Lymphomatous effusion of monomorphic epitheliotropic intestinal T-cell lymphoma is characterized by azurophilic granules and is a dismal sign: Report of two new cases with literature review.


:Lymphoma involving serous effusion is uncommon. The diagnosis of effusion lymphoma may be challenging, particularly when the lymphoid cells are small to medium-sized, which would be difficult for differentiating reactive effusions from low grade lymphomas. Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an uncommon type of aggressive intestinal T cell lymphoma with a median survival of 7 months. MEITL rarely disseminates to the body cavities. To date, there are only three reported cases of MEITL with malignant effusion. Here we report two additional cases of MEITL with lymphoma cells involving the pleural effusion and the ascites, respectively. Review of the three literature cases and our two new cases of MEITL with malignant effusion, cytoplasmic azurophilic granules were identified in both the two cases with Liu stain. The median survival time was 1.5 months after the occurrence of malignant effusion, even shorter than the median survival in patients with MEITL. Although the case number is small, malignant effusion seems to be a poor prognostic factor of MEITL.


Diagn Cytopathol


Diagnostic cytopathology


Pan ST,Wang RC,Su YZ,Hsieh YC,Chuang SS




Has Abstract


2021-01-02 00:00:00






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    abstract::Recent therapeutic progresses in nonsmall cell lung cancer (NSCLC) and in colorectal cancer (CRC) are based on agents that specifically target the epidermal growth factor receptor (EGFR). To identify the patients most likely to benefit from such therapies, EGFR or KRAS gene mutation tests are mandatory, respectively, ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Malapelle U,Bellevicine C,Zeppa P,Palombini L,Troncone G

    更新日期:2011-09-01 00:00:00

  • Diagnosis of peripheral T-cell lymphoma by fine-needle aspiration biopsy: a cytomorphologic and immunophenotypic approach.

    abstract::The diagnosis of T-cell lymphomas by fine-needle aspiration biopsies (FNAB) is extremely difficult. This is mainly due to the rarity of the disease, the morphologic similarity to reactive lymphadenopathy, and the difficulty in identifying abnormal T-cell antigen expression. We studied FNAB of histologically proven T-c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Al Shanqeety O,Mourad WA

    更新日期:2000-12-01 00:00:00

  • Cytologic features of alveolar soft part sarcoma: report of three cases.

    abstract::Alveolar soft part sarcoma (ASPS) is a rare, high-grade, epithelial-like sarcoma that shows characteristic histopathologic findings. Although a chromosomal anomaly that seems specific has been recently described, its diagnosis is based on histologic and ultrastructural features. The tumor shows no specific immunohisto...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: López-Ferrer P,Jiménez-Heffernan JA,Vicandi B,González-Peramato P,Viguer JM

    更新日期:2002-08-01 00:00:00

  • Fine-needle aspiration cytodiagnosis of recurrent carcinoma of the breast in operative scars.

    abstract::Recurrence of carcinoma in scars following surgical treatment of breast carcinoma is a frequent problem. An early diagnosis of recurrent lesions is essential to enable timely management. In this study, the role of fine-needle aspiration cytology (FNAC) in the diagnosis of scar lesions was evaluated in 156 women seen o...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gupta RK

    更新日期:1997-01-01 00:00:00

  • Hormone receptor status and HER2/neu overexpression determined by automated immunostainer on routinely fixed cytologic specimens from breast carcinoma: correlation with histologic sections determinations and diagnostic pitfalls.

    abstract::Although fine-needle aspiration cytology is a routine procedure for the diagnosis of breast carcinoma, cytologic specimens have rarely been used for evaluation of hormone receptor status and HER2/neu overexpression. In order to compare the biological markers on cytology and on histology, routinely fixed smears of 110 ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Moriki T,Takahashi T,Ueta S,Mitani M,Ichien M

    更新日期:2004-04-01 00:00:00

  • Anaplastic spindle-cell squamous carcinoma arising in association with tall-cell papillary cancer of the thyroid: A potential pitfall

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    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Saunders CA,Nayar R

    更新日期:2000-02-01 00:00:00

  • Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements.

    abstract::A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions,...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Solymosi T,Tóth V,Sápi Z,Bodó M,Gál I,Csanádi L

    更新日期:1996-03-01 00:00:00

  • Chordoma: cytologic and immunocytochemical study of four cases.

    abstract::We present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine-needle aspiration biopsies. The physaliferous cells in signet-ring, pearl-like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrangements are also desc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kontozoglou T,Qizilbash AH,Sianos J,Stead R

    更新日期:1986-01-01 00:00:00

  • Cytopathology of anaplastic carcinoma of the pancreas: Review of a rare entity and description of a variant with signet ring cell features.

    abstract::Anaplastic carcinoma of the pancreas (ACP) is a rare and aggressive variant of pancreatic ductal adenocarcinoma (PDAC). Several studies have attempted to characterize this subtype through case series or single case reports; however, ACP remains underrecognized by cytopathologists in particular, and often lumped under ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: El Hussein S,Khader SN

    更新日期:2019-09-01 00:00:00

  • Epithelioid variant of gastrointestinal stromal tumor: Diagnosis by fine-needle aspiration.

    abstract::Epithelioid gastrointestinal stromal tumors (GISTs) may cause significant diagnostic confusion on fine-needle aspiration (FNA) with carcinomas, neuroendocrine tumors, and melanoma, particularly when metastatic. This study characterizes the cytologic features of nine cases of epithelioid GISTs that were obtained by com...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Dong Q,McKee G,Pitman M,Geisinger K,Tambouret R

    更新日期:2003-08-01 00:00:00

  • An ancillary method in urine cytology: Nucleolar/nuclear volume ratio for discrimination between benign and malignant urothelial cells.

    abstract:BACKGROUND:The essential of urine cytology for the diagnosis and the follow-up of urothelial neoplasia has been widely recognized. However, there are some cases in which a definitive diagnosis cannot be made due to difficulty in discriminating between benign and malignant. This study evaluated the practicality of nucle...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Tone K,Kojima K,Hoshiai K,Kumagai N,Kijima H,Kurose A

    更新日期:2016-06-01 00:00:00

  • Rhabdoid meningioma: cytopathologic findings in cerebrospinal fluid.

    abstract::Rhabdoid meningioma is a recently described, rare, WHO Grade III intracranial tumor with an aggressive growth pattern and increased risk of recurrence. We describe the cytopathologic findings on cerebrospinal fluid of one such case in a 26-yr-old female who underwent resection of a left temporo-parietal mass. Cerebros...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Parwani AV,Mikolaenko I,Eberhart CG,Burger PC,Rosenthal DL,Ali SZ

    更新日期:2003-11-01 00:00:00

  • Acute monocytic leukemia presenting as generalized lymphadenopathy and skin rash in a toddler: highlighting the clinicopathologic mimics.

    abstract::Acute myeloid leukemia (AML) is the fifth most common malignancy in children. Extramedullary involvement in acute myeloid leukemia is rare and can be seen in soft tissues, central nervous system, skin and lymphoreticular organs. The clinical presentations can often be non-specific and hence, the diagnosis can be very ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Jain A,Gupta P,Gupta N,Senguttuvan G,Kapadia AB,Thirunavukkarasu B,Nada R,Varma N

    更新日期:2020-10-23 00:00:00

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    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Santiago K,Rivera A,Cabaniss D,Dhurhar N,Moroz K

    更新日期:2000-02-01 00:00:00

  • Hürthle cell metaplasia in chronic lymphocytic thyroiditis: Role of age factor and review of literature on its molecular pathogenesis.

    abstract:OBJECTIVES:Hürthle cell (HC) metaplasia is an important feature of chronic lymphocytic (Hashimoto) thyroiditis (HT). However, it is rarely observed in juvenile form HT. In a study based on fine needle aspiration cytology, the cytomorphological difference between pediatric HT and its adult form was studied, with special...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


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    更新日期:2019-05-01 00:00:00

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    abstract::Filariasis is a major public health problem in tropical and subtropical countries including India. Although there are reports of incidentally diagnosed cases of lymphatic filariasis in the existing literature, the significance of this finding needs to be summarised in one place. The association of filariasis with neop...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gupta S,Gupta R,Bansal B,Singh S,Gupta K,Kudesia M

    更新日期:2010-07-01 00:00:00

  • Liquid fixation of endometrial brush cytology ensures a well-preserved, representative cell sample with frequent tissue correlation.

    abstract::Endometrium was obtained by brushing 656 hysterectomy specimens with a MedScand cytobrush (Hollywood, FL) in order to evaluate linking an easy-to-use liquid fixative with brush-sampling of the endometrium, and to determine the fixative's operating characteristics when applied to brush-sampling the endometrium. Liquid-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Maksem JA,Knesel E

    更新日期:1996-06-01 00:00:00

  • FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma.

    abstract::While metastatic tumors to bone or lymph nodes from previously known primaries are often successfully diagnosed via fine-needle aspiration (FNA), a metastatic deposit in a patient with no previously known cancer may pose a diagnostic dilemma. Here, we present a case of metastatic papillary thyroid carcinoma that prese...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Jedrzkiewicz J,Witt BL

    更新日期:2014-08-01 00:00:00

  • Cytologic diagnosis of vulvar Paget's disease by means of brushing smear: report of a case.

    abstract::Paget's disease of the vulva is a rare entity; since it may show the same clinical symptoms as benign chronic vulvitis, it may result in a delayed diagnosis. A 63-year-old woman was found to have an eczematoid pink to red lesion located in the vulva. Scraping cytology of the vulva showed isolated malignant cells of Pa...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Funamoto Y,Haba R,Kobayashi TK,Kushida Y,Kouno K,Matsunaga T,Shiota A,Hata T

    更新日期:2010-02-01 00:00:00

  • Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift.

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    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Dey P,Ghosh RK

    更新日期:2019-04-01 00:00:00

  • Detection of tumor cells of serous tubal intraepithelial carcinoma (STIC) in cervical smears and rapid development of the ovarian involvement: A case report.

    abstract::Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Shintaku M,Taniguchi H,Yamamoto Y,Kono F,Sumitomo M

    更新日期:2018-11-01 00:00:00

  • Urothelial toxicity following conditioning therapy in bone marrow transplantation and bladder cancer: morphologic and morphometric comparison by exfoliative urinary cytology.

    abstract::Since cyclophosphamide and busulphan used for therapy of bone marrow transplantation (BMT) can cause urothelial cell changes similar to those found in bladder cancer, comparative morphologic and morphometric urinary cytologic research was carried out, examining 812 urine samples taken from 121 patients undergoing BMT ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Stella F,Battistelli S,Marcheggiani F,De Santis M,Donnorso RP,Baronciani D,Durazzi SM,Troccoli R,Lucarelli G

    更新日期:1992-01-01 00:00:00

  • The diagnostic utility of CK5/6 and p63 in fine-needle aspiration of the breast lesions diagnosed as proliferative fibrocystic lesion.

    abstract::Fine-needle aspiration (FNA) biopsy (FNAB) in the preoperative assessment of breast lesions has shown diagnostic limitations with false-positive and false-negative diagnoses. We investigated the diagnostic value of cytokeratin 5/6 (CK5/6) and p63 in a series of breast FNABs, diagnosed as proliferative breast lesions w...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Al-Maghraby H,Ghorab Z,Khalbuss W,Wong J,Silverman JF,Saad RS

    更新日期:2012-02-01 00:00:00

  • Pericellular lacunae in the diagnosis of metastatic carcinoma in effusions: is this a useful sign?

    abstract::The presence of pericellular lacunae has been cited as a useful criterion in distinguishing between benign and malignant effusions from body cavities. This study assessed the presence of pericellular lacunae in 75 specimens of malignant and 38 specimens of benign effusions. In a large number of cases, lacunae could no...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Thomson T,Hayes MM

    更新日期:1996-09-01 00:00:00

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    abstract:BACKGROUND:Fine-needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. While diagnostic accuracy of FNA for lymph node disease is well described, the relationship between node size, percent tumor replacement, and size of metastatic deposit with diagnostic accuracy is les...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Layfield LJ,Zhang T,Esebua M,Schmidt R

    更新日期:2021-02-01 00:00:00

  • Cardiac angiosarcoma: report of a case diagnosed by echocardiographic-guided fine-needle aspiration.

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    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Bhalla R,Nassar A

    更新日期:2007-03-01 00:00:00

  • Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review.

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    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Harbhajanka A,Bitterman P,Reddy VB,Park JW,Gattuso P

    更新日期:2016-12-01 00:00:00

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    abstract::Seventy-four fine needle aspiration biopsies (FNAB) of breast were selected from the 133 cases with surgical biopsy follow up, from a total of 1,154 consecutive breast FNAB received in a 6-month-period. These 74 cases were reviewed and scored using all relevant cytological criteria for proliferative breast lesions use...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Field A,Mak A

    更新日期:2007-08-01 00:00:00

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    abstract::A case of adrenal cryptococcosis diagnosed by fine-needle aspiration biopsy cytology in a 58-yr-old man is presented. The organisms were easily seen with routine modified Wright stain (Diff-Quik) as variably sized yeasts, some with a brightly eosinophilic capsule. The diagnosis was confirmed with mucicarmine and silve...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Powers CN,Rupp GM,Maygarden SJ,Frable WJ

    更新日期:1991-01-01 00:00:00

  • Evaluation of flow cytometric immunophenotyping and DNA analysis for detection of malignant cells in serosal cavity fluids.

    abstract::The serosal cavities are frequent sites of tumor metastasis. The distinction between carcinoma cells, inflammatory cells, and reactive or malignant mesothelial cells can be difficult in cytology. Multicolor flow cytometry (FCM) provides the opportunity to evaluate multiple antigens simultaneously, making it possible t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sayed DM,el-Attar MM,Hussein AA

    更新日期:2009-07-01 00:00:00