Abstract:
:Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could reveal important therapeutic approaches. We systematically explored two groups of environmental risk factors: chemicals (including silica, solvents, pesticides, hydrocarbons, heavy metals, and particulate matter) and drugs (including procainamide, hydralazine, quinidine, Dpenicillamine, isoniazid, and methyldopa). Furthermore, the mechanisms underlying risk factors, such as genetic factors, epigenetic change, and disrupted immune tolerance, were explored. This review identifies novel risk factors and their underlying mechanisms. Practicable measures for the management of these risk factors will benefit SLE patients and provide potential therapeutic strategies.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Pan Q,Guo Y,Guo L,Liao S,Zhao C,Wang S,Liu HFdoi
10.2174/0929867326666190404140658subject
Has Abstractpub_date
2020-01-01 00:00:00pages
5175-5188issue
31eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-97776journal_volume
27pub_type
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abstract::More than five decades since the Discovery of Penicillin, the chemistry and biological activity of b-lactams continue to attract the wide spread attention of research workers. Owing to high efficacy and extremely safe toxicological profile, they are agents of choice in the current therapeutic index for the bacterial i...
journal_title:Current medicinal chemistry
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更新日期:1999-03-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2010-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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