Effectiveness of AutoPap system location-guided screening in the evaluation of cervical cytology smears.


:Location-guided screening is a feature of the AutoPap primary screening software. Areas of the smear most likely to contain an abnormality are identified for prompt review by the cytotechnologist, thereby facilitating diagnostic accuracy and reducing laboratory workload. A two-armed retrospective study comprising 6,000 conventional smears was undertaken to compare this approach with the current practice of full manual screening of conventional smears. Discrepant diagnoses between the two study arms were subject to an internal discrepancy review process to determine the final truth diagnosis. Analysis of the results show that AutoPap location-guided screening is at least equivalent to current practice when detecting high-grade or suspected high-grade smears. However, the device does not detect low-grade abnormalities, unsatisfactory smears, an endocervical component or organisms, as well as standard screening. The device also assigns a numerical score to each slide, with abnormal smears allocated a higher rank. Slide ranking was found to be of value in triaging abnormal smears for prompt screening and reporting. The performance of the primary screening software was found to be comparable to previous studies, with the majority of abnormal smears being selected by the instrument for manual review.


Diagn Cytopathol


Diagnostic cytopathology


Stevens MW,Milne AJ,Parkinson IH,Nespolon WW,Fazzalari NL,Arora N,Dodd TJ




Has Abstract


2004-08-01 00:00:00












  • Large pulmonary cryptococcoma and cryptococcal meningitis in an immunocompetent patient: a case report.

    abstract::Pulmonary cryptococcoma is a life threatening mycosis and is an unusual disease for immunocompetent individuals. Herein we report a case of large pulmonary cryptococcoma associated with cryptococcal meningitis, presenting radiologically as a lung mass in right upper lobe, in a previously healthy, HIV negative, immunoc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Singh R,Joshi D,Gupta A,Gangane N

    更新日期:2010-12-01 00:00:00

  • How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.

    abstract:BACKGROUND:The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Roychoudhury S,Klein M,Souza F,Gimenez C,Laser A,Shaheen Cocker R,Chau K,Das K

    更新日期:2017-04-01 00:00:00

  • Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review.

    abstract::Granulosa cell tumors (GCT) of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors (MGCT). Between 2000 and 2014, eight cases of MGCT were diagnosed by FNA. Clini...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Harbhajanka A,Bitterman P,Reddy VB,Park JW,Gattuso P

    更新日期:2016-12-01 00:00:00

  • Follicular thyroid lesions coexisting with Hashimoto's thyroiditis: incidence and possible sources of diagnostic errors.

    abstract::Our objectives were to study the types and incidence of thyroid follicular lesions coexisting with Hashimoto's thyroiditis (HT), the pitfalls in their cytodiagnosis, and the effect on management. All cases of HT diagnosed by fine-needle aspiration (FNA) and/or histology over a 7-yr period were retrospectively studied....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kollur SM,El Sayed S,El Hag IA

    更新日期:2003-01-01 00:00:00

  • The cytopathology of mycobacterial infection.

    abstract::Mycobacterial infection, tuberculosis (TB) in particular, remains one of the world's deadliest communicable diseases in adults and particularly in children, in low and middle income countries. The combination of human immunodeficiency virus (HIV) and TB is often lethal with TB accounting for 25% of deaths in the HIV p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Michelow P,Omar T,Field A,Wright C

    更新日期:2016-03-01 00:00:00

  • Routine vaginal Pap test is not useful in women status-post hysterectomy for benign disease.

    abstract::The US Preventive Services Task Force (USPTF) has recommended that routine vaginal Pap (V-Pap) screening is unnecessary for women status-post (S/P) total hysterectomy (T-Hyst) for benign disease (Guide to Clinical Preventive Services. 2nd ed. Baltimore, MD: Williams & Wilkins; 1996. p 105-118). However, many US women ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Farghaly H,Bourgeois D,Houser PM,Padmanabhan V,Lage JM,Hoda RS

    更新日期:2006-09-01 00:00:00

  • Fine-needle aspiration cytology of clear-cell sarcoma of the kidney: study of eight cases.

    abstract::The largest series, to date, of fine-needle aspiration cytology (FNAC) findings in clear-cell sarcoma of the kidney (CCSK) is presented. All fine-needle aspirates of pediatric renal masses over a 17-yr period were reviewed. Eight out of 119 aspirates from late-stage childhood renal tumors (6.72%) were found to be CCSK...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Iyer VK,Agarwala S,Verma K

    更新日期:2005-08-01 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis with fine-needle aspiration in a case with nodal and nasal involvement.

    abstract::Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Alvarez Alegret R,Martinez Tello A,Ramirez T,Gállego P,Martinez D,García Julían G

    更新日期:1995-11-01 00:00:00

  • Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma.

    abstract::Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults. It has been described in numerous sites; however, the breast is one of the least common locations. We herein report a case of ALCL arising in the breast of a 36-yr-old pregnant woman. To our knowledge this is t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Iyengar P,Reid-Nicholson M,Moreira AL

    更新日期:2006-04-01 00:00:00

  • Breast filariasis diagnosed by needle aspiration cytology.

    abstract::A case of nodular lesion of the breast in a 37 year old female caused by filariasis is described. The case is instructive since the diagnosis was made by fine-needle aspiration cytology. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: SenGupta SK,Webb S,Cooke RA,Igo JD

    更新日期:1992-01-01 00:00:00

  • The diagnostic utility of cell block in fine needle aspiration cytology of palpable breast lesions in a Nigerian tertiary health institution.

    abstract:BACKGROUND:Although fine needle aspiration cytology (FNAC) is highly accurate for detecting breast malignancies, concerns remain among cytopathologists about false-positive and false-negative diagnoses. Cell block (CB) preparations have been advocated by some cytopathologists as one of the methods to improve and consol...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Obiajulu FJN,Daramola AO,Anunobi CC,Ikeri NZ,Abdulkareem FB,Banjo AA

    更新日期:2020-12-01 00:00:00

  • Lipoblastoma presenting as a rapidly growing paravertebral mass and masquerading as myxoid liposarcoma on fine needle aspiration cytology.

    abstract::Lipoblastoma is a peculiar variant of lipoma occurring almost exclusively during infancy and early childhood. It is found most commonly in the upper and lower extremities; less common sites are head and neck, trunk, mediastinum, and retroperitoneum. It has a greater predilection for boys and commonly presents as a slo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kalaivani Selvi S,Pradhan P,Rajesh NG,Gochhait D,Barwad A

    更新日期:2016-05-01 00:00:00

  • Interpretation of endometrium obtained by the Endo-pap sampler and a clinical study of its use.

    abstract::Endometrical cytology sampling using the Endo-pap sampler is an inexpensive, painless, and simple procedure. Tissue microfragments obtained include surface epithelial sheets, gland segments, and stromal cell aggregates. Gland segments are critical for evaluation of the sample. Glands are dilated in hyperplasia and the...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Palermo VG

    更新日期:1985-01-01 00:00:00

  • Lymphomatous effusion of monomorphic epitheliotropic intestinal T-cell lymphoma is characterized by azurophilic granules and is a dismal sign: Report of two new cases with literature review.

    abstract::Lymphoma involving serous effusion is uncommon. The diagnosis of effusion lymphoma may be challenging, particularly when the lymphoid cells are small to medium-sized, which would be difficult for differentiating reactive effusions from low grade lymphomas. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pan ST,Wang RC,Su YZ,Hsieh YC,Chuang SS

    更新日期:2021-01-02 00:00:00

  • Malignant mixed tumor (carcinosarcoma) of parotid gland diagnosed by fine-needle aspiration biopsy.

    abstract::True malignant mixed tumor (carcinosarcoma) of salivary gland is a very rare neoplasm. Only one brief account of the Fine-Needle Aspiration Biopsy (FNAB) cytologic findings of this tumor was found in the literature. The authors report a case of malignant mixed tumor (chondrosarcoma and epidermoid carcinoma) arising fr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Granger JK,Houn HY

    更新日期:1991-01-01 00:00:00

  • Adenomatous neuroendocrine tumors of the middle ear (MEANTs) with local invasion and lymph nodes metastasis: A brief report of a rare neoplasm.

    abstract::Adenomatous neuroendocrine tumors of the middle ear (MEANTs) are very rare neoplasms which are composed of both epithelial and neuroendocrine components. They have mostly bland histology and indolent biological behavior, yet they may recur and metastasize. Here we present a case of MEANT with ipsilateral local brain, ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Yang L,Asiry S,Khader SN

    更新日期:2020-10-12 00:00:00

  • Logistic regression analysis of myxoid sarcomas: a cytologic study.

    abstract::The objective of this study was to identify key diagnostic cytologic criteria for the most common myxoid sarcomas studied by fine-needle aspiration cytology. We reviewed 27 myxoid malignant fibrous histiocytomas, 8 chordomas, 16 chondrosarcomas, and 12 myxoid liposarcomas in which both cytologic specimens and final hi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Layfield LJ,Liu K,Dodge RK

    更新日期:1998-11-01 00:00:00

  • Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.

    abstract::Nephroblastoma (Wilms' tumor) is the most common childhood renal tumor and usually presents with a histology and cytology consisting of blastemal, epithelial, and stromal cells. Effusions are not uncommon and may suggest an unfavorable prognosis when containing anaplastic tumor cells. In the present case, we report th...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Schinstine M,Abati A,Tsokos M,Fox E,Filie AC

    更新日期:2006-09-01 00:00:00

  • Ovarian carcinoma cells in effusions show increased S-phase fraction compared to corresponding primary tumors.

    abstract::The objective of this study was to analyze large-scale genomic patterns during disease progression from primary tumor to effusion in ovarian carcinoma, and to study the association between DNA ploidy parameters in effusions, proliferation/survival markers, and clinicopathologic characteristics. DNA ploidy status, DNA ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kleinberg L,Pradhan M,Tropé CG,Nesland JM,Davidson B,Risberg B

    更新日期:2008-09-01 00:00:00

  • Metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature.

    abstract::Pancreatic pheochromocytomas are rare and typically diagnosed by local resection. We present the first reported case of metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and cytology. A 67-year-old female presented with 2 to 3 months of abdominal pai...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Yang SX,Dogra VS,Kothari TH,Reyes MCD

    更新日期:2020-03-01 00:00:00

  • Diagnosis and differential diagnosis of small-cell lesions of the liver.

    abstract::The objective of this study was to evaluate the cytologic spectrum of small cell lesions of liver as diagnosed by fine-needle aspiration (FNA). Of 304 FNAs of liver that were performed in our institution between 1990 and 1994, 29 were classified as small-cell lesions. The final diagnoses were as follows: small-cell un...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pisharodi LR,Bedrossian C

    更新日期:1998-07-01 00:00:00

  • Utility of fine needle aspiration cytology to diagnose intraoral tuberculosis and other oral granulomatous lesions.

    abstract:OBJECTIVE:Tuberculosis (TB) is a common granulomatous disease leading to high morbidity and mortality worldwide. Though rare, oral tuberculosis (OTB) may manifest during the primary and/or secondary stages of the illness. We studied the manifestations and incidence of oral granulomatous lesions (OGL) and OTB diagnosed ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Agarwal R,Singh M,Sharma S,Jaiswal A,Jain SL,Khurana N,Meher R

    更新日期:2019-03-01 00:00:00

  • Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma.

    abstract::Tumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis. Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Miyake Y,Aratake Y,Sakaguchi T,Kiyoya K,Kuribayashi T,Marutsuka K,Ohno E

    更新日期:2012-12-01 00:00:00

  • Cytopathologic characteristics of SMARCB1 (INI-1) deficient sinonasal carcinoma: A potential diagnostic pitfall.

    abstract::Tumors of the head and neck are extremely diverse and a subset are poorly differentiated and difficult to classify. Recently, a new entity has been described with rhabdoid and/or plasmacytoid cytologic features and a characteristic genetic signature-inactivation of the SMARCB1 (INI-1) tumor suppressor gene. To date, o...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Allison DB,Bishop JA,Ali SZ

    更新日期:2016-08-01 00:00:00

  • Expression of proliferating cell nuclear antigen, Ki-67 antigen, estrogen receptor protein, and tumor suppressor p53 gene in cytologic samples of breast cancer: an immunochemical study with clinical, pathobiological, and histologic correlations.

    abstract::Sixty-six unselected breast cancers were analyzed in cytologic smears and histologic sections for the expression of Ki-67, proliferating cell nuclear antigen (PCNA), estrogen receptor protein (ERP), and p53 protein using a standard immunochemical method. The results, expressed as both positive cases and labelling inde...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pelosi G,Bresaola E,Rodella S,Manfrin E,Piubello Q,Schiavon I,Iannucci A

    更新日期:1994-01-01 00:00:00

  • Cytologic diagnosis of pseudomyxoma peritonei: common and uncommon causes.

    abstract::Pseudomyxoma peritonei (PP) refers to accumulation of mucus in the peritoneal cavity, regardless of cause or pathogenesis. We have reviewed 8 cases of PP diagnosed in our institution over the past 5 years. Pertinent cytologic features include a mucinous background with mesothelial cells and histiocytes. Two cases cont...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pisharodi LR,Bedrossian CW

    更新日期:1996-02-01 00:00:00

  • Cytohistological correlation in patients with atypical glandular cells on Papanicolaou test in a Chilean population.

    abstract::The standard screening test for detecting cervical lesions and cancers is a Papanicolaou (Pap) smear. While squamous cell abnormalities remain the most common positive Pap test result, cytologic findings of glandular cell abnormalities have become more frequent in recent decades. The 2014 Bethesda System for reporting...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: González-Espinoza D,Ponce Camus K,Meneses Pérez I,Molina Cruz C

    更新日期:2020-09-01 00:00:00

  • Lipid-rich carcinoid tumor of the thymus gland: diagnosis by fine-needle aspiration biopsy.

    abstract::In this report we describe the cytologic features of an unusual thymic carcinoid tumor containing prominent cytoplasmic lipid vacuoles that was diagnosed by fine-needle aspiration biopsy. The tumor presented as a presternal subcutaneous mass in an 81-yr-old female, with a contiguous mediastinal mass on computed tomogr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Smith NL,Finley JL

    更新日期:2001-08-01 00:00:00

  • Glycogen-rich clear cell carcinoma of the breast: report of a case with fine-needle aspiration cytology and immunocytochemical and ultrastructural studies.

    abstract::Fine-needle aspiration cytology, immunocytochemistry, and electron microscopic findings are described in a case of glycogen-rich clear cell carcinoma of the breast. The aspirate contained many small and large papillary cell groups and numerous single tall columnar cells with apical cytoplasmic projections and mild to ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Alexiev BA

    更新日期:1995-02-01 00:00:00

  • Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

    abstract::Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ishida M,Arimoto T,Sandoh K,Okano K,Ebisu Y,Ito H,Matsumoto M,Mizokami T,Kita M,Okada H,Tsuta K

    更新日期:2019-03-01 00:00:00