Fine needle aspiration in the diagnosis and classification of hepatoblastoma: Analysis of 21 New Cases.

Abstract:

BACKGROUND:Diagnosis of hepatoblastoma (HBL) is based on characteristic clinical and radiological presentation, young age and marked elevation of serum α-fetoprotein (aFP). Fine needle aspiration (FNA) technique is successfully used in the diagnosis of hepatoblastoma. To evaluate the value of FNA in the diagnosis and subtyping of HBL, we report our experience correlated to histological sections (core needle biopsy, CNB). METHODS:From 1991 to 2015, 21 cases from 20 patients were cytologically diagnosed as HBL. The patients were 15 males and 5 females, mean age being 3 years, and median age being 2 years and 4 months. Serum aFP levels ranged from negative to 1,285,000 ng/ml. We defined cytological criteria to diagnose fetal, embryonal, mesenchymal, and small cell undifferentiated components. RESULTS:The accurate cytological diagnosis of HBL was made in all cases; 8 cases exhibited a single component and 13 cases exhibited two or more components. Fetal and embryonal components were seen in 18 and 13 cases, respectively, and small cell undifferentiated component was seen in one case. Mesenchymal component was seen in 12 cases. Comparing cytology and histology, identical components were identified on both, FNA and CNB in 14 cases. When analyzing only the presence of epithelial components, 17 cases were concordant in both techniques. CONCLUSION:FNA allows to accurately diagnose HBL and recognize its histological subtypes. On the basis of high concordance between cytological and histological diagnosis, FNA is validated as an alternative diagnostic method to CNB. Diagn. Cytopathol. 2017;45:91-100. © 2016 Wiley Periodicals, Inc.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Vlajnic T,Brisse HJ,Aerts I,Fréneaux P,Cellier C,Fabre M,Klijanienko J

doi

10.1002/dc.23642

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

91-100

issue

2

eissn

8755-1039

issn

1097-0339

journal_volume

45

pub_type

杂志文章
  • Dark and pale cerebriform nuclei in FNA smears of usual papillary thyroid carcinoma and its variants.

    abstract::The dark (hyperchromatic) cerebriform nucleus was recently described as a frequent finding in histopathology sections of papillary carcinoma of the thyroid. In the present study, we tried to determine the frequency of dark cerebriform nuclei in the fine-needle aspiration (FNA) smears of papillary thyroid carcinomas an...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20022

    authors: Mallik MK,Das DK,Mallik AA,Madda JP,Mirza K,Al-Bishi KK,George SS,Junaid TA

    更新日期:2004-03-01 00:00:00

  • Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review.

    abstract::Granulosa cell tumors (GCT) of the ovary are low grade tumor with a potential ability of late pelvic recurrences and distant metastases. However, there is sparse literature on the cytopathologic features of metastatic granulosa cell tumors (MGCT). Between 2000 and 2014, eight cases of MGCT were diagnosed by FNA. Clini...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23535

    authors: Harbhajanka A,Bitterman P,Reddy VB,Park JW,Gattuso P

    更新日期:2016-12-01 00:00:00

  • Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: a potential diagnostic pitfall with fine-needle aspiration cytology.

    abstract::We report three cases of cytomegalovirus (CMV) sialadenitis which presented as parotid gland nodules in patients infected with the human immunodeficiency virus. While CMV is known to widely infect patients with the acquired immunodeficiency syndrome (AIDS), we are aware of only a single report of CMV sialadenitis in a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840100216

    authors: Wax TD,Layfield LJ,Zaleski S,Bhargara V,Cohen M,Lyerly HK,Fisher SR

    更新日期:1994-01-01 00:00:00

  • Increased detection of clue cells in smears from cervical intraepithelial lesions with reduced expression of COX-2.

    abstract::The relation between the detection of clue cells in cervical smears of women with CIN and the expression of COX-2 in these lesions were determined. Samples from 228 women, treated due to CIN and who underwent cervical conization, were obtained. Hybrid Capture II and Pap smear samples were collected immediately before ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20900

    authors: Figueiredo PG,Sarian LO,Tambascia JK,Simões JA,Rabelo-Santos SH,Discacciati MG,Derchain S

    更新日期:2008-10-01 00:00:00

  • Cytology of allergic bronchopulmonary aspergillosis.

    abstract::The cytologic features of a case of allergic bronchopulmonary aspergillosis (ABPA) are reported and the literature reviewed. The bronchial brushing smears in this case showed mucus that contained laminated aggregates of eosinophils with scattered Charcot-Leyden crystals and fungal hyphae. These cytologic findings, ove...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.2840090118

    authors: Chen KT

    更新日期:1993-01-01 00:00:00

  • Inspissated cyst fluid in endoscopic ultrasound-guided fine needle aspiration of pancreatic cysts.

    abstract:BACKGROUND:Inspissated cyst fluid may be identified on pancreatic cyst aspiration cytology. We report on the cytomorphologic characteristics of inspissated cyst fluid on EUS-FNA of pancreatic cysts and correlate this finding with histopathology or multimodal (cytology, cyst fluid analysis, molecular pathology, imaging)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23912

    authors: Chebib I,Albanese E,Scourtas A,Pitman MB

    更新日期:2018-05-01 00:00:00

  • Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids.

    abstract::Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23248

    authors: Omori M,Kondo T,Yuminamochi T,Nakazawa K,Ishii Y,Fukasawa H,Hashi A,Hirata S

    更新日期:2015-07-01 00:00:00

  • Follicular thyroid lesions coexisting with Hashimoto's thyroiditis: incidence and possible sources of diagnostic errors.

    abstract::Our objectives were to study the types and incidence of thyroid follicular lesions coexisting with Hashimoto's thyroiditis (HT), the pitfalls in their cytodiagnosis, and the effect on management. All cases of HT diagnosed by fine-needle aspiration (FNA) and/or histology over a 7-yr period were retrospectively studied....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10206

    authors: Kollur SM,El Sayed S,El Hag IA

    更新日期:2003-01-01 00:00:00

  • Two AgNOR counts in fine-needle aspirates of lymphoproliferative disorders compared with acridine orange flow cytometry.

    abstract::Studies have shown that argyrophilic nucleolar organizer region-associated proteins (AgNORs) may correlate with DNA ploidy and/or proliferative activity in neoplastic and non-neoplastic conditions. However, studies have estimated only the mean AgNOR counts. Here we used two AgNOR counts, one of which may correlate wit...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080208

    authors: Mourad WA,Katz RL,Sembera D,Atkinson EN,el-Naggar AK

    更新日期:1992-01-01 00:00:00

  • Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma.

    abstract::Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults. It has been described in numerous sites; however, the breast is one of the least common locations. We herein report a case of ALCL arising in the breast of a 36-yr-old pregnant woman. To our knowledge this is t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20442

    authors: Iyengar P,Reid-Nicholson M,Moreira AL

    更新日期:2006-04-01 00:00:00

  • Progression of cervical lesions in HIV-seropositive women: a cytological study.

    abstract::It has been reported that cervical intraepithelial lesions have a more aggressive course in HIV-seropositive than in HIV-seronegative women. In the present investigation, the progression of these cervical lesions was studied in a group of HIV-seropositive women. Of 1,587 patients, 200 (12.6%) had a cytological diagnos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200102)24:2<117::aid-dc1021>3.0.

    authors: Calore EE,Pereira SM,Cavaliere MJ

    更新日期:2001-02-01 00:00:00

  • A comparative study of 200 head and neck FNAs performed by a cytopathologist with versus without ultrasound guidance: evidence for improved diagnostic value with ultrasound guidance.

    abstract::Our previous study showed that the sensitivity of head and neck fine-needle aspiration (FNA) procedures was significantly better in the cytopathologist-performed group than in the noncytopathologist-performed group (96 versus 67%). Recently, cytopathologists have learned to use ultrasound machines to assist them in pe...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21460

    authors: Wu M

    更新日期:2011-10-01 00:00:00

  • Diagnosis of umbilical metastasis (Sister Mary Joseph's nodule) by fine-needle aspiration: an immunocytochemical study.

    abstract::During a ten year period, since we introduced needle aspiration cytology at our institution, we have diagnosed five cases of umbilical metastasis (Sister Mary Joseph's nodule). In none of the cases was any false negative or false positive diagnosis rendered and the primary carcinoma was found below the diaphragm. In a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840100206

    authors: Gupta RK,Naran S,McHutchison AG,Lallu S,Fauck RJ

    更新日期:1994-01-01 00:00:00

  • The cell with a thousand faces: detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors.

    abstract::Myoepithelial cells are an important component of salivary gland tumors and are partly responsible from the diverse histology of them. In this study, we focus on the myoepithelial cell differentiation by using cytological morphology in a various types of salivary gland tumors especially with regard to their contributi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21544

    authors: Avci A,Günhan O,Cakalağaoğlu F,Günal A,Celasun B

    更新日期:2012-03-01 00:00:00

  • Urinary tract washing specimens containing atypical urothelial tissue fragments are significantly associated with urothelial neoplasia.

    abstract:BACKGROUND:We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high-grade urothelial carcinoma (HGUC) but not low-grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23767

    authors: Zhang ML,Zhou AG,Rosenthal DL,VandenBussche CJ

    更新日期:2017-09-01 00:00:00

  • Fine-needle aspiration biopsy of gouty tophi: lessons in cost-effective patient management.

    abstract::Gout, a disease resulting from the effects of hyperuricemia and a crystal-induced arthropathy, may produce soft tissue masses (tophi) which mimick neoplasia clinically and radiographically. We have recently diagnosed three cases of gouty tophus, two of which were clinically suspected to represent sarcomas, by fine-nee...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199707)17:1<30::aid-dc6>3.

    authors: Nicol KK,Ward WG,Pike EJ,Geisinger KR,Cappellari JO,Kilpatrick SE

    更新日期:1997-07-01 00:00:00

  • Neovaginal cytology after total pelvic exenteration for gynecological malignancies.

    abstract::Vaginal reconstruction has become an established method to restore sexual function in women who have undergone ultraradical surgery and/or irradiation for the treatment of gynecologic malignancies. Cytologic evaluation of the neovagina serves a major role in the detection of recurrent disease. The purpose of this retr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840130106

    authors: Selvaggi SM,Haefner HK,Lelle RJ,Pearl ML,Roberts JA

    更新日期:1995-07-01 00:00:00

  • Transthyretin, identified by proteomics, is overabundant in pancreatic juice from pancreatic carcinoma and originates from pancreatic islets.

    abstract::Analyses of pancreatic juice by proteomics have identified many proteins that are overabundant in pancreatic cancer (PC) juice. The mechanism by which secretion of these proteins occur remains unclear. Pancreatic juice was collected from patients with three pancreatic diseases: PC, chronic pancreatitis (CP), and simpl...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21484

    authors: Lv S,Gao J,Zhu F,Li Z,Gong Y,Xu G,Ma L

    更新日期:2011-12-01 00:00:00

  • Diagnosis of metastatic pancreatic mesenchymal tumors by endoscopic ultrasound-guided fine-needle aspiration.

    abstract::Involvement of the pancreas by metastatic sarcoma is rare, and can prove challenging to differentiate from sarcomatoid carcinomas which occur more commonly. The endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) technique has been successfully used for the diagnosis of pancreatic carcinomas whether primary ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21104

    authors: Varghese L,Ngae MY,Wilson AP,Crowder CD,Gulbahce HE,Pambuccian SE

    更新日期:2009-11-01 00:00:00

  • Cystic major salivary gland lesions: Utilizing fine needle aspiration to optimize the clinical management of a broad and diverse differential diagnosis.

    abstract:INTRODUCTION:The use of fine-needle aspiration (FNA) cytology for the preoperative evaluation of salivary gland lesions is an accepted but, currently, nonstandardized practice. More specifically, cystic major salivary gland lesions are relatively rare and can be very challenging to diagnose on FNA due to low cellularit...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23780

    authors: Allison DB,McCuiston AM,Kawamoto S,Eisele DW,Bishop JA,Maleki Z

    更新日期:2017-09-01 00:00:00

  • Fine-needle aspiration of scalp lesions.

    abstract::A variety of inflammatory and neoplastic scalp lesions are encountered in surgical pathology. However, the literature on fine-needle aspirations (FNAs) of the scalp is exceedingly rare. We report on a series of 70 FNAs involving cutaneous and subcutaneous lesions on the scalp. A total of 70 fine-needle aspirations of ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200007)23:1<35::aid-dc8>3.0.co;2

    authors: Spitz DJ,Reddy V,Selvaggi SM,Kluskens L,Green L,Gattuso P

    更新日期:2000-07-01 00:00:00

  • How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.

    abstract:BACKGROUND:The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23680

    authors: Roychoudhury S,Klein M,Souza F,Gimenez C,Laser A,Shaheen Cocker R,Chau K,Das K

    更新日期:2017-04-01 00:00:00

  • Cytologic characteristics of clear-cell sarcoma of the kidney (CCSK) in fine-needle aspiration biopsy (FNAB): a report of 4 cases.

    abstract::The cytologic findings observed in fine-needle aspiration biopsy (FNAB) of four cases of clear-cell sarcoma of the kidney (CCSK) are reported. Smears contained a monomorphic population of cells exhibiting non-descriptive cytoplasm and almost nude round to oval nuclei with smooth contour, evenly dispersed fine chromati...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840070612

    authors: Drut R,Pomar M

    更新日期:1991-01-01 00:00:00

  • The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions.

    abstract:BACKGROUND:All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due to injury of serosal surfaces from mesothelioma or malignant ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23653

    authors: Sadullahoglu C,Nart D,Veral A

    更新日期:2017-02-01 00:00:00

  • Nodular fasciitis: spontaneous resolution following diagnosis by fine-needle aspiration.

    abstract::Nodular fasciitis can be histologically mistaken for a sarcoma. Typical cases are less than 5 cm and enlarge rapidly over days or weeks before diagnosis. The natural history of nodular fasciitis is unknown, since the diagnosis is usually based on excised lesions. Fine-needle aspiration of nodular fasciitis has been de...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090316

    authors: Stanley MW,Skoog L,Tani EM,Horwitz CA

    更新日期:1993-01-01 00:00:00

  • Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique.

    abstract::Leydig cell tumors (LCT) are rare sex cord-stromal tumors that account for 2-3% of all testicular tumors. Approximately 10% of LCTs shows evidence of malignant behavior. We present a case of LCT with severe atypia diagnosed by fine-needle aspiration (FNA) in a 49-year-old man who presented with gynecomastia and right ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21446

    authors: Valeri RM,Kotakidou R,Michalakis K,Andreadis C,Kousi-Koliakou K,Destouni C

    更新日期:2011-05-01 00:00:00

  • Aspiration biopsy of nodular pseudoangiomatous stromal hyperplasia of the breast: clinicopathologic correlates in 10 cases.

    abstract::Nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast is rare and often indistinguishable from fibroadenoma, clinically and on aspiration biopsy smears. We report our observations in 10 patients with PASH, evaluated by fine-needle aspiration (FNA) biopsy and core biopsy. We retrospectively reviewed the cl...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20270

    authors: Levine PH,Nimeh D,Guth AA,Cangiarella JF

    更新日期:2005-06-01 00:00:00

  • Plasmablastic lymphoma of the cecum: report of a case with cytologic findings.

    abstract::Plasmablastic lymphoma (PBL) is a rare lymphoma that is characterized by a diffuse proliferation of large neoplastic cells resembling B immunoblasts, but shows the immunophenotype of plasma cells. PBL is most commonly seen in the oral cavity of human immunodeficiency virus (HIV)-positive patients. Epstein-Barr virus (...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21420

    authors: Hatanaka K,Nakamura N,Kishimoto K,Sugino K,Uekusa T

    更新日期:2011-04-01 00:00:00

  • Post-thyroid FNA testing and treatment options: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.

    abstract::The National Cancer Institute (NCI) sponsored the NCI Thyroid Fine Needle Aspiration (FNA) State of the Science Conference on October 22-23, 2007 in Bethesda, MD. The 2-day meeting was accompanied by a permanent informational Web site and several on-line discussion periods between May 1 and December 15, 2007 (http://t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20832

    authors: Layfield LJ,Abrams J,Cochand-Priollet B,Evans D,Gharib H,Greenspan F,Henry M,LiVolsi V,Merino M,Michael CW,Wang H,Wells SA

    更新日期:2008-06-01 00:00:00

  • Cytopathologic characteristics and differential diagnostic considerations of neuroglial heterotopia of the retropharyngeal space.

    abstract::Neuroglial heterotopias (NGH) are rare congenital head and neck lesions composed of differentiated neuroectodermal tissue and representing developmental heterotopias rather than true neoplasms. The case of a male neonate with respiratory distress and early feeding problems depicting a retropharyngeal space mass which ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21575

    authors: Hayashi T,Haba R,Kushida Y,Kadota K,Katsuki N,Bando K,Miyai Y,Shibuya S,Matsunaga T

    更新日期:2011-11-01 00:00:00