Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift.


:Lung carcinoma is one of the commonest causes of cancer related death. Fine-needle aspiration cytology (FNAC) is a well-established technique in the diagnosis of various malignant tumors. FNAC is now an important technique in classifying lung carcinomas and also detecting salient mutational changes in lung carcinomas. The judicious use of the various immunological markers such as TTF-1, p40, CK 5/6, CK 7 and Napsin may help in sub-classification of non-small cell lung carcinomas (NSCLC). The mutational changes in epidermal growth factor receptor (EGFR) and ALK genes are needed in targeted therapy of adenocarcinoma of lung. With the help of immunocytochemistry, polymerase chain receptor, fluorescent in situ hybridization and next generation sequencing, one can detect various mutational changes in NSCLC. In this review article, we have discussed the role of cytology and other ancillary techniques to classify lung carcinomas. The important mutational changes in lung carcinoma for targeted therapy have also been discussed in detail.


Diagn Cytopathol


Diagnostic cytopathology


Dey P,Ghosh RK




Has Abstract


2019-04-01 00:00:00












  • Cytologic features of sclerosing hemangioma of the lung on crush preparations.

    abstract::Sclerosing hemangioma of the lung is a rare benign neoplasm. The majority of the literature published on sclerosing hemangioma has focused on the histologic features, while only a few case reports have described the cytologic features. We report two additional cases of sclerosing hemangioma of the lung in which the cy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Blanco LZ,Heagley DE,Montebelli F,Gabrielli E,Reddy V,Ghai R,Gattuso P

    更新日期:2013-03-01 00:00:00

  • Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

    abstract:BACKGROUND:Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vazmitsel M,Esebua M,Layfield LJ

    更新日期:2020-05-01 00:00:00

  • The cell with a thousand faces: detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors.

    abstract::Myoepithelial cells are an important component of salivary gland tumors and are partly responsible from the diverse histology of them. In this study, we focus on the myoepithelial cell differentiation by using cytological morphology in a various types of salivary gland tumors especially with regard to their contributi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Avci A,Günhan O,Cakalağaoğlu F,Günal A,Celasun B

    更新日期:2012-03-01 00:00:00

  • Endoscopic ultrasound-guided fine needle aspiration with liquid-based cytology preparation in the diagnosis of metastatic small-cell carcinoma in the pancreas.

    abstract::Pancreatic metastasis is extremely rare, particularly from small-cell lung cancer (SCLC). Studies on the role of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with liquid-based cytology (LBC) in the diagnosis of metastatic small-cell carcinoma in the pancreas have been rarely conducted. We report herei...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Son JH,Park HK,Kim HS,Kim NH,Kim JW,Bae WK,Kim KA,Lee JS,Lee YS

    更新日期:2018-11-01 00:00:00

  • Cytological diagnosis of collagenous spherulosis of breast associated with fibroadenoma: report of a case with review of literature.

    abstract::Collagenous spherulosis of the breast is a rare incidental finding frequently associated with other benign lesions of the breast. The estimated incidence of this innocuous condition is only about 0.2% in cytological material. It is of utmost importance to differentiate collagenous spherulosis from its malignant mimics...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Gangane N,Joshi D,Anshu.,Shivkumar VB

    更新日期:2007-06-01 00:00:00

  • Familial hemophagocytic lymphohistiocytosis.

    abstract::The cytologic features of familial hemophagocytic lymphohistiocytosis in two infant siblings were reviewed and compared to the histopathologic features in the same cases. The cytologic features of familial hemophagocytic lymphohistiocytosis in imprint smears from the spleen, lymph nodes, and liver were distinct, with ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Lachman MF,Vogel EH,Kim K

    更新日期:1988-01-01 00:00:00

  • Intraoperative evaluation of sentinel lymph nodes in breast carcinoma by imprint cytology, frozen section and rapid immunohistochemistry.

    abstract::Sentinel lymph nodes (SLN) isolated in 40 patients of breast carcinoma (stage T(1)/T(2)) were evaluated intraoperatively by imprint cytology and frozen section. Rapid immunohistochemistry (IHC) was done in cases where both imprint smears and frozen sections were negative for any metastatic tumor deposits. The results ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Upender S,Mohan H,Handa U,Attri AK

    更新日期:2009-12-01 00:00:00

  • Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland.

    abstract::Sebaceous lymphadenoma (SLA) is a histologic variant of lymphadenoma or sebaceous adenoma of the salivary gland. The fine-needle aspiration (FNA) cytology of SLA has not been well-described. In this report, we reported a case that involved an 81-year-old male with a long-standing left parotid mass and was diagnosed on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vande Haar MA,DeFrias D,Lin X

    更新日期:2014-11-01 00:00:00

  • Optimization of the peritoneal lavage.

    abstract::Review of 275 consecutive peritoneal lavages and concurrent histologic material from gynecologic operations suggested that cytologic evaluation was clinically indicated for only 60.7% of the lavages, representing 46% of the patients in the study. More than one concurrent lavage was received from 21.6% of all patients ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Walts AE

    更新日期:1998-04-01 00:00:00

  • Fine-needle aspiration of hepatocellular carcinoma: False-negative result due to epithelioid cells.

    abstract::The presence of epithelioid cells in fine-needle aspirations of a liver nodule is rare, but may complicate the diagnosis of the nodule. We report on a case of a liver nodule in hepatitis C cirrhosis. Results of fine-needle aspiration mainly revealed the presence of epithelioid cells, without any recognizable tumor cel...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Mourra N,Flejou JF

    更新日期:2001-06-01 00:00:00

  • Polyoma virus infection is a prominent risk factor for bladder carcinoma in immunocompetent individuals.

    abstract::Despite various reports of BK viral (BKV) DNA sequences or proteins in tumors of the urogenital tract, there has been no study statistically linking infection by this polyoma virus (PV) to tumor development. All PV are potential transforming viruses, the large T-antigen of which interacts with tumor suppressor protein...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Weinreb DB,Desman GT,Amolat-Apiado MJ,Burstein DE,Godbold JH Jr,Johnson EM

    更新日期:2006-03-01 00:00:00

  • Metastatic inflammatory myofibroblastic tumor identified by EUS-FNA in mediastinal lymph nodes with ancillary FISH studies for ALK rearrangement.

    abstract::Inflammatory myofibroblastic tumor (IMT) is an exquisitely rare neoplasm with a low incidence of metastasis. Previously, cytologic diagnosis of this entity, by fine needle aspiration (FNA) or endoscopic ultrasound guided fine needle aspiration (EUS-FNA), was challenging, if not impossible. However, advancements in the...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Borak S,Siegal GP,Reddy V,Jhala N,Jhala D

    更新日期:2012-08-01 00:00:00

  • Intraductal carcinoma in a male breast: diagnosis by nipple discharge cytology.

    abstract::We describe a case of intraductal carcinoma (comedo type) in a 50-yr-old male. The patient had presented with a bloody nipple discharge, which had shown malignant cells on cytologic examination. In current clinical practice, the use of nipple discharge cytology as a screening and diagnostic tool for breast carcinoma i...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hirschman SA,Hoda SA,May M,Cody HS 3rd

    更新日期:1995-06-01 00:00:00

  • Fine-needle aspiration of scalp lesions.

    abstract::A variety of inflammatory and neoplastic scalp lesions are encountered in surgical pathology. However, the literature on fine-needle aspirations (FNAs) of the scalp is exceedingly rare. We report on a series of 70 FNAs involving cutaneous and subcutaneous lesions on the scalp. A total of 70 fine-needle aspirations of ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Spitz DJ,Reddy V,Selvaggi SM,Kluskens L,Green L,Gattuso P

    更新日期:2000-07-01 00:00:00

  • Fine needle aspiration cytology in sclerosing stromal tumor of the ovary: a series of three cases.

    abstract::Sclerosing stromal tumor (SST) of the ovary is a distinct subtype of sex cord-stromal tumor, which is derived from the ovarian stroma and, in turn, from the sex cords of the embryonic gonads. It is a benign tumor, predominantly, unilateral in nature and mostly involves the right side of the ovary. Histopathological fe...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Banik T,Gupta N,Dey P,Rajwanshi A,Dhaliwal LK

    更新日期:2012-04-01 00:00:00

  • Synovial sarcoma metastatic to the parotid gland: A possible pitfall in salivary gland fine needle aspiration cytology. Report of a case with immunocytochemical and fluorescence in situ hybridization findings.

    abstract::We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were sugg...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Fulciniti F,Barizzi J,Martin V,Tarallo V,Ermanni S

    更新日期:2017-09-01 00:00:00

  • Fine-needle aspiration biopsy of a case of breast carcinoma with choriocarcinomatous features.

    abstract::Breast disease is of great concern to patients and health care providers alike. Malignancies of the breast and their various presentations can pose tremendous challenges with respect to early diagnosis and effective treatment. Carcinoma of the breast may appear in several forms and produce one or more ectopic substanc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Siddiqui NH,Cabay RJ,Salem F

    更新日期:2006-10-01 00:00:00

  • Pregnancy-associated anaplastic large-cell lymphoma of the breast: a rare mimic of ductal carcinoma.

    abstract::Anaplastic large-cell lymphoma (ALCL) is a rare T-cell lymphoma typically seen in children and young adults. It has been described in numerous sites; however, the breast is one of the least common locations. We herein report a case of ALCL arising in the breast of a 36-yr-old pregnant woman. To our knowledge this is t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Iyengar P,Reid-Nicholson M,Moreira AL

    更新日期:2006-04-01 00:00:00

  • Urinary tract washing specimens containing atypical urothelial tissue fragments are significantly associated with urothelial neoplasia.

    abstract:BACKGROUND:We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high-grade urothelial carcinoma (HGUC) but not low-grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Zhang ML,Zhou AG,Rosenthal DL,VandenBussche CJ

    更新日期:2017-09-01 00:00:00

  • The aspiration cytology of pulmonary hamartomas.

    abstract::Cytodiagnosis of pulmonary hamartomas (PHs) by transthoracic fine-needle aspiration (FNA), successful in 11 of a series of 14 cases, has been found to rely less on the presence of mature cartilage than on the recognition of fibromyxoid fragments. These fragments, wispy yet discrete, consisting of variable numbers of f...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Dunbar F,Leiman G

    更新日期:1989-01-01 00:00:00

  • Detection of malignant effusions: comparison of a telomerase assay and cytologic examination.

    abstract::Telomerase is inactive in most somatic cells, but has been found to be reactivated in a majority of cancers. Our principal goal was to test whether the presence of telomerase activity concurred with positive cytology, and was thus of potential use in detecting cancer cells in effusions. The telomeric repeat amplificat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Braunschweig R,Yan P,Guilleret I,Delacretaz F,Bosman FT,Mihaescu A,Benhattar J

    更新日期:2001-03-01 00:00:00

  • Recurrent respiratory papillomatosis: cytopathological findings in an unusual case.

    abstract::Recurrent respiratory papillomatosis (RRP) primarily is a disease of children and adolescents. Most patients experience spontaneous regression at a later age, while others continue to be affected throughout their lives. Here, we present the case of a 26-yr-old man who presented with persistent cough, worsening dyspnea...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Parwani AV,Sheth S,Ali SZ

    更新日期:2004-12-01 00:00:00

  • Scrape cytology of pemphigus vulgaris of the nipple, a mimicker of Paget's disease.

    abstract::A case of histologically and immunocytochemically confirmed pemphigus vulgaris of the nipple examined by scrape cytology is reported. The scrape cytology showed isolated and somewhat loosely clustered cells with basophilic cytoplasm and vesicular hyperchromatic nuclei dysplaying prominent nucleoli, suggesting Paget's ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kobayashi TK,Ueda M,Nishino T,Kibe S,Higashida T,Watanabe S

    更新日期:1997-02-01 00:00:00

  • Cytologic diagnosis of adenocarcinoma on bile duct brushings in the presence of stent associated changes: A retrospective analysis.

    abstract:BACKGROUND:Bile duct brushing (BDB) cytology, for the characterization of bile duct strictures, can be challenging to interpret when associated with a stent. Our study aims to identify the cytologic criteria for the diagnosis of adenocarcinoma in BDBs in the presence of a stent. METHODS:A database search (January 2010...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Goyal A,Sharaiha RZ,Alperstein SA,Siddiqui MT

    更新日期:2018-10-01 00:00:00

  • A prospective study of the diagnostic accuracy of cytological criteria in the FNAB diagnosis of breast papillomas.

    abstract::Seventy-four fine needle aspiration biopsies (FNAB) of breast were selected from the 133 cases with surgical biopsy follow up, from a total of 1,154 consecutive breast FNAB received in a 6-month-period. These 74 cases were reviewed and scored using all relevant cytological criteria for proliferative breast lesions use...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Field A,Mak A

    更新日期:2007-08-01 00:00:00

  • Pseudoglandular schwannoma mimicking alveolar rhabdomyosarcoma: A diagnostic challenge on fine-needle cytology.

    abstract::Pseudoglandular schwannoma (PGS) is a rare morphological variant of benign schwannoma. PGS is quite distinct from the somewhat better characterized glandular schwannoma variant. PGS is characterized by the presence of gland-like structures lined with pseudocolumnar or cuboidal-like neoplastic Schwann cells lining vari...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Yaprak Bayrak B,Vural Ç,Paksoy N

    更新日期:2020-03-01 00:00:00

  • Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements.

    abstract::A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions,...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Solymosi T,Tóth V,Sápi Z,Bodó M,Gál I,Csanádi L

    更新日期:1996-03-01 00:00:00

  • Papanicolaou's nebular cells are related to HPV infection and HSIL.

    abstract::Metaplastic cells with nebular cytoplasmic changes in the cervical smear are classified in the Dutch coding system for cervical screening as KOPAC O8 cells. Since these nebulated cells are already documented by Papanicolaou, we refer to these cells as Papanicolaou's nebular cells. We examined the simultaneous presence...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Roeters AM,Boon ME,van Haaften M,Vernooij F,Bontekoe TR,Heintz AP

    更新日期:2012-03-01 00:00:00

  • Fine-needle aspiration biopsy of HPV-related squamous cell carcinoma of the head and neck: Current ancillary testing methods for determining HPV status.

    abstract::Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is a unique form of carcinoma that largely arises from the tonsillar tissue in the oropharynx. These tumors often present with cervical lymphadenopathy resulting in a fine needle aspiration (FNA) biopsy. Use of the cytology specimen to de...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Bernadt CT,Collins BT

    更新日期:2017-03-01 00:00:00

  • Predictors of human papilloma virus in patients with keratinization.

    abstract::Given the prevalence of human papilloma virus (HPV) infection, an attempt was made to determine whether certain factors such as keratinization and/or squamous atypia are associated with its development. Review of our gynecologic cytology files from 1989 yielded 1,615 specimens showing parakeratosis and/or hyperkeratos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hudock J,Hanau CA,Hawthorne C,Jordan AG

    更新日期:1995-02-01 00:00:00