Abstract:
:Adrenal cortical carcinoma (ACC) is a rare neoplasm that affects all age groups, with a bimodal peak of incidence, in young individuals in the first decade or two of life and in older subjects in the fifth to seventh decades. It may be clinically "functional" with Cushing's syndrome, virilization, or feminization, or it may be "nonfunctional." We report on the case of a 42-yr-old woman who complained of abdominal pain and a large adrenal tumor measuring 20 cm in size. No endocrine symptoms were observed. Laboratory tests showed increased levels of adrenocorticotropic hormone (ACTH), serum cortisol, and urinary free cortisol. Cytohistologic features were typical of ACC. A striking presence of hyaline cytoplasmatic globules was seen in cytologic smears and histologically, being immunoreactive for vimentin, consistent with an intracellular store of intermediate filaments. The tumor showed high proliferative activity (40%) with Ki-67 and negativity for p53, cerbB2, and bcl-2. Although hyaline globules are more frequent in pheochromocytomas and other neoplasms, they may also be present in ACC. These globules may be observed in cytologic smears. Also, the identification and immunohistochemical characterization of these hyaline globules in metastases may be useful in determining the origin of primary occult tumors. Diagn. Cytopathol. 1999;21:394-397.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Laforga JB,Aranda FIdoi
10.1002/(sici)1097-0339(199912)21:6<394::aid-dc5>3subject
Has Abstractpub_date
1999-12-01 00:00:00pages
394-7issue
6eissn
8755-1039issn
1097-0339pii
10.1002/(SICI)1097-0339(199912)21:6<394::AID-DC5>3journal_volume
21pub_type
杂志文章abstract::The diagnosis of nodular sclerosing classical Hodgkin lymphoma (NSCHL) by fine-needle aspiration (FNA) biopsy has historically been a diagnostic challenge due to the usual paucicellularity of the specimen. This case report, and other previously published reports, suggests that there is another facet to the potentially...
journal_title:Diagnostic cytopathology
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abstract:BACKGROUND:The incidence of anal carcinoma has risen in recent decades. Exfoliative cytology screening of selected high risk patients is performed in many centers. Unsatisfactory cytology results are frustrating to patients, clinicians, and laboratorians. The aim of this study is to ascertain outcomes of patients with ...
journal_title:Diagnostic cytopathology
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journal_title:Diagnostic cytopathology
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abstract::The aim of this study is to evaluate the diagnostic values of the fluorescence in situ hybridization (FISH), NMP22 BladderChek, and liquid-based cytology (LBC) in the detection of bladder urothelial carcinoma (UC). Consecutive voided urine samples were collected from 138 in-house patients with a variety of urologic co...
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pub_type: 杂志文章,评审
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更新日期:2001-01-01 00:00:00
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更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Diagnostic cytopathology
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2011-08-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2008-05-01 00:00:00
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更新日期:2003-10-01 00:00:00
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