Metastatic breast carcinoma in pleural fluid: Correlation of receptor and HER2 status with the primary carcinoma-a pilot study.

Abstract:

BACKGROUND:Documenting the four molecular subtypes of breast carcinoma is significant as they determine response to therapy, disease free interval and survival. Our aim was to document the subtypes defined by immunohistochemistry (IHC) expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2): namely ER + PR+ HER2+; ER + PR + HER2-; ER-PR-HER2+; and ER-PR-HER2- in metastatic breast carcinoma in pleural fluid and compare them with their expression in the primary breast tumor. METHODS:Over a period of 18 months, 13 cases of invasive breast carcinoma with metastases to the pleural cavity were studied for subtypes. ER, PR, and HER2 were determined by IHC in the primary breast tumor and the cell blocks of the pleural fluid with metastatic carcinoma. RESULTS:Age ranged from 33 to 75 years. The primary tumor was ER + PR + HER2+; ER + PR + HER2-; ER-PR-HER2+ and ER-PR-HER2- in 2,9,0 and two cases, respectively while the metastatic tumor in pleural fluid was ER + PR + HER2+; ER + PR + HER2-; ER-PR- HER2+ and ER-PR-HER2- in 6, 3, 3, and 1, respectively. In five cases there was complete correlation between the primary and metastatic tumor. In 7 cases with HER2- primary tumor the metastases was HER2+. One from ER + PR+ HER2- primary tumor showed triple negative expression in the metastasis. CONCLUSIONS:Determining the molecular subtype in metastatic breast carcinoma is of importance as it affects the management. In our series 63% of metastatic tumors to the pleural fluid became HER2 positive and would thus require appropriate therapy. Diagn. Cytopathol. 2016;44:980-986. © 2016 Wiley Periodicals, Inc.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Francis IM,Alath P,George SS,Jaragh M,Al Jassar A,Kapila K

doi

10.1002/dc.23607

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

980-986

issue

12

eissn

8755-1039

issn

1097-0339

journal_volume

44

pub_type

杂志文章
  • Update on human polyomavirus BK nephropathy.

    abstract::Polyomavirus BK (BKV) has ebeen identified as the main cause of polyomavirus-associated nephropathy, a major cause of renal allograft failure. Although BKV-associated nephropathy develops in only 2% to 5% of renal transplant recipients, its prognosis when present is very poor, with irreversible graft failure developin...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.21147

    authors: Cimbaluk D,Pitelka L,Kluskens L,Gattuso P

    更新日期:2009-10-01 00:00:00

  • Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations.

    abstract::Ciliated muconodular papillary tumors (CMPTs) of the lung are rare, likely benign neoplastic lesions. Here we describe a case of a CMPT, focusing on its cytologic features, which to our knowledge have not been reported previously. Owing to dull back pain, a 69-year-old male non-smoker underwent CT, which revealed a 1....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24169

    authors: Mikubo M,Maruyama R,Kakinuma H,Yoshida T,Satoh Y

    更新日期:2019-07-01 00:00:00

  • Clinical performance of the aptima HPV assay in 4196 women with positive high-risk HPV and ASC-US cytology: A large women hospital experience.

    abstract:BACKGROUND:Despite Aptima assay as the latest US Food Drug Administration (FDA)-approved high-risk human papillomavirus (hrHPV) test has been implemented as an adjunct in cervical cancer screening for years, histological follow-up data remain limited with respect to its performance in women with ASC-US Pap tests and po...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24592

    authors: Wang T,Pradhan D,Zhang H,Matsko J,Zhao C

    更新日期:2021-01-01 00:00:00

  • Fine-needle aspiration biopsy findings in marginal zone B cell lymphoma.

    abstract::Marginal zone B cell lymphomas (MZBCLs) represent a category of non-Hodgkin's lymphoma which may arise in a wide variety of extranodal organs where they are termed low grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT). MZBCLs may involve primarily lymph nodes and or spleen where they are designated mo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199904)20:4<190::aid-dc2>3

    authors: Matsushima AY,Hamele-Bena D,Osborne BM

    更新日期:1999-04-01 00:00:00

  • Fine-needle aspiration cytology in azoospermic males.

    abstract::Bilateral testicular fine-needle aspiration cytology (FNAC) was performed in 100 males, including 10 controls with normal fertility and 90 infertile azoospermic males. The various seminiferous tubular cells were easily identified in smears. It was possible to give a cytological diagnosis in histologic terms by analysi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840070103

    authors: Rajwanshi A,Indudhara R,Goswami AK,Radhika S,Das A,Sharma SK,Vaidyanathan S,Datta BN

    更新日期:1991-01-01 00:00:00

  • Tracheal aspirate cytology and bronchopulmonary dysplasia.

    abstract::Sequential tracheal aspirates from 39 neonates with hyaline membrane disease were examined to correlate cytological findings with the development of bronchopulmonary dysplasia (BPD). A total of 224 tracheal aspirates were examined from these infants, 15 of whom developed BPD as diagnosed by conventional clinical and r...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840020307

    authors: Rothberg AD,Miot A,Leiman G

    更新日期:1986-09-01 00:00:00

  • Atypical squamous cells of undetermined significance: A cytohistological study in a colposcopy clinic.

    abstract::Cytohistologic correlation was performed by 3 observers on 100 atypical squamous cells of undetermined significance (ASCUS) cases from a colposcopy clinic. Our objectives were to: 1) subclassify ASCUS cases and determine their clinical significance; 2) assess the independent predictive value of different cytologic par...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199909)21:3<211::aid-dc14>

    authors: Ettler HC,Joseph MG,Downing PA,Suskin NG,Wright VC

    更新日期:1999-09-01 00:00:00

  • Melanoma with cartilaginous differentiation: Diagnostic challenge on fine-needle aspiration with emphasis on differential diagnosis.

    abstract::Fine-needle aspiration (FNA) is a minimally invasive, fast, and accurate diagnostic method for the evaluation of patients with locally recurrent or distant metastases of malignant melanoma. In the vast majority of cases, the diagnosis is straightforward with the characteristic cytologic features well documented in the...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20952

    authors: Hanley KZ,Weiss SW,Logani S

    更新日期:2009-01-01 00:00:00

  • Localization of p53 and proliferating cell nuclear antigen in fine-needle aspirates of benign and primary malignant tumors of the human breast: an immunocytochemical study using supersensitive monoclonal antibodies and the biotin-streptavidin-amplified me

    abstract::p53 and proliferating cell nuclear antigen (PCNA) status was determined in fine-needle aspirates (FNAs) and methacarn-fixed paraffin-embedded tissue sections of six fibroadenomas and 50 primary breast carcinomas using supersensitive monoclonal antibodies and the biotin-streptavidin-amplified method. Nuclear accumulati...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199611)15:4<277::AID-DC5>3

    authors: Alexiev BA

    更新日期:1996-11-01 00:00:00

  • Identification of intranuclear inclusions is useful for the cytological diagnosis of ovarian clear cell carcinoma.

    abstract:OBJECTIVE:The aim of this study was to clarify the diagnostic significance of the presence of intranuclear inclusions in clear cell carcinoma (CCC). MATERIALS AND METHODS:We analyzed 98 imprint specimens and 53 ascites specimens from 98 ovarian carcinoma cases [28 CCCs, 37 serous carcinomas (SCs), 22 endometrioid carc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23322

    authors: Naka M,Ohishi Y,Kaku T,Watanabe S,Tamiya S,Ookubo F,Kato K,Oda Y,Sugishima S

    更新日期:2015-11-01 00:00:00

  • Intraductal carcinoma in a male breast: diagnosis by nipple discharge cytology.

    abstract::We describe a case of intraductal carcinoma (comedo type) in a 50-yr-old male. The patient had presented with a bloody nipple discharge, which had shown malignant cells on cytologic examination. In current clinical practice, the use of nipple discharge cytology as a screening and diagnostic tool for breast carcinoma i...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120414

    authors: Hirschman SA,Hoda SA,May M,Cody HS 3rd

    更新日期:1995-06-01 00:00:00

  • Fine-needle aspiration biopsy of HPV-related squamous cell carcinoma of the head and neck: Current ancillary testing methods for determining HPV status.

    abstract::Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to de...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.23668

    authors: Bernadt CT,Collins BT

    更新日期:2017-03-01 00:00:00

  • Micronucleus assay in buccal smears of breast carcinoma patients.

    abstract::The aim of this study is to compare micronucleus assay in buccal smear of breast carcinoma patients versus normal benign cases as control group. In this prospective study, we selected a total 32 patients of carcinoma of breast and 49 patients of benign breast lesions diagnosed in fine needle aspiration cytology (FNAC)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21589

    authors: Dey P,Samanta S,Susheilia S

    更新日期:2012-08-01 00:00:00

  • Acquired myospherulosis secondary to gluteal augmentation on fine needle aspiration cytology: A diagnostic challenge.

    abstract::A 30-year-old female presented with a three-month history of a multilocular cystic lesion over the lumbosacral spine. Fine-needle aspiration biopsy (FNA) of the lesion was performed at an outside institution, and a cytologic diagnosis, suspicious for chordoma, was rendered. The patient presented for surgical consultat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23871

    authors: Alperstein S,Dilcher T,Viswanathan K,Rao RA,Siddiqui MT,Giorgadze T

    更新日期:2018-05-01 00:00:00

  • Fine-needle-aspiration cytology of a proximal type epithelioid sarcoma: A case report.

    abstract::Epithelioid sarcoma is a rare mesenchymal neoplasm, with an as yet unidentified cell of origin. Two subtypes of epithelioid sarcoma, distal/classic and proximal/large cell type, are recognized in the literature; with the proximal-type having a lower incidence amongst the two. Here, we present a case of proximal-type e...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23294

    authors: Pendse AA,Dodd LG

    更新日期:2015-10-01 00:00:00

  • Cytologic diagnosis of vulvar Paget's disease by means of brushing smear: report of a case.

    abstract::Paget's disease of the vulva is a rare entity; since it may show the same clinical symptoms as benign chronic vulvitis, it may result in a delayed diagnosis. A 63-year-old woman was found to have an eczematoid pink to red lesion located in the vulva. Scraping cytology of the vulva showed isolated malignant cells of Pa...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21160

    authors: Funamoto Y,Haba R,Kobayashi TK,Kushida Y,Kouno K,Matsunaga T,Shiota A,Hata T

    更新日期:2010-02-01 00:00:00

  • Vaginal fine-needle aspiration: A useful alternative to biopsy.

    abstract:BACKGROUND:Vaginal fine-needle aspiration (FNA) is infrequently performed to assess palpable lesions. We perform the first multi-institutional study to evaluate this procedure. METHODS:We retrospectively reviewed vaginal FNAs performed at two institutions for the past 27 years. Clinical, cytological and histological d...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23504

    authors: Lin DM,Barkan GA,Chatt G,Park JW,Gattuso P

    更新日期:2016-08-01 00:00:00

  • Fine-needle aspiration biopsy of tibial adamantinoma: a case report.

    abstract::Adamantinoma of long bones is a rare, primary bone tumor of controversial histogenesis, usually arising in the anterior midshaft of the tibia. This slowly growing, radiolucent, expansile tumor eventually causes thinning or destruction of overlying cortical bone. Fine-needle aspiration biopsy (FNAB) is a rapid, safe, a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840040116

    authors: Hales MS,Ferrell LD

    更新日期:1988-03-01 00:00:00

  • Cytology, flow cytometry, image analysis, and interphase cytogenetics by fluorescence in situ hybridization in the diagnosis of transitional cell carcinoma in bladder washes: a comparative study.

    abstract::The diagnosis of transitional cell carcinoma (TCC) in bladder washes is a diagnostic challenge to cytology. This study assessed the role of flow cytometry (FCM), image analysis (IA), and interphase cytogenetics by fluorescence in situ hybridization (FISH) as adjuncts in the cytodiagnosis of TCC in bladder washes. Fort...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840130307

    authors: Cajulis RS,Haines GK 3rd,Frias-Hidvegi D,McVary K,Bacus JW

    更新日期:1995-10-01 00:00:00

  • Concordance between thyroid nodule sizes measured by ultrasound and gross pathology examination: effect on patient management.

    abstract::Ultrasound examination (US) is an essential tool in the evaluation of thyroid nodules. The size determined by US is used to distinguish between clinical vs. nonclinical thyroid nodules i.e. greater than or equal to or less than 1 cm. In this study, we evaluated the concordance between the sizes of thyroid nodules meas...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20714

    authors: Deveci MS,Deveci G,LiVolsi VA,Gupta PK,Baloch ZW

    更新日期:2007-09-01 00:00:00

  • Fine-needle aspiration biopsy findings in sclerosing polycystic adenosis of the parotid gland.

    abstract::Sclerosing polycystic adenosis (SPA) is a recently described, rare lesion of the salivary gland analogous to fibrocystic disease of the breast. Recognition of this benign entity is important since the differential diagnosis includes other more common benign and malignant salivary gland neoplasms, particularly mucoepid...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20671

    authors: Etit D,Pilch BZ,Osgood R,Faquin WC

    更新日期:2007-07-01 00:00:00

  • Distinction between bronchioloalveolar carcinoma and hyperplastic pulmonary proliferations: a cytologic and morphometric analysis.

    abstract::The objectives of this study were to identify key cytologic features for the morphologic differentiation of bronchioloalveolar carcinoma from reactive pulmonary proliferations, and to determine if morphometry of the cytologic specimens could provide additional data to distinguish the two processes. We analyzed 15 morp...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199705)16:5<396::aid-dc4>3

    authors: Zaman SS,van Hoeven KH,Slott S,Gupta PK

    更新日期:1997-05-01 00:00:00

  • Vaginal Enterobius vermicularis diagnosed on liquid-based cytology during Papanicolaou test cervical cancer screening: A report of two cases and a review of the literature.

    abstract::Enterobiasis is one of the most common human parasitic infections. It is considered an intestinal parasite, but cases of extra-intestinal affections exist, notably infections of the female genital tract. Enterobius vermicularis (EV) eggs (or ova) have been found in the cervical smears of two patients in our institute ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.23812

    authors: Tsai CY,Junod R,Jacot-Guillarmod M,Beniere C,Ziadi S,Bongiovanni M

    更新日期:2018-02-01 00:00:00

  • Fine-needle aspiration cytology of breast: its impact on surgical practice with an emphasis on the diagnosis of breast abnormalities in young women.

    abstract::Fine-needle aspiration cytology (FNAC) of the breast is a minimally invasive yet maximally diagnostic method, often precluding the need of an open biopsy. In young women, in whom breast cancer is a rare disorder, it is also important that carcinoma is recognized without delay so that an appropriate plan of management ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.2840040306

    authors: Gupta RK,Naran S,Buchanan A,Fauck R,Simpson J

    更新日期:1988-01-01 00:00:00

  • Epithelioid cell granulomas in urine cytology smears: Same cause, different implications.

    abstract::Tuberculosis of the urinary tract is usually secondary to tuberculosis of the kidney. Multinucleated giant cell histiocytes, often with peripheral nuclei (Langhans' cells), may be identified. Acid-fast bacilli on smear or positive urine cultures confirm the diagnosis. Similar findings can also be seen in patients trea...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21327

    authors: Arora SK,Gupta N,Nijhawan R,Mandal AK

    更新日期:2010-10-01 00:00:00

  • Usefulness of Auto Cyto Fix (membrane filter method) for the application of immunohistochemistry.

    abstract::We developed the Auto Cyto Fix (ACF) 1000 as an experimental model, which was adapted as a membrane filter method for automatically making smear preparations fixed with 95% ethanol. In this study, immunohistochemistry was applied to the cells smeared on the membrane filter, and effectiveness was examined. Twenty-four ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10041

    authors: Iijima J,Shiina Y,Ohkoudo M,Sakuma K

    更新日期:2002-01-01 00:00:00

  • Cytopathological changes in human cervix and endometrium following prolonged retention of copper-bearing intrauterine contraceptive devices.

    abstract::Since 1971, cytological evaluation of cervical smears and endometrial aspirates was carried out in 604 women wearing CuT200 intrauterine contraceptive devices (IUDs) for periods ranging from 6 mo to 15 yr. No cases of cervical neoplasia or endometrial carcinoma were encountered, even after continuous use of the device...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840050302

    authors: Misra JS,Engineer AD,Tandon P

    更新日期:1989-01-01 00:00:00

  • Monophasic synovial sarcoma: a cytologic spectrum.

    abstract::Synovial sarcoma (SS) is a high-grade sarcoma that can be diagnosed in cytology with certainty only when it presents with a biphasic pattern. Monophasic SS (MSS), however, is a diagnostic consideration when a uniform spindle cell population is present. The purpose of this study was to evaluate a series of cytologic ca...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10413

    authors: Ewing CA,Zakowski MF,Lin O

    更新日期:2004-01-01 00:00:00

  • Collision tumor of primary merkel cell carcinoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, diagnosed on ultrasound-guided fine-needle aspiration biopsy: a unique case report and review of literature.

    abstract::We report an extremely rare case of skin collision tumor between primary Merkel cell carcinoma (MCC) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) first diagnosed on ultrasound-guided fine-needle aspiration biopsy (US-FNA). A 95-year-old female with a history of CLL presented with a slow growin...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.23127

    authors: Li Z,Yang JJ,Wu M

    更新日期:2015-01-01 00:00:00

  • Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation.

    abstract::Cytological and histological findings of a rare case of a malignant phyllodes tumor (with liposarcomatous components) of the breast are presented. The atypia of the stromal cells and naked nuclei in a lesion considered benign clinically and on imaging alerted us to the possibility of a phyllodes tumor, despite the low...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(200006)22:6<364::aid-dc7>3

    authors: Satou T,Matsunami N,Fujiki C,Tanaka K,Hayashi Y,Hashimoto S

    更新日期:2000-06-01 00:00:00