Diagnosis and differential diagnosis of small-cell lesions of the liver.


:The objective of this study was to evaluate the cytologic spectrum of small cell lesions of liver as diagnosed by fine-needle aspiration (FNA). Of 304 FNAs of liver that were performed in our institution between 1990 and 1994, 29 were classified as small-cell lesions. The final diagnoses were as follows: small-cell undifferentiated carcinoma (10), neuroendocrine carcinoma (9), cloacogenic carcinoma (1), Merkel-cell carcinoma (1), cholangiocarcinoma (1), metastatic adenocarcinoma (4), small-cell sarcoma (1), lymphoma (2). Relevant clinical history and immunocytochemistry were helpful in making the final diagnosis in some cases. The diagnosis and differential diagnosis of small cell lesions of the liver are discussed in detail in this report.


Diagn Cytopathol


Diagnostic cytopathology


Pisharodi LR,Bedrossian C




Has Abstract


1998-07-01 00:00:00














  • Intraoperative evaluation of sentinel lymph nodes in breast carcinoma by imprint cytology, frozen section and rapid immunohistochemistry.

    abstract::Sentinel lymph nodes (SLN) isolated in 40 patients of breast carcinoma (stage T(1)/T(2)) were evaluated intraoperatively by imprint cytology and frozen section. Rapid immunohistochemistry (IHC) was done in cases where both imprint smears and frozen sections were negative for any metastatic tumor deposits. The results ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Upender S,Mohan H,Handa U,Attri AK

    更新日期:2009-12-01 00:00:00

  • Accuracy of the International Academy of Cytology Yokohama system of breast cytology reporting for fine needle aspiration biopsy of the breast in a dedicated breast care setting.

    abstract:BACKGROUND:The International Academy of Cytology (IAC) Yokohama system is a recently proposed system for reporting breast cytology by fine needle aspiration biopsies (FNAB). Multiple studies are needed to confirm the risk of malignancy (ROM) of the various reporting categories of this system. The present article studie...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Agarwal A,Singh D,Mehan A,Paul P,Puri N,Gupta P,Syed A,Rao S,Chowdhury N,Ravi B

    更新日期:2021-02-01 00:00:00

  • Bilateral carotid body tumor: the role of fine-needle aspiration biopsy in the preoperative diagnosis.

    abstract::Carotid body (CB) is a round to ovoid or flattened structure situated within the adventitia of the common carotid artery bifurcation on both sides of the neck. CB contains two basic types of cells: chief cells (or glomus type 1) and sustentacular cells (glomus type 2). Carotid body tumor (CBT) or paraganglioma arises ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Rosa M,Sahoo S

    更新日期:2008-03-01 00:00:00

  • Fine-needle aspiration biopsy of gouty tophi: lessons in cost-effective patient management.

    abstract::Gout, a disease resulting from the effects of hyperuricemia and a crystal-induced arthropathy, may produce soft tissue masses (tophi) which mimick neoplasia clinically and radiographically. We have recently diagnosed three cases of gouty tophus, two of which were clinically suspected to represent sarcomas, by fine-nee...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Nicol KK,Ward WG,Pike EJ,Geisinger KR,Cappellari JO,Kilpatrick SE

    更新日期:1997-07-01 00:00:00

  • Risk of death due to disease for thyroid fine-needle aspirations of well-differentiated thyroid carcinomas.

    abstract::The risk of malignancy for some diagnoses in thyroid fine-needle aspirations is higher than the actual risk of clinical progression. Other measures of prognosis may be helpful in managing patients with indeterminate thyroid fine-needle aspiration diagnoses. We estimated the risk of death due to disease (RDDD) for well...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Renshaw AA,Gould EW

    更新日期:2019-10-01 00:00:00

  • High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis.

    abstract::We report a case of high-grade endometrial stromal sarcoma with cytological and immunocytochemical findings. Cytologically, major tumor cells showed round-to-short spindle shapes with round- to oval-shaped nuclei and moderately abundant delicate cytoplasm. Tumor cells with tapered shapes and eccentric nuclei were also...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ohta Y,Suzuki T,Kojima T,Mikogami T,Omatsu M,Hamatani S,Shiokawa A,Kushima M,Ota H

    更新日期:2011-04-01 00:00:00

  • Nipple aspirate fluid and ductoscopy to detect breast cancer.

    abstract::We prospectively performed cytologic assessment and image analysis (IA) on matched nipple aspirate fluid (NAF) and mammary ductoscopy (MD) specimens to determine (1) the accuracy of these methods in cancer detection and (2) whether the two collection methods provide complementary information.NAF and MD specimens were ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sauter ER,Klein-Szanto A,Macgibbon B,Ehya H

    更新日期:2010-04-01 00:00:00

  • Ultrasound-guided fine-needle aspiration biopsy remains a valid approach in the evaluation of nonpalpable breast lesions.

    abstract::The use of ultrasound-guided fine-needle aspiration (FNA) biopsy for nonpalpable breast lesions varies considerably. This retrospective study stresses the role of breast FNA in evaluating sonographically suspicious nonpalpable breast masses using a probabilistic reporting system. One hundred and eight consecutive ultr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Liao J,Davey DD,Warren G,Davis J,Moore AR,Samayoa LM

    更新日期:2004-05-01 00:00:00

  • Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas.

    abstract::CD138 (Syndecan-1) is a transmembrane heparan sulfate proteoglycan present on the surface of plasma cells and epithelial cells. CD138 is also expressed in some hematopoietic neoplasms and has recently been observed in carcinomas. We characterized CD138 expression in cell-block preparations of fluids/effusions, focusin...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Saqi A,Yun SS,Yu GH,Alexis D,Taub RN,Powell CA,Borczuk AC

    更新日期:2005-08-01 00:00:00

  • Fine-needle aspiration cytology with histological correlation of chordoma metastatic to the lung: a diagnostic dilemma.

    abstract::Chordoma is an uncommon tumor initially believed to be benign due to the rarity of its metastasis. Cytological, morphological, and immunohistochemical features of chordoma, relating to its origin from notochordal remnants, allows for its accurate diagnosis. A 75-year-old man with a known history of tuberculosis (TB) p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kanthan R,Senger JL

    更新日期:2011-12-01 00:00:00

  • The cytopathology of mycobacterial infection.

    abstract::Mycobacterial infection, tuberculosis (TB) in particular, remains one of the world's deadliest communicable diseases in adults and particularly in children, in low and middle income countries. The combination of human immunodeficiency virus (HIV) and TB is often lethal with TB accounting for 25% of deaths in the HIV p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Michelow P,Omar T,Field A,Wright C

    更新日期:2016-03-01 00:00:00

  • Breast filariasis diagnosed by needle aspiration cytology.

    abstract::A case of nodular lesion of the breast in a 37 year old female caused by filariasis is described. The case is instructive since the diagnosis was made by fine-needle aspiration cytology. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: SenGupta SK,Webb S,Cooke RA,Igo JD

    更新日期:1992-01-01 00:00:00

  • GATA3 expression in metastatic urothelial carcinoma in fine needle aspiration cell blocks: a review of 25 cases.

    abstract::GATA binding protein 3 is a zinc finger transcription factor with high affinity for urothelial tissue and is a promising immunohistochemical marker in detection of urothelial carcinomas (UC). We studied its usefulness in metastatic high-grade UC. This study was performed on cell blocks (CB) of fine needle aspirates fr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Siddiqui MT,Seydafkan S,Cohen C

    更新日期:2014-09-01 00:00:00

  • Current utilization of breast FNA in a cytology practice.

    abstract::Over the past decade, core biopsy rapidly replaced fine needle aspiration (FNA) in evaluation of diseases of the female breast in many centers in the USA. The inability to diagnose invasive cancer by FNA, and the general feeling of unease in interpretation of cytologic specimens among pathologists who are not trained ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Simsir A,Rapkiewicz A,Cangiarella J

    更新日期:2009-02-01 00:00:00

  • Image quantification technology of the heterochromatin and euchromatin region for differential diagnosis in the lobular endocervical glandular hyperplasia.

    abstract:BACKGROUND:Lobular endocervical glandular hyperplasia (LEGH) was first described by Nucci et al. in 1999 and is believed to be a precancerous lesion of minimal deviation adenocarcinoma and gastric-type adenocarcinoma in the uterine cervix. LEGH lesions do not always exhibit apparent cellular and structural atypia, so a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kimura F,Kobayashi T,Kanai R,Kobayashi Y,Yuhi O,Ota H,Yamaguchi M,Yokokawa Y,Uehara T,Ishii K

    更新日期:2019-06-01 00:00:00

  • Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland.

    abstract::Sebaceous lymphadenoma (SLA) is a histologic variant of lymphadenoma or sebaceous adenoma of the salivary gland. The fine-needle aspiration (FNA) cytology of SLA has not been well-described. In this report, we reported a case that involved an 81-year-old male with a long-standing left parotid mass and was diagnosed on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vande Haar MA,DeFrias D,Lin X

    更新日期:2014-11-01 00:00:00

  • Metastatic small cell osteosarcoma to the liver: a diagnostic pitfall for fine-needle aspiration cytology.

    abstract::We report the fine-needle aspiration cytology of a case of metastatic small cell osteosarcoma to the liver with rosette formation, originating from distal femur, in a 36-year-old female. The aspirate of the liver metastases revealed a relatively monomorphic population of mitotically active small blue round cells arran...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ali RH,Lee CH,Hayes MM

    更新日期:2014-02-01 00:00:00

  • The expanding role of cytopathology in the diagnosis of HPV-related squamous cell carcinoma of the head and neck.

    abstract::Confirmation of human papillomavirus (HPV) as a causative agent for a subset of biologically and clinically distinct squamous cell carcinomas of the head and neck (HNSCC) has resulted in a growing need and expectation for HPV testing of head and neck cancers. At the same time, opportunities to obtain tissue samples fo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Holmes BJ,Westra WH

    更新日期:2014-01-01 00:00:00

  • Cytomorphology of yolk sac tumor of the liver in fine-needle aspiration: a pediatric case.

    abstract::Yolk sac tumors (YST) in extragonadal locations are rare. Cytologic diagnosis of YST on fine-needle aspiration (FNA) smears may be a challenge to the cytopathologist. Further neo-adjuvant therapy may be based on cytologic diagnosis making accuracy important. We studied FNA material from a hepatic mass in a pediatric p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gilbert KL,Bergman S,Dodd LG,Volmar KE,Creager AJ

    更新日期:2006-06-01 00:00:00

  • Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report with immunocytochemical analyses.

    abstract::Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor that has morphologically recognizable both adenocarcinoma and neuroendocrine carcinoma components comprising at least 30% of either components. MANEC occurring in the ampulla of Vater is extremely rare, and only 16 cases have been reported in the Englis...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Yoshioka S,Ebisu Y,Ishida M,Uemura Y,Yanagimoto H,Satoi S,Tsuta K

    更新日期:2018-06-01 00:00:00

  • Fine-needle aspiration diagnosis of giant cell tumour of bone presenting at unusual sites.

    abstract::Giant cell tumour (GCT) of bone is a distinctive neoplasm, which has only recently been included within the diagnostic purview of the cytopathologist. Four cases of GCT of bone diagnosed primarily and exclusively by fine needle aspiration cytology (FNAC), presenting at unusual sites, are presented with a view to highl...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Jain M,Aiyer HM,Singh M,Narula M

    更新日期:2002-12-01 00:00:00

  • Cerebrospinal Fluid Cytological Diagnosis in Multiple Myeloma With Leptomeningeal Involvement: A Report of Two Cases.

    abstract::Multiple myeloma (MM) with central nervous system (CNS) infiltration is uncommon and the diagnosis is more complicated than that of MM. Here we report two cases of CNS MM that was diagnosed by cerebrospinal fluid cytology examination. Cerebrospinal fluid cytology examination can help to detect malignant cells and immu...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ren H,Zou Y,Zhao Y,Li J,Han X,He J,Guan H

    更新日期:2017-01-01 00:00:00

  • Leiomyosarcoma of the urinary bladder: a diagnostic challenge in urine cytology.

    abstract::Most of the available data in the literature describe the cytomorphological features of exfoliated malignant epithelial cells in urine. There are no established diagnostic features that characterize the morphology of exfoliated malignant mesenchymal tumor in urine. Here we highlight the problems in the diagnosis of th...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hemachandran M,Nada R,Rajwanshi A

    更新日期:2004-10-01 00:00:00

  • Cytological investigation of a first case of basal cell adenocarcinoma arising in the minor salivary glands. Case report and review of the literature.

    abstract::Basal cell adenocarcinoma (BCAC) of salivary glands is uncommon low-grade malignancy. Only 19 cases of preoperative cytology were reported up to date. We present here a new case of BCAC arising in the minor salivary gland. Tumor was composed of clustered or isolated roundish, dark cells with small and regular nuclei. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Mokhniuk K,Lesnik M,Klijanienko J

    更新日期:2018-08-01 00:00:00

  • Pancreatic adenocarcinoma: regression analysis to identify improved cytologic criteria.

    abstract::The incidence of pancreatic adenocarcinoma is increasing and it is usually unresectable at the time of diagnosis. Consequently, fine-needle aspiration biopsy (FNAB) is being used more frequently for diagnosis. The reported sensitivity of diagnosing pancreatic adenocarcinoma by FNAB has varied between 50% and 100%. In ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Cohen MB,Egerter DP,Holly EA,Ahn DK,Miller TR

    更新日期:1991-01-01 00:00:00

  • ALK and ROS1 rearrangement tested by ARMS-PCR in non-small-cell lung cancer patients via cytology specimens: The experience of Shanghai Pulmonary Hospital.

    abstract:BACKGROUND:Cytology specimens are the main samples used for the diagnosis of advanced lung cancer. The objective of our study was to assess anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 receptor tyrosine kinase (ROS1) genes by an amplification refractory mutation system (ARMS)-polymerase chain reaction (PCR) us...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Cao Z,Wu W,Zhang W,Li Z,Gao C,Huang Y,Zhang L

    更新日期:2020-06-01 00:00:00

  • Fine-needle aspiration of a pleomorphic lipoma of the head and neck: a case report.

    abstract::Pleomorphic lipoma is a rare soft-tissue tumor, most commonly seen in the head and neck regions of middle-aged men. Fine-needle aspiration (FNA) of these lesions can present a diagnostic challenge. Its large, hyperchromatic cells and multinucleated forms (floret cells) can easily be mistaken for a malignancy. A patien...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Yong M,Raza AS,Greaves TS,Cobb CJ

    更新日期:2005-02-01 00:00:00

  • Familial mesothelioma in first degree relatives.

    abstract::Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exp...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kalogeraki AM,Tamiolakis DJ,Lagoudaki ED,Papadakis MN,Papadakis GZ,Agelaki SI,Stathopoulos EN,Tzardi MN

    更新日期:2013-07-01 00:00:00

  • Autofluorescence--an important ancillary technique for the detection of Mycobacterium tuberculosis: revisited.

    abstract::Tuberculosis is one of the oldest diseases known to affect humans and is caused by Mycobacterium tuberculosis. Lymph nodes are the most common site of extrapulmonary involvement. Tuberculous lymphadenitis can be presumptively diagnosed morphologically on fine-needle aspiration biopsy of lymph nodes. Additional tests l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Joshi P,Singh M,Bhargava A,Singh M,Mehrotra R

    更新日期:2013-04-01 00:00:00

  • Immature teratoma of the ovary on fluid cytology.

    abstract::A case of an immature teratoma of the ovary in the peritoneal fluid of a 10-yr-old girl who presented with a pelvic mass is presented and discussed. The ThinPrep preparation showed a few tight clusters of small tumor cells with a high nuclear/cytoplasmic ratio, round to oval nuclei with evenly distributed chromatin an...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Selvaggi SM,Guidos BJ

    更新日期:2001-12-01 00:00:00