Abstract:
:Nodular pseudoangiomatous stromal hyperplasia (PASH) of the breast is rare and often indistinguishable from fibroadenoma, clinically and on aspiration biopsy smears. We report our observations in 10 patients with PASH, evaluated by fine-needle aspiration (FNA) biopsy and core biopsy. We retrospectively reviewed the clinical, radiographic, cytologic, and histologic findings in 10 cases of pure nodular PASH. Ten patients with a presumed clinical and radiologic diagnosis of fibroadenoma underwent aspiration biopsy. The aspiration smears were diagnosed as fibroadenoma (4 cases), cellular fibroadenoma (1 case), schwannoma versus neurofibroma (1 case), fibrocystic change (3 cases; 2 with atypia), and "not specific for a lesion" (1 case). A diagnosis of PASH was not suspected in any case. A discrepant or imprecise cytologic diagnosis and/or the presence of dissociated spindle or epithelial cells, or cellular stromal fragments prompted a surgical excision in 7 of 10 patients (70%). The remaining 3 patients exhibited cytologic features of fibroadenoma and were diagnosed as such; however, surgical excision was recommended. Three patients underwent a subsequent core biopsy, with a diagnosis of PASH being made in 1 patient. FNA biopsy could not discriminate PASH from fibroadenoma in 4 of 10 patients (40%) or suggest a diagnosis of PASH in any case. On retrospective review, the finding of plump, spindle-shaped mesenchymal cells may be a cytologic clue to suggest a diagnosis of PASH.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Levine PH,Nimeh D,Guth AA,Cangiarella JFdoi
10.1002/dc.20270subject
Has Abstractpub_date
2005-06-01 00:00:00pages
345-50issue
6eissn
8755-1039issn
1097-0339journal_volume
32pub_type
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,多中心研究
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更新日期:2017-11-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22896
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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doi:10.1002/(sici)1097-0339(199703)16:3<214::aid-dc4>3
更新日期:1997-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dc.22925
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dc.21730
更新日期:2012-05-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23081
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dc.21064
更新日期:2009-08-01 00:00:00
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更新日期:2020-12-29 00:00:00
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更新日期:1997-12-01 00:00:00
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pub_type: 杂志文章
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