Role of Vitamin D in Vascular Complications and Vascular Access Outcome in Patients with Chronic Kidney Disease.

abstract：:Targeted therapy has been recently highlighted due to the reduction of side effects and improvement in overall efficacy and survival to different types of cancers. Considering the approval of many monoclonal antibodies in the last twenty years, cancer treatment can be accomplished by the combination of monoclonal anti...

journal_title：Current medicinal chemistry

authors： Petrilli R,Pinheiro DP,de Cássia Evangelista de Oliveira F,Galvão GF,Marques LGA,Lopez RFV,Pessoa C,Eloy JO

更新日期：2020-05-25 00:00:00

abstract：:The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the fundamental characteristics critical for the biology of eukaryotes, in particular, survival and malignant transformation of cells. The members of this protein family (Pim-1 to Pim-3) are aberrant...

journal_title：Current medicinal chemistry

authors： Anizon F,Shtil AA,Danilenko VN,Moreau P

更新日期：2010-01-01 00:00:00

abstract：:Whether the increased atrial fibrillation (AF) risk in metabolic syndrome (MetS) patients is due to the syndrome as a whole or simply the sum of the risks of its individual component parts is still obscure. These two clinical entities share many pathophysiological links and thus distinction between a casual observatio...

journal_title：Current medicinal chemistry

authors： Georgakopoulos C,Vlachopoulos C,Lazaros G,Tousoulis D

更新日期：2019-01-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodelin...

journal_title：Current medicinal chemistry

authors： Yamamoto D,Takai S

更新日期：2009-01-01 00:00:00

abstract：:Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotech...

journal_title：Current medicinal chemistry

authors： Bedin C,Crotti S,Tasciotti E,Agostini M

更新日期：2018-01-01 00:00:00

abstract：:Anthocyanins are generally considered to be the largest and the most important group of water-soluble pigments in plants. They are widely consumed by humans as natural compounds of vegetables, fruits, and red wine. Anthocyanins as well as other flavonoids show protective qualities against variety of pathologies, inclu...

journal_title：Current medicinal chemistry

authors： Bártíková H,Skálová L,Dršata J,Boušová I

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Fungi play an important role in terrestrial ecosystems interacting positively or negatively with plants. These interactions are complex and the outcomes are different depending on the fungal lifestyles, saprotrophic, mutualistic or pathogenic. Furthermore, fungi are well known for producing secondary metabol...

journal_title：Current medicinal chemistry

authors： Masi M,Maddau L,Linaldeddu BT,Scanu B,Evidente A,Cimmino A

更新日期：2018-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells. Several mediators can modulate activation and recruitment of these...

journal_title：Current medicinal chemistry

authors： Nucera F,Lo Bello F,Shen SS,Ruggeri P,Coppolino I,Di Stefano A,Stellato C,Casolaro V,Hansbro PM,Adcock IM,Caramori G

更新日期：2020-08-19 00:00:00

abstract：:Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properti...

journal_title：Current medicinal chemistry

authors： An L,Shah Gilani MR,Liang G

更新日期：2014-01-01 00:00:00

abstract：:Differentiation therapy of acute promyelocytic leukemia with all-trans retinoic acid represents the most successful pharmacological therapy of acute myeloid leukemia (AML). Numerous studies demonstrate that drugs that inhibit mechanistic target of rapamycin (mTOR) and activate AMP-kinase (AMPK) have beneficial effects...

journal_title：Current medicinal chemistry

authors： Visnjic D,Dembitz V,Lalic H

更新日期：2019-01-01 00:00:00

abstract：:The maximum therapeutic potentials of pharmacologically active molecules are generally not attained due to their non specific delivery. Ligands associated with drug or delivery system through which it is delivered provide navigation and direction to the carrier system(s) so as to reach and release bioactive(s) at the ...

journal_title：Current medicinal chemistry

authors： Rai S,Paliwal R,Vaidya B,Gupta PN,Mahor S,Khatri K,Goyal AK,Rawat A,Vyas SP

更新日期：2007-01-01 00:00:00

abstract：:To date, many scientific attempts have been directed towards the development of experimental models for the identification of neuronal mechanisms evoking cardiovascular and hemodynamic dysfunctions. The spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, has become a valuable rodent for th...

journal_title：Current medicinal chemistry

authors： Giusi G,Alò R,Avolio E,Zizza M,Facciolo RM,Talani G,Biggio G,Sanna E,Canonaco M

更新日期：2012-01-01 00:00:00

abstract：:Heparins are used in "therapeutic doses" for systemic anticoagulation to treat patients who have confirmed venous thromboembolism, or in "prophylactic doses "for the prevention of venous thromboembolism: they are generally lower doses and are employed once a day. Structure-function relationships are strongly influence...

journal_title：Current medicinal chemistry

authors： Stratta P,Karvela E,Canavese C,Quaglia M,Lazzarich E,Fenoglio R,Pergolini P,Bellomo G,Cena T,Magnani C

更新日期：2009-01-01 00:00:00

abstract：:The development of bacterial resistance is a significant problem in the treatment of infection, and the importance of research directed toward the discovery of novel agents to treat infections cannot be underestimated. In the past, discovery programs have focused on modification of natural products or existing classes...

journal_title：Current medicinal chemistry

authors： Harris CR,Thorarensen A

更新日期：2004-08-01 00:00:00

abstract：:The bryostatins, powerful protein kinase C (PKC) agonists, are a family of complex macrolactone natural products. They are originally isolated from the marine bryozoan Bugula neritina. So far tweenty bryostatins have been obtained naturally and exhibit a remarkable range of biological activities, including antineoplas...

journal_title：Current medicinal chemistry

authors： Ruan BF,Zhu HL

更新日期：2012-01-01 00:00:00

abstract：:Clinically significant antibiotic resistance is one of the greatest challenges of the twenty-first century. Yet new antibiotics are currently being developed at a much slower pace than our growing need for such drugs. Instead of focusing on conventional therapeutics that target in vitro bacterial viability, an alterna...

journal_title：Current medicinal chemistry

authors： Wang Y,Ma S

更新日期：2014-01-01 00:00:00

abstract：:Nuclear magnetic resonance spectroscopy has been exploited to study the metabolic characteristics (phenotype) of genetic disorders by taking advantage of some unique characteristics of the technique. The first application, metabolic profiling for diagnosis and therapeutic monitoring in vitro, demonstrates the exceptio...

journal_title：Current medicinal chemistry

authors： Iles RA

更新日期：2008-01-01 00:00:00

abstract：:Obesity is a chronic disease characterized by the accumulation of excess adipose tissue associated with an increased risk of multiple morbidities and mortality. At the present time, only three drugs have been approved by the Food and Drug Administration (FDA) for the treatment of obesity. Agonists and antagonists of s...

journal_title：Current medicinal chemistry

authors： Rivera G,Bocanegra-García V,Galiano S,Cirauqui N,Ceras J,Pérez S,Aldana I,Monge A

更新日期：2008-01-01 00:00:00

abstract：:The hemostatic system comprises platelet aggregation, coagulation and fibrinolysis also termed primary, secondary and tertiary hemostasis. From the platelet transcriptome 6000 mRNA species and represent receptors, ion channels, signalling molecules, kinases, phosphatases, and structural, metabolic and regulatory prote...

journal_title：Current medicinal chemistry

authors： Stassen JM,Arnout J,Deckmyn H

更新日期：2004-09-01 00:00:00

abstract：:Leukemia is a life threatening disease that has become increasingly common. Many categories of anti-leukemic agents have been developed by probing into the nature of leukemia. Nevertheless, the needs for potent molecules with few side effects are still not satisfied in the current anti-leukemic therapy. Targeted thera...

journal_title：Current medicinal chemistry

authors： Bian J,Zhang L,Han Y,Wang C,Zhang L

更新日期：2015-01-01 00:00:00

abstract：:Epigenetics is a field of biological sciences focused on the study of reversible, heritable changes in gene function not due to modifications of the genomic sequence. These changes are the result of a complex cross-talk between several molecular mechanisms, that is in turn orchestrated by genetic and environmental fac...

journal_title：Current medicinal chemistry

authors： De Riso G,Cocozza S

更新日期：2020-11-17 00:00:00

abstract：:Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the protein family of neurotrophins. They both display profound neuromodulatory functions and are essentially involved in the survival and homeostatic maintenance of central and peripheral neurons during development and adulthood. Moreove...

journal_title：Current medicinal chemistry

authors： Schulte-Herbrüggen O,Braun A,Rochlitzer S,Jockers-Scherübl MC,Hellweg R

更新日期：2007-01-01 00:00:00

abstract：:Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a higher degree of complexity and accuracy. Moreover, thei...

journal_title：Current medicinal chemistry

authors： Santos M,Serrano-Dúcar S,González-Valdivieso J,Vallejo R,Girotti A,Cuadrado P,Arias FJ

更新日期：2019-01-01 00:00:00

abstract：:Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen mustards, where attachment of the mustard unit to carrier molecules can change the normal patterns of both regio- and sequence-selectivity, from reaction primarily...

journal_title：Current medicinal chemistry

authors： Denny WA

更新日期：2001-04-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons which brings to muscular atrophy, paralysis and death in 3-5 years from starting symptoms. In about 10% of cases ALS is familiar and in a relevant percent of these cases, mutations of the...

journal_title：Current medicinal chemistry

authors： Contestabile A

更新日期：2011-01-01 00:00:00

abstract：:Genetic, experimental and clinical studies have consistently confirmed that inhibition of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) can result in significant lowering of LDL-C and two fully human PCSK9 monoclonal antibodies have received regulatory approval for use in highrisk patients. Co-administration o...

journal_title：Current medicinal chemistry

authors： Panagiotopoulou O,Chiesa ST,Tousoulis D,Charakida M

更新日期：2020-01-01 00:00:00

abstract：:In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect the bioactivity of flavonoids in vivo. Only when we gain adequate information on...

journal_title：Current medicinal chemistry

authors： Rice-Evans C

更新日期：2001-06-01 00:00:00

abstract：:Receptor-binding peptides have attracted an enormous interest in targeting molecules for the development of tumour specific radiopharmaceutical compounds. The overexpression of many receptors on human tumour makes such peptide-ligands attractive agents for diagnostic imaging and therapy of cancers. The use of solid-ph...

journal_title：Current medicinal chemistry

authors： Bolzati C,Refosco F,Marchiani A,Ruzza P

更新日期：2010-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted from endocrine cells in the gut mucosa in response to meal ingestion. It is an important incretin hormone; mice with a null mutation in the GLP-1 receptor gene develop glucose intolerance. In addition, it inhibits gastrointestinal secretion and moti...

journal_title：Current medicinal chemistry

authors： Holst JJ

更新日期：1999-11-01 00:00:00

abstract：:There is increasing evidence that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A reductase, can effectively be used not only in the treatment of hypercholesterolemia, but also in other human disorders; indeed, statins have strong anti-inflammatory and immunomodulatory effects, so that they can influence...

journal_title：Current medicinal chemistry

authors： Poggi A,Zocchi MR

更新日期：2011-01-01 00:00:00