A Review on GABA/Glutamate Pathway for Therapeutic Intervention of ASD and ADHD

abstract：:The development of bacterial resistance is a significant problem in the treatment of infection, and the importance of research directed toward the discovery of novel agents to treat infections cannot be underestimated. In the past, discovery programs have focused on modification of natural products or existing classes...

journal_title：Current medicinal chemistry

authors： Harris CR,Thorarensen A

更新日期：2004-08-01 00:00:00

abstract：:Aberrant activation of the signal transducer and activator of transcription (STAT) 3 occurs in many human tumors. Constitutive STAT3 activity induces specific target genes that stimulate cell proliferation, prevent apoptosis, promote angiogenesis and facilitate tumor immune evasion. Thus, STAT3 is an attractive molecu...

journal_title：Current medicinal chemistry

authors： Zhao M,Jiang B,Gao FH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:In the last two decades, there have been significant technological advances in the early detection of brain tumors. However, no notable improvements have been observed in the treatment of Glioblastoma Multiforme (GBM), the most common brain neoplasm coupled with the worst prognosis. GBM is characterized by a...

journal_title：Current medicinal chemistry

authors： Arévalo ÁST,Erices JI,Uribe DA,Howden J,Niechi I,Muñoz S,Martín RS,Monrás CAQ

更新日期：2017-01-01 00:00:00

abstract：:Protein tyrosine phosphatases (PTPs) are crucial regulators for numerous biological processes in nature. The dysfunction and overexpression of many PTP members have been demonstrated to cause fatal human diseases such as cancers, diabetes, obesity, neurodegenerative diseases and autoimmune disorders. In the past decad...

journal_title：Current medicinal chemistry

authors： He XP,Xie J,Tang Y,Li J,Chen GR

更新日期：2012-01-01 00:00:00

abstract：:The discovery of the high-affinity, high-specificity folate receptor in mamalian kidney cells, coupled with the ability of folate to enter cells by folate receptor-mediated endocytosis and the subsequent elucidation of the folate receptor's overexpression in specific cancer cell types; heralded the arrival of the area...

journal_title：Current medicinal chemistry

authors： Carron PM,Crowley A,O'Shea D,McCann M,Howe O,Hunt M,Devereux M

更新日期：2018-01-01 00:00:00

abstract：:In this review, we report the functionalization of textiles composed of nanoscale reactive materials in the treatment of wounds and skin diseases such as acne. In view of the growing demand for high-quality textiles, much research is focused on the creation of antimicrobial finishings for fabrics, in order to protect ...

journal_title：Current medicinal chemistry

authors： Gedanken A,Perkas N,Perelshtein I,Lipovsky A

更新日期：2018-01-01 00:00:00

abstract：:ATP-sensitive K(+) channels (K(ATP)channels) regulate insulin secretion by coupling intracellular metabolic changes to excitability of the plasma membrane in pancreatic beta-cells. The channels are closed when extracellular glucose levels are elevated due to enhanced feature. By contrast, cardiac-type K(ATP) channels,...

journal_title：Current medicinal chemistry

authors： Kakei M

更新日期：2003-02-01 00:00:00

abstract：:Cholecystokinin (CCK) is an important neuro-intestinal peptide hormone produced by the enteroendocrine I-cells in the upper part of small intestine. Protein- and fat-enriched food plays an important role in triggering CCK secretion from the intestine. Carbohydrates stimulate only small amounts of CCK release. The CCK-...

journal_title：Current medicinal chemistry

authors： Wang HH,Portincasa P,Wang DQ

更新日期：2019-01-01 00:00:00

abstract：:Acyclic nucleoside analogues bearing phosphonomethoxy residues in the side chain (ANP) attract much attention due to a very beneficial combination of biological properties. Intensive work of organic chemists during the last two decades resulted in a large panel of new compounds that were evaluated as potential antivir...

journal_title：Current medicinal chemistry

authors： Khandazhinskaya A,Yasko M,Shirokova E

更新日期：2006-01-01 00:00:00

abstract：:Neural differentiation of embryonic stem cells (ESC) is considered a promising model to perform in vitro testing for neuroactive and neurotoxic compounds. We studied the potential of a dual reporter murine ESC line to identify bioactive and/or toxic compounds. This line expressed firefly luciferase under the control o...

journal_title：Current medicinal chemistry

authors： Kern I,Xu R,Julien S,Suter DM,Preynat-Seauve O,Baquié M,Poncet A,Combescure C,Stoppini L,Thriel CV,Krause KH

更新日期：2013-01-01 00:00:00

abstract：AIMS:Salvianolic acid B (Sal B), one of the most active components of Danshen extracts, has beneficial roles in the prevention and treatment of cardiovascular diseases. However, the precise mechanism by which Sal B exerts its effects on vascular cells is unclear. We aimed to elucidate the effects of Sal B on vascular c...

journal_title：Current medicinal chemistry

authors： Lee HJ,Seo M,Lee EJ

更新日期：2014-01-01 00:00:00

abstract：:Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which h...

journal_title：Current medicinal chemistry

authors： Ahmed T,Javed S,Tariq A,Budzyńska B,D'Onofrio G,Daglia M,Nabavi SF,Nabavi SM

更新日期：2017-01-01 00:00:00

abstract：:Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a higher degree of complexity and accuracy. Moreover, thei...

journal_title：Current medicinal chemistry

authors： Santos M,Serrano-Dúcar S,González-Valdivieso J,Vallejo R,Girotti A,Cuadrado P,Arias FJ

更新日期：2019-01-01 00:00:00

abstract：:Osteoporosis is characterized by reduced bone mass and structural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk. Bone loss further increases in postmenopausal women when the ovaries stop making estrogens. Women undergoing treatment for osteoporosis require l...

journal_title：Current medicinal chemistry

authors： Bitto A,Polito F,Squadrito F,Marini H,D'Anna R,Irrera N,Minutoli L,Granese R,Altavilla D

更新日期：2010-01-01 00:00:00

abstract：:HupA is a potent, reversible AChEI, which crosses the blood-brain barrier smoothly, and shows high specificity for AChE with a prolonged biological half-life. It has been approved as the drug for the treatment of AD in China, and marketed in USA as a dietary supplement. HupA has been the subject of investigations by a...

journal_title：Current medicinal chemistry

authors： Jiang H,Luo X,Bai D

更新日期：2003-11-01 00:00:00

abstract：:Pyoverdine is the generic name given to a vast family of fluorescent green-yellowish pigments produced by Pseudomonas species. Pseudomonas aeruginosa is an opportunistic pathogen, particularly infecting humans with compromised natural defenses. These infections result in significantly higher morbidity, longer hospital...

journal_title：Current medicinal chemistry

authors： Cézard C,Farvacques N,Sonnet P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters regulation and release, and this ionic channel participates in biological process of memory, learning and attention. This work aims to review the structure and functioning of the α4β2 nAChR emphasizing its role in the treatment of a...

journal_title：Current medicinal chemistry

authors： Laikowski MM,Reisdorfer F,Moura S

更新日期：2019-01-01 00:00:00

abstract：:Coumarins are of many different structures. They constitute an important class of pharmacological agents possessing a range of different physiological activities including anti-cancer, anti-oxidant, anti- inflammation, anti-HIV, anti-coagulant, anti-bacterial, analgesic and comparative immune-modulation. Recently, cou...

journal_title：Current medicinal chemistry

authors： Wu L,Wang X,Xu W,Farzaneh F,Xu R

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Pollutants are diverse chemical entities, including gases such as ozone and particulate matter PM. PM contains toxic chemicals such as polycyclic aromatic hydrocarbons (PAHs). Some PAHs can induce strong oxidative stress under UVA exposure. Pollution aggravates some skin diseases such as atopy or eczema, but...

journal_title：Current medicinal chemistry

authors： Marrot L

更新日期：2018-01-01 00:00:00

abstract：:Excitatory neurotransmission mediated by NMDA (N-methyl-D-aspartic acid) receptors plays a key role in both healthy and diseased processes in the brain. Therefore, bioactive compounds that can interact selectively with these receptors have been the aim of extensive research in the search of effective therapeutic agent...

journal_title：Current medicinal chemistry

authors： Bonaccorso C,Micale N,Ettari R,Grasso S,Zappalà M

更新日期：2011-01-01 00:00:00

abstract：:Mast cells are best known as central effector cells in IgE-mediated type I allergic diseases including asthma and hay fever. An increasing amount of evidence, however, has demonstrated that mast cells are sentinel cells playing a critical role in host defense against invading microbes. Mast cells are located immediate...

journal_title：Current medicinal chemistry

authors： Matsuguchi T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family that plays a key role in the inflammatory process. It has been broadly studied in the aspect of its role in obesity and diabetes related diseases. MCP-1 causes the infiltration of macrophages into obese adipose tissue via bindi...

journal_title：Current medicinal chemistry

authors： Czemplik M,Kulma A,Wang YF,Szopa J

更新日期：2017-01-01 00:00:00

abstract：:Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates. It is involved in the metabolic transformation of arginine and proline, and it participates in the urea cycle in vertebrates and in the formation of pu...

journal_title：Current medicinal chemistry

authors： Díaz-Muñoz M,Hernández-Muñoz R

更新日期：2010-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor agent more than three decades ago, current knowledge places it central to immune system homeostasi...

journal_title：Current medicinal chemistry

authors： Richmond V,Michelini FM,Bueno CA,Alché LE,Ramírez JA

更新日期：2015-01-01 00:00:00

abstract：:The use of antisense oligonucleotides as therapeutic agents has generated considerable enthusiasm in the research and medical community. Antisense oligonucleotides as therapeutic agents were proposed as far back as in the 1970s when the antisense strategy was initially developed. Nonetheless, it has taken almost a qua...

journal_title：Current medicinal chemistry

authors： Aboul-Fadl T

更新日期：2005-01-01 00:00:00

abstract：:Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure, these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and "others". In addition, they may contain diver...

journal_title：Current medicinal chemistry

authors： Burčul F,Blažević I,Radan M,Politeo O

更新日期：2020-01-01 00:00:00

abstract：:Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β- unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical asp...

journal_title：Current medicinal chemistry

authors： De P,Baltas M,Bedos-Belval F

更新日期：2011-01-01 00:00:00

abstract：:Ion channel dysfunction has been identified as a contributor to symptom development and neurodegeneration in multiple sclerosis (MS). The molecular insights have been translated into new lines of research, with ion channel modulation now representing a therapeutic approach in MS. Studies of Na+ channel function have d...

journal_title：Current medicinal chemistry

authors： Arnold R,Huynh W,Kiernan MC,Krishnan AV

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid plaques and neurofibrillary tangles. AD pathology is derived from the cholinergic, amyloid and tau hypotheses, respectively. Curren...

journal_title：Current medicinal chemistry

authors： Mohamed T,Rao PP

更新日期：2011-01-01 00:00:00

abstract：:Nanomedicine is certainly one of the scientific and technological challenges of the coming years. In particular, biodegradable nanoparticles formulated from poly (D,L-lactide-co-glycolide) (PLGA) have been extensively investigated for sustained and targeted delivery of different agents, including recombinant proteins,...

journal_title：Current medicinal chemistry

authors： Tosi G,Bortot B,Ruozi B,Dolcetta D,Vandelli MA,Forni F,Severini GM

更新日期：2013-01-01 00:00:00