Antidiabetic agents from medicinal plants.

abstract：:Ten years elapsed since the discovery by Sanofi of SR141716A the first selective CB(1) cannabinoid receptor antagonist. Shortly after, Sanofi also reported the synthesis of the first selective CB(2) cannabinoid receptor antagonist, SR144528. Since these two milestones in the cannabinoid field, many other compounds, mo...

journal_title：Current medicinal chemistry

authors： Muccioli GG,Lambert DM

更新日期：2005-01-01 00:00:00

abstract：:The evidence seems to be growing in favor of the stem cell theory of cancer with the emergence of studies demonstrating the parallel mechanisms of self renewing pathways in stem cells and particular subsets of cancer cells. The finding of leukemia stem cells and subsequently breast cancer stem cells (BCSC) further sup...

journal_title：Current medicinal chemistry

authors： Nahas GR,Patel SA,Bliss SA,Rameshwar P

更新日期：2012-01-01 00:00:00

abstract：:During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of...

journal_title：Current medicinal chemistry

authors： Ahmadi A,Shadboorestan A,Nabavi SF,Setzer WN,Nabavi SM

更新日期：2015-01-01 00:00:00

abstract：:Sarcomas are tumours of mesenchymal origin, which can arise in bone or soft tissues. They are rare but frequently quite aggressive and with a poor outcome. New approaches are needed to characterise these tumours and their resistance mechanisms to current therapies, responsible for tumour recurrence and treatment failu...

journal_title：Current medicinal chemistry

authors： Heredia-Soto V,Redondo A,Kreilinger JJP,Martínez-Marín V,Berjón A,Mendiola M

更新日期：2020-01-01 00:00:00

abstract：:Nitric Oxide (NO) is a signaling radical, highly diffusible pleiotropic regulator of a large set of different molecular and biological pathways, including, neurotransmission, vasodilatation and macrophagemediated responses against infections. It is produced from the amino acid L-Arginine and oxygen by the enzymatic ac...

journal_title：Current medicinal chemistry

authors： Fionda C,Abruzzese MP,Santoni A,Cippitelli M

更新日期：2016-01-01 00:00:00

abstract：:Coeliac disease is a multifactorial disease characterized by a dysregulated immune response to ingested wheat gluten and related cereal proteins. With an incidence of about 1% of the general population, it is considered the most common food intolerance disorder. The mainstay of coeliac disease treatment is strict life...

journal_title：Current medicinal chemistry

authors： Esposito C,Caputo I,Troncone R

更新日期：2007-01-01 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by irreversible chronic inflammation and airflow obstruction. It affects more than 64 million patients worldwide and it is predicted to become the third cause of death in the industrialized world by 2030. Currently availab...

journal_title：Current medicinal chemistry

authors： Pirozzi F,Ren K,Murabito A,Ghigo A

更新日期：2019-01-01 00:00:00

abstract：:Functioning of G protein-coupled receptors (GPCRs) is tightly linked to the membrane environment, but a molecular level understanding of the modulation of GPCR by membrane lipids is not available. However, specific receptor-lipid interactions as well as unspecific effects mediated by the bulk properties of the membran...

journal_title：Current medicinal chemistry

authors： Sadiq SK,Guixa-Gonzalez R,Dainese E,Pastor M,De Fabritiis G,Selent J

更新日期：2013-01-01 00:00:00

abstract：:The present review aims to provide a complete and comprehensive summary of current literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the formation of a large number of oxidized products, generally known as oxysterols. They are intermediates in the biosynthesis of bile acids, ste...

journal_title：Current medicinal chemistry

authors： Samadi A,Sabuncuoglu S,Samadi M,Isikhan SY,Chirumbolo S,Peana M,Lay I,Yalcinkaya A,Bjørklund G

更新日期：2021-01-01 00:00:00

abstract：:Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen mustards, where attachment of the mustard unit to carrier molecules can change the normal patterns of both regio- and sequence-selectivity, from reaction primarily...

journal_title：Current medicinal chemistry

authors： Denny WA

更新日期：2001-04-01 00:00:00

abstract：:Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a multifactorial phenomenon involving the overexpression of defense factors and alterations in drug-target interactions. Such changes do not account for all mani...

journal_title：Current medicinal chemistry

authors： Perego P,Corna E,De Cesare M,Gatti L,Polizzi D,Pratesi G,Supino R,Zunino F

更新日期：2001-01-01 00:00:00

abstract：:Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a higher degree of complexity and accuracy. Moreover, thei...

journal_title：Current medicinal chemistry

authors： Santos M,Serrano-Dúcar S,González-Valdivieso J,Vallejo R,Girotti A,Cuadrado P,Arias FJ

更新日期：2019-01-01 00:00:00

abstract：:Universal stress proteins are ubiquitously expressed in bacteria, archaea and plants and other eukaryotes. A general property of USPs is their role in adaptation of bacteria to oxidative stress, high temperature, low pH and/or hypoxia. There is increasing evidence that these proteins facilitate the adaption of bacteri...

journal_title：Current medicinal chemistry

authors： O'Connor A,McClean S

更新日期：2017-11-24 00:00:00

abstract：BACKGROUND:Myocardial redox state is a critical determinant of atrial biology, regulating cardiomyocyte apoptosis, ion channel function, and cardiac hypertrophy/fibrosis and function. Nevertheless, it remains unclear whether the targeting of atrial redox state is a rational therapeutic strategy for atrial fibrillation ...

journal_title：Current medicinal chemistry

authors： Antonopoulos AS,Goliopoulou A,Oikonomou E,Tsalamandris S,Papamikroulis GA,Lazaros G,Tsiamis E,Latsios G,Brili S,Papaioannou S,Gennimata V,Tousoulis D

更新日期：2019-01-01 00:00:00

abstract：:Epidemiological studies demonstrated that even in the absence of other risk factors (e.g. diabetes, hypertension, hyperhomocysteinemia, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by enhancing vascular oxidative stress and inflammation. Because the population in the West...

journal_title：Current medicinal chemistry

authors： Labinskyy N,Csiszar A,Veress G,Stef G,Pacher P,Oroszi G,Wu J,Ungvari Z

更新日期：2006-01-01 00:00:00

abstract：:Despite advances in cancer treatment, a large number of patients eventually develop metastatic disease that is generally incurable. Systemic chemotherapy remains the standard treatment for these patients. Several chemotherapeutic combinations have proven effective in the management of cancer. Paradoxically, although t...

journal_title：Current medicinal chemistry

authors： Prados J,Alvarez PJ,Melguizo C,Rodriguez-Serrano F,Carrillo E,Boulaiz H,Vélez C,Marchal JA,Caba O,Ortiz R,Rama A,Aranega A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cholesterol efflux as a key event in reverse cholesterol transport (RCT) is considered now as both diagnostic tool and a promising target for the treatment of atherosclerosis. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Fluorescent t...

journal_title：Current medicinal chemistry

authors： Litvinov DY,Savushkin EV,Garaeva EA,Dergunov AD

更新日期：2016-01-01 00:00:00

abstract：:ATP-sensitive K(+) channels (K(ATP)channels) regulate insulin secretion by coupling intracellular metabolic changes to excitability of the plasma membrane in pancreatic beta-cells. The channels are closed when extracellular glucose levels are elevated due to enhanced feature. By contrast, cardiac-type K(ATP) channels,...

journal_title：Current medicinal chemistry

authors： Kakei M

更新日期：2003-02-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors, a set of three receptor sub-types encoded by distinct genes, function as lipid sensors to regulate a broad range of genes in many metabolically active tissues. Synthetic PPAR agonists have exhibited therapeutic benefits in treating diab...

journal_title：Current medicinal chemistry

authors： Shearer BG,Hoekstra WJ

更新日期：2003-02-01 00:00:00

abstract：:Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review...

journal_title：Current medicinal chemistry

authors： Piperno A,Chiacchio MA,Iannazzo D,Romeo R

更新日期：2006-01-01 00:00:00

abstract：:Polyphenolic molecules produced by higher plants in response to biotic and abiotic stresses exert numerous effects on tumorigenic cell transformation, and on tumor cells in vitro and in vivo, and may interact with conventional anti-tumor therapies. In the present review, we collected and critically discussed data on: ...

journal_title：Current medicinal chemistry

authors： Korkina LG,De Luca C,Kostyuk VA,Pastore S

更新日期：2009-01-01 00:00:00

abstract：:The market, sales and regulatory approval of new human medicines, during the past few years, indicates increasing number and share of new biologics and emergence of new multibillion dollar molecules. The global sale of monoclonal antibodies in 2006 were $20.6 billion. Remicade had annual sales gain of $1 billion durin...

journal_title：Current medicinal chemistry

authors： Maggon K

更新日期：2007-01-01 00:00:00

abstract：:The transport mechanisms of ascorbic acid (AA) are described. The metabolism of AA and its function as an antioxidant are covered in some detail. Subsequently, indications for postoperative substitution are discussed. The supplementation of up to 300 mg of AA per day in postoperative intensive care unit patients durin...

journal_title：Current medicinal chemistry

authors： Rümelin A

更新日期：2009-01-01 00:00:00

abstract：:The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid/carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide an...

journal_title：Current medicinal chemistry

authors： Hoekstra WJ

更新日期：2001-05-01 00:00:00

abstract：:Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthes...

journal_title：Current medicinal chemistry

authors： Scicinski JJ,Congreveb MS,Kay C,Ley SV

更新日期：2002-12-01 00:00:00

abstract：:Recent results using animal models of inflammatory skin conditions have shown that blockers of the voltage-gated potassium channel, Kv1.3 hold great promise for clinical utility. Kv1.3 blockers act as immunosuppressants by modulating the various subsets of inflammatory T and B cells involved in autoimmune disorders. W...

journal_title：Current medicinal chemistry

authors： Nguyen W,Howard BL,Neale DS,Thompson PE,White PJ,Wulff H,Manallack DT

更新日期：2010-01-01 00:00:00

abstract：:Modification of cysteine (Cys) residues in proteins, due to (i) the participation of the thiol moiety of this amino acid in oxido-reductions reactions; (ii) its ability to strongly coordinate transition metal ions; or (iii) its nucleophilic nature and facile reaction with electrophiles, may be of critical importance f...

journal_title：Current medicinal chemistry

authors： Scozzafava A,Casini A,Supuran CT

更新日期：2002-06-01 00:00:00

abstract：:Bone pain arising from secondary skeletal malignancy constitutes one of the most common types of chronic pain among patients with cancer which can lead to rapid deterioration of the quality of life. Radionuclide therapy using bone-seeking radiopharmaceuticals based on the concept of localization of the agent at bone m...

journal_title：Current medicinal chemistry

authors： Dash A,Das T,Knapp FFR

更新日期：2020-01-01 00:00:00

abstract：:The discovery and development of novel drugs has been influenced over the last several decades by new techniques in medicinal chemistry. Combinatorial and parallel synthesis chemistry techniques have opened up immense opportunities in drug discovery and development efforts. These techniques, which include solid phase ...

journal_title：Current medicinal chemistry

authors： Musonda CC,Chibale K

更新日期：2004-10-01 00:00:00

abstract：:Physalia physalis is a marine cnidarian from which high molecular weight toxins with hemolytic and neurotoxic effects have been isolated. In the present work, two novel toxins, PpV9.4 and PpV19.3 were purified from P. physalis by bioactive guideline isolation. It involved two steps of column chromatography, gel filtra...

journal_title：Current medicinal chemistry

authors： Diaz-Garcia CM,Fuentes-Silva D,Sanchez-Soto C,Domínguez-Pérez D,García-Delgado N,Varela C,Mendoza-Hernández G,Rodriguez-Romero A,Castaneda O,Hiriart M

更新日期：2012-01-01 00:00:00