Abstract:
BACKGROUND:Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue specific action cannot be exerted, it could lead to several endocrine-metabolic disorders closely related to PCOS, such as non-alcoholic fatty liver disease (NAFLD) and obesity. OBJECTIVE:This work aims to discuss the impact of lipid alterations on metabolic and reproductive health. Therefore, this review focus on the importance of carrying out an integrated study of the molecular pathways affected in PCOS for developing target therapies. RESULTS:Lipids play a major role in PCOS pathogenesis. In this regard, failures in lipid regulation, synthesis, and/or homeostasis contribute to metabolic and reproductive abnormalities, such as those seen in PCOS. Several lipid pathways and regulators are altered in this pathology, leading to dysfunctions that worsen reproductive functions. Therefore, there are several treatments to manage dyslipidemias. Non-pharmacological therapies are considered a first line treatment being the pharmacological treatments a second line option. CONCLUSION:The best treatment to improve the lipid profile is a lifestyle intervention, a combination of hypocaloric diet and exercise. Regarding pharmacological therapies, a combination of fibrate and statins would be the most recommended drugs. Still, in PCOS women, treatment with metformin or TZDs not only modulates the lipid metabolism, but also improves the ovulation. Also, metformin with lifestyle interventions has positive effects on the metabolic and reproductive features of PCOS patients.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Ferrer MJ,Silva AF,Abruzzese GA,Velázquez ME,Motta ABdoi
10.2174/0929867328666210106142912subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-113103pub_type
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