MUC1 Story: Great Expectations, Disappointments and the Renaissance.

Abstract:

:In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of oncogenesis, from malignant cell transformation to tumor dissemination. The story of MUC1 is full of hopes and disappointments. However, the scientific interest to MUC1 has never waned, and the more profoundly it has been investigated, the clearer its hidden potential turned to be disclosed. The therapeutic potential of mucin MUC1 has already been noted by various scientific groups at the early stages of research. Over forty years ago, the first insights into MUC1 functions became a strong ground for considering this molecule as potential target for anticancer therapy. Therefore, this direction of research has always been of particular interest and practical importance. More than 200 papers on MUC1 were published in 2016; the majority of them are dedicated to MUC1-related anticancer diagnostics and therapeutics. Here we review the history of MUC1 studies from the very first attempts to reveal its functions to the ongoing renaissance.

journal_name

Curr Med Chem

authors

Syrkina MS,Vassetzky YS,Rubtsov MA

doi

10.2174/0929867324666170817151954

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

554-563

issue

3

eissn

0929-8673

issn

1875-533X

pii

CMC-EPUB-85341

journal_volume

26

pub_type

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