Abstract:
:Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disorder characterized by irreversible chronic inflammation and airflow obstruction. It affects more than 64 million patients worldwide and it is predicted to become the third cause of death in the industrialized world by 2030. Currently available therapies are not able to block disease progression and to reduce mortality, underlying the need for a better understanding of COPD pathophysiological mechanisms to identify new molecular therapeutic targets. Recent studies demonstrated that phosphoinositide 3-kinase (PI3K) signaling is prominently activated in COPD and correlates with an increased susceptibility of patients to lung infections. PI3Ks have thus emerged as promising alternative drug targets for COPD and a wide array of pan-isoform and isoform-selective inhibitors have been tested in preclinical models and are currently being evaluated in clinical studies. Here, we summarize the recent knowledge on the involvement of PI3K enzymes in the pathophysiology of COPD, and we discuss the most recent results arising from the preclinical as well as the clinical testing of PI3K inhibitors as novel therapeutics for COPD.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Pirozzi F,Ren K,Murabito A,Ghigo Adoi
10.2174/0929867325666180320120054subject
Has Abstractpub_date
2019-01-01 00:00:00pages
2791-2800issue
16eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-89196journal_volume
26pub_type
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journal_title:Current medicinal chemistry
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