Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: a potential diagnostic pitfall with fine-needle aspiration cytology.

Abstract:

:We report three cases of cytomegalovirus (CMV) sialadenitis which presented as parotid gland nodules in patients infected with the human immunodeficiency virus. While CMV is known to widely infect patients with the acquired immunodeficiency syndrome (AIDS), we are aware of only a single report of CMV sialadenitis in a patient with AIDS (Pialoux et al.: Rev Infect Dis 1991;13:338). Utilizing fine-needle aspiration (FNA) cytology as the initial investigative modality, two cases were correctly diagnosed preoperatively while the third case displayed atypical features and was interpreted erroneously as carcinoma leading to surgical intervention. Upon review of these cases of CMV sialadenitis, the characteristic intranuclear inclusions are best identified with Papanicolaou (Pap) staining. CMV sialadenitis should be considered in the differential diagnosis of painless salivary gland enlargement in patients with AIDS. We believe this lesion can be diagnosed preoperatively with FNA and the interpretation is aided by evaluating both Pap- and Giemsa-stained material.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Wax TD,Layfield LJ,Zaleski S,Bhargara V,Cohen M,Lyerly HK,Fisher SR

doi

10.1002/dc.2840100216

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

169-72; discussion 172-4

issue

2

eissn

8755-1039

issn

1097-0339

journal_volume

10

pub_type

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