Granulocyte colony-stimulating factor-producing small-cell carcinoma of the uterine cervix: report of a case.

Abstract:

:A case of granulocyte colony-stimulating factor (G-CSF)-producing small-cell carcinoma of the uterine cervix is described. In a 70-yr-old woman, clusters of small cells with hyperchromatic nuclei at a high nuclear/cytoplasmic ratio were detected cytologically in the cervix. These clusters were diagnosed as a small-cell neuroendocrine carcinoma by the concomitant use of Grimelius staining and immunohistochemical staining, in addition to electron microscopic observation. This patient showed a significant increase in peripheral leukocytes, despite the absence of infectious signs. Immunohistochemical findings, together with a high blood G-CSF level, suggested the production of G-CSF from the tumor. Consistent with the knowledge that both small-cell carcinoma and G-CSF-producing tumors have a poor prognoses, the patient had no or partial response to therapies performed, and died from the cancer 11 mo after it was diagnosed. This case strongly indicates the need for early diagnosis of this type of tumor, based on cytological features.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Watanabe A,Wachi T,Omi H,Nishii H,Ochiai K,Tanaka T,Endo Y

doi

10.1002/1097-0339(200010)23:4<269::aid-dc11>3.0.co

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

269-74

issue

4

eissn

8755-1039

issn

1097-0339

pii

10.1002/1097-0339(200010)23:4<269::AID-DC11>3.0.CO

journal_volume

23

pub_type

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