Abstract:
:Amyloid deposits are unexpected in salivary gland tumors. A 60-year-old woman presented with a 1.8 cm, slow-growing parotid mass. Both fine-needle aspiration and frozen section were misinterpreted as pleomorphic adenoma. The final pathology was amyloid-rich low grade adenocarcinoma of the parotid gland. The aspirates consisted of three components: mucin, amyloid, and tumor cells. The mucin was unusually thick, stringy, and metachromatic. The amyloid presented as innumerable concretions scattered solitarily or in small jigsaw puzzle-like aggregates, individually wrapped by tumor cells. The tumor cells had bland oval nuclei and scant-to-abundant cytoplasm, arranged in loosely cohesive small sheets. On histology, the tumor cells were arranged in interconnecting monolayered glands of a wide range of size with small patches of cellular regions composed of plump tumor cells. As the luminal mucin and amyloid deposits enlarged, the lining tumor cells became thin and flat. The glandular lumen molded amyloid concretions into different shapes and sizes. Atrophic or pyknotic tumor cells outlined the amyloid concretions with concentric laminations, reminiscent of corpora amylacea. Alcian blue positive luminal mucin, associated with newly formed amyloid, was present in mucinous regions of the tumor. This is the first description of cytologic features of amyloid-rich low grade adenocarcinoma of the parotid and the second case in the pathology literature. The literature of amyloid-rich tumors was reviewed and the implication of the presence of abundant amyloid on the death of tumor cells suggested.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Yang GC,Kuhel WI,Scognamiglio Tdoi
10.1002/dc.23099subject
Has Abstractpub_date
2014-09-01 00:00:00pages
798-801issue
9eissn
8755-1039issn
1097-0339journal_volume
42pub_type
杂志文章abstract::Breast disease is of great concern to patients and health care providers alike. Malignancies of the breast and their various presentations can pose tremendous challenges with respect to early diagnosis and effective treatment. Carcinoma of the breast may appear in several forms and produce one or more ectopic substanc...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.20485
更新日期:2006-10-01 00:00:00
abstract::Mites were observed in 55 pulmonary specimens examined routinely over a 4.5-yr period. The 55 specimens included 33 spontaneous and 12 aerosol-induced sputum samples, nine bronchial washings, and one fine-needle aspirate. Two specimens contained only fragments of mites; however, in most cases the mites were relatively...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840050416
更新日期:1989-01-01 00:00:00
abstract::Synovial sarcoma (SS) is a high-grade sarcoma that can be diagnosed in cytology with certainty only when it presents with a biphasic pattern. Monophasic SS (MSS), however, is a diagnostic consideration when a uniform spindle cell population is present. The purpose of this study was to evaluate a series of cytologic ca...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.10413
更新日期:2004-01-01 00:00:00
abstract::Clear-cell lesions of the parotid gland are uncommon but when studied by fine-needle aspiration may result in a clinically important but cytologically difficult differential diagnosis. Clear-cell lesions involving the parotid include acinic cell neoplasm, clear cell oncocytoma, mucoepidermoid carcinoma, primary clear-...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840090621
更新日期:1993-12-01 00:00:00
abstract::Tumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis. Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thy...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21725
更新日期:2012-12-01 00:00:00
abstract::Peculiar ring-like structures identified as Liesegang rings (LRs) were found in renal cyst fluid from three patients with benign renal cysts. They ranged in size from 5 to 820 mu. Most had a double-layer outer wall with equally spaced radial cross-striations and an amorphous central nidus. Special stains were performe...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840060310
更新日期:1990-01-01 00:00:00
abstract::The presence of pericellular lacunae has been cited as a useful criterion in distinguishing between benign and malignant effusions from body cavities. This study assessed the presence of pericellular lacunae in 75 specimens of malignant and 38 specimens of benign effusions. In a large number of cases, lacunae could no...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0339(199609)15:3<193::AID-DC4>3
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Swellings in the hand and wrist are frequently encountered in clinical practice and fine needle aspiration cytology (FNAC) is used as a primary diagnostic modality in most of them. A wide spectrum of lesions can be encountered at these sites. The aim of this study was to report the prevalence and spectrum of...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24050
更新日期:2018-10-01 00:00:00
abstract::A prospective study was conducted on 100 patients divided in two groups who underwent fiberoptic bronchoscopy (FOB). Group I consisted of 60 cases of suspected lung malignancy on clinical and radiological examination, while group II consisted of 40 cases of nonneoplastic lung diseases. Pre-FOB sputum, bronchoalveolar ...
journal_title:Diagnostic cytopathology
pub_type: 临床试验,杂志文章
doi:10.1002/dc.20577
更新日期:2007-01-01 00:00:00
abstract::Metastatic urothelial carcinoma (UC) to serous effusion (SE) is extremely rare and its cytomorphological features have only been described in case reports. In this study, we searched the pathology database at University of Michigan for SEs due to metastatic UC in the last 20 years. A total of 25 cases from 20 patients...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22896
更新日期:2013-07-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia. The cardinal histopathologic features include senile plaques (SPs) and neurofibrillary tangles (NFTs), and in addition, granulovacuolar degeneration (GVD) and Hirano bodies (HBs) are frequently observed in the hippocampus. We studied hippocampal cytological...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21053
更新日期:2009-09-01 00:00:00
abstract::Synchronous malignancies in a pleural effusion are rare. A case of concurrent pleural infiltration by adenocarcinoma of unknown primary site and chronic lymphocytic leukemia (CLL) is presented in this case study, which was diagnosed by effusion cytology. Pleural effusion is not an uncommon complication in patients wit...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.22889
更新日期:2014-02-01 00:00:00
abstract::Precise preoperative diagnosis of three malignant nerve sheath tumors (MNST) was based on their remarkably uniform and highly characteristic cytologic appearance. The differential diagnosis with benign nerve sheath tumors and other spindle cell sarcomas is addressed, and the possibility of achieving confident diagnosi...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840080603
更新日期:1992-01-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin. Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs. We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20818
更新日期:2008-05-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21310
更新日期:2010-10-01 00:00:00
abstract::Giant cell glioblastoma is a histological variant of glioblastoma that accounts for less than 1% of intracranial tumors and to 5% of glioblastoma. They occur at any age and are likely to affect the younger as well the older age group unlike the conventional glioblastoma multiforme (GBM). They are often located subcort...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.21648
更新日期:2012-05-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is a malignant neoplasm most commonly originating in salivary glands of the head and neck area. When ACC presents outside of these locations, the diagnosis may become more challenging. We describe three cases of ACC presenting in extra-salivary gland sites. Two cases were metastatic; in ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20500
更新日期:2006-07-01 00:00:00
abstract::Prostate-specific antigen (PSA) is secreted by both normal and neoplastic acinar cells of the prostate gland, and the immunohistochemical detection of PSA is widely accepted as an excellent method for confirming the prostatic origin of metastatic tumor implants in men with prostate cancer. Less recognized is the obser...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199809)19:3<221::aid-dc14>
更新日期:1998-09-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(199707)17:1<74::aid-dc17>3
更新日期:1997-07-01 00:00:00
abstract::Filariasis is a major public health problem in tropical and subtropical countries including India. Although there are reports of incidentally diagnosed cases of lymphatic filariasis in the existing literature, the significance of this finding needs to be summarised in one place. The association of filariasis with neop...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21264
更新日期:2010-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20623
更新日期:2007-04-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24029
更新日期:2019-02-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24484
更新日期:2020-05-23 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.21589
更新日期:2012-08-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/1097-0339(200008)23:2<127::aid-dc13>3.0.co
更新日期:2000-08-01 00:00:00
abstract::Adenoviruses are emerging as important viral pathogens in immunocompromised patients due to immunodeficiency diseases and recently hematopoietic stem cell and solid organ transplant recipients, impacting morbidity and even mortality. Immunocompromised children are prone to respiratory infection, due to alterations in ...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24662
更新日期:2020-11-16 00:00:00
abstract::A chest wall abscess is a very rare presentation of extranodal Hodgkin's lymphoma (HL); only one case has been reported to date. Here, we describe a case of a 38-yr-old man with HL whose initial presentation was a chest wall abscess. The diagnosis of HL was suggested by cytological examination of the purulent discharg...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20220
更新日期:2005-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24202
更新日期:2019-09-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20442
更新日期:2006-04-01 00:00:00
abstract::We describe the cytomorphology of seven cases of metaplastic carcinoma of the breast studied by fine-needle aspiration cytology and by histology. All seven cases contained foci of ductual adenocarcinoma. This finding was combined with heterologous mesenchymal elements in four cases, a spindle-cell pattern of growth in...
journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840050106
更新日期:1989-01-01 00:00:00