The role of endoscopic ultrasound and endoscopic ultrasound-guided fine-needle aspiration in distinguishing pancreatic cystic lesions.

Abstract:

:Distinguishing mucinous from nonmucinous cystic lesions of the pancreas often constitutes a diagnostic dilemma. The clinical management differs between such lesions; therefore it is important to make an accurate preoperative diagnosis. Various centers have reported conflicting results regarding their ability to detect mucin-producing neoplastic cells and appropriately reach a diagnosis based on endoscopic ultrasound (EUS) guided FNA. The aim of this study is to assess the ability of EUS-FNA cytology to diagnose and differentiate mucinous from nonmucinous pancreatic cystic lesions. We reviewed records of patients who underwent EUS of pancreatic cystic lesions. If FNA was performed and mucinous neoplasm was suspected, aspirate was evaluated for cytomorphology and presence of mucin. FNA results were compared to final histologic diagnosis if surgery was performed. Cytologic diagnosis was provided for 28/30 (93%). By comparing EUS-FNA diagnoses with final surgical pathology, FNA accurately diagnosed in 10/11 cases with sensitivity and specificity for detection of malignancy of 100 and 89, respectively, while the accuracy for identification of mucinous cystic neoplasms was 100%. Our results indicate that in the appropriate clinical and imaging setting, EUS-FNA cytology with analysis for mucin production by tumor cells is an important test in distinguishing pancreatic cystic lesions and guiding further management.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Moparty B,Logroño R,Nealon WH,Waxman I,Raju GS,Pasricha PJ,Bhutani MS

doi

10.1002/dc.20558

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

18-25

issue

1

eissn

8755-1039

issn

1097-0339

journal_volume

35

pub_type

杂志文章
  • Immunocytochemical panel for distinguishing between adenocarcinomas and reactive mesothelial cells in effusion cell blocks.

    abstract::The aim of our study was to determine the value of a panel that consisted of one epithelial marker (MOC-31) and two mesothelial markers (D2-40 and calretinin) for distinguishing between reactive mesothelial cells (RMCs) and adenocarcinomas (ACs) in effusion fluids. A total of 118 cell block specimens from pleural and ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20986

    authors: Kim JH,Kim GE,Choi YD,Lee JS,Lee JH,Nam JH,Choi C

    更新日期:2009-04-01 00:00:00

  • PREPmate automated processor: comparison of automated and manual methods of liquid-based gynecologic sample preparation.

    abstract::The development of procedures for fully automated processing of liquid-based gynecologic samples has been the focus of considerable interest to the cytology laboratory. Liquid-based collection and processing technology has been shown to improve sample adequacy, resulting in an overall improvement in quality of sample ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10193

    authors: Rowe LR,Marshall CJ,Bentz JS

    更新日期:2002-11-01 00:00:00

  • Bladder-washing cytology of metastatic ovarian granulosa cell tumor.

    abstract::An 86-year-old Caucasian female presented with two weeks history of discomfort discharging urine, occasional hematuria, and suprapubic pain. The patient had a history of left salpingo-oophorectomy for an ovarian tumor, performed four years earlier. Ultrasound showed a solid mass surrounding the orifice of the left ure...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10095

    authors: Vodovnik A

    更新日期:2002-06-01 00:00:00

  • Respiratory cytology in the era of molecular diagnostics: a review.

    abstract::Carcinoma of the lungs remains one of the primary causes of cancer mortality in the United States and represents a significant diagnostic challenge. Current diagnostic protocols depend substantially on cytology as an initial diagnostic modality. Pulmonary cytology can be diagnostically challenging with false positive ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.22858

    authors: Witt BL,Wallander ML,Layfield LJ,Hirschowitz S

    更新日期:2012-06-01 00:00:00

  • Dark and pale cerebriform nuclei in FNA smears of usual papillary thyroid carcinoma and its variants.

    abstract::The dark (hyperchromatic) cerebriform nucleus was recently described as a frequent finding in histopathology sections of papillary carcinoma of the thyroid. In the present study, we tried to determine the frequency of dark cerebriform nuclei in the fine-needle aspiration (FNA) smears of papillary thyroid carcinomas an...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20022

    authors: Mallik MK,Das DK,Mallik AA,Madda JP,Mirza K,Al-Bishi KK,George SS,Junaid TA

    更新日期:2004-03-01 00:00:00

  • Fine-needle aspiration biopsy of monophasic variant of spindle epithelial tumor with thymus-like differentiation of the thyroid: report of one case and review of the literature.

    abstract::Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare biphasic tumor of the thyroid with approximately 20 well-documented cases reported in the English literature. Although a monophasic variant of SETTLE is conceivable, the majority of the reported cases were truly biphasic tumors. A minimal amo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.20579

    authors: Tong GX,Hamele-Bena D,Wei XJ,O'Toole K

    更新日期:2007-02-01 00:00:00

  • Diagnosis of lymphoma, leukemia, and metastatic tumor involvement of the cerebrospinal fluid by cytology and immunocytochemistry.

    abstract::Fifty-five cerebrospinal fluid (CSF) specimens from 42 patients with suspected meningeal tumor involvement were reviewed. Cytology in conjunction with immunocytochemistry identified 26 CSF specimens as malignant. There were fifteen cases of lymphoma, four cases of leukemia, two cases of carcinoma, and two cases of mel...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120105

    authors: Tani E,Costa I,Svedmyr E,Skoog L

    更新日期:1995-02-01 00:00:00

  • Adult ocular medulloepithelioma diagnosed by transscleral fine needle aspiration: A case report.

    abstract::Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years-old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23694

    authors: Mahdjoubi A,Cassoux N,Levy-Gabriel C,Desjardins L,Klos J,Caly M,Vlajnic T,Gardrat S,Klijanienko J

    更新日期:2017-06-01 00:00:00

  • Radiation-induced changes in the breast: a potential diagnostic pitfall on fine-needle aspiration.

    abstract::The authors report a case of fine-needle aspiration (FNA) of a breast mass in a 36-year-old woman with previous history of lumpectomy and therapeutic radiation for breast carcinoma. The changes seen were interpreted as recurrent carcinoma, while subsequent biopsy showed only radiation changes. Radiation-induced change...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080117

    authors: Dornfeld JM,Thompson SK,Shurbaji MS

    更新日期:1992-01-01 00:00:00

  • Cyclooxygenase-2 expression in lung cancer cells evaluated by immunocytochemistry.

    abstract::Cyclooxygenase-2 (COX-2) expression may be a prognostic factor in lung cancer. In previous studies, COX-2 expression has almost exclusively been evaluated with immunohistochemical methods performed on histology sections of tissue biopsies. However, in clinical practice, lung cancer is often diagnosed with cytological ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21366

    authors: Koch A,Gustafsson B,Fohlin H,Sörenson S

    更新日期:2011-03-01 00:00:00

  • Analysis of three-dimensional architecture in Feulgen-stained fine-needle liver aspirates, using confocal scanning laser microscopy.

    abstract::Early and accurate diagnosis of hepatocellular carcinoma in liver nodules using fine-needle aspiration biopsy can still pose difficulties, particularly in cirrhotic nodules containing dysplastic hepatocytes. Loss of architectural clues, which may aid diagnosis, can be overcome by using confocal scanning laser microsco...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200008)23:2<82::aid-dc3>3.0.co;2

    authors: Boon ME,Barlow Y,Marres EM,Zeppa P,Kok LP

    更新日期:2000-08-01 00:00:00

  • Liquid fixation of endometrial brush cytology ensures a well-preserved, representative cell sample with frequent tissue correlation.

    abstract::Endometrium was obtained by brushing 656 hysterectomy specimens with a MedScand cytobrush (Hollywood, FL) in order to evaluate linking an easy-to-use liquid fixative with brush-sampling of the endometrium, and to determine the fixative's operating characteristics when applied to brush-sampling the endometrium. Liquid-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199605)14:4<367::AID-DC16>

    authors: Maksem JA,Knesel E

    更新日期:1996-06-01 00:00:00

  • Fine-needle aspiration cytology of adrenal cryptococcosis: a case report.

    abstract::A case of adrenal cryptococcosis diagnosed by fine-needle aspiration biopsy cytology in a 58-yr-old man is presented. The organisms were easily seen with routine modified Wright stain (Diff-Quik) as variably sized yeasts, some with a brightly eosinophilic capsule. The diagnosis was confirmed with mucicarmine and silve...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840070123

    authors: Powers CN,Rupp GM,Maygarden SJ,Frable WJ

    更新日期:1991-01-01 00:00:00

  • Pericellular lacunae in the diagnosis of metastatic carcinoma in effusions: is this a useful sign?

    abstract::The presence of pericellular lacunae has been cited as a useful criterion in distinguishing between benign and malignant effusions from body cavities. This study assessed the presence of pericellular lacunae in 75 specimens of malignant and 38 specimens of benign effusions. In a large number of cases, lacunae could no...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199609)15:3<193::AID-DC4>3

    authors: Thomson T,Hayes MM

    更新日期:1996-09-01 00:00:00

  • Chest wall abscess: an unusual presentation of Hodgkin's lymphoma.

    abstract::A chest wall abscess is a very rare presentation of extranodal Hodgkin's lymphoma (HL); only one case has been reported to date. Here, we describe a case of a 38-yr-old man with HL whose initial presentation was a chest wall abscess. The diagnosis of HL was suggested by cytological examination of the purulent discharg...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20220

    authors: Khalbuss WE,Grigorian S,Mignone J,D'Agostino HJ

    更新日期:2005-07-01 00:00:00

  • Diagnostic intraocular fine-needle aspiration biopsy--An experience in three cases of retinoblastoma.

    abstract::Ophthalmoscopically guided intraocular fine-needle aspiration biopsy (FNAB) under general anesthesia was performed in three suspected cases of retinoblastoma (Rb). The first case presented with uveitis and the second with unusual radiological features. The third case had classical clinical features of bilateral Rb but...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199911)21:5<331::aid-dc7>3

    authors: Sen S,Singha U,Kumar H,Ghose S,Sarkar T,Bajaj MS

    更新日期:1999-11-01 00:00:00

  • Reliability of cytology to detect chlamydial infection in asymptomatic women.

    abstract::Chlamydia trachomatis is a frequent sexually transmitted disease. The diagnosis of C. trachomatis infection by cytology is controversial. We compared the ability of Papanicolaou (Pap) smears to detect C. trachomatis infection with antigen detection (enzyme immunoassay; EIA) and polymerase chain reaction (PCR). One hun...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199710)17:4<258::aid-dc4>3

    authors: Vinette-Leduc D,Yazdi HM,Jessamine P,Peeling RW

    更新日期:1997-10-01 00:00:00

  • Diagnosis and differential diagnosis of small-cell lesions of the liver.

    abstract::The objective of this study was to evaluate the cytologic spectrum of small cell lesions of liver as diagnosed by fine-needle aspiration (FNA). Of 304 FNAs of liver that were performed in our institution between 1990 and 1994, 29 were classified as small-cell lesions. The final diagnoses were as follows: small-cell un...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199807)19:1<29::aid-dc6>3.

    authors: Pisharodi LR,Bedrossian C

    更新日期:1998-07-01 00:00:00

  • Concurrent pleural infiltration by chronic lymphocytic leukemia and adenocarcinoma of unknown primary site diagnosed by effusion cytology.

    abstract::Synchronous malignancies in a pleural effusion are rare. A case of concurrent pleural infiltration by adenocarcinoma of unknown primary site and chronic lymphocytic leukemia (CLL) is presented in this case study, which was diagnosed by effusion cytology. Pleural effusion is not an uncommon complication in patients wit...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.22889

    authors: Vrettos I,Kamposioras K,Peridis S,Aninos D,Kazika S,Spathis A,Karakitsos P,Papadopoulos A

    更新日期:2014-02-01 00:00:00

  • Fine-needle aspiration of triton tumor: morphology, immunohistochemistry, electron microscopy, and cell image analysis.

    abstract::A single a case of malignant triton tumor, presented as a neck mass in a 34 year old female diagnosed solely by fine needle aspiration, is reported. The diagnosis was supported by immunohistochemical staining and electron microscopic examination that showed evidence of both schwannian and rhabdomyoblastic differentiat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199612)15:5<435::AID-DC16>

    authors: Abu-Farsakh H

    更新日期:1996-12-01 00:00:00

  • Fine-needle aspiration biopsy of tibial adamantinoma: a case report.

    abstract::Adamantinoma of long bones is a rare, primary bone tumor of controversial histogenesis, usually arising in the anterior midshaft of the tibia. This slowly growing, radiolucent, expansile tumor eventually causes thinning or destruction of overlying cortical bone. Fine-needle aspiration biopsy (FNAB) is a rapid, safe, a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840040116

    authors: Hales MS,Ferrell LD

    更新日期:1988-03-01 00:00:00

  • Malignant phyllodes tumor with liposarcomatous components: a case report with cytological presentation.

    abstract::Cytological and histological findings of a rare case of a malignant phyllodes tumor (with liposarcomatous components) of the breast are presented. The atypia of the stromal cells and naked nuclei in a lesion considered benign clinically and on imaging alerted us to the possibility of a phyllodes tumor, despite the low...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(200006)22:6<364::aid-dc7>3

    authors: Satou T,Matsunami N,Fujiki C,Tanaka K,Hayashi Y,Hashimoto S

    更新日期:2000-06-01 00:00:00

  • Fine-needle aspiration cytology of seminoma: a review of 16 cases.

    abstract::We report the cytomorphologic features of 16 fine-needle aspiration (FNA) biopsies of seminoma obtained from 16 male patients. The aspirates included two primary gonadal tumors (one occurring in a cryptorchid testis), two primary mediastinal tumors, and 12 metastases (two with unknown primaries). Analysis of the aspir...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120409

    authors: Caraway NP,Fanning CV,Amato RJ,Sneige N

    更新日期:1995-06-01 00:00:00

  • Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A case report with immunocytochemical analyses.

    abstract::Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a tumor that has morphologically recognizable both adenocarcinoma and neuroendocrine carcinoma components comprising at least 30% of either components. MANEC occurring in the ampulla of Vater is extremely rare, and only 16 cases have been reported in the Englis...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23891

    authors: Yoshioka S,Ebisu Y,Ishida M,Uemura Y,Yanagimoto H,Satoi S,Tsuta K

    更新日期:2018-06-01 00:00:00

  • Fine-needle aspiration cytology in azoospermic males.

    abstract::Bilateral testicular fine-needle aspiration cytology (FNAC) was performed in 100 males, including 10 controls with normal fertility and 90 infertile azoospermic males. The various seminiferous tubular cells were easily identified in smears. It was possible to give a cytological diagnosis in histologic terms by analysi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840070103

    authors: Rajwanshi A,Indudhara R,Goswami AK,Radhika S,Das A,Sharma SK,Vaidyanathan S,Datta BN

    更新日期:1991-01-01 00:00:00

  • Are adjunctive markers useful in routine cervical cancer screening? Application of p16(INK4a) and HPV-PCR on ThinPrep samples with histological follow-up.

    abstract::The objectives of the study were to evaluate 1) the diagnostic sensitivity and specificity of p16(INK4a) as a marker for high-grade cervical lesions, 2) the results of a real-time polymerase chain reaction detecting high-risk human papillomavirus, and 3) the interobserver variability of the p16(INK4a) interpretation.A...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20822

    authors: Schledermann D,Andersen BT,Bisgaard K,Dohse M,Ejersbo D,Hoelund B,Horal P,Lindh M,Ryd W

    更新日期:2008-07-01 00:00:00

  • Combining fine needle aspiration with brushing cytology has improved yields in diagnosing pancreatic ductal adenocarcinoma.

    abstract::The aim of this retrospective study is to evaluate the diagnostic yields of combining fine needle aspiration (FNA) with brushing cytology (BC) in clinical work-up of pancreatic ductal adenocarcinoma. The study included a total of 97 patients who underwent both FNA and BC along with histologic/clinical follow-up (F/U)....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21062

    authors: Jing X,Wamsteker EJ,Li H,Pu RT

    更新日期:2009-08-01 00:00:00

  • E-cadherin cell-adhesion molecule expression as a diagnostic adjunct in urothelial cytology.

    abstract::E-cadherin (E-CD) is a cell-adhesion molecule that has been associated with invasion and metastasis in a wide variety of human neoplasms. We have recently shown that, although decreased E-CD expression is associated with increased bladder-wall invasion and higher tumor grade of infiltrating transitional cell carcinoma...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199605)14:4<310::AID-DC6>3

    authors: Ross JS,Cheung C,Sheehan C,del Rosario AD,Bui HX,Fisher HA

    更新日期:1996-06-01 00:00:00

  • Predictors of human papilloma virus in patients with keratinization.

    abstract::Given the prevalence of human papilloma virus (HPV) infection, an attempt was made to determine whether certain factors such as keratinization and/or squamous atypia are associated with its development. Review of our gynecologic cytology files from 1989 yielded 1,615 specimens showing parakeratosis and/or hyperkeratos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840120107

    authors: Hudock J,Hanau CA,Hawthorne C,Jordan AG

    更新日期:1995-02-01 00:00:00

  • Autofluorescence--an important ancillary technique for the detection of Mycobacterium tuberculosis: revisited.

    abstract::Tuberculosis is one of the oldest diseases known to affect humans and is caused by Mycobacterium tuberculosis. Lymph nodes are the most common site of extrapulmonary involvement. Tuberculous lymphadenitis can be presumptively diagnosed morphologically on fine-needle aspiration biopsy of lymph nodes. Additional tests l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21860

    authors: Joshi P,Singh M,Bhargava A,Singh M,Mehrotra R

    更新日期:2013-04-01 00:00:00