Targeting leukocytes in immune glomerular diseases.

abstract：:The transport of organic and inorganic molecules, along with inorganic ions across the plasma membrane results in chemical fluxes that reflect the cellular function in healthy and diseased states. Measurement of these chemical fluxes enables the characterization of protein function and transporter stoichiometry, chara...

journal_title：Current medicinal chemistry

authors： Messerli MA,Sarkar A

更新日期：2019-05-06 00:00:00

abstract：:Cell products are live cells that are given to patients in order to replace or modify the function of missing or dysfunctional cells. Progress in technology and in the understanding of pathobiology may lead to the use of cell products in many areas. This review outlines the use of cell products in the treatment of aut...

journal_title：Current medicinal chemistry

authors： Ernerudh J,Berlin G,Ekerfelt C

更新日期：2002-08-01 00:00:00

abstract：:Protein-ligand docking is currently an important tool in drug discovery efforts and an active area of research that has been the subject of important developments over the last decade. These are well portrayed in the rising number of available protein-ligand docking software programs, increasing level of sophisticatio...

journal_title：Current medicinal chemistry

authors： Sousa SF,Ribeiro AJ,Coimbra JT,Neves RP,Martins SA,Moorthy NS,Fernandes PA,Ramos MJ

更新日期：2013-01-01 00:00:00

abstract：:Hypoxia in tumor cells is characterized by a lack of oxygen resulting from reduced blood supply to the surrounding tissue, and is a common characteristic of solid tumors as a consequence of rapid cell growth. Hypoxia in tumors is a predictor of both resistance to chemotherapy and of a metastatic/aggressive form of can...

journal_title：Current medicinal chemistry

authors： Liang D,Miller GH,Tranmer GK

更新日期：2015-01-01 00:00:00

abstract：:Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer's disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals pl...

journal_title：Current medicinal chemistry

authors： Jamasbi E,Wade JD,Separovic F,Hossain MA

更新日期：2016-01-01 00:00:00

abstract：:Sweat is an alternative biological matrix useful to detect drugs of abuse intake. It is produced by eccrine and apocrine glands originating in the skin dermis and terminating in secretory canals that flow into the skin surface and hair follicles. Since many years it has been demonstrated that endogenous and exogenous ...

journal_title：Current medicinal chemistry

authors： De Giovanni N,Fucci N

更新日期：2013-01-01 00:00:00

abstract：:Nitric Oxide (NO) is a signaling radical, highly diffusible pleiotropic regulator of a large set of different molecular and biological pathways, including, neurotransmission, vasodilatation and macrophagemediated responses against infections. It is produced from the amino acid L-Arginine and oxygen by the enzymatic ac...

journal_title：Current medicinal chemistry

authors： Fionda C,Abruzzese MP,Santoni A,Cippitelli M

更新日期：2016-01-01 00:00:00

abstract：:N-BP, rapamycin and its derivatives have been originally developed respectively as anti-resorptive and anti-fungal agents. In fact, in vitro and in vivo experiments demonstrated that these compounds are multi-functional molecules exerting their effects on tumour cell growth and bone remodelling. The major challenge in...

journal_title：Current medicinal chemistry

authors： Ory B,Moriceau G,Redini F,Heymann D

更新日期：2007-01-01 00:00:00

abstract：:More than five decades since the Discovery of Penicillin, the chemistry and biological activity of b-lactams continue to attract the wide spread attention of research workers. Owing to high efficacy and extremely safe toxicological profile, they are agents of choice in the current therapeutic index for the bacterial i...

journal_title：Current medicinal chemistry

authors： Kidwai M,Sapra P,Bhushan KR

更新日期：1999-03-01 00:00:00

abstract：:Currently available therapeutic options for non-insulin-dependent diabetes mellitus, such as dietary modification, oral hypoglycemics, and insulin, have limitations of their own. Many natural products and herbal medicines have been recommended for the treatment of diabetes. The present paper reviews medicinal plants t...

journal_title：Current medicinal chemistry

authors： Jung M,Park M,Lee HC,Kang YH,Kang ES,Kim SK

更新日期：2006-01-01 00:00:00

abstract：:The emergence of bacterial strains with resistance to currently marketed antibacterial agents has spurred interest in the discovery of new antibacterial agents with novel modes of action. One set of potential novel targets are the family of bacterial aminoacyltRNA synthetases (AaRS). Aminoacyl-tRNA synthetases are the...

journal_title：Current medicinal chemistry

authors： Lv PC,Zhu HL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Stimuli-responsive carriers are a class of drug delivery systems which can change their physicochemical properties and/or structural conformations in response to specific stimuli. Although passive and active drug targeting has proved to reduce the side effects to normal cells, controlled intracellular drug r...

journal_title：Current medicinal chemistry

authors： Sheng Y,Hu J,Shi J,Lee LJ

更新日期：2019-01-01 00:00:00

abstract：:Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA). Depending on the position of insertion of oxygen, LOXs are classified into 5-, 8-, 9-, 12- and 15-LOX. Among these, 5-LOX is the most predominant isoform asso...

journal_title：Current medicinal chemistry

authors： Aparoy P,Reddy KK,Reddanna P

更新日期：2012-01-01 00:00:00

abstract：:Staphylococcus aureus is a notorious pathogenic bacterium causing a wide range of diseases from soft-tissue contamination, to more serious and deep-seated infections. This species is highlighted by its ability to express several kinds of virulence factors and to acquire genes related to drug resistance. Target this nu...

journal_title：Current medicinal chemistry

authors： Diniz RC,Soares LW,Nascimento da Silva LC

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Myocardial redox state is a critical determinant of atrial biology, regulating cardiomyocyte apoptosis, ion channel function, and cardiac hypertrophy/fibrosis and function. Nevertheless, it remains unclear whether the targeting of atrial redox state is a rational therapeutic strategy for atrial fibrillation ...

journal_title：Current medicinal chemistry

authors： Antonopoulos AS,Goliopoulou A,Oikonomou E,Tsalamandris S,Papamikroulis GA,Lazaros G,Tsiamis E,Latsios G,Brili S,Papaioannou S,Gennimata V,Tousoulis D

更新日期：2019-01-01 00:00:00

abstract：:The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the fundamental characteristics critical for the biology of eukaryotes, in particular, survival and malignant transformation of cells. The members of this protein family (Pim-1 to Pim-3) are aberrant...

journal_title：Current medicinal chemistry

authors： Anizon F,Shtil AA,Danilenko VN,Moreau P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Leukotrienes (LTs) constitute a bioactive group of polyunsaturated fatty acid (PUFA) metabolites molded by the enzymatic activity of lipoxygenase (LO) and have a pivotal role in inflammation and allergy. Evidence is accumulating both by in vitro cell culture experiments and animal tumor model studies in supp...

journal_title：Current medicinal chemistry

authors： Mahboubi-Rabbani M,Zarghi A

更新日期：2019-12-09 00:00:00

abstract：:K(V)10.1 has recently become generally accepted as a promising cancer target, as it is ectopically expressed in the majority of solid tumors. Due to its cell-surface accessibility, K(V)10.1 has a strong potential for tumor treatment and diagnosis. Given that its mode of action is likely independent of conventional can...

journal_title：Current medicinal chemistry

authors： Pardo LA,Gómez-Varela D,Major F,Sansuk K,Leurs R,Downie BR,Tietze LF,Stühmer W

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue specific action cannot be exerted, it could lead to several endocrine-meta...

journal_title：Current medicinal chemistry

authors： Ferrer MJ,Silva AF,Abruzzese GA,Velázquez ME,Motta AB

更新日期：2021-01-06 00:00:00

abstract：:Drug resistance is one of the major obstacles limiting the success of cancer chemotherapy. Biological mechanisms contributing to drug resistance may be present de novo and related to inherent features or may be raised after exposure to anticancer drugs. In recent years, both clinical observations and experimental stud...

journal_title：Current medicinal chemistry

authors： Sui M,Zhang H,Fan W

更新日期：2011-01-01 00:00:00

abstract：:Borderline Personality Disorder (BPD) is a common disorder in psychiatric practice and drugs are widely used in its treatment, targeting symptom clusters, such as affective dysregulation, impulsive-behavioural dyscontrol, and cognitive-perceptual symptoms. In last period, a growing number of studies on pharmacological...

journal_title：Current medicinal chemistry

authors： Bellino S,Rinaldi C,Bozzatello P,Bogetto F

更新日期：2011-01-01 00:00:00

abstract：:The development of bacterial resistance is a significant problem in the treatment of infection, and the importance of research directed toward the discovery of novel agents to treat infections cannot be underestimated. In the past, discovery programs have focused on modification of natural products or existing classes...

journal_title：Current medicinal chemistry

authors： Harris CR,Thorarensen A

更新日期：2004-08-01 00:00:00

abstract：:Whilst knowledge of basic biology, diagnosis and prognosis of glioblastoma (GB - WHO grade IV) are steadily improving, advancements of therapy are discouragingly slow, with the only significant novelty during last ten years represented by introduction of temozolomide in chemotherapy. In order to analyze the current st...

journal_title：Current medicinal chemistry

authors： Frosina G

更新日期：2015-01-01 00:00:00

abstract：:It is well accepted that inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is one of high risk factors for colorectal cancer (CRC). This supports the notion that inflammation plays a key role in cancer development. Epidemiologic studies have shown that vitamin D (Vit D) deficiency is ...

journal_title：Current medicinal chemistry

authors： Luan Z,Ma Y,Xin Y,Qian J,Wang H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Antimicrobial resistance is found in all microorganisms and has become one of the biggest threats to global health. New antimicrobials with different action mechanisms are effective weapons to fight against antibiotic-resistance. OBJECTIVE:This review aims to find potential drugs which can be further develo...

journal_title：Current medicinal chemistry

authors： Yi L,Lü X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The sterile alpha motif (Sam) domain is a small helical protein module, able to undergo homo- and hetero-oligomerization, as well as polymerization, thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable target...

journal_title：Current medicinal chemistry

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2020-01-01 00:00:00

abstract：:Honey has successfully been used in the treatment of a broad spectrum of injuries including burns and non-healing wounds. It acts as an antibacterial and anti-biofilm agent with anti/pro-inflammatory properties. However, besides these traditional properties, recent evidence suggests that honey is also an immunomodulat...

journal_title：Current medicinal chemistry

authors： Martinotti S,Bucekova M,Majtan J,Ranzato E

更新日期：2019-01-01 00:00:00

abstract：:During this past decade, science and engineering have seen a rapid increase in interest for nanoscale materials with dimensions less than 100 nm, which lie in the intermediate state between atoms and bulk (solid) materials. Their attributes are significantly altered relative to the corresponding bulk materials as they...

journal_title：Current medicinal chemistry

authors： Banerjee R,Katsenovich Y,Lagos L,McIintosh M,Zhang X,Li CZ

更新日期：2010-01-01 00:00:00

abstract：:Atrial fibrillation is the most common disorder of cardiac rhythm. In spite of diagnosis simplicity, patients with atrial fibrillation are difficult to treat. In the recent years with the description of the phenomenon called remodelling, it has been possible to better define the principle mechanisms responsible for in...

journal_title：Current medicinal chemistry

authors： Lombardi F,Terranova P

更新日期：2005-01-01 00:00:00

abstract：:Cholecystokinin (CCK) is an important neuro-intestinal peptide hormone produced by the enteroendocrine I-cells in the upper part of small intestine. Protein- and fat-enriched food plays an important role in triggering CCK secretion from the intestine. Carbohydrates stimulate only small amounts of CCK release. The CCK-...

journal_title：Current medicinal chemistry

authors： Wang HH,Portincasa P,Wang DQ

更新日期：2019-01-01 00:00:00