A Chemical Approach to Overcome Tyrosine Kinase Inhibitors Resistance: Learning from Chronic Myeloid Leukemia.

abstract：:Drug repositioning, an innovative therapeutic application of an old drug, has received much attention as a particularly costeffective strategy in drug R&D Recent work has indicated that repositioning can be promoted by utilizing a wide range of information sources, including medicinal chemical, target, mechanism, main...

journal_title：Current medicinal chemistry

authors： Arany Á,Bolgár B,Balogh B,Antal P,Mátyus P

更新日期：2013-01-01 00:00:00

abstract：:Atrial fibrillation represents a major clinical, social and economical matter, and its importance is expected to increase even more in the near future. The progressive ageing of population is associated with an inevitable rising in incidence and prevalence of this rhythm disorder, which limits functional capability, f...

journal_title：Current medicinal chemistry

authors： Lombardi F,Terranova P

更新日期：2006-01-01 00:00:00

abstract：:It is well recognised that increased levels of high density lipoprotein (HDL) protect against atherosclerosis and correlate with improved prognosis for vascular disease associated events. While many of the atheroprotective effects of HDL are ascribed to the ability to remove cholesterol from the vasculature through th...

journal_title：Current medicinal chemistry

authors： Murphy AJ,Chin-Dusting JP,Sviridov D,Woollard KJ

更新日期：2009-01-01 00:00:00

abstract：:Nitric oxide (NO) is a diatomic free radical produced from L-arginine by constitutive and inducible nitric oxide synthase (cNOS and iNOS) in numerous mammalian cells and tissues. Nitric oxide (NO), superoxide (O2-) and their reaction product peroxynitrite (ONOO-) may be generated in excess during the host response aga...

journal_title：Current medicinal chemistry

authors： Conforti F,Menichini F

更新日期：2011-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) translationally repressing their target messenger RNAs due to their gene-regulatory functions play an important but not unexpected role in a tumour development. More surprising are the findings that levels of various miRNAs are well correlated with presence of specific tumours and formation of metas...

journal_title：Current medicinal chemistry

authors： Pekarik V,Gumulec J,Masarik M,Kizek R,Adam V

更新日期：2013-01-01 00:00:00

abstract：:Thymosin Beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis. Tβ4 is a water-soluble protein that has different promising clinical applications in the remodeling and ulcerated tissues repair following myocardial infarction, stroke, plasticity and neurovascular remo...

journal_title：Current medicinal chemistry

authors： Bjørklund G,Dadar M,Aaseth J,Chirumbolo S

更新日期：2020-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is a significant healthcare concern worldwide that affects more than 165 million individuals leading to cardiovascular disease, nephropathy, retinopathy, and widespread disease of both the peripheral and central nervous systems. The incidence of undiagnosed diabetes, impaired glucose tolerance, ...

journal_title：Current medicinal chemistry

authors： Maiese K,Chong ZZ,Shang YC

更新日期：2007-01-01 00:00:00

abstract：:Genito-urinary malignancies (prostate, bladder, renal and testicular cancers) rank high among human tumors with an incidence that varies with age and organ involvement. Prostate cancer is the most commonly detected male cancer followed by bladder and kidney cancers, less frequent in women. Testicular cancer, although ...

journal_title：Current medicinal chemistry

authors： Cantile M,Franco R,Schiavo G,Procino A,Cindolo L,Botti G,Cillo C

更新日期：2011-01-01 00:00:00

abstract：:The transport mechanisms of ascorbic acid (AA) are described. The metabolism of AA and its function as an antioxidant are covered in some detail. Subsequently, indications for postoperative substitution are discussed. The supplementation of up to 300 mg of AA per day in postoperative intensive care unit patients durin...

journal_title：Current medicinal chemistry

authors： Rümelin A

更新日期：2009-01-01 00:00:00

abstract：:Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side effects. The need of effective drugs, without adverse effects, has stimulated the search for new c...

journal_title：Current medicinal chemistry

authors： Salas CO,Faúndez M,Morello A,Maya JD,Tapia RA

更新日期：2011-01-01 00:00:00

abstract：:Despite advances in cancer treatment, a large number of patients eventually develop metastatic disease that is generally incurable. Systemic chemotherapy remains the standard treatment for these patients. Several chemotherapeutic combinations have proven effective in the management of cancer. Paradoxically, although t...

journal_title：Current medicinal chemistry

authors： Prados J,Alvarez PJ,Melguizo C,Rodriguez-Serrano F,Carrillo E,Boulaiz H,Vélez C,Marchal JA,Caba O,Ortiz R,Rama A,Aranega A

更新日期：2012-01-01 00:00:00

abstract：:The main challenge of cancer treatment is multidrug resistance during chemotherapy. Cancer cell can evade cell death during every round of orthodox chemotherapy drugs, consequently being resistant after several rounds of standard drug treatment. One of the regimens to address this multidrug resistance problem is by dr...

journal_title：Current medicinal chemistry

authors： Lou JS,Yao P,Tsim KWK

更新日期：2018-01-01 00:00:00

abstract：:Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer's disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals pl...

journal_title：Current medicinal chemistry

authors： Jamasbi E,Wade JD,Separovic F,Hossain MA

更新日期：2016-01-01 00:00:00

abstract：:DEAD-box RNA helicase DDX3 is a well-known host factor that inhibits hepatitis B viral proliferation and boosts innate immune responses via TANK-binding kinase 1 (TBK1)/IKKε-mediated and/or interferon (IFN)-β promoter stimulator-1 (IPS-1)-mediated IFN-β induction. Previously, we demonstrated the anti-hepatitis B activ...

journal_title：Current medicinal chemistry

authors： Choi YJ,Kang LJ,Lee SG

更新日期：2014-01-01 00:00:00

abstract：:G protein-coupled receptor (GPCR) (also known as seven-transmembrane domain receptor) superfamily represents the largest protein family in the human genome. These receptors respond to various physiological ligands such as photons, odors, pheromones, hormones, ions, and small molecules including amines, amino acids to ...

journal_title：Current medicinal chemistry

authors： Yonezawa T,Kurata R,Yoshida K,Murayama MA,Cui X,Hasegawa A

更新日期：2013-01-01 00:00:00

abstract：:The use of dopaminergic agonists is key in the treatment of Parkinson's disease and related central nervous system (CNS) neurodegenerative disorders. Despite there are a number of commercialized dopaminergic agonists that are currently being used successfully in the first stages of the disease, they often fail to prov...

journal_title：Current medicinal chemistry

authors： Matute MS,Matute R,Merino P

更新日期：2016-01-01 00:00:00

abstract：:The chemokine receptor, CXCR4, is a GPCR that transduces signals of its endogenous ligand, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12-CXCR4 system plays an important role in the migration of progenitors during embryologic development of the cardiovascular, hemopoietic, central nervous systems, etc. This...

journal_title：Current medicinal chemistry

authors： Tamamura H,Tsutsumi H,Masuno H,Fujii N

更新日期：2007-01-01 00:00:00

abstract：:Honey has successfully been used in the treatment of a broad spectrum of injuries including burns and non-healing wounds. It acts as an antibacterial and anti-biofilm agent with anti/pro-inflammatory properties. However, besides these traditional properties, recent evidence suggests that honey is also an immunomodulat...

journal_title：Current medicinal chemistry

authors： Martinotti S,Bucekova M,Majtan J,Ranzato E

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological environment that PTM crosstalk studies can describe. Besides gene expression and phosphorylation ...

journal_title：Current medicinal chemistry

authors： Hernandez-Valladares M,Wangen R,Berven FS,Guldbrandsen A

更新日期：2019-01-01 00:00:00

abstract：:Cell-based electrochemical biosensors have contributed tremendously to the fields of biology, medicine, chemistry, pharmacology, and environmental science. With electrochemical transducers and whole cells as the recognition elements, these biosensors provide new horizons for biosensing and life science research. This ...

journal_title：Current medicinal chemistry

authors： Ding L,Du D,Zhang X,Ju H

更新日期：2008-01-01 00:00:00

abstract：:Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to stu...

journal_title：Current medicinal chemistry

authors： Lekic T,Klebe D,Poblete R,Krafft PR,Rolland WB,Tang J,Zhang JH

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:We found a novel marine drug, SZ-685C, that was isolated from the secondary metabolites of a mangrove endophytic fungus (No. 1403) collected from the South China Sea, which has been reported to inhibit the proliferation of certain tumor cells. However, its anticancer mechanism remains unknown. The aims of thi...

journal_title：Current medicinal chemistry

authors： Chen CH,Xiao WW,Jiang XB,Wang JW,Mao ZG,Lei N,Fan X,Song BB,Liao CX,Wang HJ,She ZG,Zhu YH

更新日期：2013-01-01 00:00:00

abstract：:Limitations associated with the production cost, metabolic instability, side-effects, resistance and poor pharmacokinetics of organic protease inhibitors (PIs), which form an essential component of the front line HAART treatment for HIV, have fuelled efforts into finding novel, transition metal-based alternatives. Som...

journal_title：Current medicinal chemistry

authors： Kellett A,Prisecaru A,Slator C,Molphy Z,McCann M

更新日期：2013-01-01 00:00:00

abstract：:Poisoning of DNA topoisomerase I is the mechanism by which camptothecins interfere with tumor growth. Although the clinical use of camptothecins has had a significant impact on cancer therapy, de novo or acquired clinical resistance to these drugs is common. Clinical resistance to camptothecins is still a poorly under...

journal_title：Current medicinal chemistry

authors： Beretta GL,Gatti L,Perego P,Zaffaroni N

更新日期：2013-01-01 00:00:00

abstract：:Obesity and metabolic syndrome represent major public health problems, and are the biggest preventable causes of death worldwide. Obesity is the leading risk factor for type 2 diabetes mellitus (T2DM), cardiovascular diseases and non-alcoholic fatty liver disease. Obesity-associated insulin resistance, which is charac...

journal_title：Current medicinal chemistry

authors： Panzhinskiy E,Ren J,Nair S

更新日期：2013-01-01 00:00:00

abstract：:Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates. It is involved in the metabolic transformation of arginine and proline, and it participates in the urea cycle in vertebrates and in the formation of pu...

journal_title：Current medicinal chemistry

authors： Díaz-Muñoz M,Hernández-Muñoz R

更新日期：2010-01-01 00:00:00

abstract：:Sulfonyl group-containing compounds constitute an important class of therapeutical agents in medicinal chemistry presumably because of the tense chemical structure and functionality of the sulfonyl, which could not only form hydrogen bonding interactions with active site residues of biological targets but also, as inc...

journal_title：Current medicinal chemistry

authors： Chen X,Hussain S,Parveen S,Zhang S,Yang Y,Zhu C

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The large increase in epidemiological studies on night shift work is due to the important effects of night shift work on workers' health and psychophysical wellbeing. The short-term effects-insomnia, difficulties in managing work and private life, lower work performance, and more work and extra-work accident...

journal_title：Current medicinal chemistry

authors： Ferri GM,Cavone D,Intranuovo G,Macinagrossa L

更新日期：2019-01-01 00:00:00

abstract：:Fabry disease (FD) is an X-linked glycosphingolipid storage disorder caused by deficient activity of the lysosomal enzyme alpha-galactosidase A. This leads to a progressive accumulation of globotriaosylceramide (Gb3) in the lysosomes of different cells and tissues, causing principally ventricular hypertrophy, renal fa...

journal_title：Current medicinal chemistry

authors： Caballero L,Climent V,Hernández-Romero D,Quintanilla MA,de la Morena G,Marín F

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDAC) are an important class of enzymes that play a pivotal role in epigenetic regulation of gene expression that modifies the terminal of core histones leading to remodelling of chromatin topology and thereby controlling gene expression. HDAC inhibitors (HDACi) counter this action and ...

journal_title：Current medicinal chemistry

authors： Sultana F,Manasa KL,Shaik SP,Bonam SR,Kamal A

更新日期：2019-01-01 00:00:00