Cytomorphological features of high-grade intraepithelial neoplasia/carcinoma of the cervix following chemoradiotherapy.

Abstract:

BACKGROUND:Cervicovaginal cytology as a follow-up study in women with a history of a cervical carcinoma treated with chemo-radiotherapy (CRT) plays an important role; however, the cytomorphological characteristics for the diagnosis of high-grade squamous intraepithelial lesions (H-SIL) in post-CRT patients have not been established. The aim of the study is to find the cytomorphological characteristics that support the diagnosis of H-SIL by conventional cytology in these patients. MATERIALS AND METHODS:This is a cross-sectional study from 2009 to 2015, which includes patients with a diagnosis of squamous cell carcinoma treated with CRT, who all have cervix cytology for follow-up and a later biopsy. RESULTS:We identified 82 cases, where the most frequent clinical stage was IIA1 to IIB with 26 cases (61.9%), the most common symptom was transvaginal bleeding (64.29%). The cytological characteristics that were statistically associated with the presence of a positive biopsy were the presence of a hemorrhagic background (45.2% vs. 12.5%, P = .007), high cellularity (45.2% vs. 15%, P < .001), disposition in groups/sheets (69% vs. 22.5%, P < .001), postradiotherapy changes at the background of the smear (73.8 vs. 50%, P < .001) and an increased nuclear/cytoplasmic ratio (100% vs. 22.5%, P < .001). CONCLUSIONS:In patients with CRT, the presence of specific features can help the diagnosis of H-SIL with excellent diagnostic performance.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Serrano-Arévalo ML,Flores-Hernández L,Villegas-González LF,Zamora-Zarco S,España-Ferrufino A,Lino-Silva LS,Barquet-Muñoz SA

doi

10.1002/dc.24070

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

194-199

issue

3

eissn

8755-1039

issn

1097-0339

journal_volume

47

pub_type

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