Abstract:
:We report a case of minimal deviation adenocarcinoma (MDA) of the uterine cervix showing varicolored cytopathologic features on Papanicolaou (Pap) smear, which may indicate features suggestive of lobular endocervical glandular hyperplasia (LEGH)-adenocarcinoma sequence. A 57-year-old woman presented with a profuse amount of watery vaginal discharge. Gynecological examination revealed a cervical mass with involvement of the right parametrium. Conventional Pap smear showed hypercellularity consisting of approximately 4 types of clusters as follows: (1) clusters showing a monolayered honeycomb sheet of endocervical cells with golden-yellow mucin and bland nuclei, (2) three-dimensional clusters showing varicolored mucin and irregular nuclear overlapping, (3) irregularly shaped clusters showing distorted chicken-wire-mesh appearance with noticeable protrusions of the nuclei and clear or faint varicolored cytoplasm, and (4) crowded clusters showing scarce mucin and nuclear atypia. The surgically resected uterus revealed LEGH-mimicking lesion with fused papillae and a cribriform pattern in the endocervix and many glands exhibiting gastric differentiation that invaded deeper areas of the stroma with a subtle stromal reaction. Compared with histologic findings, two types of clusters, the crowded cluster with scarce mucin and the cluster with distorted chicken-wire-mesh-type appearance, were considered as adenocarcinoma, and the latter was interpreted as a gastric-type adenocarcinoma. Three-dimensional varicolored type clusters showed atypical features, but insufficient atypical features compared with those of adenocarcinoma. Detection of clusters with varicolored mucin on conventional Pap smear may provide a clue for the early recognition of the malignant potential of LEGH on cytology. The chicken-wire-mesh type clusters may be a characteristic cytologic finding of MDA.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Omori M,Kondo T,Nakazawa K,Shinohara S,Watanabe Y,Fukasawa H,Nakazawa T,Hashi A,Hirata Sdoi
10.1002/dc.23932subject
Has Abstractpub_date
2018-08-01 00:00:00pages
702-706issue
8eissn
8755-1039issn
1097-0339journal_volume
46pub_type
杂志文章abstract::Metaplastic breast carcinomas (MBCs) are not only uncommon neoplasms but also show a myriad of cytomorphologic patterns in aspiration samples. These tumors comprise less than 5% of breast malignancies and have an uncertain prognosis. In this study, the fine-needle aspiration cytologic features of 14 MBCs with the iden...
journal_title:Diagnostic cytopathology
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更新日期:1999-01-01 00:00:00
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2840120311
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.23653
更新日期:2017-02-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2020-05-23 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-08-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.2010
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1999-07-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.20572
更新日期:2006-12-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章,评审
doi:10.1002/dc.24402
更新日期:2020-05-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/dc.24627
更新日期:2020-10-01 00:00:00
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journal_title:Diagnostic cytopathology
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-05-01 00:00:00
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/dc.22858
更新日期:2012-06-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
doi:10.1002/(sici)1097-0339(200002)22:2<136::aid-dc19>
更新日期:2000-02-01 00:00:00