Oxazole-Based Compounds As Anticancer Agents.

Abstract:

:Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

journal_name

Curr Med Chem

authors

Chiacchio MA,Lanza G,Chiacchio U,Giofrè SV,Romeo R,Iannazzo D,Legnani L

doi

10.2174/0929867326666181203130402

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

7337-7371

issue

41

eissn

0929-8673

issn

1875-533X

pii

CMC-EPUB-94973

journal_volume

26

pub_type

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