Genistein aglycone: a dual mode of action anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation.

abstract：:Cancer is the world's second leading cause of death after heart diseases, and involves abnormal cell growth at a primary site and the potential to spread to other parts of the body. Tumors are highly heterogeneous and consist of subgroups of cells with distinct characteristics. Of these, the cancer stem cells (CSC) ni...

journal_title：Current medicinal chemistry

authors： Vizetto-Duarte C,Branco PC,Custódio L

更新日期：2020-03-20 00:00:00

abstract：:The inhibition of protein degradation through the ubiquitin-proteasome pathway is a recently developed approach to cancer treatment which extends the range of cellular targets for chemotherapy. This therapeutic strategy is very interesting since the proteasomes carry out the regulated degradation of unnecessary or dam...

journal_title：Current medicinal chemistry

authors： Gilardini A,Marmiroli P,Cavaletti G

更新日期：2008-01-01 00:00:00

abstract：:Frontotemporal Lobar Degeneration (FTLD) is characterized by behavioral changes, executive dysfunctions, and language impairment, sustained by different neuropathological patterns. The collective efforts of clinical, pathological and genetic studies have recently opened new insights into the underpinnings of pathologi...

journal_title：Current medicinal chemistry

authors： Bigni B,Premi E,Pilotto A,Padovani A,Borroni B

更新日期：2012-01-01 00:00:00

abstract：:Recent results using animal models of inflammatory skin conditions have shown that blockers of the voltage-gated potassium channel, Kv1.3 hold great promise for clinical utility. Kv1.3 blockers act as immunosuppressants by modulating the various subsets of inflammatory T and B cells involved in autoimmune disorders. W...

journal_title：Current medicinal chemistry

authors： Nguyen W,Howard BL,Neale DS,Thompson PE,White PJ,Wulff H,Manallack DT

更新日期：2010-01-01 00:00:00

abstract：:Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of...

journal_title：Current medicinal chemistry

authors： Chiacchio MA,Lanza G,Chiacchio U,Giofrè SV,Romeo R,Iannazzo D,Legnani L

更新日期：2019-01-01 00:00:00

abstract：:Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β- unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical asp...

journal_title：Current medicinal chemistry

authors： De P,Baltas M,Bedos-Belval F

更新日期：2011-01-01 00:00:00

abstract：:Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clin...

journal_title：Current medicinal chemistry

authors： Almeida Rezende B,Pereira AC,Cortes SF,Lemos VS

更新日期：2016-01-01 00:00:00

abstract：:Inflammation plays a critical role in the atherosclerotic process in various vascular beds, starting from endothelial dysfunction and counting all stages of plaque development. The significant contribution of inflammation in the initiation and progression of atherosclerosis has been documented over many years but its ...

journal_title：Current medicinal chemistry

authors： Vavuranakis M,Kariori M,Vrachatis D,Siasos G,Kalogeras K,Bei E,Moldovan C,Lavda M,Aznaouridis K,Oikonomou E,Tousoulis D

更新日期：2015-01-01 00:00:00

abstract：:The biological relevance of sulfur containing carbohydrates is gaining substantial attention. Thus the new developments, especially in the synthetic and medicinal chemistry of thio-sugars are critically important for carbohydrate drug design. New studies of biological processes including biosynthetic reactions and enz...

journal_title：Current medicinal chemistry

authors： Witczak ZJ

更新日期：1999-02-01 00:00:00

abstract：:Breast cancer arises in about 48% of patients older than 65 years and more than 30% occurs in those over 70 years being the leading cause of cancer-related death in women older than 65. Elderly patients tolerate chemotherapy poorly compared to their younger counterpart because of progressive reduction of organ functio...

journal_title：Current medicinal chemistry

authors： Rossi A,Colantuoni G,Maione P,Ferrara C,Airoma G,Barzelloni ML,Castaldo V,Gridelli C

更新日期：2005-01-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from cl...

journal_title：Current medicinal chemistry

authors： Pan Q,Guo Y,Guo L,Liao S,Zhao C,Wang S,Liu HF

更新日期：2020-01-01 00:00:00

abstract：:Polymyxins are polypeptide antibiotics, with a primary effect of membrane damaging due to their selective binding to the lipopolysaccharide of Gram-negative bacteria. Their nephro- and neurotoxic side effects limited their use, however, in the last decade the emergence of multidrug-resistant Gram-negative bacteria led...

journal_title：Current medicinal chemistry

authors： Kadar B,Kocsis B,Nagy K,Szabo D

更新日期：2013-01-01 00:00:00

abstract：:Snake venoms are natural sources of biologically active molecules that are able to act selectively and specifically on different cellular targets, modulating physiological functions. Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecular ...

journal_title：Current medicinal chemistry

authors： Almeida JR,Resende LM,Watanabe RK,Carregari VC,Huancahuire-Vega S,da S Caldeira CA,Coutinho-Neto A,Soares AM,Vale N,de C Gomes PA,Marangoni S,de A Calderon L,Da Silva SL

更新日期：2017-01-01 00:00:00

abstract：:Two-component signal transduction systems and their expanded variants known as phosphorelays are integral elements of the virulence and antimicrobial resistance responses of a wide range of pathogenic bacteria and fungi and also regulate essential functions. As a consequence, two-component systems and phosphorelays ar...

journal_title：Current medicinal chemistry

authors： Stephenson K,Hoch JA

更新日期：2004-03-01 00:00:00

abstract：:Physalia physalis is a marine cnidarian from which high molecular weight toxins with hemolytic and neurotoxic effects have been isolated. In the present work, two novel toxins, PpV9.4 and PpV19.3 were purified from P. physalis by bioactive guideline isolation. It involved two steps of column chromatography, gel filtra...

journal_title：Current medicinal chemistry

authors： Diaz-Garcia CM,Fuentes-Silva D,Sanchez-Soto C,Domínguez-Pérez D,García-Delgado N,Varela C,Mendoza-Hernández G,Rodriguez-Romero A,Castaneda O,Hiriart M

更新日期：2012-01-01 00:00:00

abstract：:Iron is a key element for every single living process. On a fundamental level, targeting iron is a valuable approach for the treatment of disorders caused by iron overload. Utilizing iron chelators as therapeutic agents has received expanding consideration in chelation therapy. Approved low molecular weight (MW) iron ...

journal_title：Current medicinal chemistry

authors： Bulbake U,Singh A,Domb AJ,Khan W

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:We found a novel marine drug, SZ-685C, that was isolated from the secondary metabolites of a mangrove endophytic fungus (No. 1403) collected from the South China Sea, which has been reported to inhibit the proliferation of certain tumor cells. However, its anticancer mechanism remains unknown. The aims of thi...

journal_title：Current medicinal chemistry

authors： Chen CH,Xiao WW,Jiang XB,Wang JW,Mao ZG,Lei N,Fan X,Song BB,Liao CX,Wang HJ,She ZG,Zhu YH

更新日期：2013-01-01 00:00:00

abstract：:Antibiotics play an irreplaceable role in the prevention and treatment of bacterial infection diseases. However, because of the improper use of antibiotics, bacterial resistance emerges as a major challenge of public health all over the world. The small thiol molecules such as glutathione can directly react and conjug...

journal_title：Current medicinal chemistry

authors： Ouyang Y,Li J,Peng Y,Huang Z,Ren Q,Lu J

更新日期：2020-01-01 00:00:00

abstract：:We apply noval techniques, the Scaling Index Method (SIM), which reveals local topology of the structure, and the Minkowski Functionals (MF), which provide four global topological characteristics, to assess strength of the trabecular network of the human bone. We compare capabilities of these methods with the standard...

journal_title：Current medicinal chemistry

authors： Sidorenko I,Monetti R,Bauer J,Mueller D,Rummeny E,Eckstein F,Matsuura M,Lochmueller EM,Zysset P,Raeth C

更新日期：2011-01-01 00:00:00

abstract：:Complete DNA sequence information has now been obtained for several prokaryotic genomes, defining the entire genetic complement of these organisms. The collection of genomic data has provided new insights into the molecular architecture of bacterial cells, revealing the basic genetic and metabolic structures that supp...

journal_title：Current medicinal chemistry

authors： Buysse JM

更新日期：2001-12-01 00:00:00

abstract：:Ion channel dysfunction has been identified as a contributor to symptom development and neurodegeneration in multiple sclerosis (MS). The molecular insights have been translated into new lines of research, with ion channel modulation now representing a therapeutic approach in MS. Studies of Na+ channel function have d...

journal_title：Current medicinal chemistry

authors： Arnold R,Huynh W,Kiernan MC,Krishnan AV

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). This review aims to provide a synopsis of the current information concerning the biologic...

journal_title：Current medicinal chemistry

authors： Pasqua T,Angelone T,Spena A,Cerra MC

更新日期：2017-01-01 00:00:00

abstract：:Although the renin-angiotensin system (RAS) is already an old acquaintance, there are often exciting discoveries that improve our knowledge of it and open new therapeutic possibilities. Moreover, well-established drugs, such as angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or be...

journal_title：Current medicinal chemistry

authors： Ramírez-Sánchez M,Prieto I,Wangensteen R,Banegas I,Segarra AB,Villarejo AB,Vives F,Cobo J,de Gasparo M

更新日期：2013-01-01 00:00:00

abstract：:Demyelination occurs in several central nervous system (CNS) disorders, including multiple sclerosis, viral infection and spinal cord injury and can result in severe functional impairment. Therefore there is great interest in developing therapies promoting repair in CNS demyelinating diseases and trauma. Cell replacem...

journal_title：Current medicinal chemistry

authors： Lavdas AA,Papastefanaki F,Thomaidou D,Matsas R

更新日期：2008-01-01 00:00:00

abstract：:The lung is a unique organ in terms of its direct exposure to high levels of oxygen and reactive compounds. Several parenchymal lung diseases (e.g. emphysema associated with smoking and a number of fibrotic lung disorders) have been proposed to be due to the exposure of the lung to exogenous irritants leading to local...

journal_title：Current medicinal chemistry

authors： Kinnula VL,Vuorinen K,Ilumets H,Rytilä P,Myllärniemi M

更新日期：2007-01-01 00:00:00

abstract：:Mitochondria are organelles which play an important role not only in cellular metabolism but also in controlling pathways related with cell death, ionic and redox regulation. Alterations in mitochondrial metabolism are implicated in a variety of diseases, including cancer. Cellular and mitochondrial metabolism are bot...

journal_title：Current medicinal chemistry

authors： Deus CM,Santos GL,Loureiro R,Vega-Naredo I,Faneca H,Oliveira PJ

更新日期：2015-01-01 00:00:00

abstract：:Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme of cholesterol synthesis. In recent years, statins have become the major choice of treatment for hypercholesterolemia. Emerging evidence from both animal and human studies indicates that mechanisms i...

journal_title：Current medicinal chemistry

authors： Luo JD,Chen AF

更新日期：2003-08-01 00:00:00

abstract：:Glucocorticoids (GC) play a fundamental role in controlling physiologic homeostasis and, when present in excess, can have a detrimental impact on glucose control, blood pressure and lipid levels. The oxidoreductase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mainly catalyzes the intracellular regeneration...

journal_title：Current medicinal chemistry

authors： Ge R,Huang Y,Liang G,Li X

更新日期：2010-01-01 00:00:00

abstract：:Cocaine is one of the most used psychomotor stimulants all over the world. On this basis, the interest for the pharmacological activity and the pharmacodynamic and pharmacokinetic aspects of this drug is very prominent in both clinical and forensic toxicological environments. The review presents and discusses 65 scien...

journal_title：Current medicinal chemistry

authors： Bortolotti F,Gottardo R,Pascali J,Tagliaro F

更新日期：2012-01-01 00:00:00

abstract：:For many years the spotlight in drug discovery has been on a relatively small number of validated therapeutic target classes, such as G-protein coupled receptors and enzymes such as protein kinases, with well characterized enzymatic and cellular activities. However, with recent progress in genomics and proteomics, pro...

journal_title：Current medicinal chemistry

authors： De Giorgi M,Voisin-Chiret AS,Rault S

更新日期：2013-01-01 00:00:00