Lack of effect of dopamine receptor blockade on the TSH response to TRH in borderline personality disorder.

Abstract:

:We recently reported that some patients with borderline personality disorder (BPD) exhibit a blunted thyrotropin (thyroid-stimulating hormone; TSH) response to thyrotropin-releasing hormone (TRH). Because it is known that dopamine can inhibit the TSH response to TRH and that some patients with BPD show improvement with antipsychotic (dopamine-blocking) medication, we investigated whether haloperidol could reverse the blunted TSH response in BPD. Of 12 patients with BPD, three showed a blunted TSH response that did not normalize with haloperidol. Furthermore, there were no overall group changes in TSH response with haloperidol. The present study suggests that reductions in TSH response in BPD are not secondary to dopamine.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Garbutt JC,Loosen PT,Glenn M

doi

10.1016/0165-1781(87)90014-x

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

307-11

issue

4

eissn

0165-1781

issn

1872-7123

pii

0165-1781(87)90014-X

journal_volume

21

pub_type

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