Instructions from the vascular system - directing neural stem cell fate in health and disease.

abstract：:Thrombomodulin (TM) is a membrane protein mainly expressed by endothelial cells. It is part of the anticoagulant protein C system but recently several effects were discovered which occur independently of protein C activation. TM binds thrombin and promotes the cleavage of protein C and the thrombin activatable fibrino...

journal_title：Current medicinal chemistry

authors： Wenzel J,Assmann JC,Schwaninger M

更新日期：2014-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted from endocrine cells in the gut mucosa in response to meal ingestion. It is an important incretin hormone; mice with a null mutation in the GLP-1 receptor gene develop glucose intolerance. In addition, it inhibits gastrointestinal secretion and moti...

journal_title：Current medicinal chemistry

authors： Holst JJ

更新日期：1999-11-01 00:00:00

abstract：:COVID-19, a type of infection that emerged in Wuhan, has become a pandemic affecting people worldwide and is rapidly spreading and evolving. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological appr...

journal_title：Current medicinal chemistry

authors： Kumar R,Harilal S,Al-Sehemi AG,Mathew GE,Carradori S,Mathew B

更新日期：2020-07-02 00:00:00

abstract：:Receptor-binding peptides have attracted an enormous interest in targeting molecules for the development of tumour specific radiopharmaceutical compounds. The overexpression of many receptors on human tumour makes such peptide-ligands attractive agents for diagnostic imaging and therapy of cancers. The use of solid-ph...

journal_title：Current medicinal chemistry

authors： Bolzati C,Refosco F,Marchiani A,Ruzza P

更新日期：2010-01-01 00:00:00

abstract：:Balance between excitatory glutamate and inhibitory GABA neurotransmitter is essential and critical for proper development and functioning of brain. GABAergic (gamma aminobutyric acid) and glutamatergic interneurons maintain excitability, integrity and synaptic plasticity. Several evidences implicated relative loss of...

journal_title：Current medicinal chemistry

authors： Purkayastha P,Malapati A,Yogeeswari P,Sriram D

更新日期：2015-05-04 00:00:00

abstract：BACKGROUND:The sterile alpha motif (Sam) domain is a small helical protein module, able to undergo homo- and hetero-oligomerization, as well as polymerization, thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable target...

journal_title：Current medicinal chemistry

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2020-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Ozkan SA

更新日期：2018-01-01 00:00:00

abstract：:Bile formation is an osmotic process driven by the vectorial transport of actively transferred biliary components across the basolateral (sinusoidal) and apical (canalicular) hepatocyte membranes, the latter being the rate-limiting step of the overall blood-to-bile transfer. The ATP-binding cassette (ABC) superfamily ...

journal_title：Current medicinal chemistry

authors： Crocenzi FA,Mottino AD,Roma MG

更新日期：2004-02-01 00:00:00

abstract：:Heparins are used in "therapeutic doses" for systemic anticoagulation to treat patients who have confirmed venous thromboembolism, or in "prophylactic doses "for the prevention of venous thromboembolism: they are generally lower doses and are employed once a day. Structure-function relationships are strongly influence...

journal_title：Current medicinal chemistry

authors： Stratta P,Karvela E,Canavese C,Quaglia M,Lazzarich E,Fenoglio R,Pergolini P,Bellomo G,Cena T,Magnani C

更新日期：2009-01-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists. Among 5-HTRs, the 5-HT(1A) subtype is the best studied and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind...

journal_title：Current medicinal chemistry

authors： López-Rodríguez ML,Ayala D,Benhamú B,Morcillo MJ,Viso A

更新日期：2002-02-01 00:00:00

abstract：:In modern industrialized societies, people are exposed to thousands of naturally occurring and synthetic chemicals throughout their lifetime. Although certain occupational chemicals are known to be carcinogenic in humans, it has been difficult to definitively determine the adverse health effects of many environmental ...

journal_title：Current medicinal chemistry

authors： Weyandt J,Ellsworth RE,Hooke JA,Shriver CD,Ellsworth DL

更新日期：2008-01-01 00:00:00

abstract：:Since its discovery in 1995 adiponectin has garnered considerable interest from the academic, clinical and biotech communities due to its proposed salutary anti-inflammatory, anti-diabetic, anti-atherogenic and cardioprotective properties. As a result our appreciation of adiponectin's structure and the importance of p...

journal_title：Current medicinal chemistry

authors： Hickman IJ,Whitehead JP

更新日期：2012-01-01 00:00:00

abstract：:The discovery and development of novel drugs has been influenced over the last several decades by new techniques in medicinal chemistry. Combinatorial and parallel synthesis chemistry techniques have opened up immense opportunities in drug discovery and development efforts. These techniques, which include solid phase ...

journal_title：Current medicinal chemistry

authors： Musonda CC,Chibale K

更新日期：2004-10-01 00:00:00

abstract：:The aminocoumarin antibiotics novobiocin, clorobiocin and coumermycin A(1) are produced by different Streptomyces strains and are potent inhibitors of DNA gyrase. The biosynthetic gene clusters of all three antibiotics have been cloned and sequenced, and the function of most genes contained therein has been elucidated...

journal_title：Current medicinal chemistry

authors： Li SM,Heide L

更新日期：2005-01-01 00:00:00

abstract：:Virtual screening is an important means for lead compound discovery. The scoring function is the key to selecting hit compounds. Many scoring functions are currently available; however, there are no all-purpose scoring functions because different scoring functions tend to have conflicting results. Recently, neural net...

journal_title：Current medicinal chemistry

authors： Shan W,Li X,Yao H,Lin K

更新日期：2020-05-26 00:00:00

abstract：:Atrial fibrillation represents a major clinical, social and economical matter, and its importance is expected to increase even more in the near future. The progressive ageing of population is associated with an inevitable rising in incidence and prevalence of this rhythm disorder, which limits functional capability, f...

journal_title：Current medicinal chemistry

authors： Lombardi F,Terranova P

更新日期：2006-01-01 00:00:00

abstract：:T helper (Th) cells belong to the adaptive immune system and provide an effective and antigen-specific means of host protection. Th17 cells are a subset of Th cells, characterized by the production of the inflammatory cytokines interleukin (IL)-17A (IL-17A) and IL-17F, which bind to a receptor complex comprised of IL-...

journal_title：Current medicinal chemistry

authors： Ghali JR,Holdsworth SR,Kitching AR

更新日期：2015-01-01 00:00:00

abstract：:Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, inclu...

journal_title：Current medicinal chemistry

authors： Moreno JA,Sanchez-Niño MD,Sanz AB,Lassila M,Holthofer H,Blanco-Colio LM,Egido J,Ruiz-Ortega M,Ortiz A

更新日期：2008-01-01 00:00:00

abstract：:To this point, efforts to develop therapeutic peptides for intracellular applications were guided by the perception that unmodified linear peptides are highly unstable and therefore structural modifications are required to reduce proteolytic breakdown. Largely, this concept is a consequence of the fact that most resea...

journal_title：Current medicinal chemistry

authors： Zuconelli CR,Brock R,Adjobo-Hermans MJW

更新日期：2017-01-01 00:00:00

abstract：:Numerous cellular pathways have a significant impact in the growth and metastatic potential of tumors. Essential element of such pathways is the epidermal growth factor receptor (EGFR), a member of the HER family of receptor tyrosine kinases. One of the most important issues in cancer, which attracted the attention of...

journal_title：Current medicinal chemistry

authors： Gialeli Ch,Kletsas D,Mavroudis D,Kalofonos HP,Tzanakakis GN,Karamanos NK

更新日期：2009-01-01 00:00:00

abstract：:Raltegravir, the only drug targeting the integration step in HIV-1 life cycle, makes β-ketoenol integrase (IN) strand transfer inhibitor (STI) gain a definitive place in the treatment of HIV-1 infection. However, the emergence of viral strains resistant to β-ketoenol STI demands a continued effort toward the discovery...

journal_title：Current medicinal chemistry

authors： Yu S,Zhao G

更新日期：2012-01-01 00:00:00

abstract：:The therapeutical use of drugs involves the application of dosage forms, serving as carrier systems together with several excipients to deliver the active ingredient to the site of action. Drug delivery technology combines an understanding of medicinal chemistry and pharmacology with the skill of formulation, aiming t...

journal_title：Current medicinal chemistry

authors： Kalász H,Antal I

更新日期：2006-01-01 00:00:00

abstract：:Many serious inflammatory disorders and nutrient deficiencies induce chronic pain, and anti-inflammatory diets have been applied successfully to modify the inflammatory symptoms causing chronic pain. Numerous scientific data and clinical investigations have demonstrated that long-term inflammation could lead to an ina...

journal_title：Current medicinal chemistry

authors： Bjørklund G,Chirumbolo S,Dadar M,Pen JJ,Doşa MD,Pivina L,Semenova Y,Aaseth J

更新日期：2020-01-01 00:00:00

abstract：:Various human tumors preferentially metastasize by lymphatic route and lymphovascular invasion predicts lymph node metastasis. In this review article, we will summarize recent literature data concerning lymphangiogenesis, focusing on tumor lymphangiogenesis. In detail, we try to answer some important questions related...

journal_title：Current medicinal chemistry

authors： Raica M,Ribatti D

更新日期：2010-01-01 00:00:00

abstract：:Andrographolide, the main bioactive component separated from Andrographis paniculata in 1951, have been scrutinized with modern drug discovery approach for anti-inflammatory properties since 1984. Identifying new uses for existing drugs can be facilitated by evidence linking them to known or yet undiscovered drug targ...

journal_title：Current medicinal chemistry

authors： Ren X,Xu W,Sun J,Dong B,Awala H,Wang L

更新日期：2020-08-10 00:00:00

abstract：:In the hit to lead process, a drug candidate is selected from a set of potential leads by screening its binding with potential targets. This review focuses on the lead identification assays that employ a bio-chemical or bio-physical test to detect molecular recognition events between proteins and small molecules in a ...

journal_title：Current medicinal chemistry

authors： Bergese P,Cretich M,Oldani C,Oliviero G,Di Carlo G,Depero LE,Chiari M

更新日期：2008-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor agent more than three decades ago, current knowledge places it central to immune system homeostasi...

journal_title：Current medicinal chemistry

authors： Richmond V,Michelini FM,Bueno CA,Alché LE,Ramírez JA

更新日期：2015-01-01 00:00:00

abstract：:Snakes are fascinating creatures and have been residents of this planet well before ancient humans dwelled the earth. Venomous snakes have been a figure of fear, and cause notable mortality throughout the world. The venom constitutes families of proteins and peptides with various isoforms that make it a cocktail of di...

journal_title：Current medicinal chemistry

authors： Waheed H,Moin SF,Choudhary MI

更新日期：2017-01-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (HoFH) represent the most severe patients within the spectrum of dyslipidemias. Untreated Low-Density Lipoprotein Cholesterol (LDL-C) levels in these patients are usually in the range 500 to 1200 mg/dL. Moreover, these patients exhibit a scarce responsiveness or e...

journal_title：Current medicinal chemistry

authors： Stefanutti C,Morozzi C,Di Giacomo S

更新日期：2012-01-01 00:00:00

abstract：:The mitotic cell cycle is a tightly regulated process that ensures the correct division of one cell into two daughter cells. Progress along the different phases of the cell cycle is positively regulated by the sequential activation of a family of serine-threonine kinases called CDKs (Cyclin Dependent Kinases). Their a...

journal_title：Current medicinal chemistry

authors： Belletti B,Nicoloso MS,Schiappacassi M,Chimienti E,Berton S,Lovat F,Colombatti A,Baldassarre G

更新日期：2005-01-01 00:00:00