Progress in computational approach to drug development against SARS.

abstract：:Plant foods are not only a main source of nutrients, but they are also rich in physiologically bioactive bionutrients or phytochemicals. Consumption of fruit and vegetables is associated with a decreased risk of pathological status, including cancer. Reactive oxygen species play a key role in the genesis and developme...

journal_title：Current medicinal chemistry

authors： Matés JM,Segura JA,Alonso FJ,Márquez J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue specific action cannot be exerted, it could lead to several endocrine-meta...

journal_title：Current medicinal chemistry

authors： Ferrer MJ,Silva AF,Abruzzese GA,Velázquez ME,Motta AB

更新日期：2021-01-06 00:00:00

abstract：:Cell-based electrochemical biosensors have contributed tremendously to the fields of biology, medicine, chemistry, pharmacology, and environmental science. With electrochemical transducers and whole cells as the recognition elements, these biosensors provide new horizons for biosensing and life science research. This ...

journal_title：Current medicinal chemistry

authors： Ding L,Du D,Zhang X,Ju H

更新日期：2008-01-01 00:00:00

abstract：:Ca(2+) is a highly versatile intracellular second messenger in the central nervous system, and regulates many complicated cellular processes, including excitation, plasticity and apoptosis. Influx of Ca(2+) from the extracellular fluid is required for sustained elevation of the cytosolic Ca(2+) concentration and full ...

journal_title：Current medicinal chemistry

authors： Yagami T,Kohma H,Yamamoto Y

更新日期：2012-01-01 00:00:00

abstract：:In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA or RNA strand to localize a specific DNA or RNA sequence on a chromosome or section of tissue (in-situ) fixed on a slide. Flourescence in-situ hybridization (FISH) technique facilitates the localization of genes to different c...

journal_title：Current medicinal chemistry

authors： Jehan Z,Uddin S,Al-Kuraya KS

更新日期：2012-01-01 00:00:00

abstract：:In this review, we report the functionalization of textiles composed of nanoscale reactive materials in the treatment of wounds and skin diseases such as acne. In view of the growing demand for high-quality textiles, much research is focused on the creation of antimicrobial finishings for fabrics, in order to protect ...

journal_title：Current medicinal chemistry

authors： Gedanken A,Perkas N,Perelshtein I,Lipovsky A

更新日期：2018-01-01 00:00:00

abstract：:Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharma...

journal_title：Current medicinal chemistry

authors： Álvarez R,Aramburu L,Puebla P,Caballero E,González M,Vicente A,Medarde M,Peláez R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:With global increase in elderly population, modern societies must find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. Th...

journal_title：Current medicinal chemistry

authors： Sarubbo F,Moranta D,Asensio VJ,Miralles A,Esteban S

更新日期：2017-01-01 00:00:00

abstract：:Gene expression, both tissue specific or inducible, is controlled at the level of transcription by various transcription factors interacting with specific sequences of DNA. Anticancer drugs and other potential therapeutic agents alter interactions of regulatory proteins with DNA by a variety of different mechanisms. T...

journal_title：Current medicinal chemistry

authors： Gniazdowski M,Denny WA,Nelson SM,Czyz M

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). Since response is often inadequate, in recent years researchers investigated whether combining CBT and SRIs, either ab initio or sequentially, results in a grea...

journal_title：Current medicinal chemistry

authors： Albert U,Di Salvo G,Solia F,Rosso G,Maina G

更新日期：2018-01-01 00:00:00

abstract：:The bryostatins, powerful protein kinase C (PKC) agonists, are a family of complex macrolactone natural products. They are originally isolated from the marine bryozoan Bugula neritina. So far tweenty bryostatins have been obtained naturally and exhibit a remarkable range of biological activities, including antineoplas...

journal_title：Current medicinal chemistry

authors： Ruan BF,Zhu HL

更新日期：2012-01-01 00:00:00

abstract：:Ion channel dysfunction has been identified as a contributor to symptom development and neurodegeneration in multiple sclerosis (MS). The molecular insights have been translated into new lines of research, with ion channel modulation now representing a therapeutic approach in MS. Studies of Na+ channel function have d...

journal_title：Current medicinal chemistry

authors： Arnold R,Huynh W,Kiernan MC,Krishnan AV

更新日期：2015-01-01 00:00:00

abstract：:The new drug class of dipeptidyl peptidase-4 (DPP4) inhibitors has been widely accepted in the daily management of type 2 diabetes since its strategic advantages with regard to body weight, risk of hypoglycaemia, and beta cell survival. We have previously evaluated the theoretical implications of DPP4 inhibition given...

journal_title：Current medicinal chemistry

authors： Matteucci E,Giampietro O

更新日期：2011-01-01 00:00:00

abstract：:Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondria...

journal_title：Current medicinal chemistry

authors： Waltz TB,Fivenson EM,Morevati M,Li C,Becker KG,Bohr VA,Fang EF

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. OBJECTIVES:The validation of novel (chemo)p...

journal_title：Current medicinal chemistry

authors： Albini A,Bassani B,Baci D,Dallaglio K,Gallazzi M,Corradino P,Bruno A,Noonan DM

更新日期：2019-01-01 00:00:00

abstract：:Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discover...

journal_title：Current medicinal chemistry

authors： Alam F,Islam MA,Kamal MA,Gan SH

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Many pathways regarding healthy cells and/or linked to diseases onset and progression depend on large assemblies including multi-protein complexes. Protein-protein interactions may occur through a vast array of modules known as Protein Interaction Domains (PIDs). OBJECTIVE:This review concerns with PIDs rec...

journal_title：Current medicinal chemistry

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2020-01-01 00:00:00

abstract：:The study of iron chelators as anti-tumor agents is still in its infancy. Iron is important for cellular proliferation and this is demonstrated by observations that iron-depletion results in cell cycle arrest and also apoptosis. In addition, many iron chelators are known to inhibit ribonucleotide reductase, the iron-c...

journal_title：Current medicinal chemistry

authors： Yu Y,Gutierrez E,Kovacevic Z,Saletta F,Obeidy P,Suryo Rahmanto Y,Richardson DR

更新日期：2012-01-01 00:00:00

abstract：:Whether the increased atrial fibrillation (AF) risk in metabolic syndrome (MetS) patients is due to the syndrome as a whole or simply the sum of the risks of its individual component parts is still obscure. These two clinical entities share many pathophysiological links and thus distinction between a casual observatio...

journal_title：Current medicinal chemistry

authors： Georgakopoulos C,Vlachopoulos C,Lazaros G,Tousoulis D

更新日期：2019-01-01 00:00:00

abstract：:The role of MRI in the armory of diagnostic modalities for the medicine of the forthcoming years largely depends on how chemistry will provide advanced tools to meet the medical needs. This review aims at outlining the most innovative approaches that have been undertaken in the recent history of MRI contrast agents fo...

journal_title：Current medicinal chemistry

authors： Terreno E,Dastrù W,Delli Castelli D,Gianolio E,Geninatti Crich S,Longo D,Aime S

更新日期：2010-01-01 00:00:00

abstract：:Signalling lipids are known to control a wide array of cellular processes, including cell proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives, eicosanoids, phosphoinositides, sphingolipids, some cannabinoid-like molecules bind and activate nuclear receptors, including peroxiso...

journal_title：Current medicinal chemistry

authors： Fidaleo M,Fanelli F,Ceru MP,Moreno S

更新日期：2014-01-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons which brings to muscular atrophy, paralysis and death in 3-5 years from starting symptoms. In about 10% of cases ALS is familiar and in a relevant percent of these cases, mutations of the...

journal_title：Current medicinal chemistry

authors： Contestabile A

更新日期：2011-01-01 00:00:00

abstract：:Fungal phytotoxins are natural secondary metabolites produced by plant pathogenic fungi during host-pathogen interactions. They have received considerable particular attention for elucidating disease etiology, and consequently to design strategies for disease control. Due to wide differences in their chemical structur...

journal_title：Current medicinal chemistry

authors： Vurro M,Boari A,Casella F,Zonno MC

更新日期：2018-01-01 00:00:00

abstract：:Atrial fibrillation (AF) and chronic kidney disease (CKD) are disorders with increasing prevalence. The presence of CKD increases the risk of incident AF and vice versa, and the presence of AF may accelerate CKD progression. Nearly a third of patients with established CKD also have AF, whilst half of AF patients may h...

journal_title：Current medicinal chemistry

authors： Potpara TS,Jokic V,Dagres N,Larsen TB,Lane DA,Hindricks G,Lip GY

更新日期：2016-01-01 00:00:00

abstract：:Sufficient organ blood flow of healthy newborn babies is maintained by relatively low systemic blood pressure. Premature infants are at an increased risk of systemic hypotension, often but not obviously, resulting in hypoperfusion of the cerebral, renal and intestinal vascular beds. Maintaining a stable blood pressure...

journal_title：Current medicinal chemistry

authors： Toth-Heyn P,Cataldi L

更新日期：2012-01-01 00:00:00

abstract：:Sarcomas are tumours of mesenchymal origin, which can arise in bone or soft tissues. They are rare but frequently quite aggressive and with a poor outcome. New approaches are needed to characterise these tumours and their resistance mechanisms to current therapies, responsible for tumour recurrence and treatment failu...

journal_title：Current medicinal chemistry

authors： Heredia-Soto V,Redondo A,Kreilinger JJP,Martínez-Marín V,Berjón A,Mendiola M

更新日期：2020-01-01 00:00:00

abstract：:It is well-recognized that the majority of cancer-related deaths is attributed to metastasis, which can arise from virtually any type of tumor. Metastasis is a complex multistep process wherein cancer cells must break away from the primary tumor, intravasate into the circulatory or lymphatic systems, extravasate, prol...

journal_title：Current medicinal chemistry

authors： Wong KM,Song J,Saini V,Wong YH

更新日期：2019-01-01 00:00:00

abstract：:Drug repositioning, an innovative therapeutic application of an old drug, has received much attention as a particularly costeffective strategy in drug R&D Recent work has indicated that repositioning can be promoted by utilizing a wide range of information sources, including medicinal chemical, target, mechanism, main...

journal_title：Current medicinal chemistry

authors： Arany Á,Bolgár B,Balogh B,Antal P,Mátyus P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Numerous studies have reported sex and gender differences in the prevalence and treatment of cardiovascular diseases. However, sex differences in the therapy of hypertension have not been completely examined. OBJECTIVE:To estimate the gender-specific dissimilarity in outcomes among patients following antihy...

journal_title：Current medicinal chemistry

authors： Giorgini P,Sahebkar A,Stamerra CA,Raparelli V,Petrarca M,Grassi D,Ferri C,Di Giosia P

更新日期：2017-01-01 00:00:00

abstract：:The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the fundamental characteristics critical for the biology of eukaryotes, in particular, survival and malignant transformation of cells. The members of this protein family (Pim-1 to Pim-3) are aberrant...

journal_title：Current medicinal chemistry

authors： Anizon F,Shtil AA,Danilenko VN,Moreau P

更新日期：2010-01-01 00:00:00