Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift.

Abstract:

:Lung carcinoma is one of the commonest causes of cancer related death. Fine-needle aspiration cytology (FNAC) is a well-established technique in the diagnosis of various malignant tumors. FNAC is now an important technique in classifying lung carcinomas and also detecting salient mutational changes in lung carcinomas. The judicious use of the various immunological markers such as TTF-1, p40, CK 5/6, CK 7 and Napsin may help in sub-classification of non-small cell lung carcinomas (NSCLC). The mutational changes in epidermal growth factor receptor (EGFR) and ALK genes are needed in targeted therapy of adenocarcinoma of lung. With the help of immunocytochemistry, polymerase chain receptor, fluorescent in situ hybridization and next generation sequencing, one can detect various mutational changes in NSCLC. In this review article, we have discussed the role of cytology and other ancillary techniques to classify lung carcinomas. The important mutational changes in lung carcinoma for targeted therapy have also been discussed in detail.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Dey P,Ghosh RK

doi

10.1002/dc.24089

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

351-358

issue

4

eissn

8755-1039

issn

1097-0339

journal_volume

47

pub_type

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