Abstract:
:We report a rare case of extranodal NK/T-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65-year-old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou-stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. A small number of individually scattered cells were also identified. These scattered cells showed pleomorphic, often cleaved, or horseshoe-shaped nuclei and pale cytoplasm. Biopsy specimens revealed a diffuse growth of atypical cells with an angiocentric pattern. Extensive necrosis and infiltration of inflammatory cells were present. There were numerous mitotic figures. The tumor cells were positive for CD45RO, CD3ε, CD56, granzyme B, TIA-1, CD7, and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization, and negative for cytokeratin, chromogranin A, synaptophysin, CD4, CD5, CD8, CD20, and CD30. Based on these findings, this tumor was diagnosed as extranodal NK/T-cell lymphoma, nasal type of the uterine cervix.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Omori M,Oishi N,Nakazawa T,Nakazawa K,Mitsumori T,Yuminamochi T,Kirito K,Hirata Sdoi
10.1002/dc.23439subject
Has Abstractpub_date
2016-05-01 00:00:00pages
430-3issue
5eissn
8755-1039issn
1097-0339journal_volume
44pub_type
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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pub_type: 临床试验,杂志文章
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更新日期:1993-01-01 00:00:00
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