Abstract:
:Cytohistologic correlation was performed by 3 observers on 100 atypical squamous cells of undetermined significance (ASCUS) cases from a colposcopy clinic. Our objectives were to: 1) subclassify ASCUS cases and determine their clinical significance; 2) assess the independent predictive value of different cytologic parameters for biopsy-proven dysplasia (BPD); and 3) calculate interobserver variability. The prevalence of BPD was 73% in the ASCUS favor dysplasia (AFD) group, and 27% in the ASCUS favor reactive (AFR) group (P 0.001). The sensitivity of cervical cytology (AFD) for detecting BPD was 88.5%. Using multiple logistic regression, only nuclear membrane irregularity was found to be independently predictive of BPD (P 0.0001). The interobserver agreement (kappa) was 0.41. Colposcopic smears were inferior to referring smears in detecting dysplasia, with 67% of patients having a referring diagnosis of dysplasia. In a colposcopy clinic population there is a high prevalence (73%) of BPD in the AFD group. Attention should be paid to nuclear membrane irregularity in the risk stratification of ASCUS cases. Diagn. Cytopathol. 1999;21:211-216.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Ettler HC,Joseph MG,Downing PA,Suskin NG,Wright VCdoi
10.1002/(sici)1097-0339(199909)21:3<211::aid-dc14>subject
Has Abstractpub_date
1999-09-01 00:00:00pages
211-6issue
3eissn
8755-1039issn
1097-0339pii
10.1002/(SICI)1097-0339(199909)21:3<211::AID-DC14>journal_volume
21pub_type
杂志文章abstract::Recurrence of carcinoma in scars following surgical treatment of breast carcinoma is a frequent problem. An early diagnosis of recurrent lesions is essential to enable timely management. In this study, the role of fine-needle aspiration cytology (FNAC) in the diagnosis of scar lesions was evaluated in 156 women seen o...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199701)16:1<14::aid-dc4>3.
更新日期:1997-01-01 00:00:00
abstract::Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to de...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.23668
更新日期:2017-03-01 00:00:00
abstract::Pseudomyxoma peritonei (PP) refers to accumulation of mucus in the peritoneal cavity, regardless of cause or pathogenesis. We have reviewed 8 cases of PP diagnosed in our institution over the past 5 years. Pertinent cytologic features include a mucinous background with mesothelial cells and histiocytes. Two cases cont...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199602)14:1<10::AID-DC3>3.
更新日期:1996-02-01 00:00:00
abstract::The present study sought possible factors leading to the cytological diagnosis of atypical squamous cells of uncertain significance (ASCUS) in cases of high-grade squamous intraepithelial lesions (HSIL). Based on retrospective histopathological analysis of loop electrical excision procedure (LEEP) products that diagno...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10035
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high-grade urothelial carcinoma (HGUC) but not low-grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more l...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23767
更新日期:2017-09-01 00:00:00
abstract::Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, benign, inflammatory disorder involving the skin and microvasculature with an undetermined etiopathogenesis. Although the histopathology is well-characterized, the cytologic features of this entity have been rarely described in literature. This study w...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24563
更新日期:2021-01-01 00:00:00
abstract::Brushing cytology is frequently utilized for the investigation of pancreatic and biliary strictures but is associated with low diagnostic sensitivity. The Papanicolaou Society of Cytopathology has presented a system for diagnostic classification which includes the categories benign, atypical, suspicious for malignancy...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23035
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Molecular testing is an essential step in providing patients with advanced non-small-cell lung cancer (NSCLC), the most appropriate front-line targeted therapies. We recently implemented targeted NGS on previously discarded cytology centrifuged supernatant (CCS). METHODS:In this study, we reviewed our imple...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24548
更新日期:2020-12-01 00:00:00
abstract::A 30-year-old female presented with a three-month history of a multilocular cystic lesion over the lumbosacral spine. Fine-needle aspiration biopsy (FNA) of the lesion was performed at an outside institution, and a cytologic diagnosis, suspicious for chordoma, was rendered. The patient presented for surgical consultat...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23871
更新日期:2018-05-01 00:00:00
abstract::The 2001 Bethesda System diagnostic category of atypical squamous cells cannot exclude a high grade squamous intraepithelial lesion (ASC-H) was developed and implemented after many studies that proved its clinical relevance. In this study, we describe the practice experience of a hospital-based reference laboratory wi...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20227
更新日期:2005-04-01 00:00:00
abstract::Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic c...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23825
更新日期:2018-03-01 00:00:00
abstract::Bilateral testicular fine-needle aspiration cytology (FNAC) was performed in 100 males, including 10 controls with normal fertility and 90 infertile azoospermic males. The various seminiferous tubular cells were easily identified in smears. It was possible to give a cytological diagnosis in histologic terms by analysi...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840070103
更新日期:1991-01-01 00:00:00
abstract::We applied TdT-mediated deoxyuridine triphosphate (dUTP)-biotin nick end labeling (TUNEL) to cytologic smears in order to detect the cells undergoing apoptosis. These smears were obtained by scraping the cut surface of 9 cases of carcinoma, including renal-cell carcinoma (3 cases), esophageal squamous-cell carcinoma (...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199806)18:6<398::aid-dc3>3
更新日期:1998-06-01 00:00:00
abstract::A case of granulocyte colony-stimulating factor (G-CSF)-producing small-cell carcinoma of the uterine cervix is described. In a 70-yr-old woman, clusters of small cells with hyperchromatic nuclei at a high nuclear/cytoplasmic ratio were detected cytologically in the cervix. These clusters were diagnosed as a small-cel...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/1097-0339(200010)23:4<269::aid-dc11>3.0.co
更新日期:2000-10-01 00:00:00
abstract::Pilomyxoid astrocytoma (PMA) is a recently identified type of pilocytic astrocytoma (PA) with shorter progression-free and overall survival, higher rate of recurrence, and higher risk of leptomeningeal spread compared to pilocytic tumors (WHO grade 2 designation). A case is presented here in which intraoperative impri...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23133
更新日期:2015-02-01 00:00:00
abstract::Fine-needle aspiration biopsies from three patients with neuroblastoma were studied by light microscopy, and the morphologic findings were correlated with those from transmission and scanning electron microscopy. Light microscopic examination of the aspiration smears from all three cases revealed small and large round...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840040410
更新日期:1988-01-01 00:00:00
abstract::Extramedullary multiple myeloma (EMM) involving the liver as a focal space-occupying lesion is very rare, especially in the patients with cirrhosis. Here, we report a case of EMM in the liver and periportal lymph node, diagnosed by endoscopic ultrasound guided-fine-needle aspiration (EUS-FNA). A 57-year-old male patie...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24416
更新日期:2020-07-01 00:00:00
abstract::Synovial sarcomas (SS) of the head and neck region are extremely rare and arise in only 5% of cases. We present a case of secondary SS of the thyroid originally diagnosed as medullary carcinoma on fine needle aspiration (FNA). A 41-year-old man presented with several weeks of dysphonia and a left thyroid mass. FNA of ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23327
更新日期:2015-11-01 00:00:00
abstract::Fine-needle aspiration biopsy findings in three cases of chromophobe cell carcinoma are described and correlated with histologic and ultrastructural observations. In addition, comparisons are made with three cases each of oncocytoma and granular cell carcinoma. The cells in aspiration smears from chromophobe cell carc...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840130403
更新日期:1995-11-01 00:00:00
abstract::Flow cytometry is a rapid method for measuring DNA content. Its high sensitivity and specificity in detecting transitional cell carcinomas in bladder washings should make it a routinely applied adjunct to cytology once universal laboratory standards are firmly established. Diagnostic and prognostic information on soli...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.2840130219
更新日期:1995-08-01 00:00:00
abstract::Cultured anaplastic cell lines with previously characterized phenotypes are considered to be the best positive controls for immunocytochemistry. We assessed the validity of using anaplastic cell line cytospins as positive controls for immunocytochemistry performed on ThinPrep-processed clinical samples. We compared Th...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2059
更新日期:2001-11-01 00:00:00
abstract::The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formalized in October 2007 by experts in thyroidology at the National Institute of Health in Bethesda, Maryland. The first edition of the TBSRTC book was published in 2010 and the second edition in 2018. The TBSRTC is widely employed in cytology prac...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24385
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Documenting the four molecular subtypes of breast carcinoma is significant as they determine response to therapy, disease free interval and survival. Our aim was to document the subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23607
更新日期:2016-12-01 00:00:00
abstract::Myoepithelial carcinoma is a rare locally aggressive malignant neoplasm of the salivary glands. The tumor is composed almost exclusively of tumor cells with myoepithelial differentiation and characterized by infiltrative growth and potential for distant metastasis. Tumor cells often display morphologic heterogeneity w...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.21196
更新日期:2010-04-01 00:00:00
abstract::Analyses of pancreatic juice by proteomics have identified many proteins that are overabundant in pancreatic cancer (PC) juice. The mechanism by which secretion of these proteins occur remains unclear. Pancreatic juice was collected from patients with three pancreatic diseases: PC, chronic pancreatitis (CP), and simpl...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21484
更新日期:2011-12-01 00:00:00
abstract::Malignant renal neoplasms are common solid tumors in pediatric oncology practice. These include the common Wilms' tumor/nephroblastoma and the uncommon neoplasms such as clear-cell sarcoma of the kidney (CCSK), rhabdoid tumor, renal-cell carcinoma, and others. The aim of this study was to describe in detail the cytopa...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20242
更新日期:2005-05-01 00:00:00
abstract::Telomerase is inactive in most somatic cells, but has been found to be reactivated in a majority of cancers. Our principal goal was to test whether the presence of telomerase activity concurred with positive cytology, and was thus of potential use in detecting cancer cells in effusions. The telomeric repeat amplificat...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/1097-0339(200103)24:3<174::aid-dc1036>3.0.
更新日期:2001-03-01 00:00:00
abstract::Our previous study showed that the sensitivity of head and neck fine-needle aspiration (FNA) procedures was significantly better in the cytopathologist-performed group than in the noncytopathologist-performed group (96 versus 67%). Recently, cytopathologists have learned to use ultrasound machines to assist them in pe...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21460
更新日期:2011-10-01 00:00:00
abstract::The authors describe a rare case of intrapulmonary solitary fibrous tumor (SFT). Morphologically, the tumor showed a disorganized or "patternless" arrangement of plump to spindle cells in a collagenous stroma. Tumor cells were immunoreactive for vimentin, but not for keratin, carcinoembryonic antigen, epithelial membr...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199602)14:1<64::AID-DC13>3
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:The essential of urine cytology for the diagnosis and the follow-up of urothelial neoplasia has been widely recognized. However, there are some cases in which a definitive diagnosis cannot be made due to difficulty in discriminating between benign and malignant. This study evaluated the practicality of nucle...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23469
更新日期:2016-06-01 00:00:00