Abstract:
:Gene expression, both tissue specific or inducible, is controlled at the level of transcription by various transcription factors interacting with specific sequences of DNA. Anticancer drugs and other potential therapeutic agents alter interactions of regulatory proteins with DNA by a variety of different mechanisms. The main ones, considered in the review, are: i) competition for the transcription factor DNA binding sequences by drugs that interact non-covalently with DNA (e.g. anthracyclines, acridines, actinomycin D, pyrrole antibiotics and their polyamide derivatives); ii) covalent modifications of DNA by alkylating agents (e.g. nitrogen mustards, cisplatin) that prevent transcription factors from recognizing their specific sequences, or that result in multiple "unnatural" binding sites in DNA which hijack the transcription factors, thus decreasing their availability in the nucleus; iii) competition with binding sites on the transcription factors by synthetic oligonucleotides or peptide nucleic acids in an antigene strategy. The latter compounds may also compete for binding sites on regulatory proteins, acting as decoys to lower their active concentration in the cell. In this review, we have summarized recent advances which have been made towards understanding the above mechanisms by which small molecules interfere with the function of transcription factors.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Gniazdowski M,Denny WA,Nelson SM,Czyz Mdoi
10.2174/0929867033457683subject
Has Abstractpub_date
2003-06-01 00:00:00pages
909-24issue
11eissn
0929-8673issn
1875-533Xjournal_volume
10pub_type
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journal_title:Current medicinal chemistry
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更新日期:2004-10-01 00:00:00
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更新日期:2004-02-01 00:00:00
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更新日期:2019-01-01 00:00:00
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更新日期:1999-03-01 00:00:00
abstract::This research evaluated the effect of multiple-wave lasertherapy on the healing process of surgical wounds based on in vitro models denominated stem-dermal equivalents. These human skin models were obtained from a co-culture of dermal cells and bone marrow mesenchymal stem cells. The experimental tests were carried ou...
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