Abstract:
:Thrombomodulin (TM) is a membrane protein mainly expressed by endothelial cells. It is part of the anticoagulant protein C system but recently several effects were discovered which occur independently of protein C activation. TM binds thrombin and promotes the cleavage of protein C and the thrombin activatable fibrinolysis inhibitor (TAFI), thereby inhibiting coagulation and fibrinolysis. Additionally, it interferes with inflammation, stabilizes barrier function, and increases blood flow under pathological conditions. Recombinant soluble TM protects against tissue damage and partially restores normal function after ischemia in several organs. Recently, it was shown to reduce the infarct size in stroke models. Compared to other anticoagulant compounds the risk of bleeding seems to be smaller in animals and humans treated with soluble TM. With its multiple actions TM represents a new candidate for stroke treatment. In this review we focus on the effects of TM in coagulation, inflammation, and on its protective roles in the prevention of ischemic brain damage.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Wenzel J,Assmann JC,Schwaninger Mdoi
10.2174/0929867321666131228204839subject
Has Abstractpub_date
2014-01-01 00:00:00pages
2025-34issue
18eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-58358journal_volume
21pub_type
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