Cytomorphologic manifestations of Alzheimer's disease using brain squash smears: an autopsy study with histology-cytology correlation.

Abstract:

:Alzheimer's disease (AD) is the most common form of dementia. The cardinal histopathologic features include senile plaques (SPs) and neurofibrillary tangles (NFTs), and in addition, granulovacuolar degeneration (GVD) and Hirano bodies (HBs) are frequently observed in the hippocampus. We studied hippocampal cytological features of AD, compared with controls. Hippocampal squash smears were prepared from 26 autopsy brains and stained with three different solutions, including Papanicolaou stain (Pap-s). The smears were evaluated for the aforementioned four structures and gliosis, and their frequency was compared between AD (n = 15) and control (n = 11) groups. Hippocampal smears of all AD cases revealed NFTs and gliosis. NFTs were light gray with thick flame-like structures on Pap-s. GVD was identified in the majority of AD cases and was most easily observed on Pap-s. SPs were difficult to identify and were seen only in AD cases. HBs were rarely identified as long light eosinophilic hyaline structures on Pap-s. Cytological findings of hippocampi reflect the characteristic histological features of AD with the exception of HBs, which are difficult to identify on smears. NFTs and gliosis, and SPs seem to be sensitive and specific cytologic markers in hippocampal smears for AD, respectively.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Takei H,Kosarac O,Powell SZ

doi

10.1002/dc.21053

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

654-60

issue

9

eissn

8755-1039

issn

1097-0339

journal_volume

37

pub_type

杂志文章
  • Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.

    abstract::We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core-needle biopsy were evaluated independently. FNA was diagnostic ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20082

    authors: Gong JZ,Snyder MJ,Lagoo AS,Vollmer RT,Dash RR,Madden JF,Buckley PJ,Jones CK

    更新日期:2004-07-01 00:00:00

  • Diagnosis of systemic lupus erythematosus in an elderly male by pericardial fluid cytology: a case report.

    abstract::Although pleural and pericardial effusions are common and may rarely be the initial manifestation of disease, there are few reports of SLE diagnosed in a cytopathology laboratory. We describe an unusual case of SLE in a 75-year-old man who presented with cardiac tamponade. Cytologic examination of the pericardial flui...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199805)18:5<346::aid-dc8>3

    authors: Fazio J,Friedman HD,Swerdlow J,Michiel RR

    更新日期:1998-05-01 00:00:00

  • A comparative analysis of fine-needle capillary cytology vs. fine-needle aspiration cytology in superficial lymph node lesions.

    abstract::Fine-needle capillary cytology (FNCC) has been attempted in various organs and studies have shown this procedure to yield qualitatively superior material compared with fine-needle aspiration cytology (FNAC). Studies evaluating the efficacy of this technique in lymph nodes are rare. The present study has attempted to a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21109

    authors: Sajeev S,Siddaraju N

    更新日期:2009-11-01 00:00:00

  • Fine-needle aspiration biopsy of monophasic variant of spindle epithelial tumor with thymus-like differentiation of the thyroid: report of one case and review of the literature.

    abstract::Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare biphasic tumor of the thyroid with approximately 20 well-documented cases reported in the English literature. Although a monophasic variant of SETTLE is conceivable, the majority of the reported cases were truly biphasic tumors. A minimal amo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.20579

    authors: Tong GX,Hamele-Bena D,Wei XJ,O'Toole K

    更新日期:2007-02-01 00:00:00

  • The use of gastric salvage cytology in the diagnosis of malignancy: a review of 731 cases.

    abstract::Over an 8-yr period at the Houston Veterans Hospital, 731 endoscopic gastric salvage cytologies were performed in 671 patients, with surgical biopsy also done in 660. Seventy-six patients subsequently had tissue biopsy-proven or resection-proven malignancies. Salvage cytology had a sensitivity of 91% and a specificity...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840060102

    authors: Green LK,Zachariah S,Graham DY

    更新日期:1990-01-01 00:00:00

  • Adenomyoepithelioma of the breast: fine-needle aspiration biopsy and histologic findings.

    abstract::Adenomyoepithelioma is an uncommon tumor of the breast which clinically presents as a discrete nodule and histologically is composed of lumenal spaces lined by a mixture of epithelial and myoepithelial cells. It has a spectrum of histologic appearances which are gradually gaining wider recognition. There are, however,...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120311

    authors: Niemann TH,Benda JA,Cohen MB

    更新日期:1995-05-01 00:00:00

  • Fine-needle aspiration cytology of soft-tissue calcinosis presenting as an enlarging mass in the chest wall.

    abstract::Calcinosis cutis is an uncommon condition, and calcific deposits in patients with end-stage renal disease are now somewhat rare, due to improvement in management. Since calcific deposits may clinically resemble a tumor, it is feasible to investigate them by fine-needle aspiration cytology (FNAC). A 52-yr-old male with...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199812)19:6<465::aid-dc13>

    authors: Gupta RK,Naran S,Cheung YK

    更新日期:1998-12-01 00:00:00

  • Microfilariae of Wuchereria bancrofti in cyst fluid of tumors of the brain: a report of three cases.

    abstract::Microfilariae of various nematodes, including Loa loa, Dirofilariae, and Onchocerca volvulus, have been identified in the central nervous system (CNS). The CNS, however, is a rare site for the isolation of microfilariae of Wuchereria bancrofti. To the best of our knowledge, the presence of microfilariae of W. bancroft...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10074

    authors: Aron M,Kapila K,Sarkar C,Verma K

    更新日期:2002-03-01 00:00:00

  • Chest wall abscess: an unusual presentation of Hodgkin's lymphoma.

    abstract::A chest wall abscess is a very rare presentation of extranodal Hodgkin's lymphoma (HL); only one case has been reported to date. Here, we describe a case of a 38-yr-old man with HL whose initial presentation was a chest wall abscess. The diagnosis of HL was suggested by cytological examination of the purulent discharg...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20220

    authors: Khalbuss WE,Grigorian S,Mignone J,D'Agostino HJ

    更新日期:2005-07-01 00:00:00

  • Lymphomatous effusion of monomorphic epitheliotropic intestinal T-cell lymphoma is characterized by azurophilic granules and is a dismal sign: Report of two new cases with literature review.

    abstract::Lymphoma involving serous effusion is uncommon. The diagnosis of effusion lymphoma may be challenging, particularly when the lymphoid cells are small to medium-sized, which would be difficult for differentiating reactive effusions from low grade lymphomas. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24690

    authors: Pan ST,Wang RC,Su YZ,Hsieh YC,Chuang SS

    更新日期:2021-01-02 00:00:00

  • The diagnostic utility of CK5/6 and p63 in fine-needle aspiration of the breast lesions diagnosed as proliferative fibrocystic lesion.

    abstract::Fine-needle aspiration (FNA) biopsy (FNAB) in the preoperative assessment of breast lesions has shown diagnostic limitations with false-positive and false-negative diagnoses. We investigated the diagnostic value of cytokeratin 5/6 (CK5/6) and p63 in a series of breast FNABs, diagnosed as proliferative breast lesions w...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21534

    authors: Al-Maghraby H,Ghorab Z,Khalbuss W,Wong J,Silverman JF,Saad RS

    更新日期:2012-02-01 00:00:00

  • Fine-needle aspiration biopsy of gouty tophi: lessons in cost-effective patient management.

    abstract::Gout, a disease resulting from the effects of hyperuricemia and a crystal-induced arthropathy, may produce soft tissue masses (tophi) which mimick neoplasia clinically and radiographically. We have recently diagnosed three cases of gouty tophus, two of which were clinically suspected to represent sarcomas, by fine-nee...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199707)17:1<30::aid-dc6>3.

    authors: Nicol KK,Ward WG,Pike EJ,Geisinger KR,Cappellari JO,Kilpatrick SE

    更新日期:1997-07-01 00:00:00

  • Infarcted intraduct papilloma diagnosed by fine-needle biopsy: a cytologic, clinical, and mammographic pitfall.

    abstract::Necrosis is a worrisome cytologic feature in breast aspirates which, when paired with suspicious clinical and mammographic findings, could potentially result in a false positive diagnosis. A 66-yr-old female presented with clinical evidence of stage 1 breast carcinoma supported by the mammographic and ultrasound findi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840110216

    authors: Greenberg ML,Middleton PD,Bilous AM

    更新日期:1994-01-01 00:00:00

  • Intraabdominal desmoplastic small round cell tumor: cytopathologic findings in two cases.

    abstract::Intraabdominal desmoplastic small round cell tumor (DSRCT) is an extremely rare entity. This study describes fine-needle aspiration, ascitic fluid, and touch imprint cytomorphology of DSRCT in 2 patients with extensive abdomino-pelvic disease. Cytopathologic features were unique and showed good morphologic correlation...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199806)18:6<449::aid-dc13>

    authors: Ali SZ,Nicol TL,Port J,Ford G

    更新日期:1998-06-01 00:00:00

  • Endoscopic ultrasound guided fine-needle aspiration diagnosis of duodenal high grade neuroendocrine carcinoma underlying a villous adenoma: report of a case.

    abstract::Endoscopic ultrasound guided fine-needle aspiration biopsy is a reliable and accurate method for the diagnosis of submucosal lesions of the gastrointestinal tract. We report the cytopathologic findings of a case of duodenal high-grade neuroendocrine carcinoma in a 68-year-old woman who presented with melena and marked...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21603

    authors: Tasso DM,Attam R,Aslan DL,Pambuccian SE

    更新日期:2012-01-01 00:00:00

  • Cytomorphological features of high-grade intraepithelial neoplasia/carcinoma of the cervix following chemoradiotherapy.

    abstract:BACKGROUND:Cervicovaginal cytology as a follow-up study in women with a history of a cervical carcinoma treated with chemo-radiotherapy (CRT) plays an important role; however, the cytomorphological characteristics for the diagnosis of high-grade squamous intraepithelial lesions (H-SIL) in post-CRT patients have not bee...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24070

    authors: Serrano-Arévalo ML,Flores-Hernández L,Villegas-González LF,Zamora-Zarco S,España-Ferrufino A,Lino-Silva LS,Barquet-Muñoz SA

    更新日期:2019-03-01 00:00:00

  • Pleomorphic adenoma with bizarre myoepithelial cells: A diagnostic challenge on cytologic smear.

    abstract::The diagnosis on fine needle aspiration of salivary gland tumors with a myoepithelial component is challenging because myoepithelial cells can have a wide cytomorphologic spectrum. The authors report a case of a pleomorphic adenoma of the parotid gland that expands the spectrum of appearances that myoepithelial cells ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24301

    authors: Taweevisit M,Thorner PS

    更新日期:2019-12-01 00:00:00

  • Cytologic diagnosis of metastatic ovarian adenocarcinoma in the urinary bladder: a case report and review of the literature.

    abstract::A 53-yr-old woman with a 13-mo history of recurrent ovarian papillary serous adenocarcinoma presented with persistent microscopic hematuria. The patient was undergoing chemotherapy for her recurrent ovarian tumor when she was referred to the urology service for microscopic hematuria. An intravenous pyelogram was norma...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0339(199903)20:3<156::aid-dc8>3

    authors: Edgerton ME,Hoda RS,Gupta PK

    更新日期:1999-03-01 00:00:00

  • Fine-needle aspiration cytology of a lipoblastoma: a case report.

    abstract::A lipoblastoma is a rare benign tumor of immature white fat, and more than 90% of lipoblastomas occur before the age of 3 years. The diagnosis of a lipoblastoma is mostly dependent on a histopathological examination of a surgically excised specimen. However, an accurate preoperative diagnosis is essential for the plan...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20826

    authors: Hong R,Choi DY,Do NY,Lim SC

    更新日期:2008-07-01 00:00:00

  • Fine-needle aspiration cytology of clear-cell sarcoma of the kidney: study of eight cases.

    abstract::The largest series, to date, of fine-needle aspiration cytology (FNAC) findings in clear-cell sarcoma of the kidney (CCSK) is presented. All fine-needle aspirates of pediatric renal masses over a 17-yr period were reviewed. Eight out of 119 aspirates from late-stage childhood renal tumors (6.72%) were found to be CCSK...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20317

    authors: Iyer VK,Agarwala S,Verma K

    更新日期:2005-08-01 00:00:00

  • Improving ROSE: Discrepant touch preparation and histology findings in cytology of renal masses: A 10-year retrospective review.

    abstract:BACKGROUND:The number of "renal incidentalomas" is on the rise due to increasing use of radiologic studies. Image-guided core needle biopsies (CNB) with touch preparations are performed to guide specimen collection and triage of sample for additional studies. Results allow the clinical team to make appropriate treatmen...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24253

    authors: Shachner TR,Nodit L,Hubbard E,Van Meter S

    更新日期:2019-10-01 00:00:00

  • Cytohistological correlation in patients with atypical glandular cells on Papanicolaou test in a Chilean population.

    abstract::The standard screening test for detecting cervical lesions and cancers is a Papanicolaou (Pap) smear. While squamous cell abnormalities remain the most common positive Pap test result, cytologic findings of glandular cell abnormalities have become more frequent in recent decades. The 2014 Bethesda System for reporting...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24421

    authors: González-Espinoza D,Ponce Camus K,Meneses Pérez I,Molina Cruz C

    更新日期:2020-09-01 00:00:00

  • Intraductal carcinoma in a male breast: diagnosis by nipple discharge cytology.

    abstract::We describe a case of intraductal carcinoma (comedo type) in a 50-yr-old male. The patient had presented with a bloody nipple discharge, which had shown malignant cells on cytologic examination. In current clinical practice, the use of nipple discharge cytology as a screening and diagnostic tool for breast carcinoma i...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120414

    authors: Hirschman SA,Hoda SA,May M,Cody HS 3rd

    更新日期:1995-06-01 00:00:00

  • Evolution of Pap testing at a community hospital: a ten year experience.

    abstract::Over a 10-year period the Pap program at our community hospital laboratory progressed from the use of 100% conventional smears to predominantly ThinPrep (TP) and then to nearly 100% SurePath (SP). During this period the annual Pap volume grew from less than 20,000 to nearly 50,000. This retrospective review focuses on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20607

    authors: Nance KV

    更新日期:2007-03-01 00:00:00

  • Effectiveness of the SurePath liquid-based Pap test in automated screening and in detection of HSIL.

    abstract::We have shown that SurePath when compared to conventional Paps fails to increase HSIL detection. In this study, assessment of test performance characteristics for the FocalPoint showed that sensitivity was 96% when manual screening was used as the "gold standard." When cervical biopsy, however, was used as the "gold s...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10373

    authors: Cengel KA,Day SJ,Davis-Devine S,Adams CL,Madison-Henness D,Hartman ME,Freund GG

    更新日期:2003-11-01 00:00:00

  • Fine-needle aspiration of cystic nephroma (multilocular cyst of the kidney).

    abstract::Cystic nephromas are rare tumors of the kidney most commonly affecting boys or adult females. The fine-needle aspiration cytomorphology has not yet been described. A renal cystic mass in a 56 year old female was aspirated under ultrasound guidance. Papanicolaou stained smears of the cyst fluid revealed markedly atypic...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080408

    authors: Clark SP,Kung IT,Tang SK

    更新日期:1992-01-01 00:00:00

  • Immunostaining of estrogen receptor, progesterone receptor, MIB1 antigen, and c-erbB-2 oncoprotein in cytologic specimens: a simplified method with formalin fixation.

    abstract::An effective but simple fixation protocol for the immunocytochemical staining of cytologic smears for estrogen and progesterone receptors, the Ki-67 antigen (using MIB1 antibody), and c-erbB-2 protein is described. One hundred twenty-seven smears from a variety of malignant and benign breast lesions showed good preser...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199708)17:2<127::aid-dc8>3

    authors: Suthipintawong C,Leong AS,Chan KW,Vinyuvat S

    更新日期:1997-08-01 00:00:00

  • Aspiration cytodiagnosis of amyloid from vitreous fluid.

    abstract::Amyloidosis of the vitreous body is a rare disorder that causes progressive visual loss. In this report, a 36-yr-old female with familial amyloidosis is described in whom a progressive reduction of vision in both eyes over the last 4 yr was ascribed to vitreous opacities due to amyloid. A left pars plana vitrectomy wa...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10090

    authors: Gupta RK,Wakefield J,Halliwell T,Foo K,Lallu S,Naran S,Fauck R

    更新日期:2002-05-01 00:00:00

  • Glycogen-rich clear cell carcinoma of the breast: report of a case with fine-needle aspiration cytology and immunocytochemical and ultrastructural studies.

    abstract::Fine-needle aspiration cytology, immunocytochemistry, and electron microscopic findings are described in a case of glycogen-rich clear cell carcinoma of the breast. The aspirate contained many small and large papillary cell groups and numerous single tall columnar cells with apical cytoplasmic projections and mild to ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120115

    authors: Alexiev BA

    更新日期:1995-02-01 00:00:00

  • Papillary tissue fragments as a diagnostic pitfall in fine-needle aspirations of thyroid nodules.

    abstract::Fine-needle aspirates of three thyroid nodules displayed hypercellularity and papillary tissue fragments that suggested neoplasms. Neither microfollicles (either empty or with inspissated colloid) nor the characteristic nuclei of papillary carcinoma were evident. Surgical specimens contained adenomatoid nodules with f...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199705)16:5<454::aid-dc14>

    authors: Faser CR,Marley EF,Oertel YC

    更新日期:1997-05-01 00:00:00