Abstract:
:Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Chiacchio MA,Lanza G,Chiacchio U,Giofrè SV,Romeo R,Iannazzo D,Legnani Ldoi
10.2174/0929867326666181203130402subject
Has Abstractpub_date
2019-01-01 00:00:00pages
7337-7371issue
41eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-94973journal_volume
26pub_type
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