Urinary tract washing specimens containing atypical urothelial tissue fragments are significantly associated with urothelial neoplasia.

Abstract:

BACKGROUND:We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high-grade urothelial carcinoma (HGUC) but not low-grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more likely to have cytologic atypia in urinary washing (UW) specimens, suggesting that cytologic atypia found in UW specimens might be associated with both LGUN and HGUC. In this study, we retrospectively examined UW specimens containing AUTF to determine whether they were associated with HGUC, LGUN, or both HGUC and LGUN. METHODS:1173 UW specimens and any follow up biopsies were identified over a 10-year period and the presence of AUTF was recorded based on the original clinical diagnosis. RESULTS:The presence of AUTF in UW specimens was significantly associated with high-risk indeterminate diagnosis or definitive diagnosis of HGUC (P < .001). In addition, AUTF specimens were significantly associated with a neoplastic diagnosis of low-grade urothelial carcinoma (LGUC) or HGUC on subsequent biopsies when compared to specimens lacking AUTF (P = .047). The overall rate of CIS/HGUC in specimens with AUTF was 33.0 vs. 13.5% for specimens without AUTF (P = .051). CONCLUSIONS:Urothelial tissue fragments (UTF) found in UW specimens should be examined for the presence of cytomorphological atypia, as the presence of AUTF almost triples the risk of HGUC. As opposed to what has been found in VU specimens, AUTF in UW specimens is also associated with an increased risk of LGUN.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Zhang ML,Zhou AG,Rosenthal DL,VandenBussche CJ

doi

10.1002/dc.23767

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

795-799

issue

9

eissn

8755-1039

issn

1097-0339

journal_volume

45

pub_type

杂志文章
  • Retroperitoneal lymph node aspiration biopsy in staging of pelvic cancer: a cytological study of 228 consecutive cases.

    abstract::Knowledge of the status of the pelvic lymph nodes is important for accurate staging and adequate treatment of patients with genitourinary tract cancer (bladder and prostatic carcinoma, testicular tumors, and uterine carcinoma). A total of 228 consecutive patients underwent preoperative evaluation of the lymph node sta...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840030203

    authors: Cochand-Priollet B,Roger B,Boccon-Gibod I,Ferrand J,Faure B,Blery M

    更新日期:1987-06-01 00:00:00

  • The diagnostic utility of CK5/6 and p63 in fine-needle aspiration of the breast lesions diagnosed as proliferative fibrocystic lesion.

    abstract::Fine-needle aspiration (FNA) biopsy (FNAB) in the preoperative assessment of breast lesions has shown diagnostic limitations with false-positive and false-negative diagnoses. We investigated the diagnostic value of cytokeratin 5/6 (CK5/6) and p63 in a series of breast FNABs, diagnosed as proliferative breast lesions w...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21534

    authors: Al-Maghraby H,Ghorab Z,Khalbuss W,Wong J,Silverman JF,Saad RS

    更新日期:2012-02-01 00:00:00

  • Comparative cytologic findings of in situ and invasive adenocarcinoma of the uterine cervix.

    abstract::The cytologic findings in 13 cases of cervical adenocarcinoma in situ (mean age 33.9 yr) were compared with those in 9 cases of cervical invasive adenocarcinoma (mean age 45.7 yr). All diagnoses were confirmed by biopsy. The major differences found were that a necrotic background (66% invasive vs. 0% in situ) and macr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120206

    authors: Keyhani-Rofagha S,Brewer J,Prokorym P

    更新日期:1995-03-01 00:00:00

  • Prognostic value of breast cancer cytologic grading: a retrospective study of 213 cases.

    abstract::The authors evaluate 213 consecutive breast cancer cases with positive fine-needle aspiration cytology. Cytologic smears were reviewed and classified according to a grading system. A correlation between cytologic grading and pathological stage (T and N category) was observed. Univariate analysis of 5-yr overall surviv...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090210

    authors: Ciatto S,Bonardi R,Herd-Smith A,Cariaggi P,Confortini M,Bulgaresi P

    更新日期:1993-01-01 00:00:00

  • Lymphomatous effusion of monomorphic epitheliotropic intestinal T-cell lymphoma is characterized by azurophilic granules and is a dismal sign: Report of two new cases with literature review.

    abstract::Lymphoma involving serous effusion is uncommon. The diagnosis of effusion lymphoma may be challenging, particularly when the lymphoid cells are small to medium-sized, which would be difficult for differentiating reactive effusions from low grade lymphomas. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24690

    authors: Pan ST,Wang RC,Su YZ,Hsieh YC,Chuang SS

    更新日期:2021-01-02 00:00:00

  • Fine-needle aspiration biopsy of metastatic small cell carcinoma from extrapulmonary sites.

    abstract::Like a pulmonary counterpart, extrapulmonary small cell carcinoma (SCC) is an aggressive tumor with a high rate of metastasis. Forty-nine fine-needle aspiration biopsies (FNABs) (36 patients) of various primary sites other than the lung diagnosed as metastatic SCC (including Merkel cell carcinoma) were reviewed. FNABs...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199809)19:3<177::aid-dc4>3

    authors: Shin HJ,Caraway NP

    更新日期:1998-09-01 00:00:00

  • Fine-needle aspiration of cytomegalovirus sialadenitis in a patient with acquired immunodeficiency syndrome: pitfalls of diff-quik staining.

    abstract::A case of cytomegalovirus (CMV) sialadenitis in a patient with acquired immunodeficiency syndrome (AIDS) diagnosed by fine-needle aspiration biopsy (FNAB) is reported. Although a diagnosis of CMV sialadenitis can be established on Diff-Quik-stained slides, the characteristic viral changes are the best appreciated on s...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(200002)22:2<101::aid-dc8>3

    authors: Santiago K,Rivera A,Cabaniss D,Dhurhar N,Moroz K

    更新日期:2000-02-01 00:00:00

  • Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

    abstract::Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24042

    authors: Ishida M,Arimoto T,Sandoh K,Okano K,Ebisu Y,Ito H,Matsumoto M,Mizokami T,Kita M,Okada H,Tsuta K

    更新日期:2019-03-01 00:00:00

  • Intranuclear cytoplasmic inclusion is a significant diagnostic feature for the differentiation of lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma of the cervix.

    abstract::Lobular endocervical glandular hyperplasia (LEGH) is a cervical lesion with pyloric gland metaplasia. Minimal deviation adenocarcinoma (MDA) is an extremely well differentiated form of endocervical adenocarcinoma (AC). To date, it is difficult to differentiate LEGH from MDA because they share similar clinical, radiolo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20859

    authors: Hashi A,Yuminamochi T,Xu JY,Kondo T,Katoh R,Hoshi K

    更新日期:2008-08-01 00:00:00

  • Fine-needle aspiration of scalp lesions.

    abstract::A variety of inflammatory and neoplastic scalp lesions are encountered in surgical pathology. However, the literature on fine-needle aspirations (FNAs) of the scalp is exceedingly rare. We report on a series of 70 FNAs involving cutaneous and subcutaneous lesions on the scalp. A total of 70 fine-needle aspirations of ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200007)23:1<35::aid-dc8>3.0.co;2

    authors: Spitz DJ,Reddy V,Selvaggi SM,Kluskens L,Green L,Gattuso P

    更新日期:2000-07-01 00:00:00

  • Update on human polyomavirus BK nephropathy.

    abstract::Polyomavirus BK (BKV) has ebeen identified as the main cause of polyomavirus-associated nephropathy, a major cause of renal allograft failure. Although BKV-associated nephropathy develops in only 2% to 5% of renal transplant recipients, its prognosis when present is very poor, with irreversible graft failure developin...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.21147

    authors: Cimbaluk D,Pitelka L,Kluskens L,Gattuso P

    更新日期:2009-10-01 00:00:00

  • Seriate cytology vs molecular analysis of peritoneal washing to improve gastric cancer cells detection.

    abstract:BACKGROUND:Intraperitoneal malignant cells detection in patients with gastric cancer is associated with a significant decrease in overall survival. The overall accuracy of cytological examination of peritoneal lavages, however, is quite low, and intraperitoneal recurrence has been observed even in patients with negativ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24165

    authors: Taffon C,Giovannoni I,Mozetic P,Capolupo GT,La Vaccara V,Cinque C,Caricato C,Rainer A,Zelano G,Crescenzi A

    更新日期:2019-07-01 00:00:00

  • GCT of proximal phalanx of ring finger: a case report.

    abstract::Giant-cell tumor (GCT) of bone arising from phalanx of a finger is extremely rare. Rizzoli Orthopedic Institute in their study on 900 treated cases of GCT from 1947-1997 reported only 0.9% incidence of GCT in bones of the hand. There was no case of GCT of the phalanges in that series. We report here a case of GCT of b...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21715

    authors: Khare P,Kishore B,Gupta RJ,Vanita,Dhal A

    更新日期:2012-08-01 00:00:00

  • Needle aspiration cytology, immunocytochemistry, and electron microscopic study of unusual pancreatic carcinoma with pleomorphic giant cells.

    abstract::Needle aspiration cytology, immunocytochemistry, and electron-microscopic findings are presented in three cases of an unusual pancreatic carcinoma in which pleomorphic giant cells formed an integral part of the tumour. All three patients were elderly males (age range 66-83 years) and had pancreatic masses. Notable cyt...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080513

    authors: Gupta RK,Wakefield SJ

    更新日期:1992-01-01 00:00:00

  • Acute monocytic leukemia presenting as generalized lymphadenopathy and skin rash in a toddler: highlighting the clinicopathologic mimics.

    abstract::Acute myeloid leukemia (AML) is the fifth most common malignancy in children. Extramedullary involvement in acute myeloid leukemia is rare and can be seen in soft tissues, central nervous system, skin and lymphoreticular organs. The clinical presentations can often be non-specific and hence, the diagnosis can be very ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24649

    authors: Jain A,Gupta P,Gupta N,Senguttuvan G,Kapadia AB,Thirunavukkarasu B,Nada R,Varma N

    更新日期:2020-10-23 00:00:00

  • The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors.

    abstract::Pancreatic adenocarcinoma is a genetic disease showing somatic mutations of multiple genes, including SMAD4. SMAD4 is a tumor suppressor gene that is inactivated in a sub-set of pancreatic adenocarcinoma, either by the intragenic mutation of one allele in combination with the loss of the other allele or by homozygous ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20715

    authors: Ali S,Cohen C,Little JV,Sequeira JH,Mosunjac MB,Siddiqui MT

    更新日期:2007-10-01 00:00:00

  • Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum.

    abstract::Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Tw...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24080

    authors: Sood N

    更新日期:2019-02-01 00:00:00

  • Diffuse large B-cell lymphoma with fibrillary matrix.

    abstract::Diffuse large B-cell lymphoma (DLBCL) with fibrillary matrix is an extremely rare variant of non-Hodgkin's lymphoma (NHL) whose pathological features are poorly known. Here, we report on our experience with such a condition arising in a 71-yr-old woman. Our findings not only demonstrate that DLBCL with fibrillary matr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10172

    authors: Dargent JL,Meiers I,Lespagnard L,Ma Y,Dehou MF,Verhest A

    更新日期:2002-10-01 00:00:00

  • Anaplastic spindle-cell squamous carcinoma arising in association with tall-cell papillary cancer of the thyroid: A potential pitfall

    abstract::The following is a correction to the original article that appeared in Diagnostic Cytopathology 1999;21:413-418. Owing to a publisher's error, Figure 4C on p. 415 was incorrectly reproduced. The correct illustrations and captions for this page are given here. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(200002)22:2<136::aid-dc19>

    authors: Saunders CA,Nayar R

    更新日期:2000-02-01 00:00:00

  • Cultured anaplastic cell lines as immunocytochemistry controls: a comparison of ThinPrep-processed smears and conventional air-dried cytospins.

    abstract::Cultured anaplastic cell lines with previously characterized phenotypes are considered to be the best positive controls for immunocytochemistry. We assessed the validity of using anaplastic cell line cytospins as positive controls for immunocytochemistry performed on ThinPrep-processed clinical samples. We compared Th...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2059

    authors: Wiatrowska BA,Berner A,Torlakovic G,Emilsen E,Mykelbost GL,Torlakovic E

    更新日期:2001-11-01 00:00:00

  • Large pulmonary cryptococcoma and cryptococcal meningitis in an immunocompetent patient: a case report.

    abstract::Pulmonary cryptococcoma is a life threatening mycosis and is an unusual disease for immunocompetent individuals. Herein we report a case of large pulmonary cryptococcoma associated with cryptococcal meningitis, presenting radiologically as a lung mass in right upper lobe, in a previously healthy, HIV negative, immunoc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21345

    authors: Singh R,Joshi D,Gupta A,Gangane N

    更新日期:2010-12-01 00:00:00

  • Cytologic features of pleomorphic xanthoastrocytoma, WHO grade II. A comparative study with glioblastoma.

    abstract::Pleomorphic xanthoastrocytoma (PXA) is a WHO grade II astrocytic tumor of children and young adults. It is characterized by pleomorphic, atypical astrocytes. Atypia is so remarkable, that PXA can be easily misdiagnosed as malignant glioma. If confused with a high-grade glioma the neurosurgeon may not proceed with a co...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23660

    authors: Jiménez-Heffernan JA,Freih Fraih A,Álvarez F,Bárcena C,Corbacho C

    更新日期:2017-04-01 00:00:00

  • GATA3 expression in metastatic urothelial carcinoma in fine needle aspiration cell blocks: a review of 25 cases.

    abstract::GATA binding protein 3 is a zinc finger transcription factor with high affinity for urothelial tissue and is a promising immunohistochemical marker in detection of urothelial carcinomas (UC). We studied its usefulness in metastatic high-grade UC. This study was performed on cell blocks (CB) of fine needle aspirates fr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23131

    authors: Siddiqui MT,Seydafkan S,Cohen C

    更新日期:2014-09-01 00:00:00

  • Follicular lesions of the thyroid: a retrospective study of 1,348 fine needle aspiration biopsies.

    abstract::Fine needle aspiration (FNA) has proven to be an effective tool in management of patients with thyroid nodules. However, the diagnosis of follicular patterned lesions can be challenging. The surgical and cytopathology computer database at a large referral medical center was searched for cases that had both cytologic a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21477

    authors: Wu S,DeMay RM,Papas P,Yan B,Reeves W

    更新日期:2012-05-01 00:00:00

  • Intraabdominal desmoplastic small round cell tumor: cytopathologic findings in two cases.

    abstract::Intraabdominal desmoplastic small round cell tumor (DSRCT) is an extremely rare entity. This study describes fine-needle aspiration, ascitic fluid, and touch imprint cytomorphology of DSRCT in 2 patients with extensive abdomino-pelvic disease. Cytopathologic features were unique and showed good morphologic correlation...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199806)18:6<449::aid-dc13>

    authors: Ali SZ,Nicol TL,Port J,Ford G

    更新日期:1998-06-01 00:00:00

  • Cytologic features of sclerosing hemangioma of the lung on crush preparations.

    abstract::Sclerosing hemangioma of the lung is a rare benign neoplasm. The majority of the literature published on sclerosing hemangioma has focused on the histologic features, while only a few case reports have described the cytologic features. We report two additional cases of sclerosing hemangioma of the lung in which the cy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21768

    authors: Blanco LZ,Heagley DE,Montebelli F,Gabrielli E,Reddy V,Ghai R,Gattuso P

    更新日期:2013-03-01 00:00:00

  • Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.

    abstract::We report a rare case of extranodal NK/T-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65-year-old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou-stained cervical smear show...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23439

    authors: Omori M,Oishi N,Nakazawa T,Nakazawa K,Mitsumori T,Yuminamochi T,Kirito K,Hirata S

    更新日期:2016-05-01 00:00:00

  • Malignant phyllodes tumor with chondrosarcomatous differentiation: report of a case with cytological presentation.

    abstract::Malignant phyllodes tumor is a rare breast tumor with neoplastic epithelial and stromal components. The stromal component may show homologous and heterologous sarcomatous elements, including chondrosarcomatous and osteosarcomatous differentiation. Because these tumors may present with an almost exclusively sarcomatous...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199904)20:4<241::aid-dc12>

    authors: Garcia FU,Soans S,Galindo LM

    更新日期:1999-04-01 00:00:00

  • Bronchioloalveolar lavage in the diagnosis of CMV pneumonitis in lung transplant recipients: an immunocytochemical study.

    abstract::Cytomegalovirus (CMV) pneumonitis is a common opportunistic infection in lung transplant recipients. Its diagnosis usually rests on the identification of viral inclusions in lung parenchyma obtained by transbronchial biopsy, or by examination of the cytologic material obtained by bronchioloalveolar lavage (BAL). To de...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199704)16:4<350::aid-dc9>3

    authors: Solans EP,Yong S,Husain AN,Eichorst M,Gattuso P

    更新日期:1997-04-01 00:00:00

  • Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

    abstract:OBJECTIVE:To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). METHODS:Patients who underwent EC surgery that included a follow-up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24444

    authors: Kilic D,Yetimalar MH,Bezircioglu I,Yigit S

    更新日期:2020-07-01 00:00:00