays an important role; however, the cytomorphological characteristics for the diagnosis of high-grade squamous intraepithelial lesions (H-SIL) in post-CRT patients have not bee...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24070

    authors: Serrano-Arévalo ML,Flores-Hernández L,Villegas-González LF,Zamora-Zarco S,España-Ferrufino A,Lino-Silva LS,Barquet-Muñoz SA

    更新日期:2019-03-01 00:00:00

  • Evaluation of flow cytometric immunophenotyping and DNA analysis for detection of malignant cells in serosal cavity fluids.

    abstract::The serosal cavities are frequent sites of tumor metastasis. The distinction between carcinoma cells, inflammatory cells, and reactive or malignant mesothelial cells can be difficult in cytology. Multicolor flow cytometry (FCM) provides the opportunity to evaluate multiple antigens simultaneously, making it possible t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21047

    authors: Sayed DM,el-Attar MM,Hussein AA

    更新日期:2009-07-01 00:00:00

  • Acquired myospherulosis secondary to gluteal augmentation on fine needle aspiration cytology: A diagnostic challenge.

    abstract::A 30-year-old female presented with a three-month history of a multilocular cystic lesion over the lumbosacral spine. Fine-needle aspiration biopsy (FNA) of the lesion was performed at an outside institution, and a cytologic diagnosis, suspicious for chordoma, was rendered. The patient presented for surgical consultat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23871

    authors: Alperstein S,Dilcher T,Viswanathan K,Rao RA,Siddiqui MT,Giorgadze T

    更新日期:2018-05-01 00:00:00

  • Does noninvasive follicular thyroid neoplasm with papillary-like nuclear features have distinctive features on sonography?

    abstract:BACKGROUND:The noninvasive encapsulated follicular variant of papillary carcinoma (nEFVPTC) has recently been reclassified to "noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)," removing this entity from the malignant category. This re-categorization has had major implications for cl...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23863

    authors: Brandler TC,Yee J,Zhou F,Cho M,Cangiarella J,Wei XJ,Yee-Chang M,Sun W

    更新日期:2018-02-01 00:00:00

  • Pilomyxoid astrocytoma of the pineal region: cytopathological features and differential diagnostic considerations by intraoperative smear preparation.

    abstract::Pilomyxoid astrocytoma (PMA) is a recently identified type of pilocytic astrocytoma (PA) with shorter progression-free and overall survival, higher rate of recurrence, and higher risk of leptomeningeal spread compared to pilocytic tumors (WHO grade 2 designation). A case is presented here in which intraoperative impri...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23133

    authors: Hayashi T,Haba R,Kushida Y,Katsuki N,Shibuya S,Kadota K,Matsunaga T,Miyake K,Tamiya T

    更新日期:2015-02-01 00:00:00