Hepatic angiomyolipoma with predominant epithelioid component: Diagnostic clues on aspiration and core needle biopsies.


:Hepatic angiomyolipoma (HAML) is a rare mesenchymal neoplasm that belongs to the perivascular epithelioid tumor family. Though it is characteristically, a triphasic tumor composed of smooth muscle, blood vessels, and adipocytes, the smooth muscle cells are often epithelioid and can represent the near-entirety of the tumor. A HAML composed predominantly of epithelioid smooth muscle cells occurring in the liver presents significant diagnostic challenges as many liver tumors are composed of large epithelioid cells. Furthermore, even if the tumor is not composed predominantly of epithelioid smooth muscle cells, this may be the only component present in a fine-needle aspiration (FNA) or core needle biopsy. A 38-year-old female with a 3 month history of abdominal pain, nausea, and diarrhea was found to have a 12 cm right hepatic lobe mass. FNA biopsy revealed a moderately cellular specimen composed of plump epithelioid cells with indistinct cell borders, low N:C ratio, round to oval nuclei, fine chromatin, occasional nucleoli, and abundant vacuolated to fibrillary cytoplasm. Rare intranuclear inclusions and occasional foamy macrophages were noted. Concurrent core biopsy revealed large polygonal cells with eccentric nuclei and clear, vacuolated to granular, eosinophilic cytoplasm that stained strongly for HMB45, confirming the diagnosis of HAML. Because HAML is a rare tumor, this diagnosis can be easily overlooked; cognizance of the typical cytologic, histologic, and immunophenotypic findings is crucial to establishing a diagnosis.


Diagn Cytopathol


Diagnostic cytopathology


De la Sancha C,Khan S,Alruwaii F,Cramer H,Saxena R




Has Abstract


2020-12-29 00:00:00






  • Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size.

    abstract:BACKGROUND:Fine-needle aspiration (FNA) is commonly used to investigate lymphadenopathy of suspected metastatic origin. While diagnostic accuracy of FNA for lymph node disease is well described, the relationship between node size, percent tumor replacement, and size of metastatic deposit with diagnostic accuracy is les...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Layfield LJ,Zhang T,Esebua M,Schmidt R

    更新日期:2021-02-01 00:00:00

  • Intraoperative consultation in ovarian lesions: a comparison between cytology and frozen section.

    abstract::Little information is available on the relative value of intraoperative cytology (IOC) and frozen section (FS) in evaluation of ovarian lesions. We compared the two methods in 63 histologically proven cases of resected ovaries studied by imprints (40 cases), FNAs (38 cases), and scrapes (5 cases). Diagnoses were: 10 n...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Michael CW,Lawrence WD,Bedrossian CW

    更新日期:1996-12-01 00:00:00

  • Fine-needle aspiration cytology of hematopoietic lesions from multiple sites.

    abstract::We reviewed 130 fine-needle aspiration (FNA) biopsies from 118 patients with a variety of benign and malignant hematopoietic lesions. There were 74 (57%) malignant, 45 (35%) benign, and 11 (8%) atypical diagnoses. Immunocytochemistry of the aspirated material was performed in 47 (36%) and electron microscopy in 4 (3%)...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Silverman JF,McLeod DL,Park HK

    更新日期:1990-01-01 00:00:00

  • Cytologic characteristics of clear-cell sarcoma of the kidney (CCSK) in fine-needle aspiration biopsy (FNAB): a report of 4 cases.

    abstract::The cytologic findings observed in fine-needle aspiration biopsy (FNAB) of four cases of clear-cell sarcoma of the kidney (CCSK) are reported. Smears contained a monomorphic population of cells exhibiting non-descriptive cytoplasm and almost nude round to oval nuclei with smooth contour, evenly dispersed fine chromati...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Drut R,Pomar M

    更新日期:1991-01-01 00:00:00

  • E-cadherin cell-adhesion molecule expression as a diagnostic adjunct in urothelial cytology.

    abstract::E-cadherin (E-CD) is a cell-adhesion molecule that has been associated with invasion and metastasis in a wide variety of human neoplasms. We have recently shown that, although decreased E-CD expression is associated with increased bladder-wall invasion and higher tumor grade of infiltrating transitional cell carcinoma...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ross JS,Cheung C,Sheehan C,del Rosario AD,Bui HX,Fisher HA

    更新日期:1996-06-01 00:00:00

  • Report of an intrapulmonary solitary fibrous tumor: fine-needle aspiration cytologic findings, clinicopathological, and immunohistochemical features.

    abstract::The authors describe a rare case of intrapulmonary solitary fibrous tumor (SFT). Morphologically, the tumor showed a disorganized or "patternless" arrangement of plump to spindle cells in a collagenous stroma. Tumor cells were immunoreactive for vimentin, but not for keratin, carcinoembryonic antigen, epithelial membr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Caruso RA,LaSpada F,Gaeta M,Minutoli I,Inferrera C

    更新日期:1996-02-01 00:00:00

  • Cytologic features of sclerosing hemangioma of the lung on crush preparations.

    abstract::Sclerosing hemangioma of the lung is a rare benign neoplasm. The majority of the literature published on sclerosing hemangioma has focused on the histologic features, while only a few case reports have described the cytologic features. We report two additional cases of sclerosing hemangioma of the lung in which the cy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Blanco LZ,Heagley DE,Montebelli F,Gabrielli E,Reddy V,Ghai R,Gattuso P

    更新日期:2013-03-01 00:00:00

  • A comparative analysis of fine-needle capillary cytology vs. fine-needle aspiration cytology in superficial lymph node lesions.

    abstract::Fine-needle capillary cytology (FNCC) has been attempted in various organs and studies have shown this procedure to yield qualitatively superior material compared with fine-needle aspiration cytology (FNAC). Studies evaluating the efficacy of this technique in lymph nodes are rare. The present study has attempted to a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sajeev S,Siddaraju N

    更新日期:2009-11-01 00:00:00

  • Plasmablastic lymphoma of the cecum: report of a case with cytologic findings.

    abstract::Plasmablastic lymphoma (PBL) is a rare lymphoma that is characterized by a diffuse proliferation of large neoplastic cells resembling B immunoblasts, but shows the immunophenotype of plasma cells. PBL is most commonly seen in the oral cavity of human immunodeficiency virus (HIV)-positive patients. Epstein-Barr virus (...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hatanaka K,Nakamura N,Kishimoto K,Sugino K,Uekusa T

    更新日期:2011-04-01 00:00:00

  • Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas.

    abstract::CD138 (Syndecan-1) is a transmembrane heparan sulfate proteoglycan present on the surface of plasma cells and epithelial cells. CD138 is also expressed in some hematopoietic neoplasms and has recently been observed in carcinomas. We characterized CD138 expression in cell-block preparations of fluids/effusions, focusin...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Saqi A,Yun SS,Yu GH,Alexis D,Taub RN,Powell CA,Borczuk AC

    更新日期:2005-08-01 00:00:00

  • Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.

    abstract::We report a rare case of extranodal NK/T-cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65-year-old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou-stained cervical smear show...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Omori M,Oishi N,Nakazawa T,Nakazawa K,Mitsumori T,Yuminamochi T,Kirito K,Hirata S

    更新日期:2016-05-01 00:00:00

  • Cytology of embryonal rhabdomyosarcoma: a cytologic, light microscopic, electron microscopic, and immunohistochemical study of seven cases.

    abstract::A correlated cytologic and histologic study of seven cases of embryonal rhabdomyosarcoma is presented. The diagnosis of rhabdomyosarcoma was established by light and electron microscopy and immunohistochemistry of the operative specimens. The cytologic appearance of the smears corresponded well with the histopathologi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Seidal T,Walaas L,Kindblom LG,Angervall L

    更新日期:1988-01-01 00:00:00

  • Spindle cell lipoma of the breast: a case report and literature review.

    abstract::Fine-needle aspiration cytology (FNA) was performed on a breast lump in a 66-year-old female, clinically thought to be a carcinoma. The cytological findings were reported as suspicious of malignancy. Subsequent histological examination showed a tumour macroscopically and microscopically identical with six other cases ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Lew WY

    更新日期:1993-08-01 00:00:00

  • Reproducibility of atypia of undetermined significance/follicular lesion of undetermined significance category using the bethesda system for reporting thyroid cytology when reviewing slides from different institutions: A study of interobserver variability

    abstract:BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Padmanabhan V,Marshall CB,Akdas Barkan G,Ghofrani M,Laser A,Tolgay Ocal I,David Sturgis C,Souers R,Kurtycz DF

    更新日期:2017-05-01 00:00:00

  • Primary pulmonary Hodgkin's lymphoma: a rare pitfall in transthoracic fine needle aspiration cytology.

    abstract::Primary pulmonary Hodgkin's lymphoma (PPHL) is extremely rare. At an extranodal location such as the lung this lymphoma is likely to be confused with the more commonly occurring carcinomas at this site. We report the fine needle aspiration cytology (FNAC) findings of a PPHL in a 36-year-old male with a view to discuss...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kumar R,Sidhu H,Mistry R,Shet T

    更新日期:2008-09-01 00:00:00

  • Monophasic synovial sarcoma: a cytologic spectrum.

    abstract::Synovial sarcoma (SS) is a high-grade sarcoma that can be diagnosed in cytology with certainty only when it presents with a biphasic pattern. Monophasic SS (MSS), however, is a diagnostic consideration when a uniform spindle cell population is present. The purpose of this study was to evaluate a series of cytologic ca...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ewing CA,Zakowski MF,Lin O

    更新日期:2004-01-01 00:00:00

  • Fine-needle aspiration cytology of lipoblastoma: a report of two cases.

    abstract::Lipoblastoma is an uncommon lipomatous tumor that typically occurs in infants and children. It may present as a single subcutaneous nodule or with multiple lesions (lipoblastomatosis). We describe fine-needle aspiration (FNA) cytologic features of two cases that presented as a subcutaneous lump in the scapular area an...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: López-Ferrer P,Jiménez-Heffernan JA,Yébenes L,Vicandi B,Viguer JM

    更新日期:2005-01-01 00:00:00

  • Cerebrospinal Fluid Cytological Diagnosis in Multiple Myeloma With Leptomeningeal Involvement: A Report of Two Cases.

    abstract::Multiple myeloma (MM) with central nervous system (CNS) infiltration is uncommon and the diagnosis is more complicated than that of MM. Here we report two cases of CNS MM that was diagnosed by cerebrospinal fluid cytology examination. Cerebrospinal fluid cytology examination can help to detect malignant cells and immu...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ren H,Zou Y,Zhao Y,Li J,Han X,He J,Guan H

    更新日期:2017-01-01 00:00:00

  • Serosal balls detected immunocytochemically in peritoneal lavage obtained during surgery.

    abstract::Using the immunoperoxidase technique, we studied "serosal balls," which have features resembling those of cells from primary and metastatic tumors, and may thus complicate cytodiagnosis. Serosal balls were detected in 32 (18%) of 174 peritoneal washings. The balls consisted of oval clusters of cells in solid masses su...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sasaki M,Wakasa K,Sakurai M,Iwa N

    更新日期:1995-08-01 00:00:00

  • Cytodiagnosis of bile microspheroliths: a case report.

    abstract::We recently observed numerous microspheroliths consisting of microscopic organized crystalline structures of varying shapes, sizes, and colors in a bile specimen from a 65-yr-old woman obtained directly from the gallbladder during a surgical procedure for cholecystectomy. Detection of microspheroliths could be very us...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sandmeier D,Mihaescu A

    更新日期:2001-04-01 00:00:00

  • Fine-needle aspiration cytology in the diagnosis of superficial lymphadenopathy: a 5-year Brazilian experience.

    abstract::To determine the accuracy of fine-needle aspiration (FNA) in the diagnostic assessment of lymphadenopathies, a retrospective study was conducted on 627 cases of FNA of the lymph nodes performed at Department of Pathology, UNIFESP (Federal University of São Paulo), between 1997 and 2001. Cytology results were compared ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Martins MR,Santos Gda C

    更新日期:2006-02-01 00:00:00

  • Fine-needle aspiration biopsy of anaplastic large cell lymphoma, small cell variant with prominent plasmacytoid features: case report.

    abstract::Anaplastic large cell lymphoma (ALCL), according to the new WHO classification, is a diagnosis limited to T/NK cell lymphomas. We present a case that demonstrates a new morphologic variant of ALCL with significant possible pitfalls for the cytopathologist. A fine-needle aspiration biopsy of a cervical lymph node showe...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gatter KM,Rader A,Braziel RM

    更新日期:2002-02-01 00:00:00

  • Mucinous metaplasia to neoplastic lesions in endometrial samples with cytohistologic correlation.

    abstract::Seven cases of endometrial mucinous metaplasia and five of well-differentiated mucinous adenocarcinoma of the endometrium were studied. Cytologic specimens were obtained by Isaacs endometrial sampler, avoiding endocervical contamination. The histologic diagnosis between the intermediate type of mucinous metaplasia and...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Galera-Davidson H,Fernandez A,Navarro J,Parrilla A,Salguero M,Rivera F

    更新日期:1989-01-01 00:00:00

  • Cytological diagnosis of osteoblastoma of cervical spine: a case report with review of literature.

    abstract::Osteoblastomas are rare benign but sometimes aggressive primary bone tumors (1%), usually seen in males in the 2nd decade. Osteoblastomas, occurring in the spine, constitute a medical emergency due to impending cord compression. Hence a rapid and simple diagnostic modality, such as fine-needle aspiration (FNA) plays a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Venugopal SB,Prasad S

    更新日期:2015-03-01 00:00:00

  • Atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion: the practice experience of a hospital-based reference laboratory with this new Bethesda system diagnostic category.

    abstract::The 2001 Bethesda System diagnostic category of atypical squamous cells cannot exclude a high grade squamous intraepithelial lesion (ASC-H) was developed and implemented after many studies that proved its clinical relevance. In this study, we describe the practice experience of a hospital-based reference laboratory wi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Duncan LD,Jacob SV

    更新日期:2005-04-01 00:00:00

  • Fine-needle aspiration cytology and immunocytochemistry of orbital masses.

    abstract::A series of 85 fine-needle aspiration (FNA) biopsies from orbital space occupying lesions of 82 patients are reviewed. A total of 32 benign lesions and 49 malignant lesions were conclusively diagnosed. In two cases the aspirates were insufficient for diagnosis. Of two cases, which were cytologically suspicious for lym...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Tani E,Seregard S,Rupp G,Söderlund V,Skoog L

    更新日期:2006-01-01 00:00:00

  • Cytological diagnosis of juvenile xanthogranuloma: A rare histiocytic disorder.

    abstract::Juvenile xanthogranuloma (JXG) is a rare type of non-Langerhan cell histiocytic disorder, which is mostly confined to skin of head and neck. It is a self-limiting benign condition, which does not require surgery. We present a case of 8-month-old girl child with multiple yellowish brown colored papules over scalp, face...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Chauhan S,Diwaker P,Singh A,Gogoi P,Arora VK

    更新日期:2020-01-01 00:00:00

  • Cytology, flow cytometry, image analysis, and interphase cytogenetics by fluorescence in situ hybridization in the diagnosis of transitional cell carcinoma in bladder washes: a comparative study.

    abstract::The diagnosis of transitional cell carcinoma (TCC) in bladder washes is a diagnostic challenge to cytology. This study assessed the role of flow cytometry (FCM), image analysis (IA), and interphase cytogenetics by fluorescence in situ hybridization (FISH) as adjuncts in the cytodiagnosis of TCC in bladder washes. Fort...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Cajulis RS,Haines GK 3rd,Frias-Hidvegi D,McVary K,Bacus JW

    更新日期:1995-10-01 00:00:00

  • Cytologic features of meningiomas on crush preparations: a review.

    abstract::Meningiomas are rarely subjected to aspiration, however, since they may occur outside the central nervous system, it is important to recognize their cytologic features. The goal of this study was to examine the cytologic features of meningiomas in crush preparations and cytologic imprints prepared at the time of froze...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Siddiqui MT,Mahon BM,Cochran E,Gattuso P

    更新日期:2008-04-01 00:00:00

  • Cytologic features of ovarian granulosa cell tumors in pleural and ascitic fluids.

    abstract::Adult granulosa cell tumor (AGCT) is an uncommon neoplasm of the ovary with potential for aggressive behavior and late recurrence. The most important prognostic factor for AGCT is tumor stage. Thus, cytological assessment of pleural or ascitic fluids is crucial for initial staging and subsequent patient management. We...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Omori M,Kondo T,Yuminamochi T,Nakazawa K,Ishii Y,Fukasawa H,Hashi A,Hirata S

    更新日期:2015-07-01 00:00:00